Patents by Inventor Hisao Osawa
Hisao Osawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240122465Abstract: A visual field testing method is a visual field testing method of testing a visual field range divided into at least a first partial area and a second partial area, the method including: a step of measuring sensitivities of a plural first test points that are included in the first partial area: and a step of performing a process of estimating sensitivities of a plural second test points that are included in the first partial area and are test points other than the first test points, by using the sensitivities of the plural first test points.Type: ApplicationFiled: December 13, 2023Publication date: April 18, 2024Applicant: NIKON CORPORATIONInventors: Chikara NAKAMURA, Taishi AOKI, Teruo HORIKAWA, Hisao OSAWA
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Patent number: 10983328Abstract: Polarized light which is emitted from an optical fiber becomes circular polarized light by passing through a first quarter wave plate. The circular polarized light which has entered a second quarter wave plate is converted into nearly linear polarized light which has S polarization. P polarization components are removed from the nearly linear polarized light by a polarizer, but the polarizer is not always necessary. The optical axis of the polarizer is set to be a direction which allows transmitting of S polarized light. The light that has passed through the polarizer is separated into diffracted lights by a diffraction grating, and is used as the structured illumination light.Type: GrantFiled: November 5, 2019Date of Patent: April 20, 2021Assignees: NIKON CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yumiko Ouchi, Hisao Osawa, Mats G. L. Gustafsson, David A. Agard
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Patent number: 10900900Abstract: A structured illumination microscope includes: a brancher that includes a first substrate on which a plurality of pixel electrodes are provided; a second substrate opposed to the first substrate; and a ferroelectric liquid crystal disposed between the first substrate and the second substrate, and branches light from a light source into diffracted light beams; an illumination optical system that illuminates a sample with interference fringes formed by at least some of the diffracted light beams; an imaging device that forms an image of the sample irradiated with the interference fringes; a demodulator; and a controller that controls a direction and a phase of the interference fringes. In one frame period during which the imaging device takes the image, the controller applies a first voltage pattern and a second voltage pattern obtained by inverting the first voltage pattern to at least some of the pixel electrodes.Type: GrantFiled: April 19, 2018Date of Patent: January 26, 2021Assignee: NIKON CORPORATIONInventors: Hisao Osawa, Fumihiro Dake
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Patent number: 10649196Abstract: A structured illumination microscope includes: a first illumination optical system configured to irradiate, from a first direction, a sample with activating light for activating a fluorescent substance included in the sample; a second illumination optical system configured to irradiate, from a second direction that is different from the first direction, the sample with interference fringes of exciting light for exciting the fluorescent substance; a control unit configured to control a direction and a phase of the interference fringes; an imaging optical system configured to form an image of the sample irradiated with the interference fringes; an imaging element configured to take the image formed by the imaging optical system to generate a first image; and a demodulation unit configured to generate a second image by using a plurality of the first images generated by the imaging element.Type: GrantFiled: August 2, 2017Date of Patent: May 12, 2020Assignee: NIKON CORPORATIONInventor: Hisao Osawa
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Publication number: 20200064617Abstract: Polarized light which is emitted from an optical fiber becomes circular polarized light by passing through a first quarter wave plate. The circular polarized light which has entered a second quarter wave plate is converted into nearly linear polarized light which has S polarization. P polarization components are removed from the nearly linear polarized light by a polarizer, but the polarizer is not always necessary. The optical axis of the polarizer is set to be a direction which allows transmitting of S polarized light. The light that has passed through the polarizer is separated into diffracted lights by a diffraction grating, and is used as the structured illumination light.Type: ApplicationFiled: November 5, 2019Publication date: February 27, 2020Applicants: NIKON CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yumiko OUCHI, Hisao OSAWA, Mats G. L. GUSTAFSSON, David A. AGARD
