Abstract: In accordance with the invention, a mode-locked laser comprises an optical gain medium disposed within an optical cavity formed by a first reflector and a wavelength selective second reflector to achieve mode-locking operation. Advantageously, the wavelength reflective reflector is a two-dimensional subwavelength resonant grating. The resulting laser is compact, tunable, reliable and inexpensive. It provides high side mode suppression and high output power.

Abstract: The present invention provides novel JNK activating phosphatase polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing JNK activating phosphatase polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with JNK activating phosphatase polypeptides.

Abstract: The present invention provides methods for treating a flavivirus infection, including hepatitis C virus (HCV) infection, in an individual suffering from a flavivirus infection. In some embodiments, the methods involve administering to an individual in need thereof an effective amount of an agent that inhibits enzymatic activity of a membrane-bound ?-glucosidase inhibitor. In other embodiments, the methods involve administering to an individual in need thereof effective amounts of an ?-glucosidase inhibitor and at least one additional therapeutic agent.

Abstract: In accordance with the invention, a tunable subwavelength resonant grating filter comprises a liquid crystal cell having a pair of major surface walls. One wall of the cell is a coated subwavelength grating of a SRGF. The coating comprises a polymer layer to fill the grating trenches and a surfactant layer to facilitate uniform alignment of the liquid crystal material. The refractive index of the LCD material in the cell can then be electrically or thermally adjusted to tune the resonant wavelength.

Abstract: The present invention provides compositions, including pharmaceutical compositions, comprising IFN-? and IFN-?. The present invention further provides methods of treating various disorders, the methods comprising administering an effective amount of a subject composition.

Abstract: In accordance with the invention, a tunable subwavelength resonant grating filter comprises a liquid crystal cell having a pair of major surface walls. One wall of the cell is a coated subwavelength grating of a SRGF. The coating comprises a polymer layer to fill the grating trenches and a surfactant layer to facilitate uniform alignment of the liquid crystal material. The refractive index of the LCD material in the cell can then be electrically or thermally adjusted to tune the resonant wavelength.

Abstract: Apparatus for double-sided imprint lithography of an apertured substrate comprises a pair of correspondingly apertured molds, a support for an assembly of the substrate and molds, and an alignment mechanism with radially movable elements for aligning the apertures of the molds and the substrate. The movable elements can be at least partially disposed in a spindle and can be removed radially outward by a conically tapered drive rod. Opposing surfaces of the substrate can then be imprinted in registration at the same time, preferably by fluid pressure imprint lithography.

Abstract: Improved apparatus for imprint lithography involves using direct fluid pressure to press a mold into a substrate-supported film. Advantageously the mold and/or substrate are sufficiently flexible to provide wide area contact under the fluid pressure. Fluid pressing can be accomplished by sealing the mold against the film and disposing the resulting assembly in a pressurized chamber. The result of this fluid pressing is enhanced resolution and high uniformity over an enlarged area.

Abstract: The present invention provides novel JNK activating phosphatase polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing JNK activating phosphatase polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with JNK activating phosphatase polypeptides.

Abstract: Compositions comprising a novel protease capable of cleaving ?-amyloid precursor protein (APP) on the amino-terminal side of the ?-amyloid peptide therein are provided. The protease is designated ?-secretase. Reaction systems comprising ?-secretase may be used in screening assays to monitor ?-secretase modulated cleavage of APP and to identify ?-secretase inhibitors, wherein the ?-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of ?-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.

Abstract: The present invention provides novel JNK activating phosphatase polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing JNK activating phosphatase polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with JNK activating phosphatase polypeptides.

Abstract: Improved apparatus for imprint lithography involves using direct fluid pressure to press a mold into a substrate-supported film. Advantageously the mold and/or substrate are sufficiently flexible to provide wide area contact under the fluid pressure. Fluid pressing can be accomplished by sealing the mold against the film and disposing the resulting assembly in a pressurized chamber. The result of this fluid pressing is enhanced resolution and high uniformity over an enlarged area.

Abstract: In accordance with the invention, a SRG filter is fabricated by disposing a moldable layer on the unpatterned grating layer, pressing a patterned molding surface into the moldable layer to produce an appropriate pattern of reduced thickness regions, removing material from the reduced thickness regions to expose the grating layer and processing the exposed grating layer to form a grating array. In a preferred embodiment the grating layer is adjacent a planar waveguiding layer overlying a substrate and the moldable material is a polymer resist. The waveguide layer advantageously has a refractive index greater than both the grating layer and the underlying substrate. And the pattern can be a one or two-dimensional array of grating elements.

Abstract: In accordance with the invention, a mode-locked laser comprises an optical gain medium disposed within an optical cavity formed by a first reflector and a wavelength selective second reflector to achieve mode-locking operation. Advantageously, the wavelength reflective reflector is a two-dimensional subwavelength resonant grating. The resulting laser is compact, tunable, reliable and inexpensive. It provides high side mode suppression and high output power.

Abstract: A system and method for the prevention of electrostatic discharge (ESD) by a hard drive magnetic head is disclosed. The magnetic head is secured to a head-gimbal assembly (HGA) by anisotropic conductive paste (ACP) to provide an improved electrostatic discharge path.

Abstract: Compositions comprising a novel protease capable of cleaving &bgr;-amyloid precursor protein (APP) on the amino-terminal side of the &bgr;-amyloid peptide therein are provided. The protease is designated &bgr;-secretase. Reaction systems comprising &bgr;-secretase may be used in screening assays to monitor &bgr;-secretase modulated cleavage of APP and to identify &bgr;-secretase inhibitors, wherein the &bgr;-secretase is in the presence of a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance. Antibodies are raised against peptides of &bgr;-secretase. Pharmaceutical compositions and methods comprise compounds identified by screening assays.

Abstract: Cubic boron nitride (C--BN) powders admixed with silicon carbide whisker (SCW) or silicon nitride whisker (SKW) may be shock-compacted to pressures of about 17 to 24 GPa. Good consolidation is achieved with 4 to 8 .mu.m particle size C--BN powder admixed with about 15 wt % SNW or about 20 to 25 wt % SCW. The mixture (26) is placed in a ring (24) mounted on a capsule (22) and is shock-compacted with a flyer (10) accelerated by a propellant gun. A sapphire plate (28) prevents penetration of metal particles into the sample during shock processing. Scanning electron microscopy (SEM) analysis demonstrate that SCW and SNW in the mixtures is highly deformed and indicates melt textures. Micro Vickers hardness values as high as 50 GPa have been obtained for consolidated C--BN and SNW mixtures. This compares to 21 GPa for single crystal Al.sub.2 O.sub.3 and 120 GPa for diamond.