Patents by Inventor Hongtao Zhang

Hongtao Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIVIRAL CELL-PENETRATING PEPTIDES
    Publication number: 20090281041
    Abstract: Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.
    Type: Application
    Filed: May 5, 2009
    Publication date: November 12, 2009
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli
  • Cooling Holes For Gas Turbine Combustor Having A Non-Uniform Diameter Therethrough
    Publication number: 20080271457
    Abstract: A gas turbine combustor liner, including a shell having a first end adjacent to an upstream end of the combustor and a second end adjacent to a downstream end of the combustor, where the shell also has a hot side, a cold side, and a centerline axis therethrough. A plurality of small, closely-spaced film cooling holes are formed in the shell through which air flows for providing a cooling film along the hot side of the shell. Each cooling hole has a non-uniform diameter as it extends through the shell. In particular, each cooling hole includes a first opening located at the cold side of the shell having a first diameter and a second opening located at the hot side of the shell having a second diameter, wherein the second diameter of the second opening is larger than the first diameter of the first opening. It is preferred that the shape of each cooling hole be substantially frusto-conical.
    Type: Application
    Filed: May 1, 2007
    Publication date: November 6, 2008
    Applicant: General Electric Company
    Inventors: Marie Ann McMasters, David Louis Burrus, George Chia-Chun Hsiao, Hongtao Zhang, Hukam Chand Mongia
  • Binding Peptidomimetics and Uses of the Same
    Publication number: 20080206136
    Abstract: A multimeric peptidomimetic that comprises two or more monomers is disclosed. The monomers comprise an exocyclic peptide comprising a ring structure, a flexible linker sequence and a multimeric motif. Use of the monomers, a nucleic acid molecule encoding monomers, recombinant expression vectors comprising the nucleic acid molecule and host cells comprising a recombinant expression vector are disclosed. Methods of delivering a drug, a toxin, a nucleic acid molecule, a radionuclide or a detectable compound to a cell are disclosed.
    Type: Application
    Filed: February 18, 2005
    Publication date: August 28, 2008
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang
  • Method, systems and kits for immuno-detection of epitopes expressed on molecules
    Patent number: 7361464
    Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific.CDR attached to an oligonucleotide.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: April 22, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, James Eberwine, Janet Estee Kacharmina, Hongtao Zhang
  • Method for immuno-detection of epitopes
    Patent number: 7341831
    Abstract: Methods, systems and kits are provided for detecting, molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR attached to an oligonucleotide.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: March 11, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, James H. Eberwine, Janet Estee Kacharmina, Hongtao Zhang
  • Reagents, Kits and Methods for Immunodetection of Epitopes on Molecules
    Publication number: 20080020374
    Abstract: Methods for detecting and/or quantifying molecules expressing a selected epitope in a sample are disclosed. Methods for profiling proteins in a cell lysate are also disclosed. Kits for detecting and/or quantifying molecules expressing a selected epitope in a sample and kits for profiling proteins in a cell lysate are also disclosed.
    Type: Application
    Filed: February 18, 2005
    Publication date: January 24, 2008
    Inventors: Mark Greene, Hongtao Zhang, Xin Cheng
  • Methods of detecting molecules expressing selected epitopes via fluorescent dyes
    Patent number: 7045286
    Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR attached to an oligonucleotide.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: May 16, 2006
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang
  • Monoclonal antibodies to activated erbB family members and methods of use thereof
    Publication number: 20060073140
    Abstract: Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Application
    Filed: August 5, 2002
    Publication date: April 6, 2006
    Inventors: Mark Greene, Hongtao Zhang, Mark Richter, Ramachandran Murali
  • Method, systems and kits for immuno-detection of epitopes expressed on molecules
    Publication number: 20050003413
    Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific.CDR attached to an oligonucleotide.
    Type: Application
    Filed: May 28, 2004
    Publication date: January 6, 2005
    Inventors: Mark Greene, James Eberwine, Janet Kacharmina, Hongtao Zhang
  • Method for immuno-detection of epitopes
    Publication number: 20040132212
    Abstract: Methods, systems and kits are provided for detecting, molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR attached to an oligonucleotide.
    Type: Application
    Filed: February 11, 2004
    Publication date: July 8, 2004
    Inventors: Mark I. Greene, James H. Eberwine, Janet Estee Kacharmina, Hongtao Zhang
  • Methods for immuno-detection of epitopes on molecules and for detection of interactions of molecules via fluorescent dyes
    Publication number: 20020028450
    Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR attached to an oligonucleotide.
    Type: Application
    Filed: February 15, 2001
    Publication date: March 7, 2002
    Inventors: Mark I. Greene, Hongtao Zhang