Patents by Inventor Hongtao Zhang

Hongtao Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8940864
    Abstract: Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus in a cell. Also provided are methods of treating a mammal infected with a capsid-containing virus. Further provided are methods of treating a mammal at risk for infection with a capsid-containing virus. Methods of making the above peptides are additionally provided, as are uses of the above peptides and pharmaceutical compositions.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: January 27, 2015
    Assignee: New York Blood Center, Inc.
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Qian Zhao
  • Patent number: 8937154
    Abstract: Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: January 20, 2015
    Assignee: New York Blood Center, Inc.
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Qian Zhao
  • Patent number: 8933019
    Abstract: Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: January 13, 2015
    Assignee: New York Blood Center, Inc.
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli
  • Publication number: 20140348831
    Abstract: Disclosed herein are antibodies that detect a lipid-like antigen on prostate cancer cells and methods of detecting and treating prostate cancer using the same.
    Type: Application
    Filed: June 4, 2014
    Publication date: November 27, 2014
    Inventors: Mark I. Greene, Hongtao Zhang, Geng Zhang
  • Publication number: 20140309246
    Abstract: This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for inhibiting cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, and methods for treating these disorders.
    Type: Application
    Filed: March 16, 2012
    Publication date: October 16, 2014
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Mark I. Greene, Hongtao Zhang, Alan Berezov, Zheng Cai
  • Publication number: 20140234221
    Abstract: Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins In addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided Vectors and cells useful for expression of the described proteins are also provided, as are methods of use.
    Type: Application
    Filed: April 2, 2014
    Publication date: August 21, 2014
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang, Xiaomin song, Ramachandran Murali, Masahide Tone
  • Publication number: 20140215245
    Abstract: Systems and methods for reducing power consumption of systems using serialized data transmission. In a multi-node system, the reiterative steps for the setup of the lanes within links between the nodes produces both a time invariant set of parameters associated with the channel properties of the lanes and a time variant set of parameters associated with receiver clock alignment. The time invariant set is stored in persistent storage. Links may be turned on and turned off. When a link is turned on again, the stored time invariant set may be used as initial values to reconfigure both the time invariant and the time variant sets, thereby greatly reducing the delay to begin using the link again. The reduced delay may significantly speed up the wakening process for the links, thereby encouraging the use of low-power techniques that include tuning off lanes.
    Type: Application
    Filed: January 29, 2013
    Publication date: July 31, 2014
    Applicant: ORACLE INTERNATIONAL CORPORATION
    Inventors: Hongtao Zhang, Da-wei Huang, Jianghui Su
  • Publication number: 20140187579
    Abstract: This invention is in the fields of immunology and autoimmunity. More particularly it concerns pharmaceutical compositions comprising compounds which are useful agents for inhibiting the functions of TIP60 and the use of such compounds in the treatment of an individual suffering, for example, from ulcerative colitis and other irritable bowel diseases.
    Type: Application
    Filed: December 2, 2011
    Publication date: July 3, 2014
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Mark I Greene, Alan Berezov, Yan Xiao, Hongtao Zhang
  • Publication number: 20140178375
    Abstract: Disclosed herein are recombinant protein scaffolds for use in producing antigen-binding proteins. Related antigen-binding proteins are also provided herein. In addition, nucleic acids encoding such recombinant protein scaffolds and antigen-binding proteins are also described. Vectors and cells useful for expression of the described proteins are also provided, as are methods of use.
    Type: Application
    Filed: March 8, 2012
    Publication date: June 26, 2014
    Applicant: The Trustees of the University pf Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang
  • Patent number: 8744024
    Abstract: In a receiver circuit, a node receives a signal that carries data from a transmitter circuit. Moreover, a clock-data-recovery (CDR) circuit in the receiver circuit recovers an at-rate clock signal from the received signal. The CDR circuit recovers the clock signal without converging a first pulse-response precursor of the signal relative to a pulse-response cursor of the signal to approximately zero (e.g., with the first pulse-response precursor h(?1) converged to a non-zero value). Furthermore, the first pulse-response precursor corresponds to at least one precurosor or postcursor of the pulse-response other than the current sample.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: June 3, 2014
    Assignee: Oracle International Corporation
    Inventors: Dawei Huang, Deqiang Song, Jianghui Su, Osman Javed, Hongtao Zhang
  • Patent number: 8728479
    Abstract: Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins In addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided Vectors and cells useful for expression of the described proteins are also provided, as are methods of use.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: May 20, 2014
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang, Xiaomin Song, Ramachandran Murali, Masahide Tone
  • Publication number: 20140135298
    Abstract: This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, particularly for expanding the efficacy of drugs previously developed for this purpose, and for methods of treatments using the compounds for this purpose.
    Type: Application
    Filed: March 16, 2012
    Publication date: May 15, 2014
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Alan Berezov, Mark I. Greene, Natalie Minkovsky, Zheng Cai, Hongtao Zhang
  • Patent number: 8546439
    Abstract: Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 1, 2013
    Assignee: New York Blood Center, Inc.
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli
  • Publication number: 20130190405
    Abstract: This application describes pharmaceutical compositions, kits, and methods for inhibiting cell proliferative disorders, especially those disorders characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, including Her2 related cancers, and methods for imaging an Her-2 expressing tumor.
    Type: Application
    Filed: May 26, 2011
    Publication date: July 25, 2013
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang
  • Publication number: 20130137774
    Abstract: This application describes pharmaceutical compositions, commercial packages, and methods for inhibiting cell proliferative disorders, especially those disorders, including Her2 related cancers, characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, and methods for imaging an HER-2 expressing tumor.
    Type: Application
    Filed: May 26, 2011
    Publication date: May 30, 2013
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang
  • Patent number: 8445644
    Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: May 21, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang, Mark Richter, Alan Berezov, Qingdu Liu, Jinqiu Chen
  • Publication number: 20130077723
    Abstract: In a receiver circuit, a node receives a signal that carries data from a transmitter circuit. Moreover, a clock-data-recovery (CDR) circuit in the receiver circuit recovers an at-rate clock signal from the received signal. The CDR circuit recovers the clock signal without converging a first pulse-response precursor of the signal relative to a pulse-response cursor of the signal to approximately zero (e.g., with the first pulse-response precursor h(?1) converged to a non-zero value). Furthermore, the first pulse-response precursor corresponds to at least one precurosor or postcursor of the pulse-response other than the current sample.
    Type: Application
    Filed: September 26, 2011
    Publication date: March 28, 2013
    Applicant: ORACLE INTERNATIONAL CORPORATION
    Inventors: Dawei Huang, Deqiang Song, Jianghui Su, Osman Javed, Hongtao Zhang
  • Publication number: 20130059776
    Abstract: Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.
    Type: Application
    Filed: October 31, 2012
    Publication date: March 7, 2013
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli
  • Publication number: 20130052194
    Abstract: Disclosed herein are antibodies that detect a lipid-like antigen on prostate cancer cells and methods of detecting and treating prostate cancer using the same.
    Type: Application
    Filed: December 16, 2010
    Publication date: February 28, 2013
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Mark I. Greene, Hongtao Zhang, Geng Zhang
  • Publication number: 20130004458
    Abstract: Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 3, 2013
    Applicant: NEW YORK BLOOD CENTER, INC.
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli