Abstract: Benzofurane derivatives of formula (I), wherein R and R′ have the meanings given in claim no. (1), and salts thereof are suitable for use as intermediate products in the synthesis of medicaments.

Abstract: The invention relates to novel oxazolidine derivatives of the formula in which R1, R2 and R3 have the meanings stated in claim 1, their salts and processes for preparing the compounds according to the invention. The compounds of the formula I act as 5-HT2A antagonists with a 5-HT reuptake-inhibiting, antidepressant or anxiolytic effect and can be used to produce pharmaceuticals.

Abstract: The present invention relates to sulphonylexazolamines of general formula (I), wherein R1, R2 represent independently from each other H, A, —(CH2)n—Ar or alkenyl with 2-6 C atoms, R1 and R2 together also represent a mononuclear saturated heterocycle with 1-2 N, O and/or S atoms, Z is H, A, CF3, NO2, Hal, OH, OA, NH2, NHA or NH2. A represents alkyl with 1-6 C atoms, Ar is Z-monosubstituted or Z-disubstituted phenyl, Hal is F, Cl, Br, or L n is 1 or 2 of the physiologically acceptable salts or solvates thereof. Said sulphonyloxazolamines are used as therapeutic active ingredients. The invention also relates to the use of sulphonyloxazolamines as therapeutic active ingredients and/or to the production of pharmaceutical preparations to combat diseases of the central nervous system. The invention further relates to a pharmaceutical preparation and the production thereof.

Abstract: Compound of the formula I in which Q and Ar have the meanings indicated herein, and their salts, exhibit actions on the central nervous system.

Abstract: Piperazine derivatives of the formula I in which R1 and R2 have the meanings given in claim 1 are dopamine ligands with a selectivity for the D4 receptor and are suitable for the treatment and prophylaxis of states of anxiety, depression, schizophrenia, obsessions, Parkinson's disease, tardive dyskinesia, nausea and disorders of the gastro-intestinal tract.

Abstract: Piperazine derivatives of the formula I in which R1, m, k and R2 have the meanings indicated in claim 1, are potent 5-HT1A agonists and exhibit 5-HT-reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depression, schizophrenia, obsessions, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive disorder, and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.

Abstract: Benzofurans of the formula I ##STR1## and their salts in which R.sup.1, R.sup.2 and X have the meanings indicated in claim 1, are suitable as intermediates in the synthesis of medicaments and show effects on the central nervous system.

Abstract: Amino(thio)ether derivatives of formula I ##STR1## wherein R.sup.0, R.sup.1, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X and Z are as defined herein, and their salts, are active on the central nervous system.

Abstract: Benzofurans of the formula I ##STR1## and their salts in whichR.sup.1, R.sup.2 and X have the meanings indicated in claim 1, are suitable as intermediates in the synthesis of medicaments and show effects on the central nervous system.

Abstract: 3-Indolylpiperidines of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are in each case independently of one another H, A, OH, OA, F, Cl, Br, Z, CN, CF.sub.3, COOH, CONH.sub.2, CONHA, CONA.sub.2, or COOA, orR.sup.1 and R.sup.2 and also R.sup.3 and R.sup.4 in each case together are also methylenedioxy,R.sup.5 is H or OH,R.sup.6 is H orR.sup.5 and R.sup.6 together are also a bond,A is alkyl having 1 to 6 C atoms andn is 2, 3, 4, 5 or 6,and to their physiologically acceptable salts, exhibit action on the central nervous system, in particular dopamine-agonistic or dopamine-antagonistic action.

