Patent number: 12383614
Abstract: The present disclosure relates to the field of biomedicine, and in particular, to an improved mutant of a respiratory syncytial virus (RSV) fusion (F) protein and uses thereof. The mutant can form a trimeric structure without introducing a heterologous trimerization domain. Meanwhile, through mutation designs such as releasing internal electrostatic repulsion, deleting the furin cleavage site, truncating the C-terminal domain, and introducing interchain disulfide bonds, the protein is stabilized in the pre-fusion conformation and exhibits enhanced stability. The mutant in the present disclosure is highly immunogenic when used as a vaccine or a vaccine component and can induce the production of a high level of neutralizing antibodies in the immunized animal, which can be used in the preparation of a vaccine for the prevention or treatment of RSV infection, and can also be used as a reagent for the detection of RSV.
Type:
Grant
Filed:
January 10, 2025
Date of Patent:
August 12, 2025
Assignee:
YIKANG BIOTECH (SUZHOU) CO., LTD.
Inventors:
Lei Chen, Yujiao Song, Min Dai, Xin Xie, Shibi Zhao, Jiahao Xu, Yujuan Hua, Chao Wu, Sufang Gu, Tao Fang, Li Chen, Jiadi Huang, Xiaoya Ding, Mingze Shi, Peizhe Li, Jiaxin Lei, Guangsha Zhang, Meng Zhang, Wendie Wang, Ruihong Jiang, Songming He, Derong Wang, Tengsen Gao, Eric Chen, Jianguo Yin
Publication number: 20250254848
Abstract: An electronic device comprises a heat source and a heat distribution structure coupled to the heat source to distribute heat generated by the heat source during operation of the electronic device.
Type:
Application
Filed:
April 21, 2025
Publication date:
August 7, 2025
Inventors:
Ritu BAWA, Ruander CARDENAS, Kathiravan D, Jia Yan GO, Chin Kung GOH, Jeff KU, Prakash Kurma RAJU, Baomin LIU, Twan Sing LOO, Mikko MAKINEN, Columbia MISHRA, Juha PAAVOLA, Prasanna PICHUMANI, Daniel RAGLAND, Kannan RAJA, Khai Ern SEE, Javed SHAIKH, Gokul SUBRAMANIAM, George Baoci SUN, Xiyong TIAN, Hua YANG, Mark CARBONE, Vivek PARANJAPE, Nehakausar PINJARI, Hari Shanker THAKUR, Christopher MOORE, Gustavo FRICKE, Justin HUTTULA, Gavin SUNG, Sammi WY LIU, Arnab SEN, Chun-Ting LIU, Jason Y. JIANG, Gerry JUAN, Shih Wei NIEN, Lance LIN, Evan KUKLINSKI