Patents by Inventor Hiroshi Kawabata
Hiroshi Kawabata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10029731Abstract: A work vehicle includes a prime mover unit disposed in a front part of the vehicle body, a driving part located in a rear part of the vehicle body, a battery disposed between the prime mover unit and the driving part, a base frame disposed in a lower part of the vehicle body and a center pillar that extends upward from the base frame. The prime mover unit includes a radiator disposed immediately forward of the center pillar.Type: GrantFiled: December 5, 2016Date of Patent: July 24, 2018Assignee: Kubota CorporationInventors: Koichiro Matsumoto, Shoichiro Nagaishi, Ryo Matsumoto, Hiroshi Kawabata, Hiroki Nagai, Masahiro Izumi, Masaki Takaoka, Tasuku Teraoka, Takashi Kumashiro
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Patent number: 9969988Abstract: The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with ?-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence repType: GrantFiled: January 27, 2015Date of Patent: May 15, 2018Assignee: API CORPORATIONInventors: Makoto Hibi, Jun Ogawa, Ryoma Miyake, Hiroshi Kawabata
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Publication number: 20180086912Abstract: A monomer composition containing an unsaturated polyalkylene glycol ether-based monomer is provided having excellent stability. The monomer composition contains an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R1O)nR2 ??(1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R1O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition, mole number of oxyalkylene groups and is a number of 5 to 500; and R2 represents a hydrogen atom, or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.Type: ApplicationFiled: November 10, 2017Publication date: March 29, 2018Inventor: Hiroshi KAWABATA
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Patent number: 9914487Abstract: A work vehicle includes: a vehicle body frame; a prime mover part that is supported by the vehicle body frame; a bonnet that is configured to vertically swing between a closed position at which the prime mover part is covered, and an open position at which the prime mover part is open; and a support frame that supports a free end side of the bonnet located at the closed position. At least left and right guide-target parts of the bonnet or left and right guiding parts of the support frame have left and right inclined surfaces that serve as centering effective surfaces.Type: GrantFiled: November 2, 2016Date of Patent: March 13, 2018Assignee: Kubota CorporationInventors: Koichiro Matsumoto, Nobuyuki Yamashita, Hiroshi Kawabata, Tomohisa Yamamoto, Masayuki Akita, Tasuku Teraoka, Yoshihisa Tonoya
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Patent number: 9850378Abstract: A monomer composition containing an unsaturated polyalkylene glycol ether-based monomer is provided having excellent stability. The monomer composition contains an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R1O)nR2??(1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R1O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition mole number of oxyalkylene groups and is a number of 5 to 500; and R2 represents a hydrogen atom or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.Type: GrantFiled: September 22, 2011Date of Patent: December 26, 2017Assignee: Nippon Shokubai Co., Ltd.Inventor: Hiroshi Kawabata
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Publication number: 20170305867Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.Type: ApplicationFiled: May 19, 2017Publication date: October 26, 2017Applicant: API CORPORATIONInventors: Naoyuki WATANABE, Tomoko MAEDA, Yasumasa DEKISHIMA, Hiroshi KAWABATA, Masaki NAGAHAMA, Kosuke ITO
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Publication number: 20170246910Abstract: A pneumatic tire is provided in the tread portion 2 with a belt 7 comprising a radially outermost first belt ply 7A and a radially inner second belt ply 7B each composed of belt cords 7C, and a band 8 thereon comprising a band ply 8A compound of a band cord 8C. At least one of axially outer edge portions of the belt 7 is provided between the first belt ply 7A and the second belt ply 7B with a first reinforcing rubber layer 11 having a radially outer surface which is convexed radially outwardly and along which an axially outer edge portion 15 of the first belt ply 7A extends in a mountain shape so as to have an axially inner portion 15a extending axially outwardly and obliquely toward the band ply 8A and an axially outer portion 15b extending axially outwardly and obliquely away from the band ply 8A.Type: ApplicationFiled: February 3, 2017Publication date: August 31, 2017Applicant: SUMITOMO RUBBER INDUSTRIES, LTD.Inventor: Hiroshi KAWABATA
