Abstract: Spherical ferrite nanoparticles produced by a method that includes the steps of: preparing a first aqueous solution containing a disaccharide, an alkaline, an oxidation agent, seed particles and divalent iron ions; and conducting particle growth in the first aqueous solution to produce the spherical ferrite nanoparticles.

Abstract: With an aim to provide means for developing a compound devoid of teratogenicity but retaining beneficial actions, a screening method for a non-teratogenic substance comprising bringing a test substance into contact with cereblon or a fragment of cereblon, evaluating the bindability of the test substance with cereblon or the fragment of cereblon, and selecting a test substance that does not bind to cereblon or the fragment of cereblon or a test substance exhibiting lower bindability with cereblon or the fragment of cereblon than does thalidomide is provided.

Abstract: Disclosed is a construct comprising a virus coat protein usable as a carrier for drug delivery adaptable to various drugs. Specifically disclosed is a construct coated with a virus coat protein, comprising a virus coat protein and a construct coated therewith, wherein the virus coat protein is attached to the surface of the construct to form a layer of the protein thereon.

Abstract: A developing cartridge includes: a casing configured of a first frame and a second frame with a space formed therebetween; and a developer-carrying member that is supported in the first frame and that is configured to carry developer. The first frame includes a bottom wall and a pair of side walls erected from both sides of the bottom wall and has a box shape that is open on a side opposite the bottom wall. The second frame is mounted over the pair of side walls so as to cover the open side of the first frame and has a partition extending into the space formed in the casing. The partition contacts the bottom wall of the first frame and spans between the pair of side walls of the first frame, thereby separating the space within the casing into a first chamber on a side near the developer-carrying member and a second chamber on a side far from the developer-carrying member. Developer is accommodated in the first chamber only.

Abstract: With an aim to provide a novel factor inducing proliferation of neural stem cells and differentiation of these cells into nerve cells, a pharmaceutical composition comprising 1) CRBN, 2) a nucleic acid encoding CRBN, or 3) a stem cell or a neural progenitor cell in which CRBN is expressed, a method including administering the pharmaceutical composition to a non-human animal and inducing proliferation of neural stem cells or neural progenitor cells of the non-human animal and differentiation of these cells into nerve cells, and a method for screening for a therapeutic drug for a disease of cerebral cortex or a surgical injury of cerebral cortex, using CRBN, are provided.

Abstract: An image forming apparatus is provided. The image forming apparatus includes an accommodating member configured to accommodate developer; a supply member configured to supply the developer of the accommodating member; a developer holding member configured to supply the developer from the supply member to an image holding member; and a voltage controller configured to apply a first predetermined voltage to the supply member and apply a second predetermined voltage to the developer holding member so as to supply the developer from the accommodating member to the electrostatic latent image formed on the image holding member through the supply member and the developer holding member. The voltage controller, when starting to apply a voltage to the supply member, applies an excessive voltage to the supply member, the excessive voltage having a polarity same as the first predetermined voltage and being larger in an absolute value than the first predetermined voltage.

Abstract: An image-forming device can include an image acquiring unit that acquires image data, an image forming unit that forms an image based on the image data, a determining unit that determines whether the image data includes a part having density greater than or equal to a prescribed density, and a controller. The image forming unit can include a developing roller, a supply roller for supplying developer to the developing roller, and a bias applying unit that applies first and second voltages between the developing roller and the supply roller in first and second modes, respectively. The controller can control the bias applying unit to apply one of the first and second voltages when the determining unit determines whether the image data includes the part having density greater than or equal to a prescribed density.

Abstract: A developing cartridge includes: a developing roller main body; a developing roller shaft, which is arranged along a central axis line of the developing roller main body, and which protrudes from both end portions of the developing roller main body along the central axis line, wherein the developing roller shaft includes a small diameter part located at a first end portion in the axis line direction, the small diameter part having an outer diameter smaller than an outer diameter of a second end portion opposite to the first end portion; and a developing gear that is fixed to the first end portion of the developing roller shaft.

Abstract: A developing apparatus comprising: a housing; a developing roller; a seal member, and a layer thickness regulating member that contacts a circumferential surface of the developing roller via developer and regulates a thickness of a developer layer on the circumferential surface of the developing roller, wherein the seal member has a sliding contact portion made of fiber having elasticity and sliding-contacting the circumferential surface of the developing roller, wherein the layer thickness regulating member has one end portion that is supported by the housing and the other end portion to which a bent portion is formed to face the seal member, and wherein the bent portion is configured to enter the sliding contact portion.

Abstract: A processing unit is provided. He processing unit comprises: a housing; a developing roller that carries developer on a surface thereof, the developing roller including, a hollow roller body, and a covering layer covering an outer circumferential surface of the roller body; a photosensitive drum that contacts the developing roller, wherein an end face of the photosensitive drum at a first side in an axial direction of the developing roller is located at an outer side in the axial direction compared to an end face of the developing roller at the first side in the axial direction, and wherein the developer on the developing roller is supplied to the photosensitive drum; and a supporting member that contacts an inner circumferential surface of the roller body at the first side in the axial direction, and supports the developing roller rotatably in the housing.

Abstract: Polymer particles are provided which contain fluorescent molecules with high presence ratio in a polymer layer thereof and a method for preparing thereof. Polymer particles are swelled in a non-aqueous solution excluding exclusively water preferably promotes selling of the polymer layer and transfer of the fluorescent molecules to the polymer layer could not protected by water molecules such that much more fluorescent molecule may be introduced into inside of the polymer layer. Furthermore, since the water is added to the reaction system prior to evaporation removal of the non-aqueous solvent, dry-up of the polymer particles is prevented by the water remained in the reaction system and the polymer particles including fluorescent molecules with high presence ratio of the fluorescent molecules preferably keep high dispersibility using the above described procedures.

Abstract: A developing device includes: a housing made of resin; a developer carrier, which is rotatably supported by the housing, and which is configured to carry developer on a circumferential surface thereof; a receiving-side coupling member, which is provided rotatably to one of end portions of the developer carrier and is configured to couple with a driving-side coupling member in the rotational axial direction to transmit driving force to the developer carrier; a blade, which is provided along the rotational axial direction, and which configured to contact the circumferential surface of the developer carrier to regulate a layer thickness of the developer on the circumferential surface; and a support member, which is bent into an L-shape as viewed from the rotational axial direction, and which supports the blade, wherein the receiving-side coupling member is overlapped with a bending portion of the support member, as viewed from the rotational axial direction.

Abstract: An image forming apparatus is configured to execute the steps including: a step of controlling a photosensitive drum and a developing roller such that the developing roller rotates in a predetermined direction and the photosensitive drum rotates in a reverse direction; and a step of controlling the photosensitive drum and the developing roller such that the developing roller stops and the photosensitive drum rotates in the reverse direction, so as to reduce toner filming.

Abstract: There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130 mM to 170 mM sodium chloride and 1.5 mM to 2.5 mM divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral particles, the substance to be encapsulated is included during the incubation.

Abstract: An image-forming device can include an image acquiring unit that acquires image data, an image forming unit that forms an image based on the image data, a determining unit that determines whether the image data includes a part having density greater than or equal to a prescribed density, and a controller. The image forming unit can include a developing roller, a supply roller for supplying developer to the developing roller, and a bias applying unit that applies first and second voltages between the developing roller and the supply roller in first and second modes, respectively. The controller can control the bias applying unit to apply one of the first and second voltages when the determining unit determines whether the image data includes the part having density greater than or equal to a prescribed density.

Abstract: Embodiments include applying or generating an alternating magnetic field near an affected area of a subject to be treated. When magnetic nanoparticles are located in the affected area, the magnetic nanoparticles are oscillated by the alternating magnetic field, which causes the magnetic nanoparticles to be dispersed within the affected area, break up the affected area, and/or heat the affected area.

Abstract: An image-forming device includes an image acquiring unit, an image forming unit, a determining unit, and a controller. The image acquiring unit acquires image data for one page. The image forming unit forms an image based on the image data. The image forming unit includes a developing roller, a supply roller, and a bias applying unit. The developing roller carries a developer. The supply roller supplies the developer to the developing roller. The bias applying unit applies a first voltage between the developing roller and the supply roller in a first mode, and applies a second voltage between the developing roller and the supply roller in a second mode. The determining unit determines whether the image data includes a part having density greater than or equal to a prescribed density.

Abstract: An object of the present invention is to provide a polymer coated magnetic fine polymer by coating an inorganic fine particle with a thin polymer layer under precise control of a polymerization reaction and a method for preparing the same. Onto a surface of the inorganic fine particle the iniferter is fixed and grafted chains are formed on the inorganic fine particle by a living radical polymerization using the iniferter as an initiator which is defined by the following chemical formula: (wherein X is a hydrophilic atomic group being capable of binding to a surface of the inorganic fine particle, R1 and R2 are each independently selected from a mono-valent hydrocarbyl group which is formed by removing one hydrogen atom from hydrocarbon.

Abstract: An object of the present invention is to provide a novel biosensing method as the novel application development of the magnetic particles in the biosensing. In an affinity reaction of biosensing, ligands are immobilized to magnetic fine particles and the magnetic fine particles are forced to reaction fields of the affinity reaction by magnetic guiding so as to bring the affinity reaction, which is the velocity controlling factor in the sensing, to high rates. According to the present invention, coated magnetic fine particles with having both of the high dispersion performance and high magnetic responsibility as the above described magnetic fine particles and the affinity reaction occurs quickly and in high density such that the present invention makes it possible to obtain relatively large signals within significantly short time duration when compared to the conventional art.

Abstract: Provided is a highly sensitive sensor system that can improve the S/N ratio by use of an electronic circuit without complicating the sensor body or degrading temporal resolution. A broad spectrum sensor element outputs an electric signal corresponding to a detected physical quantity, the sensor driven by multiplying a carrier signal by m-sequence code. The spread spectrum signal, after phase adjustment, is used to demodulate the sensor output signal, which corresponds to the broad spread spectrum of the physical quantity. The electrical noise generated in the sensor is a broad spread spectrum and is suppressed by low-pass filtering so as to improve the S/N ratio.