Patents by Inventor Hiroshi Handa
Hiroshi Handa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9632077Abstract: A detection system of a test substance, includes: a magnetic body that is modified by a first substance capable of being bound to the test substance at a first binding site of the test substance; a marker that is modified by a second substance capable of being bound to the test substance at a second binding site of the test substance, the second coupling site being a different site from the first binding site; a development medium that has a flow passage into which liquid, in which the magnetic body and the marker is dispersed, flows due to a capillary phenomenon, the development medium having a detection position for detecting the marker in a portion of the flow passage, the development medium having light transparency at least in the detection position; and a magnetic force generating portion that is equipped in the development medium.Type: GrantFiled: January 5, 2015Date of Patent: April 25, 2017Assignees: TOPPAN PRINTING CO., LTD., TOKYO INSTITUTE OF TECHNOLOGYInventors: Takumi Hirase, Masato Nakayama, Hiroshi Handa, Satoshi Sakamoto, Yasuyuki Naito
-
Patent number: 9625875Abstract: A developing cartridge includes: a housing having first and second sidewalls through which respective end portions of a developing roller shaft are rotatably inserted; a developing gear, which is arranged outside of the first sidewall, and which is fixed to the end portion of the developing roller shaft; a transmission gear, which is arranged outside of the first sidewall, and which transmits driving force to the developing gear; a first cover member, which is attached to the first sidewall, and which covers the transmission gear; and a second cover member, which is attached to the first sidewall, and which covers the developing gear from an outer side in the axis line direction. The second cover member is formed separately from the first cover member and is arranged side by side with the first cover member outside of the first sidewall.Type: GrantFiled: April 27, 2016Date of Patent: April 18, 2017Assignee: Brother Kogyo Kabushiki KaishaInventors: Hiroshi Handa, Hiroki Mori
-
Patent number: 9611465Abstract: With an aim to provide a novel factor inducing proliferation of neural stem cells and differentiation of these cells into nerve cells, a pharmaceutical composition comprising 1) CRBN, 2) a nucleic acid encoding CRBN, or 3) a stem cell or a neural progenitor cell in which CRBN is expressed, a method including administering the pharmaceutical composition to a non-human animal and inducing proliferation of neural stem cells or neural progenitor cells of the non-human animal and differentiation of these cells into nerve cells, and a method for screening for a therapeutic drug for a disease of cerebral cortex or a surgical injury of cerebral cortex, using CRBN, are provided.Type: GrantFiled: February 23, 2015Date of Patent: April 4, 2017Assignee: CELGENE CORPORATIONInventors: Hiroshi Handa, Hideki Ando, Takumi Itoh, Kentaro Hotta
-
Publication number: 20170031277Abstract: A fixing device includes a film, a first heat element, a second heat element, a nip member, a reflection member and a supporting member, which are disposed inside a loop of the film, and a pressing member. The nip member contacts the inner circumferential surface of the film. The reflection member surrounds the first heat element with the nip member and reflects a radiant heat from the first heat element to the nip member. The pressing member presses the film toward the nip member. The supporting member covers the reflection member, supports the nip member, and includes a first plate portion, a second plate portion and a third plate portion. The second heat element is disposed in at least one of the second plate portion, the third plate portion, one end portion of the nip member, and another end portion of the nip member.Type: ApplicationFiled: July 29, 2016Publication date: February 2, 2017Inventor: Hiroshi Handa
-
Publication number: 20170007645Abstract: Provided herein, for example, are methods generally relating to the expansion and/or regeneration of central nervous system (CNS) cells, such as nerve cells, astrocytes and oligodendrocytes, using an activator of cereblon (CRBN), such as an inhibitor of a CRBN substrate or downstream protein. Also provided herein, for example, are methods related to the expansion of neural stem cells, neural progenitor cells, or neural precursor cells and/or differentiation of these cells into CNS cells using a BRD7 antagonist, Ikaros antagonist, or CRBN activator. In certain embodiments, the methods further comprise differentiation of certain stem cells into the neural stem cells, neural progenitor cells, or neural precursor cells using a BRD7 antagonist, Ikaros antagonist, or CRBN activator. Also provided herein, for example, are methods of preventing or treating a CNS cell defective disease, disorder or condition, or a symptom thereof, using a BRD7 antagonist, Ikaros antagonist, or CRBN activator.Type: ApplicationFiled: February 23, 2015Publication date: January 12, 2017Inventors: Hiroshi Handa, Hideki Ando, Takumi ITO
-
Patent number: 9494580Abstract: Polymer particles are provided which contain fluorescent molecules with high presence ratio in a polymer layer thereof and a method for preparing thereof. Polymer particles are swelled in a non-aqueous solution excluding exclusively water preferably promotes selling of the polymer layer and transfer of the fluorescent molecules to the polymer layer could not protected by water molecules such that much more fluorescent molecule may be introduced into inside of the polymer layer. Furthermore, since the water is added to the reaction system prior to evaporation removal of the non-aqueous solvent, dry-up of the polymer particles is prevented by the water remained in the reaction system and the polymer particles including fluorescent molecules with high presence ratio of the fluorescent molecules preferably keep high dispersibility using the above described procedures.Type: GrantFiled: September 10, 2009Date of Patent: November 15, 2016Assignee: TOKYO INSTITUTE OF TECHNOLOGYInventors: Hiroshi Handa, Mamoru Hatakeyama, Satoshi Sakamoto, Yusuke Mochizuki, Shintaro Kawada
-
Publication number: 20160238990Abstract: A developing cartridge includes: a housing having first and second sidewalls through which respective end portions of a developing roller shaft are rotatably inserted; a developing gear, which is arranged outside of the first sidewall, and which is fixed to the end portion of the developing roller shaft; a transmission gear, which is arranged outside of the first sidewall, and which transmits driving force to the developing gear; a first cover member, which is attached to the first sidewall, and which covers the transmission gear; and a second cover member, which is attached to the first sidewall, and which covers the developing gear from an outer side in the axis line direction. The second cover member is formed separately from the first cover member and is arranged side by side with the first cover member outside of the first sidewall.Type: ApplicationFiled: April 27, 2016Publication date: August 18, 2016Inventors: Hiroshi Handa, Hiroki Mori
-
Publication number: 20160231681Abstract: An image forming apparatus includes: a heating unit; a pressure roller; a first frame supporting the heating unit; a second frame engaging the first frame; a first gear; a second gear; and a fixing member. The second frame supports a shaft portion of the pressure roller. The first gear is provided at one end of the shaft portion and rotatable with the pressure roller. The second gear engages the first gear and transmits a drive force to the first gear. The fixing member has a first portion engaging the shaft portion and a second portion engaging the second frame. At least a part of the first portion engages the shaft portion at a position on a downstream side of the shaft portion in a second direction in which the shaft portion receives a force upon transmission of the drive force.Type: ApplicationFiled: January 28, 2016Publication date: August 11, 2016Inventors: Hiroki Mori, Hiroshi Handa, Tatsuo Ogasawara, Takuji Matsuno
-
Patent number: 9348299Abstract: A developing cartridge includes: a housing having first and second sidewalls through which respective end portions of a developing roller shaft are rotatably inserted; a developing gear, which is arranged outside of the first sidewall, and which is fixed to the end portion of the developing roller shaft; a transmission gear, which is arranged outside of the first sidewall, and which transmits driving force to the developing gear; a first cover member, which is attached to the first sidewall, and which covers the transmission gear; and a second cover member, which is attached to the first sidewall, and which covers the developing gear from an outer side in the axis line direction. The second cover member is formed separately from the first cover member and is arranged side by side with the first cover member outside of the first sidewall.Type: GrantFiled: December 22, 2015Date of Patent: May 24, 2016Assignee: Brother Kogyo Kabushiki KaishaInventors: Hiroshi Handa, Hiroki Mori
-
Polymer coated ferrite fine particles and method for preparing polymer coated ferrite fine particles
Patent number: 9327024Abstract: [Object] To provide a polymer coated ferrite fine particles being possible to control a particle size uniformly while having high aqueous dispersibility and preferred biomolecule immobilization ability and an easy method for preparing the same. [Means Addressing Object] In an aqueous solvent, iron ion is protected by chelating polyacrylic acid and then alkaline is added. Thereafter, a reaction system is heated under pressurized condition to produce simultaneous precipitation of the ferrite fine particles and coating thereof. As the result, the polymer coated ferrite fine particles having uniform particle size may be prepared in one step with excellent reproducibility. The polymer coated ferrite fine particles of the present invention has high water dispersibility and has preferred biomolecule immobilization performance by carboxyl groups coming from the polyacrylic acid.Type: GrantFiled: October 28, 2010Date of Patent: May 3, 2016Assignee: TOKYO INSTITUTE OF TECHNOLOGYInventors: Hiroshi Handa, Mamoru Hatakeyama, Satoshi Sakamoto, Hiroshi Kishi -
