Patents by Inventor Herbert Merz

Herbert Merz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4536127
    Abstract: An improvement for a turbocompressor having a rotor, a stator and a casing, and an abradable coating provided between the rotor blades and the casing, or between the stator vanes and the rotor, such that the blades make initial contact with the coating to abrade the coating and produce a minimal clearance. The abradable coating is formed on a member having a first layer of carbon-fiber reinforced graphite adapted for attaching the coating member to the casing or rotor, and a second layer of graphite in the region in which the blade tips are intended to rub. The second layer may optionally contain, preferably radially oriented brush-type graphite-fiber reinforcements, or be entirely composed thereof.
    Type: Grant
    Filed: May 1, 1984
    Date of Patent: August 20, 1985
    Assignee: Motoren-Und Turbinen-Union
    Inventors: Axel Rossmann, Herbert Merz
  • Patent number: 4473573
    Abstract: The invention relates to N-(2-methoxyethyl)-noroxymorphone and pharmacologically acceptable acid addition salts thereof. These compounds are analgesically effective and can be used for controlling pain.
    Type: Grant
    Filed: May 17, 1983
    Date of Patent: September 25, 1984
    Assignee: Boehringer Ingelheim KG
    Inventors: Herbert Merz, Adolf Langbein, Klaus Stockhaus
  • Patent number: 4443343
    Abstract: Method and apparatus for manufacturing planar fiber webs from reinforcing fibers which are oriented in their passage through a hydrodynamic orientation section and deposited on a filter surface. In the process, the rotating orientation section produces a laminar flow pattern causing the reinforcing fibers in the slurry to be oriented. The filter surface is rotated, as is the orientation section, to hasten the extraction of the slurry liquid by filtration, to improve the degree of orientation of the fibers, and to fix the oriented fiber cake on the filter area. Extraction of the slurry liquid by filtration eliminates the need for washing or rewashing.
    Type: Grant
    Filed: July 29, 1982
    Date of Patent: April 17, 1984
    Assignee: Motoren- und Turbinen-Union Munich GmbH
    Inventor: Herbert Merz
  • Patent number: 4393069
    Abstract: Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: July 12, 1983
    Assignee: C. H. Boehringer Sohn
    Inventors: Adolf Langbein, Herbert Merz, Rainer Sobotta, Rudolf Bauer, Hans M. Jennewein, Joachim Mierau
  • Patent number: 4293556
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl;R.sub.2 is hydrogen, methyl or ethyl; andR.sub.3 is ##STR2## where R.sub.4 is hydrogen or methyl,R.sub.5 is methyl, ethyl or propyl, andn is 1 or 2,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as analgesics.
    Type: Grant
    Filed: May 28, 1980
    Date of Patent: October 6, 1981
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Klaus Stockhaus
  • Patent number: 4176186
    Abstract: Compounds of the formula ##STR1## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, andX is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion;the compounds prevent or relieve the intestinal mobility inhibiting side-effects of narcotic analgesics without interfering with the analgesic activity of the latter.
    Type: Grant
    Filed: July 28, 1978
    Date of Patent: November 27, 1979
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Leon I. Goldberg, Herbert Merz, Klaus Stockhaus
  • Patent number: 4133888
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl; and R.sub.2 is hydrogen, methyl or ethyl; and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and morphine antagonists.
    Type: Grant
    Filed: April 12, 1978
    Date of Patent: January 9, 1979
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Klaus Stockhaus
  • Patent number: 4100288
    Abstract: Diastereoisomers of the compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof; the isomers as well as their salts are useful as analgesics and morphine-antagonists.
    Type: Grant
    Filed: August 13, 1976
    Date of Patent: July 11, 1978
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Gerhard Walther, Adolf Langbein, Klaus Stockhaus, Helmut Wick
  • Patent number: 4087532
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl,R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl, andR.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 5 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: May 2, 1978
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Adolf Langbein, Gerhard Walther, Klaus Stockhaus
  • Patent number: 4069328
    Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the formula ##STR1## wherein R is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as morphine-antagonists and analgesics.
    Type: Grant
    Filed: October 15, 1976
    Date of Patent: January 17, 1978
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Herbert Merz, Gerhard Walther, Klaus Stockhaus
  • Patent number: 4038397
    Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl, R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl,R.sub.4 is ##STR2## R.sub.5 is hydrogen, methyl or acetyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: July 26, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Adolf Langbein, Gerard Walther, Klaus Stockhaus
  • Patent number: 4010164
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or methyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as morphine-antagonists and analgesics.
    Type: Grant
    Filed: July 28, 1975
    Date of Patent: March 1, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Herbert Merz, Gerhard Walther, Klaus Stockhaus
  • Patent number: 4003998
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is ##STR2## R.sub.2 is alkyl of 2 to 15 carbon atoms; mono-substituted alkyl of 1 to 4 carbon atoms, the substituent being halogen, cyano, carbethoxy, optionally substituted phenyl or optionally substituted phenoxy; cycloalkyl of 3 to 6 carbon atoms; cycloalkyl of 3 to 6 carbon atoms-methyl; or N-trifluoromethylcarbonyl-aminoethyl;The compounds are useful as cardiotonics.
