Patents by Inventor Hiroki Wada
Hiroki Wada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8895570Abstract: The invention provides the compound of formula (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy.Type: GrantFiled: December 14, 2011Date of Patent: November 25, 2014Assignee: AstraZeneca ABInventors: Phillip Abbott, Roger Victor Bonnert, Thomas McInally, Stephen Thom, Hiroki Wada, Satoshi Onuma
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Publication number: 20140045837Abstract: The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.Type: ApplicationFiled: October 21, 2013Publication date: February 13, 2014Applicants: AstraZeneca Aktiebolag, Dainippon Sumitomo Pharma Co., Ltd.Inventors: Ayumu Kurimoto, Kazuki Hashimoto, Yoshiaki Isobe, Stephen Brough, Ian Millichip, Hiroki Wada, Roger Bonnert, Thomas Mcinally
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Publication number: 20130338174Abstract: The invention provides the compound of formula (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy.Type: ApplicationFiled: December 14, 2011Publication date: December 19, 2013Inventors: Phillip Abbott, Roger Victor Bonnert, Thomas Mcinally, Stephen Thom, Hiroki Wada, Satoshi Onuma
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Publication number: 20130328583Abstract: A power-on self-test circuit and a pattern generation circuit are provided. The power-on self-test circuit includes a selection circuit and a comparator circuit. The selection circuit selects, instead of an external pin group corresponding to a test access port, an output of the pattern generation circuit when a self-diagnosis execution signal is asserted and supplies a test pattern generated by the pattern generation circuit to a built-in self-test circuit. The comparator circuit compares a test result of a circuit-under-test with an expected value. By asserting the self-diagnosis execution signal in this manner, the semiconductor integrated circuit mounted on a user system executes BIST.Type: ApplicationFiled: June 6, 2013Publication date: December 12, 2013Inventors: Hiroki Wada, Yoichi Maeda
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Patent number: 8575180Abstract: The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.Type: GrantFiled: July 20, 2011Date of Patent: November 5, 2013Assignees: AstraZeneca Aktiebolag, Dainippon Sumitomo Pharma Co., Ltd.Inventors: Ayumu Kurimoto, Kazuki Hashimoto, Yoshiaki Isobe, Stephen Brough, Ian Millichip, Hiroki Wada, Roger Bonnert, Thomas Mcinally
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Publication number: 20130123275Abstract: The invention concerns pyrazine derivatives of the Formula I or pharmaceutically-acceptable salts thereof; wherein each of n, m and R has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of bone-related disorders or conditions.Type: ApplicationFiled: May 7, 2012Publication date: May 16, 2013Applicant: ASTRAZENECA ABInventors: Tao FENG, Hitesh Jayantilal SANGANEE, Hiroki WADA
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Patent number: 8436178Abstract: The present invention provides compounds of formula (I) wherein Ra, R1, R2, R3, X1, Y1, Z1, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.Type: GrantFiled: May 6, 2008Date of Patent: May 7, 2013Assignees: AstraZeneca AB, Dainippon Sumitomo Pharma Co., Ltd.Inventors: Roger Victor Bonnert, Thomas McInally, Stephen Thom, Hiroki Wada
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Patent number: 8198285Abstract: The invention concerns pyrazine derivatives of the Formula I or pharmaceutically-acceptable salts thereof; wherein each of n, m and R has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of bone-related disorders or conditions.Type: GrantFiled: January 18, 2011Date of Patent: June 12, 2012Assignee: Astrazeneca ABInventors: Tao Feng, Hitesh Jayantilal Sanganee, Hiroki Wada
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Patent number: 8138172Abstract: The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the treatment of asthma, hepatitis, allergic diseases, viral and bacterial infection as well as cancer.Type: GrantFiled: July 3, 2007Date of Patent: March 20, 2012Assignees: AstraZeneca AB, Dainippon Sumitomo Pharma Co Ltd.Inventors: Anthony Cook, Tom McInally, Stephen Thom, Hiroki Wada
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Publication number: 20120022082Abstract: The invention concerns pyrazine derivatives of the Formula I or pharmaceutically-acceptable salts thereof; wherein each of n, m and R has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of bone-related disorders or conditions.Type: ApplicationFiled: January 18, 2011Publication date: January 26, 2012Applicant: ASTRAZENECA ABInventors: Tao FENG, Hitesh Jayantilal SANGANEE, Hiroki WADA
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Publication number: 20110306610Abstract: The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.Type: ApplicationFiled: July 20, 2011Publication date: December 15, 2011Applicants: AstraZeneca Aktiebolag, Dainippon Sumitomo Pharma Co., Ltd.Inventors: Ayumu KURIMOTO, Kazuki Hashimoto, Yoshiaki Isobe, Stephen Brough, Ian Millichip, Hiroki Wada, Roger Bonnert, Thomas Mcinally
