Abstract: The invention provides a cytotoxic T lymphocyte inducer comprising a virus-like particle composed of VP1 of simian virus 40. The T cell epitope peptide is inserted into a DE loop and/or an HI loop of the VP1.

Abstract: A developing device includes: a housing made of resin; a developer carrier, which is rotatably supported by the housing, and which is configured to carry developer on a circumferential surface thereof; a receiving-side coupling member, which is provided rotatably to one of end portions of the developer carrier and is configured to couple with a driving-side coupling member in the rotational axial direction to transmit driving force to the developer carrier; a blade, which is provided along the rotational axial direction, and which configured to contact the circumferential surface of the developer carrier to regulate a layer thickness of the developer on the circumferential surface; and a support member, which is bent into an L-shape as viewed from the rotational axial direction, and which supports the blade, wherein the receiving-side coupling member is overlapped with a bending portion of the support member, as viewed from the rotational axial direction.

Abstract: The present invention provides a method of artificially repressing gene expression, which is simpler to design than conventional methods (the RNAi, ribozyme and antisense methods) and which allows for easier confirmation of the effect. A method of inhibiting the translation reaction of a target gene, comprising cutting out a part of the poly(A) tail and/or 3?-terminal sequence of the target mRNA is provided.

Abstract: A developing device includes a frame, a developing roller, a blade unit, and a first seal member. A blade unit extends in an axial direction of the developing roller and in contact with the peripheral surface thereof. The first seal member is configured to seal a boundary between the frame and the axial end portions of the developing roller. The frame has a fixing portion to which end portions of the blade is fixed. The fixing portion has a support surface having an outer edge and an inner edge in the axial direction. The outer edge is positioned outward of an inner edge of the first seal member in the axial direction, and the inner edge of the support surface is positioned inward of the inner edge of the first seal member in the axial direction.

Abstract: A developing device including: a first seal member arranged between a housing and a layer thickness regulation blade, and a second seal member arranged between the housing and a developing roller, wherein the first seal member is arranged adjacent to the second seal member in a rotating direction of the developing roller, wherein the second seal member includes a first member contacting a circumferential surface of the developing roller and a second member arranged between the housing and the first member, wherein the second member includes a protruding portion that, in the rotating direction of the developing roller, protrudes more towards the first seal member than the first member, and wherein end portions of the first and second members in the rotating direction of the developing roller are respectively configured to contact with the first seal member.

Abstract: A developing device including: a housing; a developing roller including a roller main body having a recess portion recessed inwards in an axis line direction, the recess portion including, a first surface extending in the axis line direction, and a second surface extending from an inner end portion of the first surface towards a direction intersecting with the axis line direction; and a seal member arranged between the housing and the roller main body, wherein, in the axis line direction, the second surface is positioned within a range in which the seal member is arranged, and wherein, in the axis line direction, a distance from an inner end portion of the seal member to the second surface is larger than a length of a part at which the seal member and the first surface overlap with each other.

Abstract: A cartridge is configured to supply developing agent to a peripheral surface of a photosensitive drum. The cartridge includes a frame, a developing roller and first and second side seal members. The developing roller defines an axial direction, and is configured to supply developing agent in the frame to the photosensitive drum. The first side seal member is configured to seal a boundary between the frame and one end portion of the developing roller in the axial direction. The second side seal member is configured to seal a boundary between the frame and another end portion of the developing roller. The first and second side seal members define a gap therebetween in the axial direction, and the gap has a gap length smaller than a width in the axial direction of a maximum width sheet conveyed to the photosensitive drum.

Abstract: A developing cartridge includes: a developing roller main body; a developing roller shaft, which is arranged along a central axis line of the developing roller main body, and which protrudes from both end portions of the developing roller main body along the central axis line, wherein the developing roller shaft includes a small diameter part located at a first end portion in the axis line direction, the small diameter part having an outer diameter smaller than an outer diameter of a second end portion opposite to the first end portion; and a developing gear that is fixed to the first end portion of the developing roller shaft.

Abstract: It is an object of the present invention to provide a newly identified insulin secretion regulation factor that can control blood sugar in the normal range, and a method for screening an antidiabetic drug using said factor. In accordance with the present invention, there is provided a composition which is (i) a protein comprising an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4; or (ii) a protein comprising an amino acid sequence in which one or several amino acids are deleted, substituted or added in an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4 and negatively regulating insulin secretion, as well as a method for screening antidiabetic drug using said protein or a nucleic acid encoding the same.

Abstract: A processing unit is provided. The processing unit includes: a housing; a developing roller that carries developer on a surface thereof, the developing roller including, a roller body, and a covering layer covering an outer circumferential surface of the roller body; a photosensitive drum that contacts the developing roller, wherein an end face of the photosensitive drum at a first side in an axial direction of the developing roller is located at an outer side in the axial direction compared to an end face of the developing roller at the first side in the axial direction, and wherein the developer on the developing roller is supplied to the photosensitive drum; and a supporting member that contacts an inner circumferential surface of the roller body at the first side in the axial direction, and supports the developing roller rotatably in the housing.

Abstract: A casing of a developing apparatus defines a developing chamber and a developer accommodating chamber, that accommodates developer, therein. The developing chamber and the developer accommodating chamber are arranged side by side. The casing is formed with a replenishing port for supplying new developer from a developer replenishing unit into the developing chamber. The replenishing port is located right above a supply roller when the developing apparatus is disposed in an orientation in which the developing apparatus is intended to be placed in a main casing of an image forming apparatus. The control unit controls the supply roller to rotate when the developing apparatus is mounted in the main casing. The supply roller stirs old developer that have already been located in the developing chamber and the new developer, and transports the old developer and the new developer from the developing chamber into the developer accommodating chamber.

Abstract: Disclosed are a pharmaceutical composition, a screening method, and the like which use UDP-glucose glycoprotein glycosyl transferase 1 (UGGT1) or a gene encoding the same. UGGT1 has an extremely high proliferative activity compared to known pancreatic ?-cell proliferation factors; thus, UGGT1 can act as a useful therapeutic agent for diabetes without any modification and is also useful as a target substance for the development of a new therapeutic agent for diabetes.

Abstract: An image forming apparatus includes a photosensitive member, a developing roller, a toner supply roller, and a charging member. The toner supply roller supplies single-component non-magnetic toner to the developing roller for developing a latent image formed on the photosensitive drum. In a toner cleaning mode, the toner supply roller removes the toner from the developing roller. To this effect, the charging member charges up the toner held on the developing roller. A bias circuit and a controller are further provided, wherein the bias circuit applies bias voltages to the developing roller, supply roller, and charging member, and the controller controls the bias circuit to produce the bias voltages such that a potential difference between the charging member and the supply roller is greater than a potential difference between the developing roller and the supply roller in the toner cleaning mode.

Abstract: A method for producing spherical ferrite nanoparticles includes the steps of: preparing a first aqueous solution containing a disaccharide, an alkaline, an oxidation agent, seed particles and divalent iron ions; and conducting particle growth in the first aqueous solution to produce the spherical ferrite nanoparticles.

Abstract: Spherical ferrite nanoparticles produced by a method that includes the steps of: preparing a first aqueous solution containing a disaccharide, an alkaline, an oxidation agent, seed particles and divalent iron ions; and conducting particle growth in the first aqueous solution to produce the spherical ferrite nanoparticles.

Abstract: An image forming apparatus is configured to execute the steps including: a step of controlling a photosensitive drum and a developing roller such that the developing roller rotates in a predetermined direction and the photosensitive drum rotates in a reverse direction; and a step of controlling the photosensitive drum and the developing roller such that the developing roller stops and the photosensitive drum rotates in the reverse direction, so as to reduce toner filming.

Abstract: [Object] To provide a polymer coated ferrite fine particles being possible to control a particle size uniformly while having high aqueous dispersibility and preferred biomolecule immobilization ability and an easy method for preparing the same. [Means Addressing Object] In an aqueous solvent, iron ion is protected by chelating polyacrylic acid and then alkaline is added. Thereafter, a reaction system is heated under pressurized condition to produce simultaneous precipitation of the ferrite fine particles and coating thereof. As the result, the polymer coated ferrite fine particles having uniform particle size may be prepared in one step with excellent reproducibility. The polymer coated ferrite fine particles of the present invention has high water dispersibility and has preferred biomolecule immobilization performance by carboxyl groups coming from the polyacrylic acid.

Abstract: An image forming apparatus including: a photosensitive member; a charging member; a developer carrier; a transfer member; a charging control unit that applies a charging bias having the same polarity as a charged polarity of the developers to the charging member; and a transfer control unit that applies a transfer bias having a reverse polarity to the charged polarity of the developers to the transfer member, wherein when the transfer control unit sets the absolute value of the transfer bias to a first value, the charging control unit sets an absolute value of the charging bias to a third value, and wherein when the transfer control unit sets the absolute value of the transfer bias to a second value, the charging control unit sets the absolute value of the charging bias to a fourth value smaller than the third value.

Abstract: A developing device include: a case; a developing roller supported by the case to be rotatable in a rotational direction; and a blade including a base end supported by the case and a tip end provided upstream of the base end in the rotational direction and contacting the surface of the developing roller at a contact portion to regulate a thickness of the toner on the developing roller. The blade further includes a bent portion that is bent from the contact portion at a radius of curvature from 0.2 mm to 0.4 mm to be separated from the developing roller as extending toward the tip end. An angle defined between a segment connecting the contact portion with a center of curvature of the bent portion and a segment connecting the tip end with the center of curvature of the bent portion is in the range from 45° to 90°.

Abstract: Embodiments include applying or generating an alternating magnetic field near an affected area of a subject to be treated. When magnetic nanoparticles are located in the affected area, the magnetic nanoparticles are oscillated by the alternating magnetic field, which causes the magnetic nanoparticles to be dispersed within the affected area, break up the affected area, and/or heat the affected area.