    Type: Grant
    Filed: July 7, 1975
    Date of Patent: January 18, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Losel, Herbert Merz, Wolfgang Hoefke, Werner Traunecker
  • Patent number: 4004010
    Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 is methyl, phenyl or hydrogen,Z is --CH=CH-- or --CH.sub.2 --CH.sub.2 --, andR.sub.3 is hydrogen or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; and a method using the same as analgesics and antitussives.
    Type: Grant
    Filed: October 30, 1975
    Date of Patent: January 18, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Herbert Merz, Gerhard Walther, Klaus Stockhaus
  • Patent number: 3998960
    Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 and R.sub.2, which may be identical to or different from each other, are each alkyl of 1 to 3 carbon atoms,R.sub.3 is hydrogen or methyl, andY is oxygen or sulfur,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics, antitussives and opiate-antagonists.
    Type: Grant
    Filed: October 30, 1975
    Date of Patent: December 21, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Adolf Langbein, Klaus Stockhaus, Helmut Wick
  • Patent number: 3993762
    Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##WhereinR is straight or branched alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 2 carbon atoms or phenyl, andn is an integer from 2 to 4, inclusive,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as non-narcotic analgesics.
    Type: Grant
    Filed: November 18, 1975
    Date of Patent: November 23, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Herbert Merz, Gerhard Walther, Klaus Stockhaus
  • Patent number: 3992542
    Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or acetyl,R.sub.2 is hydrogen or methyl,R.sub.3 is hydrogen, methyl, n-propyl, phenethyl, or phenyl,R.sub.4 is hydrogen or methyl, andZ is --CH=CH-- or --CH.sub.2 --CH.sub.2 --,or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics and antitussives.
    Type: Grant
    Filed: October 30, 1975
    Date of Patent: November 16, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Herbert Merz, Gerhard Walther, Klaus Stockhaus
  • Patent number: 3987031
    Abstract: Compounds of the formula ##SPC1##Wherein R.sub.3 is hydrogen, methyl, cyclopropylcarbonyl, benzoyl or thenoyl, andWhen R.sub.3 is hydrogen, R.sub.2 is phenyl, phenethyl, phenyl-propyl, chloro-propyl, chloro-phenyl, fluoro-phenyl, cycloalkyl of 3 to 8 carbon atoms or (cycloalkyl of 5 to 6 carbon atoms)-methyl, orWhen R.sub.3 is other than hydrogen, R.sub.2 is methyl, ethyl, phenyl, cyclopropyl or chloropropyl; the compounds are useful as cardiotonics.
    Type: Grant
    Filed: December 5, 1973
    Date of Patent: October 19, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Walter Losel, Herbert Merz, Wolfgang Hoefke, Werner Traunecker
  • Patent number: 3982005
    Abstract: Compounds of the formula ##SPC1##Wherein R.sub.1 is methyl or phenyl, andR.sub.2 is hydrogen, methyl or acetyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.
    Type: Grant
    Filed: July 30, 1975
    Date of Patent: September 21, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Adolf Langbein, Gerhard Walther, Klaus Stockhaus
  • Patent number: RE28972
    Abstract: 5-Aryl-1H-1,5-benzodiazepine-2,4-diones of a formula selected from the group consisting of ##SPC1##Wherein ##SPC2##-- A -- Xwherein R.sub.1 is allyl, methylallyl, dimethylallyl, chloroallyl, cyclohexyl, cycloalkylmethyl, cycloalkenylmethyl of 4 to 7 carbon atoms, phenyl, tolyl, xylyl, methoxyphenyl, dimethoxyphenyl, halophenyl, phenylalkyl of 7 to 8 carbon atoms, pyridyl or--A --Xwhere A is straight or branched alkylene of 1 to 4 carbon atoms, andX is hydroxyl, alkoxy, acyloxy, dialkylamino of 2 to 4 carbon atoms, or a 5- to 6-membered nitrogen-containing heterocyclic ring linked to A through a ring nitrogen atom,R.sub.2 is hydrogen or methyl,R.sub.3 is naphthyl, pyrimidyl, thienyl, pyridyl, methylpyridyl or halopyridyl,R.sub.4 is hydrogen, methyl, methoxy, trifluoromethyl, cyano, halogen, lower alkanoyl or (lower alkoxy of 1 to 2 carbon atoms)-carbonyl,R.sub.5 is hydrogen, methyl, ethyl, methoxy, trifluoromethyl, cyano, nitro, halogen, lower alkanoyl or lower alkoxy-carbonyl,R.sub.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: September 21, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Karl-Heinz Weber, Herbert Merz, Karl Zeile, Rolf Giesemann, Peter Danneberg