Patents by Inventor Henning Bottcher

Henning Bottcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4906642
    Abstract: New Pyridine derivatives of the formula ##STR1## wherein group Y or one of the groups Z is N and the others of these groups being in each case CH;n is 1, 2 or 3;R is ##STR2## R.sup.1 and R.sup.2 are in each case phenyl or 2- or 3-thienyl radicals which are unsubstituted or mono- or di-substituted by an alkyl and/or alkoxy having 1-4 C atoms, F, Cl, Br, OH and/or CF.sub.3 ; andR.sup.3 and R.sup.4 are in each case H, alkyl or alkoxy having 1-4 C atoms, F, Cl, Br, OH or CF.sub.
    Type: Grant
    Filed: March 18, 1987
    Date of Patent: March 6, 1990
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Henning Bottcher, Christoph Seyfried, Klaus-Otto Minck
  • Patent number: 4870087
    Abstract: Indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alky, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, A is --(CH.sub.2).sub.4 -- or --CH.sub.2 --L--CH.sub.2 CH.sub.2 --, L is --S--, --SO-- or --SO.sub.2 --, and Th is a 2-- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: September 26, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Rudolf Gottschlich, Henning Bottcher, Hans-Heinrich Hausberg, Klaus-Otto Minck, Christoph Seyfried
  • Patent number: 4824852
    Abstract: New indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br,is H, OH, O-alkyl, NH.sub.2, NH-alkyl or N(alkyl).sub.2,is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 --or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,Z is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CHOH--, --CO--, S, SO, SO.sub.2 or O,is 2, 3, 4 or 5 andis 1, 2 or 3, in which the alkyl groups each have 1-4 C atoms, and their salts,have effects on the central nervous system.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: April 25, 1989
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Henning Bottcher, Hans-Heinrich Hausberg, Christoph Seyfried, Klaus-Otto Minck
  • Patent number: 4760082
    Abstract: New pyridine derivatives of the formula I ##STR1## wherein R.sup.1 and R.sup.2 are each phenyl or 2- or 3-thienyl radicals which are unsubstituted or monosubstituted or di-substituted by alkyl, alkoxy, F, Cl, Br, OH and/or CF.sub.3 and n is 1, 2 or 3, and the alkyl and alkoxy groups each have 1-4 C atoms, and salts thereof, have suppressant actions on the central nervous system, in particular neuroleptic actions.
    Type: Grant
    Filed: February 13, 1987
    Date of Patent: July 26, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Henning Bottcher, Andreas Fuchs, Christoph Seyfried
  • Patent number: 4740602
    Abstract: New indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br,W is H, OH, O-alkyl, NH.sub.2, NH-alkyl or N(alkyl).sub.2,A is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 -- or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CHOH--, --CO--, S, SO, SO.sub.2 or O,n is 2, 3, 4 or 5 andm is 1, 2 or 3,in which the alkyl groups each have 1-4 C atoms, and their salts, have effects on the central nervous system.
    Type: Grant
    Filed: June 26, 1986
    Date of Patent: April 26, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Henning Bottcher, Hans-Heinrich Hausberg, Christoph Seyfried, Klaus-Otto Minck
  • Patent number: 4711893
    Abstract: Hydroxyindole derivatives of the Formula I ##STR1## wherein Ind denotes a 4-, 5-, 6- or 7-hydroxyindole-3-yl radical, which can additionally be substituted in the 2-position by alkyl with 1-3 C atoms and/or monosubstituted or disubstituted in the benzene ring by alkyl with 1-3 C atoms, F, Cl, Br and/or CN,and their physiologically acceptable acid addition salts,are effective in lowering blood pressure.
    Type: Grant
    Filed: September 16, 1986
    Date of Patent: December 8, 1987
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans-Heinrich Hausberg, Henning Bottcher, Christoph Seyfried, Rolf Bergmann
  • Patent number: 4665187
    Abstract: New pyridine derivatives of the formula I ##STR1## wherein R.sup.1 and R.sup.2 are each phenyl or 2- or 3-thienyl radicals which are unsubstituted or monosubstituted or disubstituted by alkyl, alkoxy, F, Cl, Br, OH and/or CF.sub.3 and n is 1, 2 or 3, and the alkyl and alkoxy groups each have 1-4 C atoms, and salts thereof, have suppressant actions on the central nervous system, in particular neuroleptic actions.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: May 12, 1987
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Henning Bottcher, Andreas Fuchs, Christoph Seyfried
  • Patent number: 4618614
    Abstract: Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C--C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.
    Type: Grant
    Filed: January 15, 1986
    Date of Patent: October 21, 1986
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans-Heinrich Hausberg, Henning Bottcher, Rudolf Gottschlich, Christoph Seyfried, Klaus-Otto Minck
  • Patent number: 4617309
    Abstract: Sulfur-containing indole derivatives of the general formula I ##STR1## wherein Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN by a methylenedioxy group, A is --(CH.sub.2).sub.n --E--C.sub.m H.sub.2m -- or --(CH.sub.2).sub.n --E--C.sub.m-1 H.sub.2m-2 CO--, n is 0 or 1, m is 2, 3 or 4, E is S, SO or SO.sub.2 and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group and wherein the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.
    Type: Grant
    Filed: September 30, 1983
    Date of Patent: October 14, 1986
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Henning Bottcher, Rudolf Gottschlich, Hans-Heinrich Hausberg, Christoph Seyfried, Klaus-Otto Minck
  • Patent number: 4547576
    Abstract: Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C--C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.
    Type: Grant
    Filed: January 4, 1984
    Date of Patent: October 15, 1985
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans-Heinrich Hausberg, Henning Bottcher, Rudolf Gottschlich, Christoph Seyfried, Klaus-Otto Minck