Patents by Inventor Holger Stark
Holger Stark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240030656Abstract: A shield contact element for shielding a plug connection includes a housing shell and a contact lamella. The housing shell has a cylindrical shape and extends in an axial direction for receiving a plug connector, the plug connector connecting to a plug contact element to form the plug connection. The contact lamella extends in the axial direction and creates an electrical connection between the housing shell and a shield for shielding the plug contact element. The contact lamella has a contact foot disposed in a recess formed in the housing shell to electrically contact the housing shell with the shield in the recess.Type: ApplicationFiled: July 20, 2023Publication date: January 25, 2024Applicant: TE Connectivity Germany GmbHInventors: Gregor Panitz, Holger Starke, Marco Wolf, Kevin Keil, Luca Boehm
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Publication number: 20230114900Abstract: A connection arrangement includes an expansion ferrule insertable in a slidable manner into a central opening of an electrical contact element and an expansion element inserted into the expansion ferrule. The expansion ferrule is expanded when the expansion element is fully inserted into the expansion ferrule to clamp the electrical contact element and fasten the electrical contact element to an electrical conductor.Type: ApplicationFiled: October 7, 2022Publication date: April 13, 2023Applicant: TE Connectivity Germany GmbHInventors: Gregor Panitz, Holger Starke
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Patent number: 11401301Abstract: The present invention relates in a first aspect to a method for the purification of biological macromolecular complexes. Typically, no chromatography steps are applied. That is, the present invention relates to a method for the purification of biological macromolecular complexes Furthermore, the present invention relates to a method for crystallization of biological macromolecular complexes comprising the step of purification as described followed by crystallization in a reservoir solution containing a water-soluble polymer. Furthermore, purified biological macromolecular complexes obtainable by the method according to the present invention are provided as well as crystallized biological macromolecular complexes. Finally, a method for determining the suitability of a candidate compound for inhibiting the 20S proteasome of an individual is provided.Type: GrantFiled: October 1, 2020Date of Patent: August 2, 2022Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Ashwin Chari, Holger Stark, Jil Schrader, Fabian Henneberg
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Patent number: 11345724Abstract: The present invention relates to a compound of formula (I), wherein X is C?O, C?S or B—OH; Y is an electrophile and Z is a leaving group, or Y?Z is an electrophile; R1 comprises or consists of (a) (i) a first group binding to a proteolytic site of a proteasome, the first group being bound to X; and (ii) optionally a second group enhancing delivery; or (b) a group binding between subunits ?1 and ?2 of a proteasome; R2 and R3 are independently selected from H, methyl, methoxy, ethyl, ethenyl, ethynyl and cyano, wherein methyl and ethyl may be substituted with OH or halogen.Type: GrantFiled: June 6, 2017Date of Patent: May 31, 2022Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Ashwin Chari, Holger Stark, Jil Schrader, Fabian Henneberg
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Publication number: 20220154181Abstract: In a first aspect, the present invention relates to new recombinant polypeptides derived from the newly identified gamma subunit of the fatty acid synthase protein complex. In addition, a fatty acid synthase protein complex comprising these new recombinant polypeptides are disclosed as well as nucleic acid molecules encoding these polypeptides. Further, a host cells containing the nucleic acid molecule encoding the polypeptides according to the present invention or expressing the polypeptide according to the present invention are described. In addition, an isolated fatty acid synthase protein complex is disclosed containing the newly identified gamma subunit thereof. Moreover, methods for determining the suitability of candidate compounds capable of inhibiting either the ketoreductase, enoylreductase or malonyl/palmitoyl transferase present in the FAS protein complex and methods for designing inhibitors of said enzymes are disclosed.Type: ApplicationFiled: March 20, 2020Publication date: May 19, 2022Inventors: Ashwin CHARI, Holger STARK, Kashish SINGH, Benjamin Moritz GRAF