Publication number: 20160109849Abstract: A developing cartridge includes: a housing having first and second sidewalls through which respective end portions of a developing roller shaft are rotatably inserted; a developing gear, which is arranged outside of the first sidewall, and which is fixed to the end portion of the developing roller shaft; a transmission gear, which is arranged outside of the first sidewall, and which transmits driving force to the developing gear; a first cover member, which is attached to the first sidewall, and which covers the transmission gear; and a second cover member, which is attached to the first sidewall, and which covers the developing gear from an outer side in the axis line direction. The second cover member is formed separately from the first cover member and is arranged side by side with the first cover member outside of the first sidewall.Type: ApplicationFiled: December 22, 2015Publication date: April 21, 2016Inventors: Hiroshi Handa, Hiroki Mori
-
Patent number: 9317008Abstract: An image forming apparatus includes a developing roller and a photosensitive drum configured to rotate about a first axis, and has a peripheral surface. The developing roller is configured to contact the photosensitive drum and is configured to supply developer to the photosensitive drum by rotating about a second axis positioned lower than the first axis in a vertical direction to form a visible image on the peripheral surface. Extraneous matter on the peripheral surface is recovered only by the developing roller.Type: GrantFiled: January 9, 2015Date of Patent: April 19, 2016Assignee: Brother Kogyo Kabushiki KaishaInventors: Hiroshi Handa, Takeshi Bito, Hiroki Mori
-
Patent number: 9280082Abstract: A developing device includes: a housing made of resin; a developer carrier, which is rotatably supported by the housing, and which is configured to carry developer on a circumferential surface thereof; a receiving-side coupling member, which is provided rotatably to one of end portions of the developer carrier and is configured to couple with a driving-side coupling member in the rotational axial direction to transmit driving force to the developer carrier; a blade, which is provided along the rotational axial direction, and which configured to contact the circumferential surface of the developer carrier to regulate a layer thickness of the developer on the circumferential surface; and a support member, which is bent into an L-shape as viewed from the rotational axial direction, and which supports the blade, wherein the receiving-side coupling member is overlapped with a bending portion of the support member, as viewed from the rotational axial direction.Type: GrantFiled: June 5, 2014Date of Patent: March 8, 2016Assignee: Brother Kogyo Kabushiki KaishaInventors: Masatoshi Shiraki, Hiroshi Handa, Hiroki Mori
-
Patent number: 9268261Abstract: A developing device includes a frame, a developing roller, a blade unit, and a first seal member. A blade unit extends in an axial direction of the developing roller and in contact with the peripheral surface thereof. The first seal member is configured to seal a boundary between the frame and the axial end portions of the developing roller. The frame has a fixing portion to which end portions of the blade is fixed. The fixing portion has a support surface having an outer edge and an inner edge in the axial direction. The outer edge is positioned outward of an inner edge of the first seal member in the axial direction, and the inner edge of the support surface is positioned inward of the inner edge of the first seal member in the axial direction.Type: GrantFiled: November 27, 2013Date of Patent: February 23, 2016Assignee: Brother Kogyo Kabushiki KaishaInventors: Hiroshi Handa, Hiroki Mori
-
Publication number: 20160032130Abstract: A method of manufacturing a polymer coated single ferromagnetic particle is provided. The method includes hydrophobizing one single hydrophilic ferromagnetic particle by absorbing an aliphatic acid having a hydrophobic aliphatic group and a hydrophilic acid group onto the single ferromagnetic particle to obtain a single hydrophobic ferromagnetic particle; emulsifying the one single hydrophobic ferromagnetic particle with a monomer liquid comprising a nonionic surface activating agent which re-hydrophilizes the one single hydrophobic ferromagnetic particle, to obtain an emulsified liquid; adding a radical addition initiator to the emulsified liquid; and emulsion polymerizing the monomer by radical addition polymerization.Type: ApplicationFiled: August 20, 2015Publication date: February 4, 2016Applicants: TOKYO INSTITUTE OF TECHNOLOGY, TAMAGAWA SEIKI KABUSHIKI KAISHAInventors: Hiroshi HANDA, Kosuke NISHIO, Nobuyuki GOKON, Masanori ABE
