Patents by Inventor Hing C. Wong

Hing C. Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20160355567
    Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
    Type: Application
    Filed: July 19, 2016
    Publication date: December 8, 2016
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-ping Han
  • Fusion molecules and IL-15 variants
    Patent number: 9464127
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: October 11, 2016
    Assignee: Altor Bioscience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-ping Han
  • Multimeric IL-15 soluble fusion molecules and methods of making and using same
    Patent number: 9428573
    Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: August 30, 2016
    Assignee: Altor Bioscience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-ping Han
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20160213750
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: March 29, 2016
    Publication date: July 28, 2016
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • SOLUBLE TCR MOLECULES AND METHODS OF USE
    Publication number: 20160199523
    Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.
    Type: Application
    Filed: February 10, 2016
    Publication date: July 14, 2016
    Inventors: SHARI A. PRICE-SCHIAVI, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
  • Multimeric IL-15 soluble fusion molecules and methods of using same
    Patent number: 9328159
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: May 3, 2016
    Assignee: Altor Bioscience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-ping Han
  • Soluble TCR molecules and methods of use
    Patent number: 9290560
    Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: March 22, 2016
    Assignee: ALTOR BIOSCIENCE CORPORATION
    Inventors: Shari A. Price-Schiavi, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
  • Multimeric IL-15 soluble fusion molecules and methods of treating neoplasia and HIV using same
    Patent number: 9255141
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 9, 2016
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-ping Han
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20150374790
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: June 30, 2015
    Publication date: December 31, 2015
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • METHODS FOR TREATING NEOPLASIA
    Publication number: 20150216937
    Abstract: The invention provides methods of treating neoplasia, for example bladder cancer, by administering an IL-2 fusion protein and one or more therapeutic agents, where the IL-2 fusion protein does not necessarily have to target the neoplasia.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 6, 2015
    Inventors: Jinghai Wen, Wenxin Xu, Peter Rhode, Hing C. Wong
  • FUSION MOLECULES AND IL-15 VARIANTS
    Publication number: 20150132257
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Application
    Filed: December 12, 2014
    Publication date: May 14, 2015
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-ping Han
  • HIV VPR-SPECIFIC T-CELL RECEPTORS
    Publication number: 20150087059
    Abstract: The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQQL).
    Type: Application
    Filed: December 4, 2014
    Publication date: March 26, 2015
    Inventors: Marilyn Fernandez, Bai Liu, Warren D. Marcus, Hing C. Wong
  • T CELL RECEPTOR FUSIONS AND CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20150079025
    Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.
    Type: Application
    Filed: June 12, 2014
    Publication date: March 19, 2015
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu
  • Fusion molecules and IL-15 variants
    Patent number: 8940289
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: January 27, 2015
    Assignee: Altor BioScience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-ping Han
  • HIV VPR-specific T cell receptors
    Patent number: 8933198
    Abstract: The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQL (SEQ ID NO: 1)).
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: January 13, 2015
    Assignee: Altor BioScience Corporation
    Inventors: Marilyn Fernandez, Bai Liu, Warren D. Marcus, Hing C. Wong
  • COMPOSITIONS AND METHODS FOR TREATING COAGULATION RELATED DISORDERS
    Publication number: 20150010558
    Abstract: Disclosed are methods for preventing or treating sepsis, a sepsis-related condition or an inflammatory disease in a mammal. In one embodiment, the method includes administering to the mammal a therapeutically effective amount of at least one humanized antibody, chimeric antibody, or fragment thereof that binds specifically to tissue factor (TF) to form a complex in which factor X or factor IX binding to the complex is inhibited and the administration is sufficient to prevent or treat the sepsis in the mammal. The invention has a wide spectrum of useful applications including treating sepsis, disorders related to sepsis, and inflammatory diseases such as arthritis.
    Type: Application
    Filed: February 11, 2014
    Publication date: January 8, 2015
    Applicant: GENENTECH, INC.
    Inventors: Jin-An JIAO, Hing C. WONG, Jack O. EGAN
  • SOLUBLE TCR MOLECULES AND METHODS OF USE
    Publication number: 20140378656
    Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.
    Type: Application
    Filed: February 18, 2014
    Publication date: December 25, 2014
    Applicant: ALTOR BIOSCIENCE CORPORATION
    Inventors: Shari A. Price-Schiavi, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20140242025
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: February 15, 2013
    Publication date: August 28, 2014
    Applicant: ALTOR BIOSCIENCE CORPORATION
    Inventors: HING C. WONG, PETER RHODE, BAI LIU, XIAOYUN ZHU, KAI-PING HAN
  • FUSION MOLECULES AND IL-15 VARIANTS
    Publication number: 20140219955
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Application
    Filed: July 19, 2013
    Publication date: August 7, 2014
    Applicant: Altor BioScience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-ping Han
  • MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
    Publication number: 20140205560
    Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
    Type: Application
    Filed: July 19, 2013
    Publication date: July 24, 2014
    Applicant: Altor BioScience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-ping Han