Abstract: Piperidine and piperazine derivatives of the formula I ##STR1## wherein Ind is an indol-3-yl radical which is unsubstituted or mono- or polysubstituted by OH, OA, CN, Hal, COR.sup.2 or CH.sub.2 R.sup.2,R.sup.1 is benzofuran-5-yl or 2,3-dihydrobenzofuran-5-yl, chroman-6-yl, chroman-4-on-6-yl, 3-chromen-6-yl or chromen-4-on-6-yl, which is unsubstituted or monosubstituted by CN, CH.sub.2 OH, CH.sub.2 OA or COR.sup.2,Q is C.sub.m H.sub.2m,N or CR.sup.3,A is alkyl having 1-6 C atoms,Hal is F, C1, Br or I,R.sup.2 is OH, OA, NH.sub.2, NHA or NA.sub.2,R.sup.3 is H, OH or OA andm is 2, 3 or 4,and their physiologically acceptable salts, are active on the central nervous system.

Abstract: Indole derivatives of formula I ##STR1## wherein Ind, Q and Ar are as defined herein, and their salts, are active on the central nervous system.

Abstract: The invention relates to benzylidene-quinuclidinone derivatives of the formula I ##STR1## in which R.sup.1 is A;R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are in each case independently of one another H, A, OA or OH; andA is a straight-chain or branched alkyl radical having 1 to 10 C atomsand processes for their preparation and their use in cosmetic and/or pharmaceutical preparations.

Abstract: Indole derivatives of the general formula I ##STR1## wherein Ind is an indol-3-yl radical which is substituted by a hydroxymethyl or COW group and can additionally be monosubstituted or disubstituted by alkyl, O-alkyl, OH, F, Cl or Br,W is H, OH, Oalkyl, NH.sub.2, NHalkyl or N(alkyl).sub.2,A is --(CH.sub.2).sub.n --, CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.

Abstract: Novel oxazolidinones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, Z and n have the meanings defined herein, and their salts have effects on the central nervous system, in particular calming effects.

Abstract: 3-(3-Indolyl)quinuclidines for the formula IInd--R Iin whichInd is a 3-indolyl group which is unsubstituted or monosubstituted to tetrasubstituted by C.sub.1-4 -alkyl, trifluoromethyl, C.sub.1-4 -alkoxy, C.sub.1-4 -alkylthio, fluorine, chlorine, hydroxyl, hydroxymethyl, C.sub.6-10 -aryloxy, C.sub.7-11 -aralkyloxy, C.sub.1-5 -acyloxy, C.sub.6-10 -aroyloxy, C.sub.1-4 -alkylsulfonyloxy, C.sub.6-10 -arylsulfonyloxy, carboxyl, C.sub.1-4 -alkoxycarbonyl and/or methylenedioxy andR is 3-quinuclidinyl or 2,3-dehydro-3-quinuclidinyl,and their physiologically acceptable salts can be used as psychopharmaceuticals.

Abstract: The invention relates to a novel process for the preparation of carebastine and similar materials from ebastine or terfenadine by oxidization using microorganisms. Carebastine and similar materials are used for the treatment of allergic disorders and as antihistamines.

Abstract: Novel oxazolidinones of the formula I ##STR1## Z is O or S, R.sup.1 and R.sup.2 are each phenyl or benzyl radicals which are unsubstituted or mono- or disubstituted by alkyl, alkoxy, alkylthio, alkylsulfinyl and/or alkylsulfonyl having each 1-4 C atoms, alkanoyloxy and/or alkanoylamino having each 1-6 C atoms, F, Cl, Br, OH and/or CF.sub.3 or are heteroaryl radicals containing 1-4 heteroatoms and R.sup.3 and R.sup.4 are each H, alkyl or alkoxy having each 1-4 C atoms or are F, Cl, Br, OH or CF.sub.3, and also their salts have effects on the central nervous system, in particular neuroleptic effects.

Abstract: Hydroxyindole esters of the formula ##STR1## wherein Ind is 3-indolyl substituted in the 4-, 5-, 6- or 7-position by acyloxy having 1-12 C atoms,A is --(CH.sub.2).sub.4 -- or --CH.sub.2 --SO.sub.n --CH.sub.2 CH.sub.2 -- andn is 0, 1 or 2, or physiologically acceptable salts thereof exhibit effects on the central nervous system.

Abstract: 3-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-5-hydroxy-indole methanesulfonate can be used in the therapy of Parkinsonism and is particularly readily soluble.