Abstract: The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis.

Abstract: A method for correcting artifacts in artificial reality headsets is provided. The method includes coupling a first image portion into a waveguide in a display for an artificial reality device, provided by a first array of pixels, coupling a second image portion into the waveguide in the display, provided by a second array of pixels, directing the first image portion through an eyebox, directing the second image portion through the eyebox, and tiling, in a user's retina, the first image portion and the second image portion to form an image having an extended field of view that includes an overlapping area comprising light provided by the first array of pixels and the second array of pixels. A system including a memory storing instructions and a processor to execute the instructions to cause the system to perform the above method are also provided.

Abstract: A pupil-replicating lightguide includes an in-coupling grating structure, an out-coupling grating structure, and a phase compensation layer. The out-coupling grating structure has a spatially varying parameter such as grating duty cycle or grating thickness for evening out out-coupled distribution of light. The spatially varying out-coupling grating parameter disturbs the phase of the propagating image light. The phase compensation layer has a spatially varying optical thickness that compensates that disturbed phase to planarize an optical phase profile of out-coupled light, thereby improving a modulation transfer function of the pupil-replicating lightguide.

Abstract: A waveguide assembly is provided. The waveguide assembly includes a pair of pupil-replicating waveguides. The first pupil-replicating waveguide is configured for receiving an input beam of image light and providing an intermediate beam comprising multiple offset portions of the input beam. The second pupil-replicating waveguide is configured for receiving the intermediate beam from the first pupil-replicating waveguide and providing an output beam comprising multiple offset portions of the intermediate beam. The input beam may be expanded by the waveguide assembly in such a manner that pupil gaps are reduced or eliminated.

Abstract: An output grating for waveguide of a head-mounted display is configured to suppress the (1, 1) diffraction order of the output grating. The grating has a design of two or more materials having different refractive indices. The design is repeated periodically in a first dimension and repeated periodically in a second dimension, to form a two-dimensional pattern. A refractive index of the two-dimensional pattern is approximated by a two-dimensional Fourier series comprising a first coefficient of order (1, 0), a second coefficient of order (0, 1), and a third coefficient of order (1, 1). The third coefficient is less than half the first coefficient and less than half the second coefficient, such that light from the (1, 1) diffraction order of the grating is suppressed.

Abstract: A method for correcting artifacts in artificial reality headsets is provided. The method includes coupling a first image portion into a waveguide in a display for an artificial reality device, provided by a first array of pixels, coupling a second image portion into the waveguide in the display, provided by a second array of pixels, directing the first image portion through an eyebox, directing the second image portion through the eyebox, and tiling, in a user's retina, the first image portion and the second image portion to form an image having an extended field of view that includes an overlapping area comprising light provided by the first array of pixels and the second array of pixels. A system including a memory storing instructions and a processor to execute the instructions to cause the system to perform the above method are also provided.

Abstract: A waveguide display includes a waveguide, an input coupler configured to couple display light into the waveguide, and a surface-relief grating on the waveguide and configured to couple the display light out of the waveguide towards an eyebox of the waveguide display on a first side of the waveguide. The surface-relief grating is formed in a plurality of grating layers having uniform or non-uniform thickness profiles. The plurality of grating layers is characterized by a refractive index modulation that increases and then decreases as the distance of the grating layer from the waveguide increases.

Abstract: A pupil-replicating waveguide includes a high-index substrate and a low-index substrate coupled by an intermediate layer between the substrates. The refractive index of the intermediate layer is lower than the refractive index of the low-index substrate. The intermediate layer prevents highly oblique rays of image light from entering the low-index substrate, thereby reducing intensity drops in the field of view conveyed by the pupil-replicating waveguide, the intensity drops caused by insufficient replication of the highly oblique rays in the low-index substrate.

Abstract: A system for making a holographic medium for use in generating light patterns for eye tracking includes a light source configured to provide light and a beam splitter configured to separate the light into a first portion of the light and a second portion of the light that is spatially separated from the first portion of the light. The system also includes a first set of optical elements configured to transmit the first portion of the light for providing a first wide-field beam onto an optically recordable medium and one or more diffractive optical elements configured to receive the second portion of the light and project a plurality of separate light patterns onto the optically recordable medium for forming the holographic medium.

Abstract: An apparatus may include (1) a planar liquid-crystal structure including a plurality of liquid crystals, and (2) a plurality of electrodes coupled to the planar liquid-crystal structure such that (a) when a first plurality of voltages are applied to at least some of the plurality of electrodes, the plurality of liquid crystals are oriented such that the planar liquid-crystal structure operates as a diffraction grating having a first pitch, and (2) when a second plurality of voltages are applied to at least some of the plurality of electrodes, the plurality of liquid crystals are oriented such that the planar liquid-crystal structure operates as a diffraction grating having a second pitch different from the first pitch.

