Patents by Inventor Hongkun Park

Hongkun Park has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11209440
    Abstract: This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: December 28, 2021
    Inventors: Vijay Kuchroo, Aviv Regev, Jellert Gaublomme, Youjin Lee, Alexander K. Shalek, Chao Wang, Nir Yosef, Hongkun Park
  • Publication number: 20210371846
    Abstract: Methods and systems for stimulating and monitoring electrogenic cells are described. Some systems for stimulating electrogenic cells are based on the injection of electric currents into the cells via electrodes connected to the cells. Such stimulators may comprise an impedance element having an input terminal and an output terminal coupled to an electrode, and a voltage follower coupled between the input terminal and the output terminal of the impedance element, the voltage follower being configured to maintain a substantially constant voltage between the input terminal and the output terminal of the impedance element. The impedance element may comprise one or more switched capacitors at least in some embodiments. In some embodiments, the voltage follower may be implemented using a source follower.
    Type: Application
    Filed: July 6, 2018
    Publication date: December 2, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donhee Ham, Jeffrey T ABBOTT, Hongkun PARK, Wenxuan WU
  • Publication number: 20210187280
    Abstract: The present invention generally relates to nanowires. In one aspect, the present invention is generally directed to systems and methods of individually addressing nanowires on a surface, e.g., that are substantially upstanding or vertically-oriented with respect to the surface. In some cases, one or more nanowires may be individually addressed using various integrated circuit (“IC”) technologies, such as CMOS. For example, the nanowires may form an array on top of an active CMOs integrated circuit.
    Type: Application
    Filed: January 8, 2021
    Publication date: June 24, 2021
    Applicant: President and Fellows of Harvard College
    Inventors: Hongkun Park, Donhee Ham, Jeffrey T. Abbott, Ling Qin, Marsela Jorgolli, Tianyang Ye
  • Patent number: 10910794
    Abstract: A light-emitting device includes a substrate including a photonic cavity and configured to function as a gate, an active layer including a two-dimensional material, a first conductive contact, and a second conductive contact. The wavelength range of light generated by the light-emitting device may be narrowed based on the photonic cavity being included in the substrate, and the intensity and wavelength range of the generated light may be controlled based on the substrate functioning as a gate.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: February 2, 2021
    Assignees: Samsung Electronics Co., Ltd., President and Fellows of Harvard College
    Inventors: Jinseong Heo, Minhyun Lee, Seongjun Park, Philip Kim, Hongkun Park, Donhee Ham
  • Patent number: 10895617
    Abstract: A method for probing the properties of nanoscale materials, such as 2D materials or proteins, via nanometer-scale nuclear quadrupole resonance (NQR) spectroscopy using individual atom-like impurities in diamond. Coherent manipulation of shallow nitrogen-vacancy (NV) color centers enables the probing of the NQR spectrum of nanoscale ensembles of nuclear spins. Measuring the NQR spectrum at different magnetic field orientations and magnitudes and fitting to a theoretical model allows for the extraction of atomic structural properties of the material with nanoscale resolution.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: January 19, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Igor Lovchinsky, Javier Sanchez, Elana K. Urbach, Soonwon Choi, Trond Andersen, Philip Kim, Hongkun Park, Mikhail D. Lukin
  • Patent number: 10870885
    Abstract: This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences dendritic cell (DC) response(s), for example, dendritic cell maturation, dendritic cell antiviral response(s) and/or dendritic cell inflammatory response(s), as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences dendritic cell response(s) in a variety of therapeutic and/or diagnostic indications.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: December 22, 2020
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Aviv Regev, Alexander K. Shalek, Rahul Satija, Hongkun Park
  • Publication number: 20200347393
    Abstract: The present invention generally relates to micro- and nanoneedles, e.g., for use in penetrating plant cells, or other cells. In some embodiments, delivery of target biomolecules into cells with protective outer layers (e.g. plant cells or plant pollen), cells in seeds, or cells in tissues may be achieved. These outer layers could be native biological protections (e.g. complex exines for pollens), other types of cells, or general biological materials. In some cases, the needles are attached at an end on a surface. In some cases, pollen or seeds may have substantially thick and tough layers (intine and exine), which may render it more difficult to penetrate such materials, as compared with cell membranes, e.g., in mammalian cells.
