Patents by Inventor He Zhao

He Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOFURO[3,2-c] PYRIDINES AND RELATED ANALOGS AS SEROTONIN SUB-TYPE 6 (5-HT6) MODULATORS FOR THE TREATMENT OF OBESITY, METABOLIC SYNDROME, COGNITION AND SCHIZOPHRENIA
    Publication number: 20120184531
    Abstract: The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.
    Type: Application
    Filed: January 18, 2012
    Publication date: July 19, 2012
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Peter R. GUZZO, Alan J. HENDERSON, Matthew ISHERWOOD, Chong Yew LEE, Animesh GHOSH, He ZHAO
  • 4,5-disubstituted-2-aryl pyrimidines
    Patent number: 8129395
    Abstract: 4,5-disubstituted-2-arypyrimidines of Formula I and Formula II are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I and II bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 4,5-disubstituted-2-arylpyrimidines, which are useful as probes for the localization of C5a receptors.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: March 6, 2012
    Assignee: Novartis International Pharmaceutical Ltd.
    Inventors: George D. Maynard, Manuka Ghosh, Jun Yuan, Kevin S. Currie, Scott Mitchell, Qin Guo, He Zhao
  • Aryl imidazoles and related compounds as C5a receptor modulators
    Patent number: 8119665
    Abstract: The invention provides packaged pharmaceutical preparations of Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the variables are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: February 21, 2012
    Assignee: Novartis International Pharmaceutical Ltd.
    Inventors: George P. Luke, George D. Maynard, Scott Mitchell, Andrew Thurkauf, Linghong Xie, LuYan Zhang, Suoming Zhang, He Zhao, Bertrand L. Chenard, Yang Gao, Bingsong Han, Xiao Shu He
  • Amino methyl imidazoles and related compounds as C5a receptor modulators
    Patent number: 8007767
    Abstract: Amino methyl imidazoles of Formula I are provided: wherein R, R1, R2, R3, R4, R5, and R6 are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. Additionally, this invention provides labeled amino methyl imidazoles compounds, which are useful as probes for the localization of C5a receptors.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: August 30, 2011
    Assignee: Novartis International Pharmaceutical Ltd.
    Inventors: Andrew Thurkauf, He Zhao, Suoming Zhang, Yang Gao
  • Heteroaryl Amide Derivatives
    Publication number: 20100216763
    Abstract: Heteroaryl amide derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
    Type: Application
    Filed: November 27, 2007
    Publication date: August 26, 2010
    Applicant: H. LUNDBECK A/S
    Inventors: Alan J. Hutchison, Hongbin Li, Jianmin Mao, David J. Wustrow, Jun Yuan, He Zhao
  • Support stand for flat-panel display monitor
    Patent number: 7764491
    Abstract: An exemplary support stand for a flat-panel display monitor, includes a base member, an elevating mechanism, and a rotatable mechanism. The elevating mechanism includes a support member and an elevating member. The support member is fixed on the base member. The elevating member is slidably connected to the support member. The rotatable mechanism includes a rotatable body. The rotatable body is rotatably positioned on the elevating member.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: July 27, 2010
    Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.
    Inventors: Cheng-He Zhao, Zhi-Guo Sun, Zhi-Bin Liu
  • Hybrid laser and resistance welding system and method
    Patent number: 7718917
    Abstract: An improved fusion welding system having a heating unit and welding device is adapted for increasing the efficiency of welding a plurality of workpieces. The system preferably presents a single-sided process, and includes first and second electrode wheels operable to heat a portion of the workpieces to a minimum temperature, and a translatable laser cooperatively configured to form a continuous weld within the heated portion. The preferred system provides the advantages of laser welding, such as precision, while enabling weld production at lower laser power outputs or faster welding speeds than conventional laser welding systems.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: May 18, 2010
    Assignees: GM Global Technology Operations, Inc., Jilin University
    Inventors: Pei-Chung Wang, Xihua Zhao, He Zhao
  • 4,5-Disubstituted-2-aryl pyrimidines
    Publication number: 20100022516
    Abstract: 4,5-disubstituted-2-arypyrimidines of Formula I and Formula II are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I and II bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 4,5-disubstituted-2-arylpyrimidines, which are useful as probes for the localization of C5a receptors.
    Type: Application
    Filed: January 26, 2009
    Publication date: January 28, 2010
    Inventors: George D. MAYNARD, Manuka GHOSH, Jun YUAN, Kevin S. CURRIE, Scott MITCHELL, Qin GUO, He ZHAO
  • SUPPORT STAND FOR FLAT-PANEL DISPLAY MONITOR
    Publication number: 20090256047
    Abstract: An exemplary support stand for a flat-panel display monitor, includes a base member, an elevating mechanism, and a rotatable mechanism. The elevating mechanism includes a support member and an elevating member. The support member is fixed on the base member. The elevating member is slidably connected to the support member. The rotatable mechanism includes a rotatable body. The rotatable body is rotatably positioned on the elevating member.
    Type: Application
    Filed: September 8, 2008
    Publication date: October 15, 2009
    Applicants: HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD ., HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: CHENG-HE ZHAO, ZHI-GUO SUN, ZHI-BIN LIU
  • Electrical connector
    Patent number: D586295
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: February 10, 2009
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D588992
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: March 24, 2009
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Xiao-Li Li, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D589453
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: March 31, 2009
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Xiao-Li Li, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D602871
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: October 27, 2009
    Assignee: Hon Hai Precision Ind. Co., Ltd
    Inventors: Jing-He Zhao, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D603339
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: November 3, 2009
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D603800
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: November 10, 2009
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D604247
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: November 17, 2009
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D605131
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: December 1, 2009
    Assignee: Hon Hai Precsion Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D610547
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: February 23, 2010
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Ping-Sheng Su
  • Cable connector assembly
    Patent number: D612809
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: March 30, 2010
    Assignee: Hon Hai Precision Ind. Co., Ltd
    Inventors: Jing-He Zhao, Ping-Sheng Su
  • Mouse
    Patent number: D619578
    Type: Grant
    Filed: May 24, 2009
    Date of Patent: July 13, 2010
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Jing-He Zhao, Ping-Sheng Su