Patents by Inventor Hua Zhang

Hua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR T CELL ENGINEERING
    Publication number: 20230113157
    Abstract: The present disclosure relates to an engineered immune cell and use thereof. The present disclosure provides an engineered immune cell comprising a CAR or engineered TCR, which CAR or engineered TCR can comprise a first antigen binding domain and a second antigen binding domain. The engineered immune cells of the present disclosure, when administered into a subject, can inhibit the host immune cells such as T cells and/or NK cells and enhance the survival and persistence of the engineered immune cells in vivo, thereby exhibiting more effective tumor killing activity.
    Type: Application
    Filed: September 27, 2020
    Publication date: April 13, 2023
    Inventors: Jianning GE, Chunhui YANG, Xinxin WANG, Hua ZHANG, Lianjun SHEN
  • THE COMBINATION OF CYCLIN DEPENDENT KINASE 7 INHIBITOR AND IMMUNOTHERAPY FOR TREATMENT OF CANCER
    Publication number: 20230114207
    Abstract: The present disclosure provides methods and compositions related to combination therapy of a CDK7 inhibitor and immunotherapy. The combination of the CDK7 inhibitor and immunotherapy is useful in treating and/or preventing cancer in a subject. The combination therapy may further comprise chemotherapy (e.g., chemotherapeutic agents).
    Type: Application
    Filed: December 16, 2020
    Publication date: April 13, 2023
    Applicants: Dana-Farber Cancer Institute, Inc., New York University
    Inventors: Nathanael S. Gray, Kwok-kin Wong, Hua Zhang, Camilla Laulund Christensen Ross
  • High temperature resistant Portland cement slurry and production method thereof
    Patent number: 11618844
    Abstract: The invention provides a high temperature resistant Portland cement slurry and a production method thereof. The high temperature resistant Portland cement slurry comprises the following components by weight: 100 parts of an oil well Portland cement, 60-85 parts of a high temperature reinforcing material, 68-80 parts of fresh water, 1-200 parts of a density adjuster, 0.1-1.5 parts of a suspension stabilizer, 0.8-1.5 parts of a dispersant, 3-4 parts of a fluid loss agent, 0-3 parts of a retarder and 0.2-0.8 part of a defoamer. The high temperature resistant Portland cement slurry has a good sedimentation stability at normal temperature, and develops strength rapidly at a low temperature. The compressive strength is up to 40 MPa or more at a high temperature of 350° C., and the long-term high-temperature compressive strength develops stably without degradation.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: April 4, 2023
    Assignees: CHINA NATIONAL PETROLEUM CORPORATION, CNPC ENGINEERING TECHNOLOGY R&D COMPANY LIMITED
    Inventors: Hua Zhang, Jianzhou Jin, Shuoqiong Liu, Fengzhong Qi, Yongjin Yu, Ming Xu, Jinping Yuan, Zhiwei Ding, Chongfeng Zhou, Chi Zhang, Zishuai Liu, Yusi Feng, Yuchao Guo
  • Ejector unit for detaching an electronic element from an adhesive carrier
    Patent number: 11618172
    Abstract: An ejector unit for detaching an electronic element from an adhesive carrier has an ejector housing with a supporting deck, a light source disposed therein and an ejector lens. The ejector lens has a protruding face. The ejector lens is disposed and oriented with an optical axis extending between the light source and an opening in the supporting deck, and the protruding face of the lens directed towards the opening. The ejector lens is movable relative to the supporting deck along the optical axis to project the protruding face through the opening against the electronic element for lifting the electronic element.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: April 4, 2023
    Assignee: ASMPT SINGAPORE PTE. LTD.
    Inventors: Chi Keung Leung, Hua Zhang, Qing Long Zhang
  • THERAPEUTIC TARGETING OF KMT2D MUTANT LUNG SQUAMOUS CELL CARCINOMA THROUGH RTK-RAS SIGNALING INHIBITION
    Publication number: 20230102398
    Abstract: Provided is a method for treatment of lung squamous cell carcinoma (LUSC) by administering to an individual in need of treatment one or more inhibitors of the RTK-Ras signaling pathway. The LUSC cells may carry a mutation in a KMT2D gene. The inhibitors of the RTK-Ras signaling pathway are SHP2 inhibitors or epidermal growth factor receptor (EGFR) inhibitors. Combinations of the SHP2 inhibitors and EGFR inhibitors can be used.
    Type: Application
    Filed: September 27, 2022
    Publication date: March 30, 2023
    Inventors: Kwok-Kin Wong, Yuanwang Pan, Han Han, Hua Zhang
  • MICROFLUIDICS-BASED NANOPARTICLE SYNTHESIS SYSTEM, AND DEVICE AND METHOD USING SAME
    Publication number: 20230080771
    Abstract: A microfluidics-based nanoparticle synthesis system, a device and a synthesis method thereof are provided. The nanoparticle synthesis system comprises: a microfluidic chip; a reagent bottle which is connected with the microfluidic chip; and a flow control assembly comprising a pressure controller which is used for controlling the pressure in the reagent bottle. The system achieves high-accuracy flow control, and a microfluidic chip that can achieve high-efficiency and rapid mixing is also used in combination to finally achieve high-throughput and high-uniformity nanoparticle synthesis. A user may adjust the same instrument as required to achieve different throughputs without redesigning the instrument.
    Type: Application
    Filed: September 9, 2022
    Publication date: March 16, 2023
    Applicants: Suzhou Precigenome Ltd, Co.
    Inventors: Yaqi WANG, Yiqiu XIA, Yunfeng LING, Chen LI, Zihao DAI, Hua ZHANG, Xuemei LI
  • ANAEROBIC IMMOBILIZED BACTERIAL AGENT, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF
    Publication number: 20230063738
    Abstract: Provided are an anaerobic immobilized bacterial agent, a preparation method for same, and applications thereof. The preparation method for the bacterial agent is: selecting four different anaerobic functional bacterial strains, utilizing a pure bacteria culturing technique to produce corresponding culture broths, then mixing the four culture broths according to a certain volume ratio to acquire a compound functional broth, subsequently concentrating into a functional flora precipitation, then dissolving the functional flora precipitation into a polyvinyl alcohol aqueous solution, dripping the solution into a first buffer solution to produce polyvinyl alcohol gel beads, and placing the gel beads produced into a second sulfate-containing buffer solution to produce sulfate-modified polyvinyl alcohol gel beads, that is, the anaerobic immobilized bacterial agent.
    Type: Application
    Filed: April 15, 2021
    Publication date: March 2, 2023
    Inventors: PINJING HE, HAOWEN DUAN, FAN LYU, HUA ZHANG, LIMING SHAO
  • Antimicrobial, non-thrombogenic polymer composition
    Patent number: 11578205
    Abstract: The disclosed technology provides thermoplastic polyurethane compositions having antimicrobial properties while still maintaining good physical properties and good non-fouling properties, methods of making the same, and articles, including medical devices, made from such compositions. The disclosed technology includes a process of making an antimicrobial polymer composition, where the process includes mixing an antimicrobial additive into a base polymer and further includes mixing in a non-fouling additive, where the antimicrobial additive is chemically held in the composition and the antimicrobial and non-fouling additives do not negatively impact each other's effectiveness.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 14, 2023
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventors: Roger W. Day, Hua Zhang, Richard Woofter, Umit G. Makal, Kiara L. Smith
  • PREPARATION METHOD FOR HIGH NICKEL TERNARY PRECURSOR CAPABLE OF PREFERENTIAL GROWTH OF CRYSTAL PLANES BY ADJUSTING AND CONTROLLING ADDITION AMOUNT OF SEED CRYSTALS
    Publication number: 20230035993
    Abstract: A preparation method for a high nickel ternary precursor capable of preferential growth of crystal planes by adjusting and controlling the addition amount of seed crystals. The method comprises the following steps: 1) feeding a ternary metal solution into a reaction kettle containing a first base liquid for reaction, and when the particle size reaches 1.5 to 3.0 ?m, stopping the feeding, so as to obtain a seed crystal slurry; 2) simultaneously adding the ternary metal solution, a liquid alkali solution, and an ammonia solution in cocurrent flow into a growth kettle containing a second base solution for reaction, when the particle size reaches 6 to 8 ?m, adding the seed crystal slurry into the reaction system, and controlling the particle size to be 9.0 to 11.0 ?m by adjusting the feed rate of the seed crystal, so as to obtain the target object.
    Type: Application
    Filed: December 30, 2019
    Publication date: February 2, 2023
    Inventors: Kaihua XU, Zhenkang JIANG, Zhou TANG, Tao LI, Xiuping DU, Liang BAI, Hua ZHANG, Zhijiang WU, Shifeng JIANG
  • ELECTRICAL CONNECTOR WITH IMPROVED TERMINAL HOLES
    Publication number: 20230033842
    Abstract: An electrical connector includes: an insulative housing defining a terminal hole, the terminal hole defining two opposite narrow sides and two opposite wide sides; and a first terminal having a fixing portion fixed in the terminal hole, the fixing portion having two opposite narrow surfaces and two opposite wide surfaces, the narrow surfaces defining barbs interference fit with the narrow sides of the terminal hole, wherein the fixing portion further defines a tab protruding from one wide surface thereof, the terminal hole further defines a front groove with a blocking face and a rear groove with a guiding face, and the tab passes across the guiding face to press against the blocking face for preventing the fixing portion from moving rearward.
    Type: Application
    Filed: July 21, 2022
    Publication date: February 2, 2023
    Inventors: YAN-YAN HAN, XIAO-BO DU, GUO-HUA ZHANG, ZI-QIANG ZHU
  • Information Acquiring Method, Apparatus, and System
    Publication number: 20230015624
    Abstract: Various embodiments include a method for deploying field device into an Internet of Things (IoT). The method may include: acquiring information from a field device using an edge device; transmitting the acquired information to a cloud platform; wherein the information comprises data and an industrial IoT model; converting the industrial IoT model into a graph; performing similarity analysis based on the graph; classifying the industrial IoT model based on the similarity analysis; generating a first industrial IoT model comprising a type or an example; performing data mapping on the first industrial IoT model; and operating the field device as part of the IoT.
    Type: Application
    Filed: December 9, 2019
    Publication date: January 19, 2023
    Applicant: Siemens Aktiengesellschaft
    Inventors: Qi Wang, He Yu, Jun Jie Chen, Wen Jing Zhou, Yue Hua Zhang, Teng Fei Wu, Yang Wang
  • METHOD AND DEVICE FOR DOWNLINK SIGNAL TRANSMISSION IN DUAL-CONNECTION ARCHITECTURE, AND TERMINAL
    Publication number: 20230006705
    Abstract: A method and device for downlink signal transmission in a dual-connection architecture, and a terminal. The method comprises: when a first signal receiver and a second signal transmitter both operate, after a second uplink signal and a higher harmonic signal of a first uplink signal enter a first downlink and before entering the first signal receiver, using a notch filter arranged on the first downlink to filter out a signal located in a preset frequency band in the second uplink signal.
    Type: Application
    Filed: January 6, 2020
    Publication date: January 5, 2023
    Applicant: HUIZHOU TCL MOBILE COMMUNICATION CO., LTD.
    Inventors: Hua Zhang, Dingning Wen, Yu Jia, Longxi Tao, Yanyun Zen
  • Micro puree machine
    Patent number: 11540669
    Abstract: The present invention relates to a micro puree machine that includes a blade assembly, a lid assembly, and a clip mechanism. The blade assembly has a central support hub, a blade, and an undercut. The lid assembly is configured to cooperate with a bowl assembly and includes a lid and a clip mechanism. The clip mechanism is movable between a first position and a second position and cooperates with the undercut at times the clip mechanism is the in the first position. The blade assembly is retained in the lid assembly at times the clip mechanism is in or near the first position, and the blade assembly is disengaged from the undercut and removable from the lid assembly at times the clip mechanism is in or near the second position.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: January 3, 2023
    Assignee: SHARKNINJA OPERATING LLC
    Inventors: Nicholas Michael O'Loughlin, Xu Sheng Deng, Ting Hua Zhang, Ming Li Shi, Michelle Hilary Power
  • GCGR antibody and GLP-1 fusion protein thereof, pharmaceutical composition thereof and application thereof
    Patent number: 11542336
    Abstract: Provided herein are a glucagon receptor (GCGR) antibody and its fusion protein with glucagon-like peptide-1 (GLP-1), and a pharmaceutical composition thereof. Also provided herein is a method for using the GCGR antibody and its fusion protein with GLP-1 to treat, prevent or improve one or more symptoms of hyperglycemia, type 2 diabetes, metabolic syndrome or dyslipidemia.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: January 3, 2023
    Assignee: GMAX BIOPHARM LLC
    Inventors: Cheng Zhang, Hua Zhang, Xiaofeng Wang, Chenjiang Yao, Yan Jiang, Liangliang Bi, Shuqian Jing
  • GIPR ANTIBODY AND FUSION PROTEIN BETWEEN SAME AND GLP-1, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
    Publication number: 20220411520
    Abstract: Provided herein are a gastric inhibitory polypeptide receptor (GIPR) antibody and its fusion protein with glucagon-like peptide-1 (GLP-1), and a pharmaceutical composition thereof. Also provided herein is a method for using the GIPR antibody and its fusion protein with GLP-1 to treat, prevent or improve one or more symptoms of non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, type 2 diabetes or obesity.
    Type: Application
    Filed: September 16, 2020
    Publication date: December 29, 2022
    Applicant: GMAX BIOPHARM LLC
    Inventors: Hua ZHANG, Xiaofeng WANG, Chenjiang YAO, Cheng ZHANG, Shuqian JING
  • OPTICAL MODULE
    Publication number: 20220390692
    Abstract: An optical module includes a shell, a circuit board, a display light and a light guide pipe. The circuit board is disposed in the shell. The display light is disposed on the circuit board, and is configured to emit light of different colors. The light guide pipe is disposed between the shell and the circuit board. An input end of the light guide pipe is arranged to correspond to the display light, an output end of the light guide pipe is configured to transmit light emitted by the display light to an outside of the optical module. The shell includes a groove. The output end of the light guide pipe is fixed in the groove, so that the shell is fixed with the light guide pipe.
    Type: Application
    Filed: August 16, 2022
    Publication date: December 8, 2022
    Applicant: Hisense Broadband Multimedia Technologies Co., Ltd.
    Inventors: Liu YANG, Jinlei CHEN, Qiang ZHANG, Shihai YANG, Wei CUI, Baofeng SI, Yuqing HONG, Hongchao PAN, Hua ZHANG
  • Shuffle-less Reclustering of Clustered Tables
    Publication number: 20220374455
    Abstract: A method for shuffle-less reclustering of clustered tables includes receiving a first and second group of clustered data blocks sorted by a clustering key value. A range of clustering key values of one or more the data blocks in the second group overlaps with the range of clustering key values of a data block in the first group. The method also includes generating split points for partitioning the first and second groups of clustered data blocks into a third group. The method also includes partitioning using the split points, the first and second groups into the third group. Each data block in the third group includes a range of clustering key values that do not overlap with any other data block in the third group. Each split point defines an upper limit or lower limit for the range of clustering key values a data block in the third group.
    Type: Application
    Filed: August 3, 2022
    Publication date: November 24, 2022
    Applicant: Google LLC
    Inventors: Hua Zhang, Pavan Edara, Nhan Nguyen
  • HETEROGENEOUS REAL-TIME STREAMING AND DECODING OF ULTRA-HIGH RESOLUTION VIDEO CONTENT
    Publication number: 20220368946
    Abstract: Systems, apparatuses and methods may provide for encoder technology that selects, in response to a request from a client device, a first video stream from a first plurality of video streams dedicated to a first tile in video content and selects, in response to the request, a second video stream from a second plurality of video streams dedicated to a second tile in the video content. The encoder technology may also send the selected first and second video streams to a client device. Additionally, decoder technology may allocate a first decoder device to the first video stream and allocate a second decoder device to the second video stream. In one example, the first video stream and the second video stream include one or more different codec parameter values.
    Type: Application
    Filed: November 7, 2019
    Publication date: November 17, 2022
    Inventors: Junyong Ding, Mohammad Haghighat, Lei Zhai, Gang Shen, Jianhui Dai, Hua Zhang, Yanying Sun
  • Medical sample test device
    Patent number: D983402
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: April 11, 2023
    Assignees: ZHEJIANG ORIENT GENE BIOTECH CO., LTD, HEALGEN SCIENTIFIC LIMITED
    Inventors: Jianqiu Fang, Siyu Lei, Hua Zhang
  • Medical sample test device
    Patent number: D983403
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: April 11, 2023
    Assignees: ZHEJIANG ORIENT GENE BIOTECH CO., LTD, HEALGEN SCIENTIFIC LIMITED
    Inventors: Jianqiu Fang, Siyu Lei, Hua Zhang