    Type: Application
    Filed: December 7, 2018
    Publication date: November 5, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: Hongkun Park, Xing Liao, Jeffrey T. Abott, Steven Ban, Tianyang Ye
  • Patent number: 10822587
    Abstract: This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: November 3, 2020
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Aviv Regev, Vijay Kuchroo, Hongkun Park, Nir Yosef, Alexander K. Shalek, Jellert Gaublomme, Nicole C. Joller, Chuan Wu, Ana Carrizosa Anderson
  • Publication number: 20200292482
    Abstract: Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.
    Type: Application
    Filed: October 30, 2018
    Publication date: September 17, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: Donhee Ham, Hongkun Park, Keith Krenek, Tianyang Ye, Jeffrey T. Abbott, Wenxuan Wu
  • Publication number: 20200225302
    Abstract: A method for probing the properties of nanoscale materials, such as 2D materials or proteins, via nanometer-scale nuclear quadrupole resonance (NQR) spectroscopy using individual atom-like impurities in diamond. Coherent manipulation of shallow nitrogen-vacancy (NV) color centers enables the probing of the NQR spectrum of nanoscale ensembles of nuclear spins. Measuring the NQR spectrum at different magnetic field orientations and magnitudes and fitting to a theoretical model allows for the extraction of atomic structural properties of the material with nanoscale resolution.
    Type: Application
    Filed: May 24, 2017
    Publication date: July 16, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: Igor X. LOVCHINSKY, Javier Daniel SANCHEZ-YAMAGISHI, Elana K. URBACH, Soonwon CHOI, Trond ANDERSEN, Philip KIM, Hongkun PARK, Mikhail D. LUKIN
  • Publication number: 20200081017
    Abstract: This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
    Type: Application
    Filed: November 6, 2019
    Publication date: March 12, 2020
    Inventors: Vijay K. Kuchroo, Aviv Regev, Jellert Gaublomme, Youjin Lee, Alexander K. Shalek, Chao Wang, Nir Yosef, Hongkun Park
  • Patent number: 10436650
    Abstract: An approach to nanoscale thermometry that utilizes coherent manipulation of the electronic spin associated with nitrogen-vacancy (NV) color centers in diamond is disclosed. The methods and apparatus allow for detection of temperature variations down to milli-Kelvin resolution, at nanometer length scales. This biologically compatible approach to thermometry offers superior temperature sensitivity and reproducibility with a reduced measurement time. The disclosed apparatus can be used to study heat-generating intracellular processes.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: October 8, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Peter Christian Maurer, Hyun Ji Noh, Georg Kucsko, Mikhail D. Lukin, Hongkun Park, Minako Kubo
  • Publication number: 20190127782
    Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 2, 2019
    Inventors: Aviv REGEV, Evan Zane MACOSKO, Steven Andrew MCCARROLL, Alexander K. SHALEK, Anindita BASU, Christopher B. FORD, Hongkun PARK, David A. WEITZ
  • Patent number: 10197497
    Abstract: A method of making measurements includes providing a sensor with at least one solid state electronic spin; irradiating the sensor with radiation from an electromagnetic radiation source that manipulates the solid state electronic spins to produce spin-dependent fluorescence, wherein the spin-dependent fluorescence decays as a function of relaxation time; providing a target material in the proximity of the sensor, wherein, thermally induced currents (Johnson noise) present in the target material alters the fluorescence decay of the solid state electronic spins as a function of relaxation time; and determining a difference in the solid state spins spin-dependent fluorescence decay in the presence and absence of the target material and correlating the difference with a property of the sensor and/or target material.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: February 5, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Shimon Jacob Kolkowitz, Arthur Safira, Alexander A. High, Robert C. Devlin, Soonwon Choi, Quirin P. Unterreithmeier, David Patterson, Alexander S. Zibrov, Vladimir E. Manucharyan, Mikhail D. Lukin, Hongkun Park
  • Publication number: 20190013648
    Abstract: A light-emitting device includes a substrate including a photonic cavity and configured to function as a gate, an active layer including a two-dimensional material, a first conductive contact, and a second conductive contact. The wavelength range of light generated by the light-emitting device may be narrowed based on the photonic cavity being included in the substrate, and the intensity and wavelength range of the generated light may be controlled based on the substrate functioning as a gate.