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Publication number: 20210017224Abstract: The present invention relates in a first aspect to a method for the purification of biological macromolecular complexes. Typically, no chromatography steps are applied. That is, the present invention relates to a method for the purification of biological macromolecular complexes Furthermore, the present invention relates to a method for crystallization of biological macromolecular complexes comprising the step of purification as described followed by crystallization in a reservoir solution containing a water-soluble polymer. Furthermore, purified biological macromolecular complexes obtainable by the method according to the present invention are provided as well as crystallized biological macromolecular complexes. Finally, a method for determining the suitability of a candidate compound for inhibiting the 20S proteasome of an individual is provided.Type: ApplicationFiled: October 1, 2020Publication date: January 21, 2021Inventors: Ashwin CHARI, Holger STARK, Jil SCHRADER, Fabian HENNEBERG
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Patent number: 10829515Abstract: The present invention relates in a first aspect to a method for the purification of biological macromolecular complexes. Typically, no chromatography steps are applied. That is, the present invention relates to a method for the purification of biological macromolecular complexes Furthermore, the present invention relates to a method for crystallization of biological macromolecular complexes comprising the step of purification as described followed by crystallization in a reservoir solution containing a water-soluble polymer. Furthermore, purified biological macromolecular complexes obtainable by the method according to the present invention are provided as well as crystallized biological macromolecular complexes. Finally, a method for determining the suitability of a candidate compound for inhibiting the 20S proteasome of an individual is provided.Type: GrantFiled: June 6, 2017Date of Patent: November 10, 2020Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Ashwin Chari, Holger Stark, Jil Schrader, Fabian Henneberg
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Publication number: 20200325171Abstract: The present invention relates to a compound of formula (I), wherein X is C?O, C?S or B—OH; Y is an electrophile and Z is a leaving group, or Y?Z is an electrophile; R1 comprises or consists of (a) (i) a first group binding to a proteolytic site of a proteasome, said first group being bound to X; and (ii) optionally a second group enhancing delivery; or (b) a group binding between subunits ?1 and ?2 of a proteasome; R2 and R3 are independently selected from H, methyl, methoxy, ethyl, ethenyl, ethinyl and cyano, wherein methyl and ethyl maybe substituted with OH or halogen.Type: ApplicationFiled: June 6, 2017Publication date: October 15, 2020Inventors: Ashwin Chari, Holger Stark, Jil Schrader, Febian Henneberg
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Publication number: 20190177364Abstract: The present invention relates in a first aspect to a method for the purification of biological macromolecular complexes. Typically, no chromatography steps are applied. That is, the present invention relates to a method for the purification of biological macromolecular complexes Furthermore, the present invention relates to a method for crystallization of biological macromolecular complexes comprising the step of purification as described followed by crystallization in a reservoir solution containing a water-soluble polymer. Furthermore, purified biological macromolecular complexes obtainable by the method according to the present invention are provided as well as crystallized biological macromolecular complexes. Finally, a method for determining the suitability of a candidate compound for inhibiting the 20S proteasome of an individual is provided.Type: ApplicationFiled: June 6, 2017Publication date: June 13, 2019Inventors: Ashwin CHARI, Holger STARK, Jil SCHRADER, Fabian HENNEBERG
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Patent number: 9869326Abstract: The invention relates to a centrifugal pump, in particular a waste water submersible pump having an impeller (1), of which the end face facing the pump intake opening is open and only the end face of the impeller facing away from the intake opening (8) is covered by a circular coaxial impeller hub (2), on which the curved vanes (3, 4) are fastened, and in particular molded on, wherein the base plate (7) having the intake opening (8) facing the impeller (1) or at least one segment (7a) of the base plate is mounted so as to be movable against spring pressure (20) in such a way that the distance thereof from the impeller (1) and thus from the impeller vanes (3, 4) changes.Type: GrantFiled: December 2, 2013Date of Patent: January 16, 2018Assignee: WILO SEInventors: Holger Stark, Alfred J. Otto, Wolfgang Geier, Bernd Kretschmer, Wolfgang Stroessner
