Abstract: The invention discloses a method for synthesizing 1,7-naphthyridine derivatives, which relates to the technical field of synthesizing pharmaceutical intermediates and organic chemical intermediates, wherein the method includes: (1) 2-chloro-3-amino-pyridine being used as Compound I as a starting material, and protecting an amino group to prepare Compound II; (2) the Compound II reacting with an aldehydation reagent under alkaline conditions to obtain Compound III; (3) cyclizing the Compound III with acrylate compounds under the action of Lewis acid to prepare compound IV.

Abstract: In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.

Abstract: Provided is a thermostable glucose oxidase obtained by introducing at least one pair of disulfide bonds into an amino acid sequence of a wild-type Aspergillus niger glucose oxidase or a mutant Aspergillus niger glucose oxidase. The glucose oxidase is suitable for application in the fields of food, chemical engineering, medicine, agriculture and feeds.

Abstract: An electrophoretic display device and a driving method for electrophoretic display device are provided. The electrophoretic display device includes an electrophoretic display panel, a network module, a processor and an electrophoretic display driver. The network module is configured to transmit a panel information of the electrophoretic display panel to a web application programming interface. The processor is coupled to the electrophoretic panel and the network module. The processor is configured to receive an image information packet corresponding to the panel information via the web application programming interface. The electrophoretic display driver is coupled to the processor and the electrophoretic display panel. The processor makes the electrophoretic display driver drive the electrophoretic display panel to display an image information according to the image information packet.

Abstract: A smart display card and an operation method thereof are provided. The smart display card includes a connection interface, a security chip, a processing chip, and a display. The connection interface receives a power signal and a data signal provided by an external card reader when the smart display card is connected to the external card reader. The security chip is coupled to the connection interface and receives the power signal and the data signal. The security chip complies with a first communication protocol. The processing chip is coupled to the connection interface and receives the power signal and the data signal. The processing chip complies with a second communication protocol different from the first communication protocol. The display is coupled to the processing chip. The processing chip drives the display based on the power signal and the data signal.

Abstract: Composite articles comprising a porous prepreg or core layer and a powder coated layer thereon are described. In some instances, a thermoplastic composite article comprises a porous core layer comprising a web of reinforcing fibers held together by a thermoplastic material, and a powder coated layer disposed on the porous core layer, in which a particle size of the powder coated layer is selected to provide an interface between the powder coated layer and the porous core layer, wherein at least 50% by weight of the disposed powder coated layer is present above the interface.

Abstract: A high-power semiconductor chip and a preparation method therefor. The semiconductor chip comprises: a substrate (1), a lower confinement layer (2), a lower waveguide layer (3), an active layer (4), an upper waveguide layer (5), a lateral grating layer (10), an upper confinement layer (6), a contact layer (7), a current isolation dielectric layer (8) and a metal layer (9), sequentially arranged from bottom to top, wherein the lateral grating layer (10) comprises a plurality of groups of lateral gratings; the plurality of groups of lateral gratings are sequentially arranged in a first direction; the periods of the plurality of groups of lateral gratings are different from each other; each group of lateral gratings comprises a plurality of gratings; the plurality of gratings are arranged in a second direction; and the first direction intersects with the second direction.

Abstract: Disclosed herein is a method for expressing phytase in a filamentous fungus by using an optimized Escherichia coli phytase gene having a nucleotide sequence as shown in SEQ ID NO. 7 and a signal peptide having a nucleotide sequence as shown in SEQ ID NO. 12.

Abstract: A system and method for supplying on-premise hyper-converged systems uses a cloud service to receive orders for the on-premise hyper-converged systems from customers and to request a system integrator to procure hardware components of the on-premise hyper-converged systems and to assemble hardware components to produce assembled systems. Software components are remotely installed and configured in the assembled systems from the cloud service using bring-up appliances in virtual private clouds created for the on-premise hyper-converged systems to deploy software-defined data centers (SDDCs) in the on-premise hyper-converged systems. The resulting on-premise hyper-converged systems with the deployed SDDCs can then used by the customers.

Abstract: An LED tube lamp comprises: a glass lamp tube; a light diffusion layer disposed on a surface of the glass lamp tube; an LED light strip, which comprises a fixing portion and an extending portion disposed in the glass lamp tube; a plurality of LED light sources mounted on the fixing portion of the LED light strip; a fixing structure disposed between the fixing portion and the inner circumferential surface the glass lamp tube; a power supply module disposed on the fixing structure and electrically connecting to the LED light strip and two end caps attached to two ends of the glass lamp tube respectively. The fixing structure comprises a first end fixedly connected to the inner circumferential surface of the glass lamp tube and a second end fixedly connected to the fixing portion of the LED light strip and not connected to the extending portion of the LED light strip.

Abstract: The present disclosure relates generally to complexes comprising an interleukin-15 (“EL-15”) polypeptide chain non-covalently bonded to an IL-15 receptor ?-Fc fusion polypeptide (“IL-15R?-Fc”), and multimers (e.g., trimers) thereof. The complexes of the present technology are useful in methods for enhancing immune cell function and immunotherapy in a patient in need thereof. Also provided herein are methods for preventing or treating a disease or condition in which enhancing IL-15-mediated function is beneficial (such as cancer, infectious diseases, immunodeficiencies and leukopenia) in a patient in need thereof.