Abstract: A diffraction grating includes a substrate and a plurality of fringes supported by the substrate. The fringes run parallel to each other in a first direction. A refractive index of a material of the plurality of fringes is anisotropic, whereby a refractive index contrast of the diffraction grating depends on direction of electric field of an impinging light beam, and through that dependence is a function of an azimuthal angle of the impinging light beam. A dependence of the diffraction efficiency on the azimuthal angle is affected by the dependence of the refractive index contrast on the direction of electric field of an impinging light beam. A pupil-replicating waveguide may use such a diffraction grating as a coupler for in- our out-coupling image light.

Abstract: A display waveguide configured for conveying image light to a viewer has a waveguide body whose refractive index varies in the thickness direction to include a high-index region between lower-index regions. Multi-layer and gradient index implementations are described. The waveguide transmits a portion of image light within the high-index region of the waveguide to provide a wider field of view.

Abstract: A waveguide display includes a display projector for emitting polychromatic image light, and a waveguide assembly for transmitting image light to an exit pupil. The waveguide assembly includes two or more waveguides disposed in a stack, each having an in-coupler aligned with the other in-couplers and an offset out-coupler aligned with the other out-couplers. The assembly is configured so that at least one color channel of the image light propagates to the exit pupil along at least two waveguides. A method for selecting the waveguides of the stack to suppress color channel splitting at the exit pupil is provided.

Abstract: A waveguide display includes a source assembly, an output waveguide, and a controller. The source assembly includes a light source and an optics system. The light source includes source elements arranged in a 1D or 2D array that emit image light. The optics system includes a scanning mirror assembly that scans the image light to particular locations based on scanning instructions. The output waveguide receives the scanned image light from the scanning mirror assembly and outputs an expanded image light. In some embodiments, the waveguide display includes a source waveguide and the 1D array of source elements. The source waveguide receives a conditioned image light from the source assembly. The controller generates the scanning instructions and provides the scanning instructions to the scanning mirror assembly. In some embodiments, the controller provides the scanning instructions to an actuator assembly of the source waveguide.

Abstract: A pupil replication waveguide for a projector display includes a slab of transparent material for propagating display light in the slab via total internal reflection. A diffraction grating is supported by the slab. The diffraction grating includes a plurality of tapered slanted fringes in a substrate for out-coupling the display light from the slab by diffraction into a blazed diffraction order. A greater portion of the display light is out-coupled into the blazed diffraction order, and a smaller portion of the display light is out-coupled into a non-blazed diffraction order. The tapered fringes result in the duty cycle of the diffraction grating varying along the thickness direction of the diffraction grating, to facilitate suppressing the portion of the display light out-coupled into the non-blazed diffraction order.

Abstract: A system for making a holographic medium for use in generating light patterns for eye tracking includes a light source configured to provide light and a beam splitter configured to separate the light into a first portion of the light and a second portion of the light that is spatially separated from the first portion of the light. The system also includes a first set of optical elements configured to transmit the first portion of the light for providing a first wide-field beam onto an optically recordable medium and one or more diffractive optical elements configured to receive the second portion of the light and project a plurality of separate light patterns onto the optically recordable medium for forming the holographic medium.

Abstract: A system for making a holographic medium for use in generating light patterns for eye tracking includes a light source configured to provide light and a beam splitter configured to separate the light into a first portion of the light and a second portion of the light that is spatially separated from the first portion of the light. The system also includes a first set of optical elements configured to transmit the first portion of the light for providing a first wide-field beam onto an optically recordable medium and one or more diffractive optical elements configured to receive the second portion of the light and project a plurality of separate light patterns onto the optically recordable medium for forming the holographic medium.

Abstract: Techniques disclosed herein relate to modifying refractive index modulation in a holographic optical element, such as a holographic grating. According to certain embodiments, a holographic optical element or apodized grating includes a polymer layer comprising a first region characterized by a first refractive index and a second region characterized by a second refractive index. The holographic optical element or apodized grating includes a plurality of nanoparticles dispersed in the polymer layer. The nanoparticles have a higher concentration in either the first region or the second region. In some embodiments, the nanoparticles may be configured to increase the refractive index modulation. In some embodiments, the nanoparticles may be configured to apodize the grating by decreasing the refractive index modulation proximate to sides of the grating. The refractive index may be modulated by applying a monomer reservoir buffer layer to the polymer layer, either before or after hologram fabrication.

Abstract: The present disclosure relates to a pharmaceutical composition for suppressing cancer metastasis containing, as an active ingredient, an activator compound of the cancer metastasis inhibitor Nm23, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The compound according to the present disclosure may suppress the metastasis of cancer cells by promoting the activity of Nm23 associated with cancer metastasis, and thus may be useful as a pharmaceutical composition for suppressing cancer metastasis.