Patents by Inventor Hing C. Wong

Hing C. Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTIMERIC IL-15-BASED MOLECULES
    Publication number: 20200261575
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Application
    Filed: January 24, 2020
    Publication date: August 20, 2020
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20200190164
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor a/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: January 22, 2020
    Publication date: June 18, 2020
    Inventors: HING C. WONG, PETER RHODE, BAI LIU, XIAOYUN ZHU, KAI-PING HAN
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20200181237
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: January 22, 2020
    Publication date: June 11, 2020
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • T CELL RECEPTOR FUSIONS AND CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20200172594
    Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.
    Type: Application
    Filed: August 2, 2019
    Publication date: June 4, 2020
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu
  • FUSION MOLECULES AND IL-15 VARIANTS
    Publication number: 20200140513
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Application
    Filed: October 16, 2019
    Publication date: May 7, 2020
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • IL-15-based molecules and methods of use thereof
    Patent number: 10537615
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: January 21, 2020
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20200016239
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: June 18, 2019
    Publication date: January 16, 2020
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • ANTI-PDL1, IL-15 AND TGF-BETA RECEPTOR COMBINATION MOLECULES
    Publication number: 20200002425
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant, a cytokine receptor or cytokine ligand, and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Application
    Filed: March 26, 2019
    Publication date: January 2, 2020
    Inventors: Qiongzhen Li, Xiaoyun Zhu, Hing C. Wong
  • COMPOSITIONS COMPRISING IL-2 FUSION PROTEINS AND METHODS FOR TREATING NEOPLASIA
    Publication number: 20190328838
    Abstract: The invention provides methods of treating neoplasia, for example bladder cancer, by administering an IL-2 fusion protein and one or more therapeutic agents, where the IL-2 fusion protein does not necessarily have to target the neoplasia.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 31, 2019
    Inventors: Jinghai Wen, Wenxin Xu, Peter Rhode, Hing C. Wong
  • SUPERKINE
    Publication number: 20190330309
    Abstract: Contemplated compositions and methods comprise chimeric molecule complexes that advantageously provide activating signaling to immune competent cells when bound to ALL cells. Furthermore, chimeric molecule complexes include an Fc portion to extend serum half live time and facilitate purification.
    Type: Application
    Filed: June 14, 2019
    Publication date: October 31, 2019
    Inventors: Patrick Soon-Shiong, Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • IL-15 variants and uses thereof
    Patent number: 10450359
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: October 22, 2019
    Assignee: Altor Bioscience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-ping Han
  • IL-15-BASED FUSIONS TO IL-7 AND IL-21
    Publication number: 20190300591
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
    Type: Application
    Filed: August 28, 2018
    Publication date: October 3, 2019
    Inventor: Hing C. Wong
  • SOLUBLE TCR MOLECULES AND METHODS OF USE
    Publication number: 20190269807
    Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.
    Type: Application
    Filed: April 29, 2019
    Publication date: September 5, 2019
    Inventors: Shari A. Price-Schiavi, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
  • Multimeric IL-15 soluble fusion molecules and methods of making and using same
    Patent number: 10358478
    Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: July 23, 2019
    Assignee: Altor Bioscience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-ping Han
  • IL-15-BASED FUSIONS TO IL-12 AND IL-18
    Publication number: 20190046623
    Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.
    Type: Application
    Filed: March 6, 2018
    Publication date: February 14, 2019
    Inventors: Warren D. Marcus, Robert Newman, Bai Liu, Lijing You, Lin Kong, Peter Rhode, Hing C. Wong
  • ALT-803 IN COMBINATION WITH ANTI-CD38 ANTIBODY FOR CANCER THERAPIES
    Publication number: 20190048055
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: March 27, 2018
    Publication date: February 14, 2019
    Inventors: Niraj Shrestha, Bai Liu, Peter Rhode, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20190022187
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: March 14, 2018
    Publication date: January 24, 2019
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20190023766
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: April 11, 2018
    Publication date: January 24, 2019
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • Multimeric IL-15 soluble fusion molecules and methods of making and using same
    Patent number: 10150805
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: December 11, 2018
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • MULTIMERIC IL-15-BASED MOLECULES
    Publication number: 20180200366
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Application
    Filed: October 21, 2017
    Publication date: July 19, 2018
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robby Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong