Abstract: Oral or peroral administration, including intragastrically, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with an adjuvant such as cholera toxin provides protection in a host, animal or human, against pneumococcal infection, including colonization, and systemic infection, such as sepsis. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, which can lead to elimination of disease from the population as a whole.

Abstract: Oral or peroral administration, including intragastrically, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with an adjuvant such as cholera toxin provides protection in a host, animal or human, against pneumococcal infection, including colonization, and systemic infection, such as sepsis. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, which can lead to elimination of disease from the population as a whole.

Abstract: Oral or peroral administration, including intragastrically, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with an adjuvant such as cholera toxin provides protection in a host, animal or human, against pneumococcal infection, including colonization, and systemic infection, such as sepsis. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, which can lead to elimination of disease from the population as a whole.

Abstract: A plastic foamed sheet of excellent quality is produced by preheating in a chamber including a conveyor means for continuously conveying a thermoplastic resin sheet containing a heat-decomposable blowing agent in the horizontally supported state and a heating means for heating the sheet to a temperature lower than the decomposition temperature of the blowing agent, and foaming in a foaming chamber connected to the preheating chamber and including a heating means for heat-foaming the sheet as it is continuously conveyed while being perpendicularly suspended from the terminal of the conveyor means.

Abstract: A plastic foamed sheet of excellent quality is produced by using an apparatus comprising a preheating chamber including a conveyor means for continuously conveying a thermoplastic resin sheet containing a heat-decomposable blowing agent in the horizontally supported state and a heating means for heating the sheet to a temperature lower than the decomposition temperature of the blowing agent, and a foaming chamber connected to the preheating chamber and including a heating means for heat-foaming the sheet as it is continuously conveyed while being perpendicularly suspended from the terminal end portion of the conveyor means.