Abstract: The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.

Abstract: A substrate processing method of processing a substrate includes: a carry-in process of carrying the substrate into a processing container; a first process of forming a first carbon film on the substrate with plasma of a first mixture gas containing a carbon-containing gas in a state in which interior of the processing container is maintained at a first pressure; and a second process of changing a pressure in the processing container to a second pressure higher than the first pressure.

Abstract: The present invention provides a method capable of sufficiently reducing impurities with excellent separation efficiency even from a crystal-containing slurry that contains a low-purity mother liquor and has poor solid-liquid separation properties. The present invention relates to a method for producing a compound, the method including: a step of feeding a slurry containing crystals of the compound to a hydraulic wash column; a step of melting crystals in a crystal-containing circulation slurry discharged from the hydraulic wash column; and a step of returning a portion of a circulation liquid containing a melt obtained in the melting step to the hydraulic wash column, wherein the circulation liquid returned in the returning step in an amount of more than 30% by mass relative to 100% by mass of the melt serves as a washing liquid for crystals.

Abstract: Provided is a method for purifying a compound capable of providing a high purity compound in high yield and at low cost. The present invention relates to the method for purifying a compound using a purification apparatus, the purification apparatus including: a crystallizing unit including a crystal forming section; and a wash column including a mechanism that forcibly transfers crystals. The crystallizing unit includes N tanks connected in series, wherein N is 2 or greater, a 1st tank is a most downstream tank, a (N)th tank is a most upstream tank, at least the 1st tank is a crystallization tank including a cooling mechanism, and a 2nd and subsequent tanks are each a crystallization tank or a ripening tank. The purification apparatus includes a line that feeds a compound-containing liquid to be purified to at least one of the N tanks.

Abstract: The present invention aims to provide a compound purification apparatus capable of providing a high purity compound in high yield and at low cost.

Abstract: The present invention provides a method for obtaining high-quality products. The present invention relates to a purification apparatus that purifies crystals, the purification apparatus including: a hydraulic wash column that includes a discharging port for a crystal-containing circulation slurry and a return port for a circulation liquid containing a melt of discharged crystals; a pipe that feeds a crystal-containing slurry to the hydraulic wash column; a filter that filters the crystal-containing slurry in the hydraulic wash column; a pipe that is connected to the filter and discharges a mother liquor; and a unit that melts crystals in a circulation slurry discharged through the discharging port, wherein a distance between a lower end of the filter and an average bottom surface level of the hydraulic wash column is 1000 mm or more.

Abstract: An object of the present invention is to provide a fermented seasoning containing 5?-nucleotides derived from fermentation at a high concentration without externally adding 5?-nucleotides and a method of producing the same. In a case where the nucleic acids are externally added, display of additives is indispensable on an ingredients description, and thus it cannot be said that the fermented seasoning have no chemical seasoning additive or made by natural brewing; however, with the fermented seasoning relating to the present invention, it is unnecessary to display additives on the ingredients description, and thus it is possible to appeal an added value to nature oriented or natural oriented consumers.

Abstract: A mounting structure for a power conversion device includes: a vehicle body component extending in a front-rear direction of a vehicle; a mounting component provided on the vehicle body component; a drive unit held by the vehicle body component via the mounting component; and a power conversion device attached to the mounting component. A stiffness of the mounting component is greater than a stiffness of the vehicle body component. The power conversion device is arranged between a front end and a rear end of the drive unit in a side view of the vehicle.

Abstract: An object of the present invention is to provide a fermented seasoning containing 5?-nucleotides derived from fermentation at a high concentration without externally adding 5?-nucleotides and a method of producing the same. In a case where the nucleic acids are externally added, display of additives is indispensable on an ingredients description, and thus it cannot be said that the fermented seasoning have no chemical seasoning additive or made by natural brewing; however, with the fermented seasoning relating to the present invention, it is unnecessary to display additives on the ingredients description, and thus it is possible to appeal an added value to nature oriented or natural oriented consumers.

