Abstract: Provided herein are compositions comprising a Clostridium botulinum neurotoxin serotype A (BoNT/A) complex comprising a 150 kDa BoNT/A. Said 150 kDa BoNT/A is in the form of a plurality of sequence variant species, wherein the plurality of sequence variant species comprises a 150 kDa BoNT/A sequence variant species with a C-terminal truncated light chain.

Abstract: The present invention provides topical dosages and formulations of lidocaine and pharmaceutically acceptable salts thereof, which are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly for debridement pain, and increase the duration of pain relief, and thereby provide more effective treatment to chronic open wounds, particularly those in non-mucosal tissue.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may transmit an indication that the UE supports a plurality of cyclic prefix configurations. The UE may receive, from a network entity, an indication of a first cyclic prefix configuration of the plurality of cyclic prefix configurations, the first cyclic prefix configuration indicating a first symbol period structure that includes a guard interval that occurs in a symbol period prior to a portion of the symbol period copied as a cyclic prefix based at least in part on a delay spread exceeding a length of the cyclic prefix. The UE may communicate one or more messages with the network entity in accordance with the first cyclic prefix configuration.

Abstract: An oral pharmaceutical composition is provided that can comprise a rho kinase inhibitor, for example, fasudil, a pharmaceutically acceptable salt thereof, a hydrate thereof, a prodrug thereof, a substituted derivative thereof, or a metabolite thereof, or any combination thereof, the rho kinase inhibitor having a bitter taste; and an ion exchange resin. The ion exchange resin can partially or fully mask the bitter taste of the rho kinase inhibitor, making the composition more palatable. The composition can comprise a solid dosage form, and/or a liquid dosage form. The solid dosage form can comprise a powder, granules, a tablet, or a capsule, or any combination thereof. The composition can be present, for example, in a unit dose, in an amount sufficient to treat a neurodegenerative disease. A method of treating the neurodegenerative disease with the oral pharmaceutical composition is provided. The method can ameliorate a symptom of a neurodegenerative disease.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a first user equipment (UE) may transmit, to a second UE, reference signals using transmit (Tx) beams of the first UE based at least in part on a Tx beam sweeping, wherein self-interference measurements associated with the first UE are based at least in part on the reference signals. The first UE may transmit, to the second UE, an indication of candidate full duplex Tx-Rx beam pairs, wherein the candidate full duplex Tx-Rx beam pairs are based at least in part on the self-interference measurements. The first UE may receive, from the second UE, an indication of a full duplex Tx-Rx beam pair selection from the candidate full duplex Tx-Rx beam pairs. Numerous other aspects are described.

Abstract: A method for wireless communication at a first network entity and related apparatus are provided. In the method, the first network entity communicates, with a second network entity, information indicative of a guard interval length. The information indicative of the guard interval length is based on transmission information. The first network entity further communicates, with the second network entity, a transmission including one or more symbols. Each symbol of the one or more symbols includes a particular guard interval based on the information indicative of the guard interval length. The method enables the GI length to be flexibly configured depending on various waveforms or channel parameters and characteristics of the transmission. The method enables transmission resources to be fully utilized according to actual operating conditions. Thus, it improves the efficiency and flexibility of wireless communication.

Abstract: The present invention provides industrially applicable, commercially viable, eco-friendly processes for the preparation of Ivacaftor. The present invention also provides novel solvates of Ivacaftor.

Abstract: A system and method for optimized processing of requirements data in a software development life cycle is provided. The present invention provides for determining a first pre-defined parameter, a second pre-defined parameter, a third pre-defined parameter, a fourth pre-defined parameter, a fifth pre-defined parameter, a sixth pre-defined parameter, and a seventh pre-defined parameter associated with user story by applying pre-defined rules respectively. Further, an output is rendered as Requirement Completeness Index (RCI) for user story data, and corrective actions are automatically carried out on user story data based on the generated RCI.

Abstract: A method, computer system, and a computer program product for environment mapping is provided. The present invention may include generating a digital twin, wherein the digital twin is a digital representation of a smart building. The present invention may include applying the digital twin to a second building. The present invention may include providing an implementation assessment, wherein the implementation assessment includes at least the environmental impact of preferences of a user in the second building.

Abstract: Methods, systems, and devices for wireless communication are described. Some user equipments (UEs) and base stations may communicate in a set of transmission time intervals (TTIs) according to a configured subcarrier spacing (SCS). Each TTI may include, in accordance with the SCS, a quantity of symbols, a corresponding quantity of cyclic prefixes, and a padding duration that may be longer than a symbol duration. The base station may transmit a control signal to the UE to indicate a configuration for the padding duration. The configuration may allocate the padding duration for reference signal repetition or one or more other operations. In some examples, the padding duration may be allocated for beam switching, and the one or more other operations may be different than beam switching. The UE and the base station may perform the reference signal repetition or the other operations during the padding duration based on the configuration.