    Type: Application
    Filed: April 25, 2018
    Publication date: January 10, 2019
    Applicants: Samsung Electronics Co., Ltd., President and Fellows Of Harvard College
    Inventors: Jinseong HEO, Minhyun LEE, Seongjun PARK, Philip KIM, Hongkun PARK, Donhee HAM
  • Publication number: 20180341090
    Abstract: A method of fabricating a visible spectrum optical component includes: providing a substrate; forming a resist layer over a surface of the substrate; patterning the resist layer to form a patterned resist layer defining openings exposing portions of the surface of the substrate; performing deposition to form a dielectric film over the patterned resist layer and over the exposed portions of the surface of the substrate, wherein a top surface of the dielectric film is above a top surface of the patterned resist layer; removing a top portion of the dielectric film to expose the top surface of the patterned resist layer and top surfaces of dielectric units within the openings of the patterned resist layer; and removing the patterned resist layer to retain the dielectric units over the substrate.
    Type: Application
    Filed: November 23, 2016
    Publication date: November 29, 2018
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Robert C. DEVLIN, Mohammadreza KHORASANINEJAD, Federico CAPASSO, Hongkun PARK, Alexander Arthur HIGH
  • Publication number: 20180275057
    Abstract: A method of making measurements includes providing a sensor with at least one solid state electronic spin; irradiating the sensor with radiation from an electromagnetic radiation source that manipulates the solid state electronic spins to produce spin-dependent fluorescence, wherein the spin-dependent fluorescence decays as a function of relaxation time; providing a target material in the proximity of the sensor, wherein, thermally induced currents (Johnson noise) present in the target material alters the fluorescence decay of the solid state electronic spins as a function of relaxation time; and determining a difference in the solid state spins spin-dependent fluorescence decay in the presence and absence of the target material and correlating the difference with a property of the sensor and/or target material.
    Type: Application
    Filed: January 29, 2016
    Publication date: September 27, 2018
    Inventors: Shimon Jacob KOLKOWITZ, Arthur SAFIRA, Alexander A. HIGH, Robert C. DEVLIN, Soonwon CHOI, Quirin P. UNTERREITHMEIER, David PATTERSON, Alexander S. ZIBROV, Vladimir E. MANUCHARYAN, Mikhail D. LUKIN, Hongkun PARK
  • Publication number: 20180169403
    Abstract: The present invention generally relates to nanowires. In one aspect, the present invention is generally directed to systems and methods of individually addressing nanowires on a surface, e.g., that are substantially upstanding or vertically-oriented with respect to the surface. In some cases, one or more nanowires may be individually addressed using various integrated circuit (“IC”) technologies, such as CMOS. For example, the nanowires may form an array on top of an active CMOs integrated circuit.
    Type: Application
    Filed: January 8, 2016
    Publication date: June 21, 2018
    Applicant: President and Fellows of Harvard College
    Inventor: Hongkun Park
  • Publication number: 20180119172
    Abstract: A molecular delivery system including a plurality of nanowires (e.g., Si NWs), each of the nanowires having a surface layer formed of a silicon-containing material and a covalently bound linker (e.g., silane linker) attached to the surface layer and optionally including a substrate to which the nanowires are adhered or a molecule to be delivered attached to the linker. Also disclosed is a method of delivering into a cell an exogenous molecule.
    Type: Application
    Filed: October 27, 2017
    Publication date: May 3, 2018
    Inventors: Hongkun Park, EunGyeong Yang, Alexander K. Shalek, JinSeok Lee, Jacob Robinson, Amy Sutton, Myung-Han Yoon, Marsela Jorgolli
  • Patent number: 9891297
    Abstract: Systems and methods for magnetic sensing and imaging include a sensor having a network of isolated electron-spin quantum bits (qubits) disposed on the surface of the sensor; and a solid state electronic spin system disposed below the surface of the sensor, wherein the solid state electronic spin system has a spin-state dependent fluorescence; a source of light; a source of first external perturbation, wherein the source of first external perturbation generates a magnetic field; a source of second external perturbation; wherein, the source of light and the first and second external perturbations are configured to coherently and independently manipulate the spin states of at least one qubit and at least one solid state electronic spin system; and a detector to optically measure the solid-state electronic spins spin-state dependent fluorescence.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: February 13, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Alexander Sushkov, Igor Lovchinsky, Nicholas Chisholm, Ronald L. Walsworth, Hongkun Park, Mikhail D. Lukin