-
Patent number: 9250603Abstract: A developing cartridge includes: a housing having first and second sidewalls through which respective end portions of a developing roller shaft are rotatably inserted; a developing gear, which is arranged outside of the first sidewall, and which is fixed to the end portion of the developing roller shaft; a transmission gear, which is arranged outside of the first sidewall, and which transmits driving force to the developing gear; a first cover member, which is attached to the first sidewall, and which covers the transmission gear; and a second cover member, which is attached to the first sidewall, and which covers the developing gear from an outer side in the axis line direction. The second cover member is formed separately from the first cover member and is arranged side by side with the first cover member outside of the first sidewall.Type: GrantFiled: May 27, 2015Date of Patent: February 2, 2016Assignee: Brother Kogyo Kabushiki KaishaInventors: Hiroshi Handa, Hiroki Mori
-
Patent number: 9239975Abstract: Image forming apparatus includes: image forming unit for forming an image on a sheet, and controller for controlling the image forming unit. The controller includes process modules to carry out: counting process for performing counting in accordance with the number of sheets printed by the image forming unit; first bias applying process for setting a developing bias to be applied to the developer carrier to a first bias if a count value in the counting process has not reached a predetermined threshold value; bias changing process for changing the developing bias to a second bias whose absolute value is smaller than that of the first bias if the count value has reached the threshold value; and delaying process for causing an execution timing of the bias changing process to be delayed if the number of sheets printed in a unit of time is not smaller than a reference number.Type: GrantFiled: March 25, 2015Date of Patent: January 19, 2016Assignee: BROTHER KOGYO KABUSHIKI KAISHAInventors: Hiroshi Handa, Masahito Saeki
-
Patent number: 9217743Abstract: With an aim to provide means for developing a compound devoid of teratogenicity but retaining beneficial actions, a screening method for a non-teratogenic substance comprising bringing a test substance into contact with cereblon or a fragment of cereblon, evaluating the bindability of the test substance with cereblon or the fragment of cereblon, and selecting a test substance that does not bind to cereblon or the fragment of cereblon or a test substance exhibiting lower bindability with cereblon or the fragment of cereblon than does thalidomide is provided.Type: GrantFiled: October 18, 2010Date of Patent: December 22, 2015Assignees: Tokyo Institute of Technology, Fujimoto Pharmaceutical CorporationInventors: Hiroshi Handa, Hideki Ando, Takumi Itoh, Kentaro Hotta
-
Patent number: 9164420Abstract: A developing device including: a housing; a developing roller including a roller main body having a recess portion recessed inwards in an axis line direction, the recess portion including, a first surface extending in the axis line direction, and a second surface extending from an inner end portion of the first surface towards a direction intersecting with the axis line direction; and a seal member arranged between the housing and the roller main body, wherein, in the axis line direction, the second surface is positioned within a range in which the seal member is arranged, and wherein, in the axis line direction, a distance from an inner end portion of the seal member to the second surface is larger than a length of a part at which the seal member and the first surface overlap with each other.Type: GrantFiled: November 27, 2013Date of Patent: October 20, 2015Assignee: Bother Kogyo Kabushiki KaishaInventor: Hiroshi Handa
-
Publication number: 20150278657Abstract: Image forming apparatus includes: image forming unit for forming an image on a sheet, and controller for controlling the image forming unit. The controller includes process modules to carry out: counting process for performing counting in accordance with the number of sheets printed by the image forming unit; first bias applying process for setting a developing bias to be applied to the developer carrier to a first bias if a count value in the counting process has not reached a predetermined threshold value; bias changing process for changing the developing bias to a second bias whose absolute value is smaller than that of the first bias if the count value has reached the threshold value; and delaying process for causing an execution timing of the bias changing process to be delayed if the number of sheets printed in a unit of time is not smaller than a reference number.Type: ApplicationFiled: March 25, 2015Publication date: October 1, 2015Applicant: BROTHER KOGYO KABUSHIKI KAISHAInventors: Hiroshi HANDA, Masahito SAEKI