Abstract: The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for delivering such compositions. For example, the disclosure relates to modifying a gene sequence using a CRISPR-Cas9 or other nucleic acid editing system, and methods and delivery systems for achieving such gene modification, such as viral or non-viral delivery systems.

Abstract: The present disclosure relates to a power connector which comprises an insulative housing and a terminal. The insulative housing defines a terminal receiving groove therein and comprises a stopping wall. The terminal is positioned in the terminal receiving groove and comprises a mating portion, a stopping portion and a wire connecting portion. The stopping portion abuts against the stopping wall and comprises a first horizontal portion and a second horizontal portion. The first horizontal portion comprises a first front end edge. The second horizontal portion comprises a second front end edge.

Abstract: The present invention relates to the use of a plurality of dependency trees in tree-based statistical machine translation and proposes a dependency forest to effectively process the plurality of dependency trees. The present invention can improve a translation capability by generating a translation rule and a dependency language model by using the dependency forest and applying the generated translation rule and dependency language model when a source language text is converted to a target language text.

Abstract: A light emitting diode (LED) package includes an aluminum nitride (AlN) substrate, a patterned copper layer with polished portions formed on a first side of the substrate, at least one LED disposed over the polished portions of the patterned copper layer, covers incorporating one or more phosphors disposed over the LEDs, a silicone fill and dam walls. The silicone fill, which is bordered by silicone dam walls and silicon fill surfaces, is formed in between the LEDs and covers. In some embodiments, the silicone fill does not extend over the covers. The silicone fill surface and the ends of the dam walls are substantially planar with an end of the substrate. The LED package can also include a thermal pad disposed on an opposite side of the substrate. Embodiments also include methods for make the LED package.

Abstract: A method for identifying metadata for cyber content sharing and governance (abbreviated as an MDCCSG method) and application method thereof. The MDCCSG method is proposed based on the requirements of big data sharing and governance under a big data and pan media environment, and is applicable for generating unified identifications on various categories of content resources; and the application method matched with the MDCCSG method can effectively support high-efficient sharing and governance of the big data, wherein the MDCCSG method comprises a unified description framework of metadata, a unified specification method of metadata, and a definition of the core MDCCSG identification element; and the MDCCSG method not only can describe rich semantics of contents in detail, but also has a built-in content trust authentication and security assurance ability.

Abstract: The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for delivering such compositions. For example, the disclosure relates to modifying a gene sequence using a CRISPR-Cas9 or other nucleic acid editing system, and methods and delivery systems for achieving such gene modification, such as viral or non-viral delivery systems.

Abstract: The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or in combination with one another or Cas system components. Compositions comprising modified ribonucleic acids have been designed with chemical modification for even higher efficiency as unmodified native strand of sgRNA. Administration of modified ribonucleic acids will allow decreased immune response when administered to a subject, increased stability, increased editing efficiency and facilitated in vivo delivery of sgRNA via various delivery platforms. The disclosure also relates to methods of decreasing off-target effect of CRISPR and a CRISPR complex.

Abstract: The present disclosure relates to a syntax parsing apparatus based on syntax preprocessing and a method thereof. In specific, the present disclosure parses syntaxes that can be parsed by rules and patterns without ambiguity by syntax parsing preprocessing, draws all possible syntax parsing results by applying syntax rules based on a result of syntax parsing preprocessing in which ambiguity is partially resolved, and resolves structural ambiguity by applying a statistic syntax parsing model learned from a syntax tree attachment learning corpus so as to reduce ambiguity in rule-based syntax parsing and to resolve ambiguity by a statistics-based scheme so that parsing correctness and processing efficiency in a syntax parsing method can be enhanced.

Abstract: The present invention discloses a 3D food printer, which comprises a large hopper in a print head with a cooling system, so as to store and supply a large amount of a food material and print reliably at a high ambient temperature, and an automatic conveying system for printed products, so as to automatically output the food product after printing it, and then proceed with the next one. These features make the printer more effective, easier to operate, and in line with the requirements of food hygiene.

Abstract: The present disclosure relates to a syntax parsing apparatus based on syntax preprocessing and a method thereof. In specific, the present disclosure parses syntaxes that can be parsed by rules and patterns without ambiguity by syntax parsing preprocessing, draws all possible syntax parsing results by applying syntax rules based on a result of syntax parsing preprocessing in which ambiguity is partially resolved, and resolves structural ambiguity by applying a statistic syntax parsing model learned from a syntax tree attachment learning corpus so as to reduce ambiguity in rule-based syntax parsing and to resolve ambiguity by a statistics-based scheme so that parsing correctness and processing efficiency in a syntax parsing method can be enhanced.

