Patents by Inventor Hing C. Wong

Hing C. Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fusion molecules and IL-15 variants
    Patent number: 11673932
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: June 13, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • ANTI-CD26 PROTEINS AND USES THEREOF
    Publication number: 20230174666
    Abstract: Provided herein are proteins comprising an anti-CD26 antigen-binding domain. Also provided herein are methods of treating an aging-related disease or an inflammatory disease in a subject that include administering to the subject one of these proteins or a cell expressing one of these proteins.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Inventors: Hing C. Wong, Bai Liu, Lin Kong, Xiaoyun Zhu, Catherine Spanoudis
  • MULTI-CHAIN CHIMERIC POLYPEPTIDES AND USE THEREOF IN THE TREATMENT OF LIVER DISEASES
    Publication number: 20230125173
    Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases.
    Type: Application
    Filed: August 11, 2022
    Publication date: April 27, 2023
    Applicant: HCW Biologics, Inc.
    Inventors: Hing C. Wong, Xiaoyun Zhu, Pallavi Chaturvedi, Varghese George, Niraj Shrestha, Michael Dee
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11612645
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: August 19, 2022
    Date of Patent: March 28, 2023
    Assignee: Altor Bioscience, LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-based fusions to IL-12 and IL-18
    Patent number: 11571470
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: February 7, 2023
    Assignee: Altor Bioscience LLC
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20220387570
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: August 19, 2022
    Publication date: December 8, 2022
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • Fusion molecules and IL-15 variants
    Patent number: 11498950
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: November 15, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-based molecules and methods of use thereof
    Patent number: 11471511
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: October 18, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20220305087
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 29, 2022
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • FUSION MOLECULES AND IL-15 VARIANTS
    Publication number: 20220281937
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Application
    Filed: April 8, 2022
    Publication date: September 8, 2022
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • Multimeric IL-15-based molecules
    Patent number: 11369679
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: June 28, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
  • Interleukin 15 (IL-15) variants
    Patent number: 11365231
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: June 21, 2022
    Assignee: Altor BioScience, LLC
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • Multimeric IL-15-based molecules
    Patent number: 11318201
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: May 3, 2022
    Assignee: Altor Bioscience, LLC.
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert G. Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
  • METHODS OF TREATING AGING-RELATED DISORDERS
    Publication number: 20220073578
    Abstract: Provided herein are methods of killing or reducing the number of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, decreasing the accumulation of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more common gamma-chain family cytokine receptor activating agent(s) and/or one or more agent(s) that result(s) in a decrease in the activation of a TGF-? receptor.
    Type: Application
    Filed: June 1, 2021
    Publication date: March 10, 2022
    Inventors: Hing C. Wong, Xiaoyun Zhu, Bai Liu, Pallavi Chaturvedi, Varghese George
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20220062399
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: September 27, 2021
    Publication date: March 3, 2022
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • IL-15-BASED FUSIONS TO IL-7 AND IL-21
    Publication number: 20220033455
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
    Type: Application
    Filed: October 18, 2021
    Publication date: February 3, 2022
    Inventor: Hing C. Wong
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20220002383
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: July 26, 2021
    Publication date: January 6, 2022
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • Multimeric IL-15-based molecules
    Patent number: 11197929
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: December 14, 2021
    Assignees: NantCell, Inc., Altor BioScience, LLC.
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert G. Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
  • IL-15-based molecules and methods of use thereof
    Patent number: 11173191
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: November 16, 2021
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Anti-PDL1, IL-15 and TGF-beta receptor combination molecules
    Patent number: 11168138
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant, a cytokine receptor or cytokine ligand, and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: November 9, 2021
    Assignee: Altor Bioscience, LLC
    Inventors: Qiongzhen Li, Xiaoyun Zhu, Hing C. Wong