Patents by Inventor Herwig Buchholz

Herwig Buchholz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of flavone derivatives
    Publication number: 20040059100
    Abstract: The invention relates to a process for the preparation of flavone derivatives in which a 2-hydroxyacetophenone compound is metallated using a lithium compound at low temperatures and subsequently reacted with a keto compound, and where the ratio of the molar equivalents of lithium compound to the 2-hydroxyacetophenone compound functional groups to be metallated is from 1 to 1.2. The resultant &bgr;-diketone compound is subsequently cyclised with warming in an acidic medium.
    Type: Application
    Filed: July 31, 2003
    Publication date: March 25, 2004
    Inventors: Herwig Buchholz, Sophie Perruchon
  • Flavonoid derivatives for the treatment of eczema
    Publication number: 20040053860
    Abstract: The invention relates to the use of certain flavonoid derivatives for the preparation of formulations which are suitable for the prophylaxis and/or therapy of eczema. The formulations are particularly suitable for the prophylaxis and/or therapy of atopic eczema.
    Type: Application
    Filed: September 2, 2003
    Publication date: March 18, 2004
    Applicant: Merck Patent GmbH
    Inventors: Herwig Buchholz, Corinna Wirth
  • Conjugate, its preparation and use
    Patent number: 6685924
    Abstract: The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: February 3, 2004
    Assignee: Merck Patent GmbH
    Inventors: Herwig Buchholz, Ralf Anselmann, Hansjuergen Driller, Michael Kirschbaum, Frank Pflücker
  • Recovery of isoquercetin from bioflavanoid pastes
    Patent number: 6683164
    Abstract: The invention relates to a method for recovering high-purity isoquerectin from bioflavonoid pastes, that is from mother-liquor residues which are produced during the recovery of flavonoids, by extraction with a solvent mixture of methyl acetate and water.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: January 27, 2004
    Assignee: Merck Patent GmbH
    Inventors: Herwig Buchholz, Michael Jungnitz, Michael Grund, Ralf Rosskopf, Hartmut Härtner
  • Conjugate, its preparation and use
    Patent number: 6673336
    Abstract: The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: January 6, 2004
    Assignee: Merck Patent, GmbH
    Inventors: Herwig Buchholz, Eike Poetsch, Ralf Rosskopf, Ralf Anselmann, Michael Kirschbaum, Frank Pflücker
  • Coreactive supporting materials for heterogenization of catalysts, cocatalysts and ligands
    Patent number: 6639031
    Abstract: The invention relates to a process for preparing a support material having an increased number of reactive groups and to a process for preparing coreactive surfaces that may have catalytic or cocatalytic properties.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: October 28, 2003
    Assignee: Merck GmbH
    Inventors: Eike Poetsch, Herwig Buchholz
  • Process for the catalytic asymmetric disubstitution of carboxamides using 2 different Grignard reagents
    Publication number: 20030125549
    Abstract: The invention relates to a method for asymmetrically disubstituting carboxylic acid amides on the geminal carbonyl-C atom using two different grignard reagents in the presence of a metal alcoholate compound used as a catalyst and in the presence of another organometallic compound used as a co-catalyst.
    Type: Application
    Filed: December 19, 2002
    Publication date: July 3, 2003
    Inventors: Herwig Buchholz, Urs Welz-Biermann
  • Formulation for protection against oxidative stress containing benzofuranone derivatives
    Publication number: 20030060426
    Abstract: The invention relates to a cosmetic or pharmaceutical formulation comprising at least one compound of formula (I). The cosmetics or pharmaceutical products are particularly suitable for the care of the skin in protecting against oxidative stress and ageing phenomena.