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Patent number: 10502945Abstract: Polarized light which is emitted from an optical fiber becomes circular polarized light by passing through a first quarter wave plate. The circular polarized light which has entered a second quarter wave plate is converted into nearly linear polarized light which has S polarization. P polarization components are removed from the nearly linear polarized light by a polarizer, but the polarizer is not always necessary. The optical axis of the polarizer is set to be a direction which allows transmitting of S polarized light. The light that has passed through the polarizer is separated into diffracted lights by a diffraction grating, and is used as the structured illumination light.Type: GrantFiled: August 25, 2015Date of Patent: December 10, 2019Assignees: NIKON CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yumiko Ouchi, Hisao Osawa, Mats G. L. Gustafsson, David A. Agard
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Patent number: 10400236Abstract: There is provided a method of manufacturing a protein array or peptide array suitable for an efficient screening of a functional protein or functional peptide. The method of manufacturing a protein array or peptide array includes the steps of: (a) preparing a nucleic acid immobilized on a solid support and a cell-free synthesis system in a reactor, in which a reactor array includes the reactor having a specific aperture shape and a protein capture molecule or a peptide capture molecule provided on at least a portion of wall surface and bottom surface in the reactor; and (c) synthesizing a protein or peptide from the nucleic acid using the cell-free synthesis system and immobilizing the protein or peptide in the reactor.Type: GrantFiled: October 13, 2017Date of Patent: September 3, 2019Assignees: The University of Tokyo, Nikon CorporationInventors: Takanori Ichiki, Shingo Ueno, Hisao Osawa
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Patent number: 10228552Abstract: In order to realize a high-speed switching of structured pattern, a structured illuminating microscopy includes a driving unit generating a sonic standing wave in a sonic wave propagation path by giving a driving signal for vibrating a medium of the sonic wave propagation path to a light modulator, an illuminating optical system making at least three diffracted components of the exit light flux passed through the sonic wave propagation path to be interfered with one another, and forming interference fringes on an observational object, an image-forming optical system forming an image by an observational light flux from the observational object on a detector, and a controlling unit controlling a contrast of an image by modulating at least one of an intensity of the exit light flux, an intensity of the observational light flux, and the detector with a modulating signal of 1/N frequency of the driving signal.Type: GrantFiled: November 28, 2016Date of Patent: March 12, 2019Assignee: NIKON CORPORATIONInventors: Tatsushi Nomura, Hisao Osawa, Naoki Fukutake
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Patent number: 10126113Abstract: A spectroscope including: a spectral element that is configured to spectrally separate signal light; a first optical system that is configured to condense spectroscopic light spectrally separated by the spectral element; and an optical receiver that is configured to receive the spectroscopic light; wherein the optical receiver includes a plurality of regions different sensitivities with respect to a wavelength characteristics of the spectroscopic light.Type: GrantFiled: June 26, 2015Date of Patent: November 13, 2018Assignee: NIKON CORPORATIONInventors: Ryoichi Sataka, Hisao Osawa
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Patent number: 10067331Abstract: A structured illumination microscope device includes acquisition unit that repeats a series of processing steps including controlling a combination of a wave vector and phase of fringes and acquiring N images; and computing unit in which processing for demodulating the image of the sample using a required M types of images from an image set of consecutive P images. The M types of images include: Q types (where Q?3) of modulated images; and one type of modulated image having the wave vector in common with and the phase differing from at least one among the Q types of modulated images, or one unmodulated image. An arrangement of the N images satisfies the uniformity condition, meaning “intensity distribution of the fringes is spatially uniform when accumulated between the N images” and the refresh condition, meaning “the M types of images are always included in the image set”.Type: GrantFiled: April 7, 2016Date of Patent: September 4, 2018Assignee: NIKON CORPORATIONInventors: Yosuke Okudaira, Hisao Osawa
