Abstract: In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.

Abstract: A digital control method is to accurately calculate the real-time addition amount of each dye in the solution replenishment system in the whole dyeing process based on the initial dyeing rate of each dye, and replenish the dye solution according to the real-time addition amount. A digital control system includes an automatic calculation K0,n value unit, a central processing unit and a replenishment pump. The automatic calculation K0,n value unit is composed of a dye solution concentration detection instrument, a sensor I and a BP neural network model. The BP neural network model is a BP neural network trained by a dye database. The automatic calculation K0,n value unit transmits the K0,n value to the central processing unit, calculates the replenishment amount through the central processing unit, and controls the replenishment pump to replenish the solution.

Abstract: A rail temperature expansion joint and a laying and mounting method thereof relate to the technical field of track transit. The rail temperature expansion joint includes a sleeper, the upper surface of the sleeper is symmetrically mounted with two first rails and two second rails, and the first rail and the second rail on one side are arranged on the same straight line; a gap is arranged between end faces of the first rail and the second rail; the adjacent ends of the first rail and the second rail are fastened and positioned by a group of adjustment components, the adjustment components are fixedly mounted on the embedded part, and the embedded part is located at the outer side of the first rail and the second rail.

Abstract: An electronic paper display, comprising a carrier device, a memory, a display panel, a sensing device and a processing device. The carrier device is arranged on a logistics box. The memory is arranged on the carrier device, and is configured to store a logistics data. The display panel is arranged on the carrier device, and is configured to generate a control voltage according to the logistics data to adjust a plurality of positions of a plurality of electrophoretic particles. The sensing device comprises at least one sensor, and is configured to sense at least one state parameter of the logistics box to generate at least one sensing signal. The processing device is coupled to the memory, the display panel and the sensing device, and is configured to send the at least one sensing signal through wireless transmission technology.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions such as antibodies or antigen binding fragments thereof that can bind to and neutralize the activity of A33 protein. The antibodies of the present technology are useful in methods for detecting and treating an A33-positive cancer in a subject in need thereof.

Abstract: A genetically engineered bacterium and a preparation method and use thereof are disclosed. The genetically engineered bacteria contain a gene encoding ?-1,2-fucosyltransferase, and a gene encoding a protein tag is connected to the gene encoding ?-1,2-fucosyltransferase; the protein tag is MBP, SUMO1, SUMO2 or TrxA, the amino acid sequence of the MBP is shown in SEQ ID NO: 2, the amino acid sequence of the SUMO1 is shown in SEQ ID NO: 3, the amino acid sequence of the SUMO2 is shown in SEQ ID NO: 4, the amino acid sequence of the TrxA is shown in SEQ ID NO: 5. Fermentation with the genetically engineered bacteria can greatly increase the yield of 2?-fucosyllactose compared to the genetically engineered bacteria that only expresses ?-1,2-fucosyltransferase exogenously, and the yield can be more than doubled in a preferred case.

Abstract: The invention discloses a genetically engineered bacterium and a method for preparing a fucosylated oligosaccharide using the same. The method includes: transferring a fucosyl group of a donor to an oligosaccharide receptor by a fucosyltransferase heterologously expressed in a genetically engineered bacterium; wherein the donor is a nucleotide-activated donor, the fucosyltransferase has ?-1,2-fucosyltransferase activity; wherein, the fucosyltransferase is selected from one or more of the enzymes corresponding to NCBI Accession Numbers WP_109047124.1, RTL12957.1, MBP7103497.1, WP_120175093.1, RYE22506.1, WP_140393075.1 and HJB91111.1. The preparation method of the invention has high yield, greatly improved substrate conversion rate and product conversion rate, and has the potential to be applied to industrial production.

Abstract: The present invention discloses a genetically engineered bacteria, which is E. coli integrated with lysogenic ?DE3, and lacZ gene is completely inactivated, but does not affect exogenous protein expression of the genetically engineered bacteria. The present invention also discloses a method for culturing the genetically engineered bacteria, and a method for preparing human milk oligosaccharides using the same, and use of the genetically engineered bacteria. The genetically engineered bacteria of the present invention can efficiently produce human milk oligosaccharides, such as 2?-fucosyllactose, and have wide industrial application prospects.

Abstract: The invention discloses a genetically engineered bacterium and its application in the preparation of sialyllactose. The genetically engineered bacterium has an N-acetylneuraminic acid biosynthesis pathway, includes multiple copies of a gene neuB for encoding sialic acid synthase, and the gene neuB is initiated for expression by a strong promoter. Using the genetically engineered bacteria of the invention to produce sialyllactose has the advantages of high yield and low overall cost.

