Patents by Inventor Hongyu Zhao

Hongyu Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of c-Jun N-terminal kinases
    Publication number: 20060173050
    Abstract: The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
    Type: Application
    Filed: January 23, 2006
    Publication date: August 3, 2006
    Inventors: Gang Liu, Hing Sham, Bruce Szczepankiewicz, Zhili Xin, Hongyu Zhao, Michael Serby, Bo Liu, Mei Liu
  • Isoxazole carboxamide derivatives as ghrelin receptor modulators
    Publication number: 20060089398
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
    Type: Application
    Filed: March 10, 2004
    Publication date: April 27, 2006
    Inventors: Gang Liu, Hongyu Zhao, Michael Serby, Bo Liu, Zhili Xin, Lissa Nelson, Bruce Szczepankiewicz, Hing Sham
  • Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists
    Publication number: 20050171132
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity and disorders associated with obesity such as non-insulin dependent diabetes mellitus.
    Type: Application
    Filed: September 23, 2004
    Publication date: August 4, 2005
    Inventors: Zhili Xin, Bo Liu, Gang Liu, Mei Liu, Michael Serby, Hongyu Zhao
  • Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists
    Publication number: 20050171131
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity, and disorders associated with obesity such as noninsulin dependent diabetes mellitus.
    Type: Application
    Filed: September 23, 2004
    Publication date: August 4, 2005
    Inventors: Christi Kosogof, Bo Liu, Gang Liu, Mei Liu, Lissa Nelson, Michael Serby, Hing Sham, Bruce Szczepankiewicz, Zhili Xin, Hongyu Zhao
  • Pyrimidine derivatives as ghrelin receptor modulators
    Publication number: 20050070712
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
    Type: Application
    Filed: September 26, 2003
    Publication date: March 31, 2005
    Inventors: Christi Kosogof, Bo Liu, Gang Liu, Mei Liu, Lissa Nelson, Michael Serby, Hing Sham, Bruce Szczepankiewicz, Zhili Xin, Hongyu Zhao
  • Classification of disease states using mass spectrometry data
    Publication number: 20050048547
    Abstract: A method for identification of biological characteristics is achieved by collecting a data set relating to individuals having known biological characteristics and analyzing the data set to identify biomarkers potentially relating to selected biological state classes. A system for identification of biological characteristics is also provided. A methodology is also provided for utilizing mass spectroscopy data to identify peptide and protein biomarkers that can be used to optimally discriminate experimental from control samples—where the experimental samples may, for instance, be derived from patients with various diseases such as ovarian cancer.
    Type: Application
    Filed: July 19, 2004
    Publication date: March 3, 2005
    Inventors: Hongyu Zhao, Kenneth Williams, Baolin Wu, Kathryn Stone, Walter McMurray, Thomas Abbott
  • Thienopyridones as AMPK activators for the treatment of diabetes and obesity
    Publication number: 20050038068
    Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
    Type: Application
    Filed: May 17, 2004
    Publication date: February 17, 2005
    Inventors: Rajesh Iyengar, Andrew Judd, Gang Zhao, Philip Kym, Hing Sham, Yugui Gu, Gang Liu, Mei Liu, Hongyu Zhao, Richard Clark, Ernst Frevert, Barbara Cool, Tianyuan Zhang, Robert Keyes, Todd Hansen, Zhili Xin
  • Tetraline derivatives as ghrelin receptor modulators
    Publication number: 20050014794
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
    Type: Application
    Filed: July 16, 2004
    Publication date: January 20, 2005
    Inventors: Bo Liu, Gang Liu, Lisa Nelson, Jyoti Patel, Hing Sham, Zhili Xin, Hongyu Zhao
  • Protein-tyrosine phosphatase inhibitors and uses thereof
    Publication number: 20040214870
    Abstract: The present invention is directed to compounds of formula (I), 1
    Type: Application
    Filed: February 4, 2004
    Publication date: October 28, 2004
    Inventors: Zhili Xin, Gang Liu, Zhonghua Pei, Bruce G. Szczepankiewicz, Michael D. Serby, Hongyu Zhao
  • Protein-tyrosine phosphatase inhibitors and uses thereof
    Publication number: 20040167188
    Abstract: The present invention is directed to compounds of formula (I), 1
    Type: Application
    Filed: February 14, 2003
    Publication date: August 26, 2004
    Inventors: Zhili Xin, Gang Liu, Zhonghua Pei, Bruce G. Szczepankiewicz, Michael D. Serby, Hongyu Zhao