Patents by Inventor Hiroshi Kiyono

Hiroshi Kiyono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210308278
    Abstract: The present invention provides a nanogel nasal vaccine that induces cell-mediated immunity. Specifically, the present invention relates to a vaccine preparation comprising a complex of a nanogel, a vaccine antigen, and an adjuvant, wherein the vaccine preparation can efficiently induce the cell-mediated immunity, and can also induce a systemic and mucosal immune response.
    Type: Application
    Filed: August 2, 2019
    Publication date: October 7, 2021
    Applicants: The University of Tokyo, HANAVAX INC.
    Inventors: Yoshikazu YUKI, Rika NAKAHASHI, Hiroshi KIYONO
  • Patent number: 11117962
    Abstract: The present invention provides an antibody to a fibrosis-related molecule and medical application thereof. The antibody of the present invention is an antibody that binds to CHL1 protein and an antibody that neutralizes the binding of the CHL1 protein to a fibroblast.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: September 14, 2021
    Assignee: The University of Tokyo
    Inventors: Yosuke Kurashima, Hiroshi Kiyono
  • Publication number: 20210087258
    Abstract: An antibody is provided that inhibits infection of cells with a norovirus. The antibody is a nanoantibody comprising a polypeptide described in (a), (b), or (c), and inhibiting infection of intestinal cells with HuNoV GII.4: (a) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13; (b) a polypeptide consisting of an amino acid sequence comprising a substitution, deletion, insertion and/or addition of one or several amino acids with respect to the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13; and (c) a polypeptide consisting of an amino acid sequence having a sequence identity of 80% or more to the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13.
    Type: Application
    Filed: March 30, 2018
    Publication date: March 25, 2021
    Applicant: The University of Tokyo
    Inventors: Yoshikazu Yuki, Hiroshi Kiyono, Shiho Kurokawa
  • Publication number: 20200300944
    Abstract: A magnetic field detection device includes a magnetism detection element, a modulator, and a demodulator. The magnetism detection element has a sensitivity axis along a first direction. The modulator is configured to impart a spin torque to the magnetism detection element. The spin torque has a rotational force and oscillates at a first frequency. The rotational force is exerted on a plane including the first direction and a second direction orthogonal to the first direction. The demodulator is configured to demodulate an output signal received from the magnetism detection element and to detect an intensity of a measurement target magnetic field exerted on the magnetism detection element on the basis of an amplitude of the output signal. The output signal has the first frequency.
    Type: Application
    Filed: February 10, 2020
    Publication date: September 24, 2020
    Applicant: TDK Corporation
    Inventors: Kenzo MAKINO, Hiroshi KIYONO
  • Publication number: 20200200838
    Abstract: A magnetic field detection device includes a magnetic field detection element, a modulation coil, and a demodulator. The magnetic field detection element has a sensitivity axis in a first direction. The modulation coil is configured to apply, to the magnetic field detection element, an alternating current magnetic field having a first frequency and a component in a second direction, the second direction being orthogonal to the first direction. The demodulator is configured to demodulate an output signal having the first frequency and outputted from the magnetic field detection element, and detect, on a basis of an amplitude of the output signal, an intensity of a measurement magnetic field to be received by the magnetic field detection element.
    Type: Application
    Filed: December 2, 2019
    Publication date: June 25, 2020
    Applicant: TDK CORPORATION
    Inventor: Hiroshi KIYONO
  • Publication number: 20200017585
    Abstract: The present invention provides an antibody to a fibrosis-related molecule and medical application thereof. The antibody of the present invention is an antibody that binds to CHL1 protein and an antibody that neutralizes the binding of the CHL1 protein to a fibroblast.
    Type: Application
    Filed: December 1, 2017
    Publication date: January 16, 2020
    Applicant: The University of Tokyo
    Inventors: Yosuke Kurashima, Hiroshi Kiyono
  • Publication number: 20190351043
    Abstract: The present embodiments provide compositions and methods related to novel recombinant protein immunogens, comprising specific portions of alpha helical domains (aHD) and proline rich regions (PRD) of pneumococcal surface protein A (PspA), which portions are linked to provide aHD-PRD constructs. The aHD and PRD proteins constituting the aHD-PRD constructs are selected to maximize cross-reactivity and provide protection against a broad spectrum of pneumococcal serotypes. Immunogenic compositions, including vaccines, comprising at least one aHD PRD construct may also include a non-linked aHD portion. Also provided are recombinant nucleic acid molecules that encode aHD-PRD constructs, vectors and recombinant host cells containing such molecules, aHD-PRD expression products, use of such nucleic acid molecules to express aHD-PRD constructs by recombinant techniques, and use of the expression products to elicit an immune or protective response against pneumococcal disease in a suitable host.
    Type: Application
    Filed: December 1, 2017
    Publication date: November 21, 2019
    Applicants: The UAB Research Foundation, The University of Tokyo
    Inventors: David E. BRILES, Hiroshi KIYONO, Robert KNELLER, Reshmi MUKERJI, Kristopher GENSCHMER, Yoshikazu YUKI
  • Patent number: 9833407
    Abstract: The present invention provides a nasal vaccine for Streptococcus pneumoniae, and a production method therefor. This nasal vaccine formulation for primates includes a complex of PspA, i.e. the vaccine antigen, and a nanogel in which hydrophobic cholesterol is added, as side chains, to pullulan having amino groups. Furthermore, the present invention provides a production method for the nasal vaccine formulation for primates.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: December 5, 2017
    Assignee: Intellectual Property Strategy Network, Inc.
    Inventors: Yoshikazu Yuki, Hiroshi Kiyono, Kazunari Akiyoshi, Shinichi Sawada
  • Publication number: 20170014338
    Abstract: The present invention provides a nasal vaccine for Streptococcus pneumoniae, and a production method therefor. This nasal vaccine formulation for primates includes a complex of PspA, i.e. the vaccine antigen, and a nanogel in which hydrophobic cholesterol is added, as side chains, to pullulan having amino groups. Furthermore, the present invention provides a production method for the nasal vaccine formulation for primates.
    Type: Application
    Filed: February 16, 2015
    Publication date: January 19, 2017
    Inventors: Yoshikazu YUKI, Hiroshi KIYONO, Kazunari AKIYOSHI, Shinichi SAWADA
  • Publication number: 20150380029
    Abstract: Using a thermally assisted magnetic recording head, reference signals are recorded into a magnetic recording medium; reproduction signal intensity of the reference signals is measured in a state where the thermally assisted magnetic head has been moved in the track width direction from the track width center of the track where the reference signals are recorded; a mean signal output of each sector in the track where the reference signals are recorded is calculated from the measurement results of the reproduction signal intensity of the reference signals; and the recording characteristics of a thermally assisted magnetic head are evaluated based upon the mean signal output of the sectors.
    Type: Application
    Filed: June 30, 2014
    Publication date: December 31, 2015
    Inventors: Makoto MORIYA, Hiroshi KIYONO
  • Patent number: 9218841
    Abstract: Using a thermally assisted magnetic recording head, reference signals are recorded into a magnetic recording medium; reproduction signal intensity of the reference signals is measured in a state where the thermally assisted magnetic head has been moved in the track width direction from the track width center of the track where the reference signals are recorded; a mean signal output of each sector in the track where the reference signals are recorded is calculated from the measurement results of the reproduction signal intensity of the reference signals; and the recording characteristics of a thermally assisted magnetic head are evaluated based upon the mean signal output of the sectors.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: December 22, 2015
    Assignee: TDK Corporation
    Inventors: Makoto Moriya, Hiroshi Kiyono
  • Patent number: 8961983
    Abstract: A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of a mucosal adjuvant. The mucosal vaccine comprises a composite of a nanogel comprising a hydrophilic polysaccharide having a cationic functional group and a hydrophobic cholesterol added thereto as a side chain and a vaccine antigen. The vaccine is administered via a mucosal route.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 24, 2015
    Assignee: National University Corporation Tokyo Medical and Dental University
    Inventors: Kazunari Akiyoshi, Hiroshi Kiyono, Yoshikazu Yuki, Tomonori Nochi
  • Publication number: 20140370056
    Abstract: A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of a mucosal adjuvant. The mucosal vaccine comprises a composite of a nanogel comprising a hydrophilic polysaccharide having a cationic functional group and a hydrophobic cholesterol added thereto as a side chain and a vaccine antigen. The vaccine is administered via a mucosal route.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 18, 2014
    Applicant: National University Corporation Tokyo Medical and Dental University
    Inventors: Kazunari Akiyoshi, Hiroshi Kiyono, Yoshikazu Yuki, Tomonori Nochi
  • Patent number: 8666692
    Abstract: In exemplary embodiments, first and second parameters are obtained for each of different temperatures of the magnetic recording layer. The absolute value of the first parameter for each magnetic grain has a minimum value when the temperature of each magnetic grain reaches a predetermined temperature that increases as the Curie temperature increases, and decreases as the Curie temperature decreases. The second parameter is related to the standard deviation of the coercivity distribution of the magnetic grains divided by the coercivity of the magnetic recording layer. The method calculates a value where the absolute measurement value of the first parameter has a minimum value and the temperature of the magnetic recording layer at which the standard deviation of the coercivity distribution of the magnetic grains divided by the coercivity of the magnetic recording layer has a maximum value.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: March 4, 2014
    Assignee: TDK Corporation
    Inventors: Tomohito Mizuno, Koji Shimazawa, Hiroshi Kiyono
  • Patent number: 8665548
    Abstract: A magnetic disk device includes: a recording medium provided with a plurality of write tracks; a magnetic write head including a magnetic pole, side shields, and a leading shield, a distance from the magnetic pole to each of the side shields being maintained to be uniform with a gap layer therebetween, and a distance from the magnetic pole to the leading shield being maintained to be uniform with a gap layer therebetween; and a control section rotating the recording medium, and allowing magnetic information to be recorded on the recording medium while allowing the magnetic write head to travel in a direction from an inner write track toward an outer write track or in a direction from the outer write track toward the inner write track, across write tracks in the recording medium. With such a configuration, format efficiency may be improved, and a width of an erase band on a magnetic disk may be minimized.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: March 4, 2014
    Assignee: TDK Corporation
    Inventors: Kei Hirata, Hiroshi Kiyono, Osamu Nakada, Kenkichi Anagawa
  • Patent number: 8619510
    Abstract: A measurement method of a magnetic field gradient of a recording magnetic field generated by a magnetic head in a recording medium includes a step of locally heating the recording medium in a nonmagnetic field state where a magnetic field is not applied to the recording medium at all and measuring a temperature gradient of the recording medium in the nonmagnetic field state, a step of locally heating the recording medium in a recording magnetic field application state where the recording magnetic field is applied to the recording medium and measuring a temperature gradient of the recording medium in the recording magnetic field application state, and a step of calculating a magnetic field gradient of the recording magnetic field based on the temperature gradient of the recording medium in the nonmagnetic field state and the temperature gradient of the recording medium in the recording magnetic field application state.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: December 31, 2013
    Assignee: TDK Corporation
    Inventors: Ken-ichi Takano, Satoshi Tomikawa, Tomohito Mizuno, Hiroshi Kiyono
  • Patent number: 8416650
    Abstract: A magnetic head slider includes a near-field light generator, an incorporated heater is activated to thermally-expand the magnetic head slider so that a first protrusion is generated on the air bearing surface, and a second protrusion protruding from the first protrusion is generated by a thermal expansion of the near-field light generator. A standard signal is written to a recording medium with a predetermined magnetization. A relation between a residual magnetization of the standard signal and a power of the heater is obtained by lowering the magnetization of the standard signal by heating the recording medium with the near-field light while light output of laser light is maintained to be constant and the power of the heater is varied. Further, a relation between the first spacing and the residual magnetization is obtained.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: April 9, 2013
    Assignee: TDK Corporation
    Inventors: Takahiro Mori, Satoshi Tomikawa, Hiroshi Kiyono
  • Publication number: 20130044575
    Abstract: A magnetic head slider includes a near-field light generator, an incorporated heater is activated to thermally-expand the magnetic head slider so that a first protrusion is generated on the air bearing surface, and a second protrusion protruding from the first protrusion is generated by a thermal expansion of the near-field light generator. A standard signal is written to a recording medium with a predetermined magnetization. A relation between a residual magnetization of the standard signal and a power of the heater is obtained by lowering the magnetization of the standard signal by heating the recording medium with the near-field light while light output of laser light is maintained to be constant and the power of the heater is varied. Further, a relation between the first spacing and the residual magnetization is obtained.
    Type: Application
    Filed: August 18, 2011
    Publication date: February 21, 2013
    Applicant: TDK Corporation
    Inventors: Takahiro Mori, Satoshi Tomikawa, Hiroshi Kiyono
  • Patent number: 8374060
    Abstract: A thermally-assisted magnetic recording method includes first and second steps. The first step applies heat to part of a hard disk medium and forms a moving high-temperature region in a magnetic recording layer of the hard disk medium. The high-temperature region is higher in temperature than a region therearound and has a temperature equal to or higher than the maximum coercivity vanishing temperature of a plurality of magnetic grains contained in the magnetic recording layer. At least one magnetic grain that is adjacent to the rear end of the high-temperature region in the direction of movement of the high-temperature region has a coercivity of a value other than 0. The second step applies a write magnetic field to the hard disk medium such that the write magnetic field applied to the at least one magnetic grain adjacent to the rear end of the high-temperature region is 3 kOe or smaller in magnitude.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: February 12, 2013
    Assignee: TDK Corporation
    Inventors: Koji Shimazawa, Tomohito Mizuno, Hiroshi Kiyono
  • Publication number: 20120236431
    Abstract: A magnetic disk device includes: a recording medium provided with a plurality of write tracks; a magnetic write head including a magnetic pole, side shields, and a leading shield, a distance from the magnetic pole to each of the side shields being maintained to be uniform with a gap layer therebetween, and a distance from the magnetic pole to the leading shield being maintained to be uniform with a gap layer therebetween; and a control section rotating the recording medium, and allowing magnetic information to be recorded on the recording medium while allowing the magnetic write head to travel in a direction from an inner write track toward an outer write track or in a direction from the outer write track toward the inner write track, across write tracks in the recording medium. With such a configuration, format efficiency may be improved, and a width of an erase band on a magnetic disk may be minimized.
    Type: Application
    Filed: March 14, 2011
    Publication date: September 20, 2012
    Applicant: TDK CORPORATION
    Inventors: Kei HIRATA, Hiroshi KIYONO, Osamu NAKADA, Kenkichi ANAGAWA