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Publication number: 20180238803Abstract: A structured illumination microscope includes: a brancher that includes a first substrate on which a plurality of pixel electrodes are provided; a second substrate opposed to the first substrate; and a ferroelectric liquid crystal disposed between the first substrate and the second substrate, and branches light from a light source into diffracted light beams; an illumination optical system that illuminates a sample with interference fringes formed by at least some of the diffracted light beams; an imaging device that forms an image of the sample irradiated with the interference fringes; a demodulator; and a controller that controls a direction and a phase of the interference fringes. In one frame period during which the imaging device takes the image, the controller applies a first voltage pattern and a second voltage pattern obtained by inverting the first voltage pattern to at least some of the pixel electrodes.Type: ApplicationFiled: April 19, 2018Publication date: August 23, 2018Applicant: NIKON CORPORATIONInventors: Hisao OSAWA, Fumihiro DAKE
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Patent number: 10018552Abstract: A particle analysis apparatus includes: an acquisition unit that acquires a plurality of images each captured at a different time in each of which a particle moving in a predetermined direction in a medium is imaged; and a determination unit that determines, based on a movement amount of a particle due to Brownian motion in the medium, whether or not an image of a first particle included in an image captured at a first time of the plurality of images acquired by the acquisition unit and an image of a second particle included in an image captured at a second time which is different from the first time of the plurality of images acquired by the acquisition unit are images indicating the same particle.Type: GrantFiled: July 14, 2016Date of Patent: July 10, 2018Assignee: Nikon CorporationInventors: Daishi Tanaka, Hisao Osawa, Kuno Suzuki
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Publication number: 20180044665Abstract: There is provided a method of manufacturing a protein array or peptide array suitable for an efficient screening of a functional protein or functional peptide. The method of manufacturing a protein array or peptide array includes the steps of: (a) preparing a nucleic acid immobilized on a solid support and a cell-free synthesis system in a reactor, in which a reactor array includes the reactor having a specific aperture shape and a protein capture molecule or a peptide capture molecule provided on at least a portion of wall surface and bottom surface in the reactor; and (c) synthesizing a protein or peptide from the nucleic acid using the cell-free synthesis system and immobilizing the protein or peptide in the reactor.Type: ApplicationFiled: October 13, 2017Publication date: February 15, 2018Applicants: THE UNIVERSITY OF TOKYO, NIKON CORPORATIONInventors: Takanori ICHIKI, Shingo UENO, Hisao OSAWA
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Publication number: 20170329122Abstract: A structured illumination microscope includes: a first illumination optical system configured to irradiate, from a first direction, a sample with activating light for activating a fluorescent substance included in the sample; a second illumination optical system configured to irradiate, from a second direction that is different from the first direction, the sample with interference fringes of exciting light for exciting the fluorescent substance; a control unit configured to control a direction and a phase of the interference fringes; an imaging optical system configured to form an image of the sample irradiated with the interference fringes; an imaging element configured to take the image formed by the imaging optical system to generate a first image; and a demodulation unit configured to generate a second image by using a plurality of the first images generated by the imaging element.Type: ApplicationFiled: August 2, 2017Publication date: November 16, 2017Applicant: NIKON CORPORATIONInventor: Hisao OSAWA
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Publication number: 20170276922Abstract: In order to realize a high-speed switching of structured pattern, a structured illuminating microscopy includes a driving unit generating a sonic standing wave in a sonic wave propagation path by giving a driving signal for vibrating a medium of the sonic wave propagation path to a light modulator, an illuminating optical system making at least three diffracted components of the exit light flux passed through the sonic wave propagation path to be interfered with one another, and forming interference fringes on an observational object, an image-forming optical system forming an image by an observational light flux from the observational object on a detector, and a controlling unit controlling a contrast of an image by modulating at least one of an intensity of the exit light flux, an intensity of the observational light flux, and the detector with a modulating signal of 1/N frequency of the driving signal.Type: ApplicationFiled: November 28, 2016Publication date: September 28, 2017Applicant: NIKON CORPORATIONInventors: Tatsushi NOMURA, Hisao OSAWA, Naoki FUKUTAKE
