Publication number: 20050075269
Abstract: Compounds of the formula (I), in which D, R1, R2 and n are defined in Claim 1, are potent 5-HT1A agonists and 5-HT reuptake inhibitors and are suitable for the treatment of depression, anxiety states, panic attacks, obsessive-compulsive disorders, psychiatric illnesses, cerebral infarction, cerebral ischaemia, tension states, side-effects in the treatment of high blood pressure, for the prophylaxis and therapy of cerebral illnesses, acromegaly, hypogonadism, secondary amenorrhoea, premenstrual syndrome, undesired puerperal lactation, pain, sleep disorders, narcolepsy, bipolar illnesses, mania, dementia, addiction illnesses, sexual dysfunction, eating disorders, obesity or fibromyalgia.
Type:
Application
Filed:
February 27, 2002
Publication date:
April 7, 2005
Inventors:
Dieter Dorsch, Henning Böttcher, Christoph van Amsterdam, Wilfried Rautenberg, Gerd Bartoszyk
Patent number: 6737426
Abstract: The invention relates to compounds of the general formula (I)
where
R1 and R2 independently of one another are H, —R6, C3-C8-cycloalkyl, —(CH2)n—R7, —(CH2)n—O—R6, —(CH2)n—NH2, —(CH2)n—NHR6, —(CH2)—N(R6)2, C2-C6-alkenyl or, where appropriate, together form a mononuclear saturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms,
R3 and R4 independently of one another are H, —R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2,
R5 is a 5- or 6-membered, saturated or unsaturated heterocycle having one or two nitrogen, oxygen and/or sulfur atoms which may be mono- or disubstituted by R6, —CF3, —NO2, —Hal, —OH, —O—R6, —NH2, —NH—R6 or —N(R6)2, and
R6 is C1-C6-alkyl,
R7 is R3- and/or R4-substituted phenyl,
n is 0 to 2,
and physiologically acceptable salts or solvates thereo
Type:
Grant
Filed:
May 28, 2002
Date of Patent:
May 18, 2004
Assignee:
Merck Patent GmbH
Inventors:
Rolf Gericke, Henning Böttcher, Michael Gassen, Hartmut Greiner