    Type: Application
    Filed: July 29, 2002
    Publication date: March 27, 2003
    Inventors: Frank Pflcker, Herwig Buchholz, Ralf Rosskopf, Joachim Bnger
  • Method for producing luteolin and luteolin derivatives
    Patent number: 6538021
    Abstract: Disclosed is a method for producing compounds of formula (I), wherein R1 represents H or (CH2)mOH, R2 represents H or (CH2)nOH, R3 represents H or (CH2)pOH and m, n and p represent 2-8 independently from one another. Said compounds are particularly suitable for use as food supplements. They are highly suitable for use in cosmetic formulations as UV filters, for instance.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: March 25, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Herwig Buchholz, Ralf Rosskopf, Alice Lichtenberg, Christine Kraus
  • N(CF3)2 anion generation and its use
    Patent number: 6534682
    Abstract: The invention relates to a process of generating N(CF3)2 anions by reacting a metal fluoride of formula MFx with a compound of formula RFSO2N(CF3)2, (CF3)2N(SO2CF2)mSO2N(CF3)2 or RFCON(CF3)2. The invention further relates to the use of the N(CF3)2 anions as a reagent for the introduction of halogen or other organic groups into organic molecules.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: March 18, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Völker Hilarius, Herwig Buchholz, Peter Sartori, Nikolai Ignatiev, Andrei Kucherina, Sergii Datsenko
  • Compositions comprising a mixture of bioflavonols
    Patent number: 6514527
    Abstract: The present invention relates to novel compositions containing a mixture of two or three bioflavonols like isoquercetin, quercetin-4′-glycoside, rutin and quercetin, which show differences in their pharmacokinetics. These compositions are useful as food supplements possessing preventive properties against damage to human tissues due to their antioxidant properties. Furthermore, these compositions secure a continuum of the presence of bioflavonols having the same aglycone in human plasma over an extended period of time.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: February 4, 2003
    Assignee: Merck Patentgesellschaft
    Inventors: Herwig Buchholz, Jerzy Meduski
  • Method for the catalytic, symmetric disubstitution of carboxylic acid amides with grignard reagents
    Patent number: 6515180
    Abstract: The invention relates to a method for symmetrically disubstituting carboxylic acid amides on the geminal carbonyl-C-atom using grignard reagents in the presence of a metal alcoholate compound used as a catalyst and in the presence of another organometalic compound used as a co-catalyst.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: February 4, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Herwig Buchholz, Urs Welz-Biermann, Armin Meijere
  • Compositions for the treatment and prevention of neurological and pathopsychological diseases
    Patent number: 6514973
    Abstract: This invention relates to a composition containing the three active ingredients: a) one or more phosphatidyl serines, b) one or more methyl transporters, and c) one or more compounds selected from methyl and methylene donors.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: February 4, 2003
    Assignee: Merck Patent Geseilschaft Mit Beschrankter Haftung
    Inventors: Herwig Buchholz, Jerzy D. Meduski
  • Compositions comprising a mixture of bioflavonols
    Publication number: 20030022845
    Abstract: The present invention relates to novel compositions containing a mixture of two or three bioflavonols like isoquercetin, quercetin-4′-glycoside, rutin and quercetin, which show differences in their pharmacokinetics. These compositions are useful as food supplements possessing preventive properties against damage to human tissues due to their antioxidant properties. Furthermore, these compositions secure a continuum of the presence of bioflavonols having the same aglycone in human plasma over an extended period of time.
    Type: Application
    Filed: September 26, 2002
    Publication date: January 30, 2003
    Applicant: MERCK PATENT GMBH
    Inventors: Herwig Buchholz, Jerzy Meduski
  • Method for the catalytic, asymmetric disubstitution of carboxylic acid amides with two different grignard reagents
    Patent number: 6512145
    Abstract: The invention relates to a method for asymmetrically disubstituting carboxylic acid amides on the geminal carbonyl-C-atom using two grignard reagents in the presence of a metal alcoholate compound used as a catalyst and in the presence of another organometalic compound used as a co-catalyst.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: January 28, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Herwig Buchholz, Urs Welz-Biermann
  • Catalytic titanium (IV) oxide, mediated geminal symmetric dialkylation of carboxamides
    Publication number: 20030009029
    Abstract: The present invention relates to a process preparing compounds of the general formula (I) 1
    Type: Application
    Filed: June 5, 2002
    Publication date: January 9, 2003
    Applicant: Merck Patent GmbH
    Inventors: Herwig Buchholz, Urs Welz-Biermann
  • Composition comprising isoquercetin and ascorbic acid in a sustained release form
    Patent number: 6491948
    Abstract: The present invention relates to novel, orally administered compositions comprising two redox systems: reduced ascorbic acid in a sustained release form and oxidized isoquercetin with an increased concentration of reduced vitamin C over a prolonged time in the brain. These compositions are useful as neuroprotective agents possessing preventive properties against memory dysfunctions.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: December 10, 2002
    Assignee: Merck Patent GmbH
    Inventors: Herwig A. Buchholz, Jerzy D. Meduski
  • Method for symmetrically and asymmetrically disubstituting carboxylic acid amides with organotitanates and grignard reagents
    Patent number: 6479661
    Abstract: The invention relates to a method for disubstituting carboxylic acid amides on a geminal carbonyl-C-atom using a Grignard reagent in the presence of an organotitanate.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: November 12, 2002
    Assignee: Merck Patent Gesellschaft
    Inventors: Herwig Buchholz, Urs Welz-Biermann, Armin Meijere, Vladimir Chaplinski
  • Conjugate, its preparation and use
    Publication number: 20020160027
    Abstract: The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.
    Type: Application
    Filed: November 7, 2001
    Publication date: October 31, 2002
    Inventors: Herwig Buchholz, Eike Poetsch, Ralf Rosskopf, Ralf Anselmann, Michael Kirschbaum, Frank Pflucker
  • Conjugate, its preparation and use
    Publication number: 20020150600
    Abstract: The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.
    Type: Application
    Filed: November 7, 2001
    Publication date: October 17, 2002
    Inventors: Herwig Buchholz, Ralf Anselmann, Hansjuergen Driller, Michael Kirschbaum, Frank Pflucker