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Patent number: 9643737Abstract: Method, apparatus, and computer program product for providing a cause of a scent and/or sound detected during operation of a vehicle are provided. In the event a vehicle operator hears a sound or smells a scent while operating a vehicle, a microphone can sample the sound and/or an electronic nose can sample the scent. A sound and/or scent profile is generated from the sampled sound and/or sampled scent. The generated sound and/or scent profile are compared to known sound and/or scent profiles stored in a data structure. In the event the generated sound and/or scent profile matches a known sound and/or scent profile, the data structure is checked for correspondences between the matched, known sound and/or scent profile and a cause of the sound and/or scent. In the event a correspondence to a cause exists, then the cause is output to a user to identify the cause of the sound and/or scent.Type: GrantFiled: August 19, 2015Date of Patent: May 9, 2017Assignee: THE BOEING COMPANYInventors: Nima Barraci, Jendrick Westphal, Niels-Holger Stark, Merian Kindermann
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Publication number: 20170050750Abstract: Method, apparatus, and computer program product for providing a cause of a scent and/or sound detected during operation of a vehicle are provided. In the event a vehicle operator hears a sound or smells a scent while operating a vehicle, a microphone can sample the sound and/or an electronic nose can sample the scent. A sound and/or scent profile is generated from the sampled sound and/or sampled scent. The generated sound and/or scent profile are compared to known sound and/or scent profiles stored in a data structure. In the event the generated sound and/or scent profile matches a known sound and/or scent profile, the data structure is checked for correspondences between the matched, known sound and/or scent profile and a cause of the sound and/or scent. In the event a correspondence to a cause exists, then the cause is output to a user to identify the cause of the sound and/or scent.Type: ApplicationFiled: August 19, 2015Publication date: February 23, 2017Inventors: Nima BARRACI, Jendrick WESTPHAL, Niels-Holger STARK, Merian KINDERMANN
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Patent number: 9412558Abstract: A method for performing high resolution electron microscopy of a soft matter object is described. The method comprises irradiating a soft matter object using an electron microscope having a spherical aberration correction with a substantially constant transfer function in a frequency band of thermal diffuse scattered electrons scattered at the soft matter object. The method comprises detecting the thermal diffuse scattered (TDS) electrons scattered at the soft matter, and using the detected thermal diffuse scattered electrons for deriving therefrom an image of the soft matter object.Type: GrantFiled: February 14, 2014Date of Patent: August 9, 2016Assignees: UNIVERSITEIT ANTWERPEN, FEI COMPANYInventors: Dirk Van Dyck, Uwe Lucken, Holger Stark, Sara Bals
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Patent number: 9406964Abstract: A fuel cell stack is formed from a plurality of stacked fuel cell units and at least one stack end element. The stacked fuel cell units being surrounded by a housing. A frame element is situated on the at least one stack end element and the housing on the end-face side. At least one seal is situated at least between the stack end element and the housing in the area of the frame element.Type: GrantFiled: December 15, 2012Date of Patent: August 2, 2016Assignee: Daimler AGInventors: Holger Stark, Ulf-Michael Mex
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Patent number: 9385394Abstract: A fuel cell stack includes a plurality of stacked fuel cell units and at least one stack end element that are clamped a clamping device. The clamped fuel cell units are surrounded by a housing. A circumferential seal, in particular a lip seal, which has recesses for accommodating the clamping device is situated between the housing and the at least one stack end element. The clamping device is electrically insulated at least in the area of the recesses.Type: GrantFiled: December 15, 2012Date of Patent: July 5, 2016Assignee: Daimler AGInventors: Matthias Guenthart, Ulf-Michael Mex, Holger Stark, Uwe Werner, Pius Kobler