Abstract: A method and apparatus for deploying edge servers are provided. The method includes: obtaining IP addresses of target users for the edge server to be deployed; mapping the IP addresses of the target users into a virtual geometric space; clustering the target users based on coordinates of the target users in the virtual geometric space, to obtain a plurality of user groups; and determining locations of the edge servers corresponding to the plurality of user groups based on the coordinates of the target users in the plurality of user groups.

Abstract: The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for deliverying such compositions. For example, the disclosure relates to modifying a gene sequence using a CRISPR-Cas9 or other nucleic acid editing system, and methods and delivery systems for achieving such gene modification, such as viral or non-viral delivery systems.

Abstract: The present disclosure relates to a syntax parsing apparatus based on syntax preprocessing and a method thereof. In specific, the present disclosure parses syntaxes that can be parsed by rules and patterns without ambiguity by syntax parsing preprocessing, draws all possible syntax parsing results by applying syntax rules based on a result of syntax parsing preprocessing in which ambiguity is partially resolved, and resolves structural ambiguity by applying a statistic syntax parsing model learned from a syntax tree attachment learning corpus so as to reduce ambiguity in rule-based syntax parsing and to resolve ambiguity by a statistics-based scheme so that parsing correctness and processing efficiency in a syntax parsing method can be enhanced.

Abstract: An electrical connector includes a housing and a conductive terminal. The housing includes a terminal slot and an insertion entrance in front of the terminal slot. The conductive terminal is correspondingly mounted in the terminal slot. The conductive terminal comprises a base portion, two side portions and two elastic arms, the base portion extends in a front-rear direction, the two side portions extend upwardly respectively at two sides of a rear end of the base portion, the two elastic arms extend respectively from the two side portions toward the insertion entrance of the housing so that a front end of each elastic arm is close to the insertion entrance. As depicted, a clamping portion is formed close to the front end of each elastic arm by punching a tab therein.

Abstract: Methods of transfecting cells in vivo, by administering an injectable pharmaceutical composition including a genome editing composition and a pharmaceutically acceptable carrier to a subject by hydrodynamic injection into a vessel of the subject are disclosed. Typically, the pharmaceutical composition is administered in a volume and at rate of injection suitable to transfect target eukaryotic cells in the subject with an effective amount of the genome editing composition to alter the genome of the target cells. In preferred embodiments the subject is a mammal, such as rodent, or a primate such as a human. The methods can be used to treat one or more symptoms of a genetic disease or condition.

Abstract: The present invention provides a compound of Formula (I) and a salt thereof, wherein, m is an integer of 2 to 7, and R is independently at least one selected from the group consisting of hydrogen and C1-C20 alkyl. The compound promotes apoptosis in cancer cell and inhibits its growth. The present invention also provides a pharmaceutical composition which comprises the compound of Formula (I), a salt thereof and a pharmaceutically acceptable carrier. The present invention further provides a method for production of the pharmaceutical composition used for treating cancer.

Abstract: The invention discloses a Pseudonocardia sp. and a method for preparing Deoxynyboquinone by utilizing the same. Pseudonocardia sp. SCSIO 01299 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011255 on Jul. 18, 2011. The Pseudonocardia sp. SCSIO 01299 can produce antibiotic Deoxynyboquinone, so that the Pseudonocardia sp. SCSIO 01299 can be utilized for preparing Deoxynyboquinone and a new way is provided for producing antibiotic Deoxynyboquinone with anti-tumor activity.

Abstract: The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.

Abstract: The present invention provides a compound of Formula (I) and a salt thereof, wherein, m is an integer of 2 to 7, and R is independently at least one selected from the group consisting of hydrogen and C1-C20 alkyl. The compound promotes apoptosis in cancer cell and inhibits its growth. The present invention also provides a pharmaceutical composition which comprises the compound of Formula (I), a salt thereof and a pharmaceutically acceptable carrier. The present invention further provides a method for production of the pharmaceutical composition used for treating cancer.

Abstract: The invention discloses marine Streptomyces sp., a Pyranosesquiterpene compound, as well as a preparation method and uses thereof. Streptomyces sp. SCSIO 01689 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011257 on Jul. 18, 2011. The Streptomyces sp. SCSIO 01689 can produce the Pyranosesquiterpene compound with better anti-Escherichia coli activity and anti-Artemia activity, as well as Cyclo(D)-Pro-(D)-Ile, Cyclo(D)-Pro-(D)-Leu and Cyclo(D)-trans-4-OH-Pro-(D)-Phe with better anti-Vibrio anguillarum activity and anti-Artemia activity, thereby providing a new way for preparing the Cyclo(D)-Pro-(D)-Ile, the Cyclo(D)-Pro-(D)-Leu and the Cyclo(D)-trans-4-OH-Pro-(D)-Phe. The Pyranosesquiterpene compound can be used for preparing anti-Escherichia coli medicaments and anti-Artemia medicaments, as well as preparing condiments as a condiment precursor compound.