Abstract: A mounting structure for a power conversion device includes: a vehicle body component extending in a front-rear direction of a vehicle; a mounting component provided on the vehicle body component; a drive unit held by the vehicle body component via the mounting component; and a power conversion device attached to the mounting component. A stiffness of the mounting component is greater than a stiffness of the vehicle body component. The power conversion device is arranged between a front end and a rear end of the drive unit in a side view of the vehicle.

Abstract: The invention provides a brush bristle and a brush roll that exhibit a suitable abrasive force and that can reduce or eliminate the abrasion of a mill roll as much as possible. The brush bristle is for use in a brush roll B configured to scour a mill roll for rolling a metal sheet S, and includes one or more monofilaments 2 made of a thermoplastic resin containing abrasive particles. The abrasive particles have a hardness lower than the hardness of the mill roll, and higher than the hardness of the metal sheet S.

Abstract: A semiconductor device includes a FIFO, a test data write circuit that sequentially writes a plurality of test data to the FIFO in synchronization with a first clock signal, and a test control circuit that, in parallel with writing of the plurality of test data to the FIFO by the test data write circuit, sequentially reads a plurality of test data stored in the FIFO in synchronization with a second clock signal that is not synchronous with the first clock signal and performs a scan test of a circuit to be tested.

Abstract: Provided herein is a soy sauce-like seasoning containing at least 0.3 mM ?-ketoglutaric acid.

Abstract: A semiconductor device includes a FIFO, a test data write circuit that sequentially writes a plurality of test data to the FIFO in synchronization with a first clock signal, and a test control circuit that, in parallel with writing of the plurality of test data to the FIFO by the test data write circuit, sequentially reads a plurality of test data stored in the FIFO in synchronization with a second clock signal that is not synchronous with the first clock signal and performs a scan test of a circuit to be tested.

Abstract: The invention provides a brush bristle and a brush roll that exhibit a suitable abrasive force and that can reduce or eliminate the abrasion of a mill roll as much as possible. The brush bristle is for use in a brush roll B configured to scour a mill roll for rolling a metal sheet S, and includes one or more monofilaments 2 made of a thermoplastic resin containing abrasive particles. The abrasive particles have a hardness lower than the hardness of the mill roll, and higher than the hardness of the metal sheet S.

Abstract: An object is to prevent the occurrence of contact failure between a cartridge equipped with a recording medium and an ink jet recording apparatus. A bottle body is crushed to reduce the volume thereof when an ink or solvent is sucked out of the bottle body. A bottle has a neck and a mouth. The neck is rigid. The ROM unit records therein an ink or solvent type, a serial number, the capacity of the bottle, and the amount of remaining ink or solvent. The ROM unit has first and second arms, and freely movably attached to the neck by the first and second arms. A positioning hole is formed on a ROM holder body which houses therein a recording medium. The positioning hole positions the ROM holder body in cooperation with a positioning pin of a reservoir.

Abstract: A power-on self-test circuit and a pattern generation circuit are provided. The power-on self-test circuit includes a selection circuit and a comparator circuit. The selection circuit selects, instead of an external pin group corresponding to a test access port, an output of the pattern generation circuit when a self-diagnosis execution signal is asserted and supplies a test pattern generated by the pattern generation circuit to a built-in self-test circuit. The comparator circuit compares a test result of a circuit-under-test with an expected value. By asserting the self-diagnosis execution signal in this manner, the semiconductor integrated circuit mounted on a user system executes BIST.

Abstract: An object is to prevent the occurrence of contact failure between a cartridge equipped with a recording medium and an ink jet recording apparatus. A bottle body is crushed to reduce the volume thereof when an ink or solvent is sucked out of the bottle body. A bottle has a neck and a mouth. The neck is rigid. The ROM unit records therein an ink or solvent type, a serial number, the capacity of the bottle, and the amount of remaining ink or solvent. The ROM unit has first and second arms, and freely movably attached to the neck by the first and second arms. A positioning hole is formed on a ROM holder body which houses therein a recording medium. The positioning hole positions the ROM holder body in cooperation with a positioning pin of a reservoir.

Abstract: The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.