Abstract: The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

Abstract: The present invention discloses a high resistance panel for thermal insulation consisting of an impermeable barrier and backing, a surface of low emissivity, an adhesive, a mixture of phononic cocrystals at both sides, and a support material in a honeycomb structure in between two sides. The high resistance panel reduces heat transfer and has an overall thermal conductivity in order of 10?3 w/(m·K), and a density of 20-100 kg/m3. The high resistance panel can be cut to any sizes to meet requirements for installation, and can be stacked or piled up to meet the requirements of thickness and thermal resistance in application.

Abstract: The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

Abstract: The present invention is a method of shoot apical meristem transformation for dicot plant via sufficient and micro wounding (SMW). The technical process includes: germinate the seeds in Petri dish or in the nutrient matrix which can be transplanted with the seedling; expose the shoot apical meristem by removing one cotyledon away; make sufficient and micro wounding transformation treatment in vivo to the apical meristem by stabbing and brushing for 2-3 times using the SMW brush having 100-5000 bristles which is 4-20 ?m in diameter for each one and 0.

Abstract: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

Abstract: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.

Abstract: The present invention is a method of shoot apical meristem transformation for monocot plant via sufficient and micro wounding (SMW). The technical process includes: expose the apical meristem by removing the coleoptile away when the shoot grows to 0.2-2 cm after 1-2 days of seed germination; make sufficient and micro wounding transformation to the apical meristem by stabbing and brushing for 2-3 times using the SMW brush having 100-5000 bristles which is 4-20 ?m in diameter for each one and 0.5-3 mm in exposed length, and dipped with the Agrobacterium tumefaciens containing binary vector harboring exogenous genes; develop the treated meristems directly to normal plants after co-cultivation; promote the plants to develop big spikes and set more seeds; harvest the seeds of T0 plants separately; detect and identify the transformation results in T1 generation which is bred from each individual T0 plant.

Abstract: A computerized method manages passwords to unlock an electronic device from a standby mode by taking changed GPS coordinates of a location of the electronic device and utilizing the changed coordinates in preset formulas to establish and require a new password in substitution for a current password, to allow unlocking of the electronic device.

Abstract: The present invention provides a method and a reactor for removing organic matters by immobilized-enzymatic electrode coupled electro-coagulation. In the method, in a single electrochemical system, an enzyme-modified electrode is combined with electro-coagulation to synergistically remove organic matters from water. Certain electrochemical parameters are controlled such that a polymerization reaction is performed between hydrogen peroxide generated by a cathode reaction and organic matters catalyzed by the immobilized-enzymatic electrode. After the polymerization reaction, the organic product enters an anode chamber through a pump. The organic product is precipitated and removed by performing a reaction between the organic product and different hydrolysis products from the electro-coagulation through a coagulating/flocculating effect of compression of a double electric layer, adsorption and electric neutralization as well as precipitation capture.

Abstract: The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.

Abstract: A method of using tester data packet signals and control instructions for testing multiple data packet signal transceiver devices under test (DUTs). During mutually alternating time intervals, selected ones of which are substantially contemporaneous, multiple tester data packet signals and DUT control instructions are used for concurrent testing of multiple DUTs.

Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.

Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.

Abstract: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

Abstract: A system may be configured to receive a request to generate code based on a model. The model may include a logical entity associated with a variable. The system may further be configured to identify a boundary for the variable based on a code section of the code corresponding to the logical entity and add alignment code to the code. The alignment code may be for the variable and based on the boundary.

Abstract: A computerized method manages passwords to unlock an electronic device from a standby mode by taking changed GPS coordinates of a location of the electronic device and utilizing the changed coordinates in preset formulas to establish and require a new password in substitution for a current password, to allow unlocking of the electronic device.

Abstract: A method for switching radio receivers includes: directing a FM radio receiver or an Internet radio receiver of an electronic device to receive radio signals; monitoring the intensity of radio signals received by the FM radio receiver and the network data stream received by the Internet radio receiver periodically; determining whether a switch condition for switching radio receivers between the FM radio receiver and the Internet radio receiver is satisfied according to the radio receiver currently employed, the intensity of radio signals received by the FM radio receiver, and the network data stream received by the Internet radio receiver; and switching between the FM radio receiver and the Internet radio receiver if the switch condition is satisfied. A related electronic device is also provided.

Abstract: Heteroaryl amide derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Abstract: The present invention relates to compounds of the general formula (I): wherein ring A, ring B, G, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.