Abstract: An LED tube lamp comprises: a glass lamp tube; an LED light strip disposed inside the glass lamp tube and comprised a mounting region and a connecting region; an LED module comprised a plurality of LED light sources mounted on the mounting region; two first connecting pads arranged on the connecting region, each of the first connecting pads comprising a through hole therein; a fixing structure disposed inside the glass lamp tube and extending along the longitudinal direction of the glass lamp tube, the fixing structure comprising a first end fixedly connected to the inner circumferential surface of the glass lamp tube and a second end fixedly connected to the LED light strip; a circuit board separate from the light strip and soldered to the LED light strip via the two first connecting pads, and a solder be disposed on each of the first connecting pads and in the through hole of each first connecting pad and a power supply module.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives, from a client device, a request for information associated with a category. In response to the request, the program further accesses a storage to retrieve a first value associated with the category. The program also determines a set of values associated with the category based on a plurality of transactions. The program further determines an optimization level value associated with the category. The program also determines a second value associated with the category based on the first value, the set of values, and the optimization level value. The program further provides, by an application operating on the device, a graphical user interface (GUI) to the client device, the GUI comprising the second value.

Abstract: Prepregs, composites and articles are described that comprise a porous core layer and a surface layer comprising bi-component fibers which can enhance formability of the article without breakthrough. The enhanced formability can permit forming or drawing of the article to increased depths without breakthrough. Interior and exterior automotive components including the articles are described.

Abstract: Disclosed are various examples for providing a single sign-on experience for mobile applications that may or may not be managed. A first application executed in a client device sends an access request to a service provider. The first application receives a redirection response from the service provider that redirects the first application to an identity provider. The first application then receives a further redirection response from the identity provider that causes the first application to request an identity assertion from a second application executed in the client device. The first application receives the identity assertion from the second application. The first authentication then authenticates with the service provider using the identity assertion.

Abstract: An LED filament comprising a plurality of LED filament units, each of the plurality of LED filament units includes a LED chip with an upper surface and a lower surface opposite to the upper surface of the LED chip, and a light conversion layer comprising a top layer and a base layer, and the base layer comprises an upper surface and a lower surface opposite to the upper surface of the base layer, where the top layer with an upper surface and a lower surface opposite to the upper surface of the top layer is disposed on at least two sides of each of the LED chips, the lower surface of each of the LED chips is close to the upper surface of the base layer, and the upper surface of the top layer is away from each of the LED chips.

Abstract: Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2-related cancers.

Abstract: The present invention discloses a manual type C-shaped wire clamp operating device, includes an insulating operating rod, wherein an upper end of the insulating operating rod is provided with a threaded rod, and the threaded rod includes an upper thread and a lower thread; a wire clamp clamping device, wherein the wire clamp clamping device includes a first spring, a wire clamp seat and a floating clamping block located above the wire clamp seat, a wire clamp seat threaded hole is formed in the wire clamp seat, the wire clamp seat threaded hole is in fit connection with the lower thread of the threaded rod; a drainage wire pressing device, wherein the drainage wire pressing device includes a guide rod arranged on the wire clamp seat and a drainage wire pressing block sliding along the guide rod, and a pressing block threaded hole is formed in the drainage wire pressing block.

Abstract: A chimeric lysozyme variant has an improved heat resistance and is encoded by a polynucleotide. A novel chimeric lysozyme sequence is constructed, and high-efficiency expression in a host cell is achieved. The thermal stability of the chimeric lysozyme under the condition of 60° C. is nearly doubled compared to a parental sequence. The chimeric lysozyme variant can be used to prepare product that is antibiotic, for example, animal feed additive containing the chimeric lysozyme variant and an animal feed containing the animal feed additive.

Abstract: An anti-ANGPTL3 antibody or an antigen-binding fragment thereof. The present invention provides an anti-ANGPTL3 antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region includes complementarity determining regions (CDRs), including CDR-H1 having an amino acid sequence as set forth in SEQ ID No. 1, CDR-H2 having an amino acid sequence as set forth in SEQ ID No. 2, and CDR-H3 having an amino acid sequence as set forth in SEQ ID No. 3; and the CDRs of a light chain variable region includes CDR-L1 having an amino acid sequence as set forth in SEQ ID No. 4, CDR-L2 having an amino acid sequence as set forth in SEQ ID No. 5, and CDR-L3 having an amino acid sequence as set forth in SEQ ID No. 6. The antibody or the antigen-binding fragment thereof provided in the present invention can specifically recognize ANGPTL3.

Abstract: Examples of detecting whether a device meets an enrollment level are disclosed. In one case, a method for providing access to an application on a client device includes receiving a request to access an application from the client device, determining an enrollment level associated with the application, and determining that multi-factor authentication is required for access to the application on the client device based on the enrollment level associated with the application. The method can also include initiating multi-factor authentication on the client device before access to the application is permitted. The method can also include determining that multi-factor authentication is successful on the client device, transmitting a management component to the client device, and installing the management component on the client device for enrollment as a managed device with a management service.

Abstract: Disclosed is a method and system for predicting a touch interaction position on a large display based on a binocular camera. The method includes: separately acquiring arm movement video frames of a user and facial and eye movement video frames of the user by a binocular camera; extracting a video clip of each tapping action from the arm movement video frames and the facial and eye movement video frames and obtaining a key frame by screening; marking the key frame of each tapping action with coordinates to indicate coordinates of a finger in a display screen; inputting the marked key frame to an efficient convolutional network for online video understanding (ECO)-Lite neural network for training to obtain a predictive network model; and inputting a video frame of a current operation to be predicted to the predictive network model and outputting a touch interaction position predicted for the current operation.