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Publication number: 20170181374Abstract: A mid-mount mower has a mower unit mounted under a vehicle body between front wheels and rear wheels. The mower includes a lift link mechanism having a front link and a rear link, an intermediate structure interconnecting one end of the front link and one end of the rear link via a pivot axis, a blade housing having an engaged portion engageable with an engaging potion of the intermediate structure and a guide face configured to guide the engaging portion ad the engaged portion to an engaging position so as to establish connection between the blade housing placed on a ground surface and the intermediate structure in association with a movement of the vehicle body in a front/rear direction.Type: ApplicationFiled: March 10, 2017Publication date: June 29, 2017Inventors: Hiroyuki Tada, Akira Minoura, Takeshi Komorida, Azusa Furihata, Hiroshi Kawabata, Ryo Matsumoto
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Publication number: 20170158242Abstract: A work vehicle includes a prime mover unit disposed in a front part of the vehicle body, a driving part located in a rear part of the vehicle body, a battery disposed between the prime mover unit and the driving part, a base frame disposed in a lower part of the vehicle body and a center pillar that extends upward from the base frame. The prime mover unit includes a radiator disposed immediately forward of the center pillar. The driving part includes a steering wheel disposed above the battery.Type: ApplicationFiled: December 5, 2016Publication date: June 8, 2017Inventors: Koichiro Matsumoto, Shoichiro Nagaishi, Ryo Matsumoto, Hiroshi Kawabata, Hiroki Nagai, Masahiro Izumi, Masaki Takaoka, Tasuku Teraoka, Takashi Kumashiro
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Publication number: 20170129543Abstract: A work vehicle includes: a vehicle body frame; a prime mover part that is supported by the vehicle body frame; a bonnet that is configured to vertically swing between a closed position at which the prime mover part is covered, and an open position at which the prime mover part is open; and a support frame that supports a free end side of the bonnet located at the closed position. At least left and right guide-target parts of the bonnet or left and right guiding parts of the support frame have left and right inclined surfaces that serve as centering effective surfaces.Type: ApplicationFiled: November 2, 2016Publication date: May 11, 2017Inventors: Koichiro Matsumoto, Nobuyuki Yamashita, Hiroshi Kawabata, Tomohisa Yamamoto, Masayuki Akita, Tasuku Teraoka, Yoshihisa Tonoya
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Patent number: 9622406Abstract: A mid-mount mower has a mower unit mounted under a vehicle body between front wheels and rear wheels. The mower includes a lift link mechanism having a front link and a rear link, an intermediate structure interconnecting one end of the front link and one end of the rear link via a pivot axis, a blade housing having an engaged portion engageable with an engaging potion of the intermediate structure and a guide face configured to guide the engaging portion ad the engaged portion to an engaging position so as to establish connection between the blade housing placed on a ground surface and the intermediate structure in association with a movement of the vehicle body in a front/rear direction.Type: GrantFiled: September 18, 2014Date of Patent: April 18, 2017Assignee: Kubota CorporationInventors: Hiroyuki Tada, Akira Minoura, Takeshi Komorida, Azusa Furihata, Hiroshi Kawabata, Ryo Matsumoto
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Patent number: 9512452Abstract: The present invention aims to provide a method for efficiently producing hydroxy-L-lysine. The present invention provides a method for producing hydroxy-L-lysine, the method comprising allowing 2-oxoglutarate-dependent L-lysine hydroxylase, a cell containing 2-oxoglutarate-dependent L-lysine hydroxylase, a processed product of the cell, and/or a culture broth obtained by culturing the cell, to act on L-lysine to produce hydroxy-L-lysine represented by the following General Formula (I) (wherein each of R1, R2 and R3 represents a hydrogen atom or hydroxyl group, with the proviso that at least one of R1, R2 and R3 represents a hydroxyl group).Type: GrantFiled: February 18, 2014Date of Patent: December 6, 2016Assignee: API CorporationInventors: Kuniki Kino, Ryotaro Hara, Ryoma Miyake, Hiroshi Kawabata
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Publication number: 20160348081Abstract: The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with ?-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence repType: ApplicationFiled: January 27, 2015Publication date: December 1, 2016Applicant: API CORPORATIONInventors: Makoto HIBI, Jun OGAWA, Ryoma MIYAKE, Hiroshi KAWABATA
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Publication number: 20160347718Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.Type: ApplicationFiled: February 6, 2015Publication date: December 1, 2016Applicants: API CORPORATION, API CORPORATIONInventors: Naoyuki WATANABE, Yasumasa DEKISHIMA, Masaki NAGAHAMA, Tomoko MAEDA, Takashi OHTANI, Kosuke ITO, Hiroshi KAWABATA