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Patent number: 9366677Abstract: In a first aspect, provided herein is a method of determining assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes. In particular, the method allows determining maximum stability of the complexes based on fluorescence changes at an appropriate wavelength as a function of temperature whereby the fluorescence changes reflect the status of assembly, homogeneity and/or thermodynamic stability of the biological macromolecular complexes. The method is based on identifying two state and multistate unfolding fluorescence curves as a function of temperature by fitting the curves according to a multistate unfolding model. In addition, a computer program and a computer program storage medium as well as an apparatus and a system is provided for determining the assembly, homogeneity and/or thermodynamic stability of biological macromolecular complexes.Type: GrantFiled: September 6, 2011Date of Patent: June 14, 2016Assignee: Max-Planck-Gesellshaft zur Foerderung der Wissenschaften e.V.Inventors: Holger Stark, Ashwin Chari, David Haselbach, Jan-Martin Kirves
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Patent number: 9302294Abstract: A cobalt coincidence radioactivity detector is used to separate radioactive concrete dust from uncontaminated dust resulting from dismantling a nuclear power plant. A suction air stream carries the dust through a vacuum line to a cyclone segregator. The dust falls into a smaller first container from the segregator, and the detector detects radioactivity in the filled first container. The dust is transferred from the first container to a second container if the detected radioactivity exceeds a predetermined threshold. The dust is transferred from the first container to a third container if the detected radioactivity does not exceed the predetermined threshold. A filter collects the dust carried past the segregator by the suction air stream. If the radioactivity detected in the dust that collects on the filter exceeds the predetermined threshold, the dust in the first container is transferred to the second container before the first container is allowed to fill.Type: GrantFiled: July 15, 2014Date of Patent: April 5, 2016Assignee: Babcock Noell GmbHInventor: Holger Starke
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Publication number: 20150380211Abstract: A method for performing high resolution electron microscopy of a soft matter object is described. The method comprises irradiating a soft matter object using an electron microscope having a spherical aberration correction with a substantially constant transfer function in a frequency band of thermal diffuse scattered electrons scattered at the soft matter object. The method comprises detecting the thermal diffuse scattered (TDS) electrons scattered at the soft matter, and using the detected thermal diffuse scattered electrons for deriving therefrom an image of the soft matter object.Type: ApplicationFiled: February 14, 2014Publication date: December 31, 2015Inventors: Dirk VAN DYCK, Uwe LUCKEN, Holger STARK, Sara BALS
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Publication number: 20150292519Abstract: The invention relates to a centrifugal pump, in particular a waste water submersible pump having an impeller (1), of which the end face facing the pump intake opening is open and only the end face of the impeller facing away from the intake opening (8) is covered by a circular coaxial impeller hub (2), on which the curved vanes (3, 4) are fastened, and in particular moulded on, wherein the base plate (7) having the intake opening (8) facing the impeller (1) or at least one segment (7a) of the base plate is mounted so as to be movable against spring pressure (20) in such a way that the distance thereof from the impeller (1) and thus from the impeller vanes (3, 4) changes.Type: ApplicationFiled: December 2, 2013Publication date: October 15, 2015Applicant: WILO SEInventors: Holger Stark, Alfred J. Otto, Wolfgang Geier, Bernd Kretschmer, Wolfgang Stroessner
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Publication number: 20150180051Abstract: A fuel cell module includes at least one fuel cell stack with a housing. The at least one fuel cell stack is arranged, with a plurality of system components for conducting and/or conditioning the fluids for the supply of the at least one fuel cell stack, with a mechanical interface for fastening the fuel cell module to the vehicle. The mechanical interface is arranged on the housing, wherein the housing forms a carrier for the system components.Type: ApplicationFiled: March 27, 2013Publication date: June 25, 2015Inventors: Felix Blank, Simon Hollnaicher, Martin Keuerleber, Jan Martinec, Cosimo Mazzotta, Uwe Pfister, Michael Procter, Pavel Sarkady, Wolfgang Schmid, Holger Stark