Patents by Inventor Hongtao Zhang

Hongtao Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8324153
    Abstract: Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: December 4, 2012
    Assignee: New York Blood Center, Inc.
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli
  • Patent number: 8299093
    Abstract: Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: October 30, 2012
    Assignee: New York Blood Center, Inc.
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli
  • Publication number: 20120165249
    Abstract: Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus.
    Type: Application
    Filed: February 2, 2012
    Publication date: June 28, 2012
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Qian Zhao
  • Publication number: 20120164066
    Abstract: Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins In addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided Vectors and cells useful for expression of the described proteins are also provided, as are methods of use.
    Type: Application
    Filed: March 31, 2010
    Publication date: June 28, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang, Xiaomin Song, Ramachandran Murali, Masahide Tone
  • Patent number: 8168379
    Abstract: The present invention discloses using SPR technology to simultaneously and qualitatively detect different HPV genotypes. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HPV specific DNA probes used for the detection of different HPV genotypes.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: May 1, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Huawei Yang, Hongtao Zhang, Yuye Yang, Yuyang Hu, Sheng Wang, Qingmei Ma
  • Patent number: 8057799
    Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: November 15, 2011
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang, Mark Richter, Alan Berezov, Qingdu Liu, Jinqiu Chen
  • Publication number: 20110257024
    Abstract: The present invention discloses using SPR technology to simultaneously and qualitatively detect different HPV genotypes. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HPV specific DNA probes used for the detection of different HPV genotypes.
    Type: Application
    Filed: October 4, 2007
    Publication date: October 20, 2011
    Inventors: Zhong Chen, Ning Liu, Huawei Yang, Hongtao Zhang, Yuye Yang, Yuyang Hu, Sheng Wang, Qingmei Ma
  • Patent number: 7936788
    Abstract: A method for signal transporting in an optical transport network comprises: presetting frame structures for an optical channel payload unit OPUx and an optical channel data unit ODUx of a 5G-path transporting constant-bit-rate CBR5G rate-level signals in an optical channel layer; and according to the frame structures of the optical channel payload unit OPUx and the optical channel data unit ODUx, mapping and multiplexing the constant-bit-rate CBR5G rate-level signals to the optical channel layer of the optical transport network for transport through the optical transport network. The present invention also discloses a corresponding device for signal transporting. Since there are provided OPUx/ODUx/OTUx for transporting CBR5G rate-level signals in the OTN, thus enabling transparent transport of the CBRG5 signals in the OTN as well as direct scheduling, supervision and management on the CBR5G signals in the OTN.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: May 3, 2011
    Assignee: Huawei Technologies Co., Ltd.
    Inventor: Hongtao Zhang
  • Patent number: 7906624
    Abstract: A multimeric peptidomimetic that comprises two or more monomers is disclosed. The monomers comprise an exocyclic peptide comprising a ring structure, a flexible linker sequence and a multimeric motif. Use of the monomers, a nucleic acid molecule encoding monomers, recombinant expression vectors comprising the nucleic acid molecule and host cells comprising a recombinant expression vector are disclosed. Methods of delivering a drug, a toxin, a nucleic acid molecule, a radionuclide or a detectable compound to a cell are disclosed.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: March 15, 2011
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang
  • Patent number: 7842456
    Abstract: Methods for detecting and/or quantifying molecules expressing a selected epitope in a sample are disclosed. Methods for profiling proteins in a cell lysate are also disclosed. Kits for detecting and/or quantifying molecules expressing a selected epitope in a sample and kits for profiling proteins in a cell lysate are also disclosed.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: November 30, 2010
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang, Xin Cheng
  • Publication number: 20100239587
    Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Application
    Filed: May 26, 2010
    Publication date: September 23, 2010
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang, Mark Richter, Alan Berezov, Qingdu Liu, Jinqiu Chen
  • Patent number: 7781566
    Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: August 24, 2010
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang, Mark Richter, Alan Berezov, Qingdu Liu, Jinqiu Chen
  • Publication number: 20100189649
    Abstract: Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Application
    Filed: January 4, 2010
    Publication date: July 29, 2010
    Applicant: TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Mark I. Greene, Hongtao Zhang, Mark Richter, Ramachandran Murali
  • Publication number: 20100130430
    Abstract: Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus in a cell. Also provided are methods of treating a mammal infected with a capsid-containing virus. Further provided are methods of treating a mammal at risk for infection with a capsid-containing virus. Methods of making the above peptides are additionally provided, as are uses of the above peptides and pharmaceutical compositions.
    Type: Application
    Filed: October 2, 2007
    Publication date: May 27, 2010
    Applicant: New York Blood Center, Inc
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Qian Zhao
  • Publication number: 20100120688
    Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Application
    Filed: November 25, 2009
    Publication date: May 13, 2010
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang, Mark Richter, Alan Berezov, Qingdu Liu, Jinqiu Chen
  • Publication number: 20100076174
    Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Application
    Filed: November 25, 2009
    Publication date: March 25, 2010
    Inventors: Mark I. Greene, Ramachandran Murali, Hongtao Zhang, Mark Richter, Alan Berezov, Qingdu Liu, Jinqiu Chen
  • Publication number: 20100061984
    Abstract: Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed.
    Type: Application
    Filed: January 22, 2007
    Publication date: March 11, 2010
    Applicants: The Trustees of the University of Pennsylvania, The Children's Hospital of Philadelphia
    Inventors: Mark L. Greene, Sandra W. Saouaf, Bin Li, Hongtao Zhang, Wayne Hancock
  • Patent number: 7662374
    Abstract: Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: February 16, 2010
    Assignee: The Trustees of The University of Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang, Mark Richter, Ramachandran Murali
  • Publication number: 20100035912
    Abstract: Chemical compounds that disrupt retroviral assembly and maturation are presented herein. More particularly, this disclosure provides small molecule compounds that disrupt the formation and maturation of virus particles and methods of using such small molecules to treat HIV-1 infection.
    Type: Application
    Filed: August 6, 2009
    Publication date: February 11, 2010
    Inventors: Asim Kumar Debnath, Hongtao Zhang, Francesca Curreli
  • Publication number: 20100015619
    Abstract: This invention relates to assays used to detect and confirm genomic aberrations, such as chromosomes 13, 18, 21, X and Y aneuploidy as well as 22q11.2 deletions, for prenatal diagnosis. For the detection, combined STR markers (all tetra-nucleotide repeats) are employed to cover different chromosome regions. For the confirmation step, individual chromosome specific STR markers (tetra-nucleotide repeats) are utilized. This invention particularly relates to multiplex analysis for the presence or absence of STR markers in genomic DNA isolated from peripheral blood, amniotic fluid, cultured amniocytes, chorionic villi, or fetal cells existing in maternal blood. This invention offers an efficient approach to identify chromosomal abnormalities by using STR markers.
    Type: Application
    Filed: September 21, 2007
    Publication date: January 21, 2010
    Applicant: CYTOTREND (BEIJING) BIOTECH ENGINEERING CO., LTD.
    Inventors: Hongtao Zhang, Ning Liu, Zhong Chen