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Patent number: 9334509Abstract: It is an object of the present invention to provide a novel hydrolase, which is used when dialkyl 2-vinylcyclopropane-1,1-dicarboxylate is hydrolyzed with an enzyme, so as to efficiently obtain (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropanecarboxylic acid that is useful as an intermediate for synthesizing therapeutic agents for hepatitis C. According to the present invention, there is provided a hydrolase protein, which consists of the amino acid sequence shown in any one of SEQ ID NOS. 2 to 5 and which has activity of catalyzing, at higher selectivity than the protein consisting of the amino acid sequence shown in SEQ ID NO. 1, a reaction of producing (1S,2S)-1-ethoxycarbonyl-2-vinylcyclopropanecarboxylic acid from diethyl 2-vinylcyclopropane-1,1 -dicarboxylate.Type: GrantFiled: March 4, 2015Date of Patent: May 10, 2016Assignee: API CORPORATIONInventors: Hiroshi Kawabata, Ryoma Miyake, Kuniko Asada, Ryouhei Katou
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Publication number: 20160083341Abstract: According to the present invention, it becomes possible to perform a process for converting into an ?-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance.Type: ApplicationFiled: May 1, 2014Publication date: March 24, 2016Applicant: API CorporationInventors: Yuuki Asuma, Hisatoshi Uehara, Tomoko Maeda, Yasuyo Saito, Ryoma Miyake, Hiroshi Kawabata
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Publication number: 20150259715Abstract: The present invention aims to provide a method for efficiently producing hydroxy-L-lysine. The present invention provides a method for producing hydroxy-L-lysine, the method comprising allowing 2-oxoglutarate-dependent L-lysine hydroxylase, a cell containing 2-oxoglutarate-dependent L-lysine hydroxylase, a processed product of the cell, and/or a culture broth obtained by culturing the cell, to act on L-lysine to produce hydroxy-L-lysine represented by the following General Formula (I) (wherein each of R1, R2 and R3 represents a hydrogen atom or hydroxyl group, with the proviso that at least one of R1, R2 and R3 represents a hydroxyl group).Type: ApplicationFiled: February 18, 2014Publication date: September 17, 2015Applicant: API CorporationInventors: Kuniki Kino, Ryotaro Hara, Ryoma Miyake, Hiroshi Kawabata
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Publication number: 20150252393Abstract: It is an object of the present invention to provide a novel hydrolase, which is used when dialkyl 2-vinylcyclopropane-1,1-dicarboxylate is hydrolyzed with an enzyme, so as to efficiently obtain (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropanecarboxylic acid that is useful as an intermediate for synthesizing therapeutic agents for hepatitis C. According to the present invention, there is provided a hydrolase protein, which consists of the amino acid sequence shown in any one of SEQ ID NOS. 2 to 5 and which has activity of catalyzing, at higher selectivity than the protein consisting of the amino acid sequence shown in SEQ ID NO. 1, a reaction of producing (1S,2S)-1-ethoxycarbonyl-2-vinylcyclopropanecarboxylic acid from diethyl 2-vinylcyclopropane- 1,1 -dicarboxylate.Type: ApplicationFiled: March 4, 2015Publication date: September 10, 2015Applicant: API CORPORATIONInventors: Hiroshi KAWABATA, Ryoma MIYAKE, Kuniko ASADA, Ryouhei KATOU
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Patent number: 9079797Abstract: The present application relates to a production method for a polycarboxylic acid-based copolymer including a structural unit (I) derived from an unsaturated polyalkylene glycol ether-based monomer (a) and a structural unit (II) derived from an unsaturated carboxylic acid-based monomer (b), in which monomer components including the monomer (a) and the monomer (b) are polymerized using a peroxide and a reductant as polymerization initiators in combination while the pH during polymerization is controlled to 3 or less in the presence of a pH adjustor. The present application also relates to a polycarboxylic acid-based copolymer for a high-performance cement admixture including a structural unit (I) derived from an unsaturated polyalkylene glycol ether-based monomer (a) and a structural unit (II) derived from an unsaturated carboxylic acid-based monomer (b), and a nonpolymerizable organic sulfonic acid having a molecular weight of 300 or less and/or a salt thereof.Type: GrantFiled: May 8, 2009Date of Patent: July 14, 2015Assignee: NIPPON SHOKUBAI CO., LTD.Inventors: Hiroshi Kawabata, Noboru Sakamoto
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Publication number: 20150181803Abstract: A mid-mount mower has a mower unit mounted under a vehicle body between front wheels and rear wheels. The mower includes a lift link mechanism having a front link and a rear link, an intermediate structure interconnecting one end of the front link and one end of the rear link via a pivot axis, a blade housing having an engaged portion engageable with an engaging potion of the intermediate structure and a guide face configured to guide the engaging portion ad the engaged portion to an engaging position so as to establish connection between the blade housing placed on a ground surface and the intermediate structure in association with a movement of the vehicle body in a front/rear direction.Type: ApplicationFiled: September 18, 2014Publication date: July 2, 2015Inventors: Hiroyuki Tada, Akira Minoura, Takeshi Komorida, Azusa Furihata, Hiroshi Kawabata, Ryo Matsumoto