Patents by Inventor Hing C. Wong

Hing C. Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF MODULATING CIRCADIAN CLOCK GENE EXPRESSION
    Publication number: 20260137759
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in modulating circadian clock gene expression in a subject.
    Type: Application
    Filed: April 13, 2023
    Publication date: May 21, 2026
    Inventors: Hing C. WONG, Christopher JANNEY, Varghese GEORGE, Niraj SHRESTHA, Pallavi CHATURVEDI
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20260137757
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: November 13, 2025
    Publication date: May 21, 2026
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF LIVER DISEASES
    Publication number: 20260131018
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases.
    Type: Application
    Filed: December 19, 2025
    Publication date: May 14, 2026
    Inventors: Hing C. Wong, Xiaoyun Zhu, Pallavi Chaturvedi, Varghese George, Niraj Shrestha, Michael Dee
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    Publication number: 20260132185
    Abstract: Provided herein are multi-chain chimeric polypeptides that include: (a) a first chimeric polypeptide including a first target-binding domain a soluble T cell receptor ?-chain constant region (TR?C) domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.
    Type: Application
    Filed: August 19, 2025
    Publication date: May 14, 2026
    Applicant: HCW Biologics, Inc.
    Inventor: Hing C. Wong
  • Methods of reducing neuroinflammation
    Patent number: 12594323
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in reducing neuroinflammation in a subject.
    Type: Grant
    Filed: April 13, 2023
    Date of Patent: April 7, 2026
    Assignee: ImmunityBio, Inc.
    Inventors: Hing C. Wong, Varghese George, Niraj Shrestha, Pallavi Chaturvedi
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20260092097
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: June 25, 2025
    Publication date: April 2, 2026
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20260061033
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: August 11, 2025
    Publication date: March 5, 2026
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • SINGLE-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    Publication number: 20260049118
    Abstract: Provided herein are single-chain chimeric polypeptides that include: (i) a first target-binding domain; (ii) a soluble T cell receptor ?-chain constant region (TR?C) domain; and (iii) a second target-binding domain. Also provided here are methods of making and using these single-chain chimeric polypeptides and nucleic acids encoding these single-chain chimeric polypeptides.
    Type: Application
    Filed: August 19, 2025
    Publication date: February 19, 2026
    Applicant: HCW Biologics, Inc.
    Inventor: Hing C. Wong
  • Anti-CD26 proteins and uses thereof
    Patent number: 12497462
    Abstract: Provided herein are proteins comprising an anti-CD26 antigen-binding domain. Also provided herein are methods of treating an aging-related disease or an inflammatory disease in a subject that include administering to the subject one of these proteins or a cell expressing one of these proteins.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: December 16, 2025
    Assignee: ImmunityBio, Inc.
    Inventors: Hing C. Wong, Bai Liu, Lin Kong, Xiaoyun Zhu, Catherine Spanoudis
  • Multi-chain chimeric polypeptides and uses thereof
    Patent number: 12479899
    Abstract: The present disclosure relates to methods that include the use of a first multi-chain chimeric polypeptide and a second multi-chain chimeric polypeptide for stimulating the NK cells, inducing or increasing proliferation of the NK cells, inducing differentiation of the NK cells, and treating a subject in need thereof using activated NK cells.
    Type: Grant
    Filed: July 19, 2023
    Date of Patent: November 25, 2025
    Assignee: ImmunityBio, Inc.
    Inventor: Hing C. Wong
  • METHODS OF TREATING BRONCHOPULMONARY DYSPLASIA
    Publication number: 20250352618
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in treating bronchopulmonary dysplasia in a subject.
    Type: Application
    Filed: May 20, 2025
    Publication date: November 20, 2025
    Inventors: Hing C. Wong, Niraj Shrestha, Mark Leonard Ormiston, Declan Joseph Gainer
  • Methods of activating regulatory T cells
    Patent number: 12398189
    Abstract: Provided herein are methods of stimulating or increasing the proliferation of a Treg cell, compositions including a population of Treg cells generated by these methods, and methods of treating a subject using these compositions.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: August 26, 2025
    Assignee: HCW Biologics, Inc.
    Inventors: Hing C. Wong, Niraj Shrestha, Varghese George, Michael Dee
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20250262277
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: April 30, 2025
    Publication date: August 21, 2025
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20250262278
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: April 30, 2025
    Publication date: August 21, 2025
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Multimeric IL-15 soluble fusion molecules and methods of making and using same
    Patent number: 12371472
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Grant
    Filed: October 31, 2023
    Date of Patent: July 29, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • METHOD OF TREATING PANCREATIC CANCER
    Publication number: 20250195614
    Abstract: Provided herein are methods of treating unresectable advanced/metastatic pancreatic cancer in a subject.
    Type: Application
    Filed: March 2, 2023
    Publication date: June 19, 2025
    Inventors: Hing C. WONG, Peter RHODE
  • BCG and IL-15 based molecules
    Patent number: 12318432
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: June 7, 2024
    Date of Patent: June 3, 2025
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20250152686
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: January 15, 2025
    Publication date: May 15, 2025
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    Publication number: 20250136663
    Abstract: Provided herein are multi-chain chimeric polypeptides and uses thereof for treating cancer, aging related diseases or conditions, and/or an infectious disease. Further provided, are methods for stimulating an immune cell, inducing or increasing proliferation of an immune cell, and/or inducing differentitation of an immune cell into a memory-like immune cell by contacting the immune cell with the multi-chain chimeric polypeptides disclosed herein.
    Type: Application
    Filed: October 31, 2024
    Publication date: May 1, 2025
    Inventors: Hing C. Wong, Bai Liu, Xiaoyun Zhu, Varghese George, Pallavi Chaturvedi
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF ADVANCED SOLID TUMORS
    Publication number: 20250134974
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of an unresectable, advanced, recurrent, and/or metastatic solid tumor or an unresectable, advanced, recurrent, and/or metastatic solid cancer.
    Type: Application
    Filed: October 30, 2024
    Publication date: May 1, 2025
    Inventors: Hing C. Wong, Peter Rhode