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Patent number: 8012964Abstract: The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.Type: GrantFiled: March 24, 2005Date of Patent: September 6, 2011Assignees: Dainippon Sumitomo Pharma Co., Ltd., Astrazeneca AktiebolagInventors: Ayumu Kurimoto, Yoshiaki Isobe, Stephen Brough, Hiroki Wada, Roger Bonnert, Thomas McInally
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Publication number: 20100280001Abstract: The present invention provides compounds of formula (I) wherein Ra, R1, R2, R3, X1, Y1, Z1, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.Type: ApplicationFiled: May 6, 2008Publication date: November 4, 2010Inventors: Roger Victor Bonnert, Thomas McInally, Stephen Thom, Hiroki Wada
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Publication number: 20100240623Abstract: The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the treatment of asthma, hepatitis, allergic diseases, viral and bacterial infection as well as cancer.Type: ApplicationFiled: July 3, 2007Publication date: September 23, 2010Inventors: Anthony Cook, Tom McInally, Stephen Thom, Hiroki Wada
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Publication number: 20090143400Abstract: The present invention provides compounds of formula wherein n, Y, Z, R, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.Type: ApplicationFiled: September 12, 2006Publication date: June 4, 2009Inventors: Thomas McInally, Stephen Thom, Hiroki Wada
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Publication number: 20080269240Abstract: An adenine compound useful as a medicine represented by the following formula (1): [wherein R1 is halogen atom, optionally substituted alkyl group, optionally substituted aryl group, etc.; X is oxygen atom, sulfur atom, a single bond, etc.; A1 is optionally substituted and optionally saturated 4 to 8 membered heterocyclic group containing 1 to 2 hetero atoms selected from 1 to 3 nitrogen atoms, 0 to 1 oxygen atom, and 0 to 1 sulfur atom; A2 is optionally substituted 6 to 10 cyclic aromatic hydrocarbon group or optionally substituted 5 to 10 membered heterocyclic aromatic group; L1 and L2 are independently, substituted straight or branched alkylene or a single bond, etc.; L3 is optionally substituted straight or branched alkylene, etc.; R2 is hydrogen atom, optionally substituted alkyl group.] or its pharmaceutically acceptable salt.Type: ApplicationFiled: September 21, 2006Publication date: October 30, 2008Applicants: Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan, AstraZeneca Aktiebolag A Corporation of SwedenInventors: Kazuki Hashimoto, Tomoaki Nakamura, Kei Nakamura, Shingo Tojo, Ayumu Kurimoto, Yoshiaki Isobe, Hiroki Wada, Roger Bonnert
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Publication number: 20070190071Abstract: The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.Type: ApplicationFiled: March 24, 2005Publication date: August 16, 2007Applicants: Dainippon Sumitomo Pharma Co., Ltd., AstraZeneca AktiebolagInventors: Ayumu Kurimoto, Kazuki Hashimoto, Yoshiaki Isobe, Stephen Brough, Ian Millichip, Hiroki Wada, Roger Bonnert, Thomas Mcinally
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Patent number: 7227482Abstract: In a first-order complex band-pass filter, multiplexers are alternately switched over between time intervals of phases A and B, where the multiplexers includes two multiplexers provided at input and output stages, and a multiplexer provided in a feedback circuit of each of first-order filters and being switching over whether to invert a sign of a feedback signal. Then in a circuit part sandwiched between the multiplexers, a processing performed by an I circuit part and a processing performed by a Q circuit part are alternately switched over so that a sign of a signal inputted to an adder is inverted.Type: GrantFiled: April 24, 2006Date of Patent: June 5, 2007Assignee: Semiconductor Technology Academic Research CenterInventors: Hao San, Haruo Kobayashi, Hiroki Wada, Akira Hayakawa, Hiroyuki Hagiwara, Yoshitaka Jingu, Kazuyuki Kobayashi, Toshiro Tsukada
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Publication number: 20060284751Abstract: In a first-order complex band-pass filter, multiplexers are alternately switched over between time intervals of phases A and B, where the multiplexers includes two multiplexers provided at input and output stages, and a multiplexer provided in a feedback circuit of each of first-order filters and being switching over whether to invert a sign of a feedback signal. Then in a circuit part sandwiched between the multiplexers, a processing performed by an I circuit part and a processing performed by a Q circuit part are alternately switched over so that a sign of a signal inputted to an adder is inverted.Type: ApplicationFiled: April 24, 2006Publication date: December 21, 2006Applicant: Semiconductor Technology Academic Research CenterInventors: Hao San, Haruo Kobayashi, Hiroki Wada, Akira Hayakawa, Hiroyuki Hagiwara, Yoshitaka Jingu, Kazuyuki Kobayashi, Toshiro Tsukada
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Patent number: D722642Type: GrantFiled: December 13, 2013Date of Patent: February 17, 2015Assignee: Keyence CorporationInventors: Hiroki Wada, Junji Ogawa