Abstract: An LED light bulb includes a lamp housing, an LED filament in the lamp housing and a power module. The LED filament includes a first and a second LED sections, a conductive section, a first and a second conductive electrodes and a light conversion layer. Each LED section includes LED chips connected in serial to from a LED string. The conductive section connects one end of the LED string of the first LED section with one end of the LED string of the second sections. The polarities of the ends of the LED strings are the same. The other ends of the LED strings are respectively connected to the first and the second conductive electrodes. The light conversion layer is coated on at least two sides of the LED chips. The power module's terminals are connected to the conductive section and the conductive electrodes.

Abstract: An LED light bulb comprising a lamp housing, a bulb base, connected to the lamp housing, a stem connected to the bulb base and located in the lamp housing; an LED filament, disposed in the lamp housing, where points of the LED filament in an xyz coordinates are defined as x, y, and z, an x-y plane of the xyz coordinates is perpendicular to the height direction of the LED light bulb, an z-axis of xyz coordinates is parallel with the stem, and the projection of the LED filament on the x-y plane, y-z plane and x-z plane respectively has a length L1, L2 and L3, and the length L1, the length L2, and the length L3 are substantially in a ratio of 1:(0.5 to 1):(0.6 to 0.9).

Abstract: An LED light bulb comprising a lamp housing, a bulb base, connected to the lamp housing, a spectral distribution of the light bulb is generally between a wavelength range of about 400 nm to 800 nm, and three peak wavelengths P1, P2, and P3 appear in wavelength ranges corresponding to light emitted by the light bulb, wherein a wavelength of the peak P1 is between 430 nm and 480 nm, a wavelength of the peak P2 is between 480 nm and 530 nm, a wavelength of the peak P3 is between 630 nm and 680 nm.

Abstract: An high-efficiency light bulb, comprising: a lamp housing with inner surface and outer surface opposite to the inner surface of the lamp housing, the lamp housing includes a layer of luminescent material, which is formed on the inner surface or the outer surface of the lamp housing or integrated in the material of the lamp housing; a bulb base connected to the lamp housing; a stem connected to the bulb base and located in the lamp housing; and a single filament, disposed in the light housing, further comprising a plurality of supporting arms, connected with and supporting the LED filament, wherein the stem comprises a stand extending to the center of the lamp housing, the stand supports the supporting arms.

Abstract: A network service transmission method includes obtaining network topology information and network service information, and determining a node centrality of each node in a set of other nodes; determining at least one segment node in the set of other nodes, determining at least one transmission path used to transmit each network service; and determining traffic of a network service that is to be transmitted on the at least one transmission path used to transmit the network service. After the segment node is determined, traffic of a network service transmitted on each transmission path is determined, and the transmission paths of the network services share the same segment node.

Abstract: An LED filament comprising a plurality of LED filament units, each of the plurality of LED filament units includes a LED chip with an upper surface and a lower surface opposite to the upper surface of the LED chip, and a light conversion layer comprising a top layer and a base layer, and the base layer comprises an upper surface and a lower surface opposite to the upper surface of the base layer, where the top layer with an upper surface and a lower surface opposite to the upper surface of the top layer is disposed on at least two sides of each of the LED chips, the lower surface of each of the LED chips is close to the upper surface of the base layer, and the upper surface of the top layer is away from each of the LED chips.

Abstract: This application provides a latency-based transmission path control method, an apparatus, and a system. Device latencies of network node devices on an active transmission path, device latencies of network node devices on a standby transmission path, latencies of links between the network node devices on the active transmission path, and latencies of links between the network node devices on the active transmission path are obtained, and calculation is performed based on the respective device latencies and link latencies to obtain an active transmission path latency and a standby transmission path latency. Then, based on a latency-based switching mechanism, when the active transmission path latency is greater than a switching threshold and the standby transmission path latency is less than the switching threshold, an active-to-standby path switching command is generated.

Abstract: A nucleic acid amplification blocker for detecting a low-abundance mutation sequence and an application thereof in detecting a low-abundance mutation sequence are provided. The nucleic acid amplification blocker is an oligonucleotide modified by locked nucleic acid (LNA), and the matching region of the nucleic acid amplification blocker is located between amplified sequences. The nucleic acid amplification blocker is completely complementary to wild-type gene sequence, and contains at least one mismatch with mutant sequence. The nucleic acid amplification blocker has a great difference in affinity with mutant nucleic acid sequence/wild-type nucleic acid sequence, so as to achieve the purpose of highly selective amplification/enrichment of mutant sequence in samples. The nucleic acid amplification blocker has more significant detection effect on deletion mutation and insertion mutation.

Abstract: An LED tube lamp comprises: a glass lamp tube; a light diffusion layer disposed on a surface of the glass lamp tube; an LED light strip, which comprises a fixing portion and an extending portion disposed in the glass lamp tube; a plurality of LED light sources mounted on the fixing portion of the LED light strip; a fixing structure disposed between the fixing portion and the inner circumferential surface the glass lamp tube; a power supply module disposed on the fixing structure and electrically connecting to the LED light strip and two end caps attached to two ends of the glass lamp tube respectively. The fixing structure comprises a first end fixedly connected to the inner circumferential surface of the glass lamp tube and a second end fixedly connected to the fixing portion of the LED light strip and not connected to the extending portion of the LED light strip.