Patents by Inventor Helmut Buschmann

Helmut Buschmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8207156
    Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: June 26, 2012
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens, Jordi Quintana, Helmut Buschmann, Albert Dordal, Josep Mas
  • Publication number: 20110306673
    Abstract: This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.
    Type: Application
    Filed: February 21, 2006
    Publication date: December 15, 2011
    Applicant: GRUENENTHAL GMBH
    Inventors: Michael Gruss, Helmut Buschmann, Andreas Fischer, Wolfgang Hell, Dagmar Lischke
  • Publication number: 20110294898
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Application
    Filed: June 29, 2011
    Publication date: December 1, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Andreas FISCHER, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • Patent number: 8048890
    Abstract: Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compounds and processes for their production, the use thereof for producing pharmaceutical compositions, pharmaceutical compositions containing these compounds and methods of treatment using these compounds.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: November 1, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Heinrich Helmut Buschmann, Guenter Werner Englberger, Tieno Germann, Hagen-Heinrich Hennies, Corinna Maul, Bernd Sundermann, Joerg Holenz
  • Publication number: 20110263699
    Abstract: Metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament used for treating depression, and related methods of treating depression, pain and urinary incontinence.
    Type: Application
    Filed: July 1, 2011
    Publication date: October 27, 2011
    Applicant: GRUENENTHAL GmbH
    Inventors: Elmar Friderichs, Wolfgang Strassburger, Ulrich Jahnel, Derek Saunders, Hagen-Heinrich Hennies, Werner Englberger, Helmut Buschmann, Joerg Holenz, Oswald Zimmer
  • Patent number: 8044053
    Abstract: The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: October 25, 2011
    Assignee: Laboratories del Dr. Esteve, S.A.
    Inventors: Helmut Buschmann, Antonio Torrens-Jover, Josef Mas-Prio, Susana Yenes-Minguez
  • Publication number: 20110224172
    Abstract: Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compounds and processes for their production, the use thereof for producing pharmaceutical compositions, pharmaceutical compositions containing these compounds and methods of treatment using these compounds.
    Type: Application
    Filed: May 26, 2011
    Publication date: September 15, 2011
    Applicant: GRUENENTHAL GmbH
    Inventors: Heinrich Helmut BUSCHMANN, Guenter Werner Englberger, Tieno Germann, Hagen-Heinrich Hennies, Corinna Maul, Bernd Sundermann, Joerg Holenz
  • Patent number: 7994364
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: August 9, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Andreas Fischer, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • Publication number: 20110160181
    Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Application
    Filed: February 28, 2011
    Publication date: June 30, 2011
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: ANTONI TORRENS, JORDI QUINTANA, HELMUT BUSCHMANN, ALBERT DORDAL, JOSEP MAS
  • Publication number: 20110124657
    Abstract: The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor; to a method for identifying them as 5-HT7 ligands, especially as agonists, by using a pharmacophore and a descriptor's profile filter; to pharmaceutical compositions comprising them; and to their use in therapy, in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.
    Type: Application
    Filed: July 30, 2009
    Publication date: May 26, 2011
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Rosalia Pascual-Ramon, H. Helmut Buschmann
  • Patent number: 7897589
    Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: March 1, 2011
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens, Jordi Quintana, Helmut Buschmann, Albert Dordal, Josep Mas
  • Patent number: 7816358
    Abstract: Pharmaceutical formulations comprising N,N?disubstituted piperazine compounds and related methods of treatment using these formulations.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: October 19, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Heinz Uragg, Corinna Maul, Helmut Buschmann, Bernd Sundermann, Michael Haubrand, Boris Chizh
  • Patent number: 7790898
    Abstract: Substituted 3-phenylpiperidine compounds corresponding to Formula I in which R1 and R2 have the meanings defined in the specification, methods for preparing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting various conditions, especially pain.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: September 7, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Joerg Holenz, Helmut Buschmann, Michael Finkam
  • Publication number: 20100160447
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Application
    Filed: December 10, 2009
    Publication date: June 24, 2010
    Applicant: Gruenenthal GmbH
    Inventors: Andreas Fischer, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • Publication number: 20100105684
    Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment or prophylaxis of various disorders of humans or animals.
    Type: Application
    Filed: March 28, 2008
    Publication date: April 29, 2010
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Monica Garcia-Lopez, Antonio Torrens-Jover, Helmut Buschmann
  • Publication number: 20100075992
    Abstract: The present invention refers to the use of a sodium channel blocker such as tetrodotoxin or saxitoxin, their analogues and derivatives as well as their physiologically acceptable salts, in medicinal products for human therapeutics for the treatment of peripheral-nervously derived neuropathic pain.
    Type: Application
    Filed: September 20, 2005
    Publication date: March 25, 2010
    Applicant: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Helmut Buschmann, Frank Hay Kong Shum, Kim Noel Fisher, Anh Ho Ngoc, Michel Hamon
  • Publication number: 20100035936
    Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.
    Type: Application
    Filed: February 6, 2008
    Publication date: February 11, 2010
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Monica Garcia-Lopez, Antonio Torrens-Jover, Helmut Buschmann
  • Patent number: 7569585
    Abstract: Substituted 1,5-diaminopentan-3-ol compounds and methods of making the same. Pharmaceutical compositions containing these compounds and methods of treatment using these pharmaceutical compositions.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: August 4, 2009
    Assignee: Gruenenthal GmbH
    Inventors: Heinz Uragg, Corinna Maul, Helmut Buschmann, Bernd Sundermann, Werner Englberger
  • Publication number: 20090186947
    Abstract: A hitherto unknown crystalline form of (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use including treatment of, e.g., pain and/or urinary incontinence.
    Type: Application
    Filed: November 20, 2008
    Publication date: July 23, 2009
    Applicant: Gruenenthal GmbH
    Inventors: Andreas Fischer, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • Patent number: 7550624
    Abstract: Pharmaceutically active salts and esters of 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol and 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)-phenol, and methods of using the same for treating or inhibiting increased urinary urgency or urinary incontinence and/or pain.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: June 23, 2009
    Assignee: Gruenenthal GmbH
    Inventors: Joerg Holenz, Helmut Buschmann