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Patent number: 9612156Abstract: A spectroscope used for a microspectroscopic system includes: a collimating optical system that causes signal light to be substantially collimated light; spectroscopic optical systems and each of which includes at least one of each of spectral elements and in which a wavelength band for spectral separation varies depending on an incident angle of the signal light; at least one of each of optical receivers that detect the signal light spectrally separated by the spectroscopic optical systems; a mechanism that varies the incident angles of the signal light on the spectral elements; and a controller unit that determines the incident angles of the signal light on the spectral elements in accordance with the wavelength band for spectrally separating the signal light and controls the mechanism so as to attain the incident angles.Type: GrantFiled: December 29, 2015Date of Patent: April 4, 2017Assignee: NIKON CORPORATIONInventors: Ryoichi Sataka, Hisao Osawa
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Patent number: 9535241Abstract: In order to realize a high-speed switching of structured pattern, a structured illuminating microscopy includes a driving unit generating a sonic standing wave in a sonic wave propagation path by giving a driving signal for vibrating a medium of the sonic wave propagation path to a light modulator, an illuminating optical system making at least three diffracted components of the exit light flux passed through the sonic wave propagation path to be interfered with one another, and forming interference fringes on an observational object, an image-forming optical system forming an image by an observational light flux from the observational object on a detector, and a controlling unit controlling a contrast of an image by modulating at least one of an intensity of the exit light flux, an intensity of the observational light flux, and the detector with a modulating signal of 1/N frequency of the driving signal.Type: GrantFiled: October 31, 2013Date of Patent: January 3, 2017Assignee: NIKON CORPORATIONInventors: Tatsushi Nomura, Hisao Osawa, Naoki Fukutake
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Publication number: 20160320289Abstract: A particle analysis apparatus includes: an acquisition unit that acquires a plurality of images each captured at a different time in each of which a particle moving in a predetermined direction in a medium is imaged; and a determination unit that determines, based on a movement amount of a particle due to Brownian motion in the medium, whether or not an image of a first particle included in an image captured at a first time of the plurality of images acquired by the acquisition unit and an image of a second particle included in an image captured at a second time which is different from the first time of the plurality of images acquired by the acquisition unit are images indicating the same particle.Type: ApplicationFiled: July 14, 2016Publication date: November 3, 2016Inventors: Daishi TANAKA, Hisao OSAWA, Kuno SUZUKI
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Publication number: 20160289671Abstract: There is provided a method of manufacturing a protein array or peptide array suitable for an efficient screening of a functional protein or functional peptide. The method of manufacturing a protein array or peptide array includes the steps of: (a) preparing a nucleic acid immobilized on a solid support and a cell-free synthesis system in a reactor, in which a reactor array includes the reactor having a specific aperture shape and a protein capture molecule or a peptide capture molecule provided on at least a portion of wall surface and bottom surface in the reactor; and (c) synthesizing a protein or peptide from the nucleic acid using the cell-free synthesis system and immobilizing the protein or peptide in the reactor.Type: ApplicationFiled: August 5, 2014Publication date: October 6, 2016Applicants: The University of Tokyo, NIKON CORPORATIONInventors: Takanori ICHIKI, Shingo UENO, Hisao OSAWA
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Publication number: 20160216505Abstract: A structured illumination microscope device includes acquisition unit that repeats a series of processing steps including controlling a combination of a wave vector and phase of fringes and acquiring N images; and computing unit in which processing for demodulating the image of the sample using a required M types of images from an image set of consecutive P images. The M types of images include: Q types (where Q?3) of modulated images; and one type of modulated image having the wave vector in common with and the phase differing from at least one among the Q types of modulated images, or one unmodulated image. An arrangement of the N images satisfies the uniformity condition, meaning “intensity distribution of the fringes is spatially uniform when accumulated between the N images” and the refresh condition, meaning “the M types of images are always included in the image set”.Type: ApplicationFiled: April 7, 2016Publication date: July 28, 2016Applicant: NIKON CORPORATIONInventors: Yosuke OKUDAIRA, Hisao OSAWA