Abstract: An implementation of a device disclosed herein includes a field programmable gate array (FPGA) circuit and a non-volatile memory (NVM) configured external to the FPGA circuit and configured to communicate with an in-system programming (ISP) manager configured on the FPGA circuit, wherein the NVM is further configured to store one or more system parameters and one or more firmware images, wherein the ISP manager being configured to detect an ISP mode in response to receiving a signal from an ISP switch and executing an ISP state machine to update one or more FPGA CPU control registers with one or more of the system parameters and the one or more of the firmware images stored on the NVM.

Abstract: Separators for use with gas turbine engines are disclosed herein. An example separator disclosed herein includes a first ring including a first surface, a second surface opposite the first surface, and a first opening extending from the first surface to the second surface, a second ring surrounding the first ring, the second ring including a third surface, a fourth surface, and a second opening extending from the first surface to the second surface, and a filter disposed between the first ring and the second ring, the filter disposed in a fluid pathway extending between the first opening and the second opening.

Abstract: A method for authorizing a client application to access resources using a distributed cache is provided. The method includes: receiving, from the client application, a login request at an identity management (IDM) tool; providing, by the IDM tool to the distributed cache, a token session state of a first access token and permission information of the first access token; masking the permission information from the first access token and providing an updated access token to the client application with the permission information masked; receiving, at an application programming interface (API) gateway from the client application, a service request comprising the updated access token; validating the updated access token using the distributed cache; and providing a response to the client application based on the validation.

Abstract: A method for dynamically rearranging one or more packages for delivery on a delivery vehicle in response to unforeseen changes in a pre-planned delivery route. The method detects, via one or more sensor-enabled shelves in a delivery vehicle, an address and package details of a respective delivery package. The method further integrates the one or more sensor-enabled shelves with a route map that depicts the pre-planned delivery route. The method further assigns new values to the one or more sensor-enabled shelves, in response to a change in the pre-planned delivery route, indicating a new sequence of delivery for each respective delivery package. The method further notifies a delivery person which delivery package is to be delivered at a current stop by illuminating the one or more sensor-enabled shelves containing the respective delivery package.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a first user equipment (UE) may transmit, using a sidelink with a second UE, a first indication of one or more candidate full-duplex (FD) beam pairs selected by the first UE for an FD sidelink transmission. The UE may receive, using the sidelink, a second indication that specifies at least part of an FD beam set that includes a first FD beam pair associated with the first UE and a second FD beam pair associated with the second UE, the FD beam set being based at least in part on the one or more candidate FD beam pairs. The UE may communicate with the second UE using the sidelink based at least in part on the FD beam set and the FD sidelink transmission. Numerous other aspects are described.

Abstract: Disclosed embodiments provide techniques for analyzing a semantic priority of an activity utilizing computing resources, and provides mitigation actions to resolve resource shortages in real-time. The computing resources can include network bandwidth usage, as well as processing cycles, memory usage, and/or other shared computing resources. Disclosed embodiments perform a semantic priority analysis of user activities. The semantic priority analysis can include utilizing natural language processing (NLP), analysis of a user calendar, and/or additional application data to infer a semantic priority. When computing resources such as network bandwidth exceed a predetermined level, then a mitigation action is executed, enabling the computing resources to be reduced while still allowing the higher priority activities (e.g., work and school) to continue.

Abstract: The present invention provides a novel, cost-effective and simple synthetic process for preparing a nano ZSM-5 catalyst which is further utilized in fluid catalytic cracking of feedstock oil containing organic compounds. The nano-ZSM-5 catalyst shows higher selectivity towards olefines and low selectivity towards LCO and bottoms.

Abstract: The present disclosure provides systems, apparatuses, methods, and computer-readable media for event identification for beam failure reporting in a wireless communication system. A user equipment (UE) may detect a beam failure event associated with a downlink communication beam and may transmit a beam failure report (BFR) message associated with the beam failure event. The BFR message may include an event identifier (ID) associated with a time of the beam failure event. Alternatively, or in addition to the event ID, the BFR message may include one or more other features, such as an indication of a priority level associated with the BFR message. A network node may receive the BFR message and may transmit a response to the BFR message. The response may indicate one or more operations to be performed by the UE, such as a beam recovery operation to “recover” the downlink communication beam.

Abstract: A data storage system employing distributed memories can have at least one host connected to a plurality of data storage devices via a network controller. One or more performance bottlenecks through the network controller may be identified with a performance module. A peer group consisting of at least two of the plurality of data storage devices is created with the performance module in response to the identified performance bottleneck so that a task can be assigned by the performance module to the peer group. The task may be chosen to mitigate the performance bottleneck by avoiding involvement of the network controller in the task.