Patents by Inventor Hing C. Wong

Hing C. Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating neoplasia with an anti-CD38 antibody and an IL-15:IL-15R complex
    Patent number: 11925676
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: March 12, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20240076354
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: October 31, 2023
    Publication date: March 7, 2024
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-BASED FUSIONS TO IL-7 AND IL-21
    Publication number: 20240076340
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
    Type: Application
    Filed: September 21, 2023
    Publication date: March 7, 2024
    Inventor: Hing C. Wong
  • Method of treating cancer with composition comprising IL-15-based molecules and BCG
    Patent number: 11890323
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: February 6, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11872272
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: January 16, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • Multimeric IL-15 soluble fusion molecules and methods of making and using same
    Patent number: 11845783
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: December 19, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USES THEREOF
    Publication number: 20230381238
    Abstract: The present disclosure relates to methods that include the use of a first multi-chain chimeric polypeptide and a second multi-chain chimeric polypeptide for stimulating the NK cells, inducing or increasing proliferation of the NK cells, inducing differentiation of the NK cells, and treating a subject in need thereof using activated NK cells.
    Type: Application
    Filed: July 19, 2023
    Publication date: November 30, 2023
    Applicant: HCW Biologics, Inc.
    Inventor: Hing C. Wong
  • METHODS OF REDUCING NEUROINFLAMMATION
    Publication number: 20230372444
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in reducing neuroinflammation in a subject.
    Type: Application
    Filed: April 13, 2023
    Publication date: November 23, 2023
    Inventors: Hing C. Wong, Varghese George, Niraj Shrestha, Pallavi Chaturvedi
  • Multi-chain chimeric polypeptides and uses thereof
    Patent number: 11738052
    Abstract: The present disclosure relates to methods that include the use of a first multi-chain chimeric polypeptide and a second multi-chain chimeric polypeptide for stimulating the NK cells, inducing or increasing proliferation of the NK cells, inducing differentiation of the NK cells, and treating a subject in need thereof using activated NK cells.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: August 29, 2023
    Assignee: HCW Biologics, Inc.
    Inventor: Hing C. Wong
  • FUSION MOLECULES AND IL-15 VARIANTS
    Publication number: 20230257437
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Application
    Filed: April 24, 2023
    Publication date: August 17, 2023
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20230248813
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: February 13, 2023
    Publication date: August 10, 2023
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230241174
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: December 9, 2022
    Publication date: August 3, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230241175
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: February 28, 2023
    Publication date: August 3, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230233649
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: February 27, 2023
    Publication date: July 27, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230190877
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: October 11, 2022
    Publication date: June 22, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based molecules and methods of use thereof
    Patent number: 11679144
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: June 20, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Fusion molecules and IL-15 variants
    Patent number: 11673932
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: June 13, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • ANTI-CD26 PROTEINS AND USES THEREOF
    Publication number: 20230174666
    Abstract: Provided herein are proteins comprising an anti-CD26 antigen-binding domain. Also provided herein are methods of treating an aging-related disease or an inflammatory disease in a subject that include administering to the subject one of these proteins or a cell expressing one of these proteins.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Inventors: Hing C. Wong, Bai Liu, Lin Kong, Xiaoyun Zhu, Catherine Spanoudis
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF LIVER DISEASES
    Publication number: 20230125173
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases.
    Type: Application
    Filed: August 11, 2022
    Publication date: April 27, 2023
    Applicant: HCW Biologics, Inc.
    Inventors: Hing C. Wong, Xiaoyun Zhu, Pallavi Chaturvedi, Varghese George, Niraj Shrestha, Michael Dee
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11612645
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: August 19, 2022
    Date of Patent: March 28, 2023
    Assignee: Altor Bioscience, LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong