Abstract: The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.

Abstract: The present invention relates to pharmaceutical composition comprising the naturally occurring compounds selected from (±) Marmesin, Columbianetin, Dihydroxanthyletin and substituted coumarin derivatives of 7-allyloxy coumarin, 7-benzyloxy coumarin, 7-methoxy coumarin, 7-acetyloxy coumarin, 4-methyl-7-hydroxy coumarin and 4-methyl-7-acetyloxy coumarin. The said compositions posses a high degree of acetylcholinesterase inhibitory (AChE) property.

Abstract: An injection molding machine can include a base, a stationary platen fixed to the base for holding a first mold section and a moving platen for holding a second mold section. The moving platen can be slidably supported on a platen slide surface fixed to the base. The injection molding machine can also include a stack mold carriage for holding a mold center section. An actuator can be coupled to the stack mold carriage for translating the stack mold carriage along the machine axis towards and away from the stationary platen, the actuator comprising a driven member coupled to a carriage connection portion. The carriage connection portion can transfer motion from the driven member to translation of the stack mold carriage. The carriage connection portion can be joined to the stack mold carriage at an elevation below the platen slide surface.

Abstract: The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(?CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.

Abstract: Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

Abstract: A method for detecting the presence of a leak between two fluid paths of an assembled plate heat exchanger by evacuating one or both fluid paths to a low pressure, introducing a test gas to one of the fluid paths to create a pressure differential between the fluid paths, and testing for the presence of test gas in the second fluid path.

Abstract: A method for detecting the presence of a leak between two fluid paths of an assembled plate heat exchanger by evacuating one or both fluid paths to a low pressure, introducing a test gas to one of the fluid paths to create a pressure differential between the fluid paths, and testing for the presence of test gas in the second fluid path.

Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.

Abstract: A double-walled plate heat exchanger and method of managing the same includes a first plate including a first skin, a second skin, at least two port holes, and a leakage escape path between the first and second skins for allowing leaked fluid to exit the double-walled plate heat exchanger, the leakage escape path being in contact with a leakage orifice in one of the skins, and an outer edge of the double-walled plate heat exchanger, the first plate further including a second plate in contact with the second skin.

Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.

Abstract: The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.

Abstract: A classification engine is capable of receiving a plurality of protocol data units (PDUs) and performing a tree-based classification on the PDUs. The classification engine includes: input means for receiving the PDUs; parsing means capable of parsing the PDUs to generate an abstracted protocol structure for at least one of the PDUs; classifier capable of performing the tree-based classification, said classifier being capable of enforcing policy using the abstracted protocol structure; and output means for transmitting the PDUs.

Abstract: The invention relates to the use of one or more water-soluble reactive liquid component capable of subsequent polymerization or cross-linking to form a solid to improve the zonal isolation and alleviate the impacts of cracks and fissures in the cement sheath around a completed subterranean well. It includes the steps of injecting a wellbore fluid carrying the reactive component or additive into the wellbore, injecting a cementitious composition as slurry into the wellbore and letting said reactive liquid component pass through at least one of the interfaces between cement and formation, cement and filter cake, and filter cake and formation before forming a solid of said reactive liquid component that traverses said at least one of the interfaces.

Abstract: The present invention provides an integrated prevention of header, state, rate and content anomalies along with network policy enforcement for domain name service (DNS). A hardware-based apparatus helps identifying DNS rate-thresholds through continuous and adaptive learning. The apparatus can determine DNS header and DNS state anomalies and drop packets containing those anomalies. DNS queries and responses are inspected for known malicious contents using a Content Inspection Engine. The apparatus integrates advantageous solutions to prevent anomalous packets and enables a policy based packet filter for DNS.

Abstract: The present invention provides an integrated prevention of header, state, rate and content anomalies along with network policy enforcement. A hardware based apparatus classifies layers 2, 3, 4 and 7 network data and maintains rate-thresholds through continuous and adaptive learning. In the process of classifying the packets, the apparatus can determine header and state anomalies and drop packets containing those anomalies. Accurate detection and prevention of layer 7 content anomalies is achieved using fragment assembly, TCP reorder and retransmission removal components, which also identify anomalies in those areas. Content inspection is achieved at high speed through a Content Inspection Engine. The apparatus integrates advantageous solutions to prevent anomalous packets and enables a policy based packet filter.

Abstract: Exemplary methods, computer-readable media, and systems for maintaining an inbound network path to a host in a sleep or a hibernation mode behind a plurality of network address translators (NAT) or firewalls. A network interface card (NIC) of a host is configured to periodically send or receive keep-alive packets. These packets enable network mappings that would ordinarily expire while a host is in a sleep or a hibernation mode. Power is maintained on the NIC while the host is in such mode, and the NIC responds as programmed including waking a host upon a certain event, such as receiving a data packet matching a preconfigured signature. During such time, the host may be in a wake on LAN mode.

Abstract: A method for detecting the presence of a leak between two fluid paths of an assembled plate heat exchanger by evacuating one or both fluid paths to a low pressure, introducing a test gas to one of the fluid paths to create a pressure differential between the fluid paths, and testing for the presence of test gas in the second fluid path.

Abstract: A fluid flow moderator for a plate heat exchange device comprises an open-sided fluid conduit adapted for positioning adjacent to a fluid port of a plate heat exchange device wherein said fluid conduit has a fluid deflection surface for moderating fluid flow. A method of moderating fluid flow in a plate heat exchange device comprises positioning an open-sided fluid conduit adjacent to a fluid port of a plate heat exchange device wherein said fluid conduit has a surface for deflecting a fluid and moderating fluid flow in said heat exchange device.

Abstract: The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(?CH2) CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.

Abstract: The present invention provides a method and apparatus for detecting and preventing a plurality of denial of service (DOS) and distributed denial of service (DDOS) attacks. The apparatus includes classifiers for parsing packets; meters storing statistics for the classified packets and detecting flood thresholds; an Ager for maintaining timeouts; a decision multiplexer for multiplexing inputs from various meters and determines whether to allow or deny the packet; and a threshold estimation means for estimating thresholds based on past data from meters, baselines, trends and seasonality. The apparatus includes a PCI interface through which a host can interact, learn continuously and set thresholds in a continuous and adaptive manner so as to prevent rate based DOS and DDOS attacks. The apparatus includes a mechanism to track culprit sources at layer 2 and layer 3 through a multiplicative increment method.