Abstract: Disclosed herein are methods of detecting sepsis in a patient in need thereof, the method comprising: receiving a patient sample, a pathogenic primer mix, a fluorophore label probe, and a dPCR buffer in one or more wells of a microfluidic device and detecting fluorescent light signal from the droplets to determine sepsis in the patient. The microfluidic device comprises a droplet generation channel in fluid communication with the one or more wells, adapted to generate droplets comprising the patient sample, one or more pathogenic primers, a fluorophore label probe, and dPCR buffer. Furthermore, the microfluidic device comprises a chamber in fluid communication with the droplet generation channel for collecting the droplets generated by the droplet generation channel and performing a PCR reaction in the droplets.

Abstract: Provided herein are a stable solution formulation of an ETAR antibody, and use thereof in treating, preventing, or alleviating one or more symptoms of pulmonary arterial hypertension or one or more symptoms of cancer of a reproductive organ.

Abstract: An aspect of the disclosure relates to a dialysate regenerator for connecting to a dialysis apparatus, the dialysate regenerator including a regenerator inlet for receiving dialysate; a regenerator outlet for dispensing regenerated dialysate; a hydraulic circuit connected between the regenerator inlet and the regenerator outlet, and further including a fluid portioning system to divide a dialysate flow into uniform portions for sequential regeneration An aspect of the disclosure relates to a dialysis system including a dialysis apparatus including: a fresh dialysate input; a spent dialysate output; and the dialysate regenerator, wherein the regenerator inlet may be coupled to the spent dialysate output for receiving spent dialysate, and wherein the regenerator outlet may be coupled to the fresh dialysate input for dispensing regenerated dialysate.

Abstract: A general and controlled method for synthesizing amorphous Pd-based nanoparticles is provided. The provided method comprises: dissolving a Pd precursor in a first solvent to form a first solution; mixing the first solution with a second solvent to form a first mixture; adding surfactant into the first mixture to form a second mixture; heating the second mixture to render a second solution; adding other metal precursor into the second solution to form a third mixture; heating the third mixture to render a third solution; naturally cooling down the third solution; adding ethanol to the third solution to form a fourth solution; and collecting the amorphous Pd-based nanoparticles from the fourth solution.

Abstract: Various embodiments of the teachings herein include a method for generating a virtual Internet-of-things device on the basis of an Internet-of-things model. The method may include: obtaining a first number of Internet-of-things models for an Internet-of-things solution; subjecting a variable in the first number of Internet-of-things models to variable attribute expansion to add an extended variable attribute to the variable, wherein the variable subjected to variable attribute expansion is capable of data simulation; configuring variable link relations and variable link processing rules for the extended Internet-of-things models to obtain an Internet-of-things model configuration file; and obtaining a second number of virtual Internet-of-things devices on the basis of a virtual physical network device architecture by using the Internet-of-things model configuration file.

Abstract: The present disclosure provides a winding device for producing a fiber composite loop chain and a winding method, and belongs to the field of production equipment. The problem that an existing composite loop chain forming technology has tension defects is solved. The winding device includes a main shaft assembly, a clamp pushing-in mechanism, travel switch assemblies, a mold pushing mechanism, a clamp pulling-out mechanism, a positioning and clamping mechanism and a tension control mechanism which are fixedly connected to a rack. The main shaft assembly includes a driving mechanism, a bearing pedestal, a rotating main shaft, clamp sliding shafts and a supporting block. The driving mechanism is connected with one end of the rotating main shaft, and the other end of the rotating main shaft is connected with the supporting block. The rotating main shaft is connected with the bearing pedestal through a bearing, and the bearing pedestal is fixed to the rack. Two clamp sliding shafts are provided.

Abstract: Provided herein are a gastric inhibitory polypeptide receptor (GIPR) antibody and its fusion protein with glucagon-like peptide-1 (GLP-1), and a pharmaceutical composition thereof. Also provided herein is a method for using the GIPR antibody and its fusion protein with GLP-1 to treat, prevent or improve one or more symptoms of non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, type 2 diabetes or obesity.

Abstract: The present invention provides a device for detecting an analyte in a sample, including a chamber for receiving a testing element, where the testing element has a first position and a second position in the chamber; the testing element is not in contact with a fluid sample when the testing element is located in the first position, and the testing element is in contact with a fluid sample when the testing element is located in the second position.

Abstract: A method can include receiving pressure data with respect to time acquired via a pressure sensor disposed in an uphole region of a bore of a well, where a plug is disposed in the bore to define the uphole region to one side of the plug and a corresponding downhole region to the other side of the plug; using at least physical properties of liquid in the uphole region and thermal information, computing a temperature and gravitational head induced density variation of the liquid in the uphole region; and, based at least in part on at least a portion of the pressure data and the temperature and gravitational head induced density variation of the liquid, determining a state of the plug and the bore from a plurality of states.

Abstract: A power switch circuit includes a switch circuit, a solar photovoltaic panel and a detection circuit and connected with the solar photovoltaic panel and the switch circuit respectively. The solar photovoltaic panel is configured to provide an electrical signal to the detection circuit, the detection circuit is configured to detect whether the power in the electric signal exceeds a preset threshold, and when the power exceeds the preset threshold, the detection circuit outputs a first control signal to the switch circuit to turn on the switch circuit; when the switch circuit is turned on, the solar photovoltaic panel supplies power to the load through the switch circuit, and the switch circuit feeds back a second control signal to the detection circuit so that the detection circuit stops working.

Abstract: A method can include receiving pressure data with respect to time acquired via a pressure sensor disposed in an uphole region of a bore of a well, where a plug is disposed in the bore to define the uphole region to one side of the plug and a corresponding downhole region to the other side of the plug; using physical properties of liquid in the uphole region and thermal information, computing a temperature induced density variation of the liquid in the uphole region; and, based at least in part on at least a portion of the pressure data and the temperature induced density variation of the liquid, determining a state of the plug and the bore from a plurality of states.

Abstract: The embodiment of the present invention discloses an anti-drowning safety alarm method and device for swimming pools. Acquiring images taken by multiple cameras; inputting the images into a target detection model to detect human bodies and heads, so as to obtain human body target detection boxes and human head target detection boxes; calculating the relationship between the human heads and the human bodies according to these boxes; performing multi-camera fusion on the human body target detection boxes and the human head target detection boxes to obtain the human body boxes and head boxes; determining the relative position relationship between the human bodies or the human heads and the water surface; calculating the correlation between the bounding box sequence at the current moment and that at the previous moment to obtain the human tracking trajectory; updating the state database; generating alarm information according to the state database.

Abstract: A high-strength Portland cement slurry for ultra-high-temperature cementing, a preparation method therefor and an application thereof. In parts by weight, the composition of the cement slurry comprises: 100 parts of Portland cement, 4-6 parts of a high temperature anti-cracking material, 80-105 parts of a high-temperature reinforcing material, 70-78 parts of water, 0.5-1.5 parts of a dispersant, 1-3 parts of a fluid loss reducer, 0.5-2.5 parts of a retarder and 0.2-0.5 parts of a defoamer; the high-temperature reinforcing material is a combination of acid-washed quartz sand, metakaolin and aluminum sulfate, a combination of acid-washed quartz sand, metakaolin, feldspar and sodium sulfate, or a combination of acid-washed quartz sand, metakaolin, feldspar and calcium nitrite. The cement slurry has good settling stability, rapid strength development in low temperatures, high compressive strength of cement stone at a high temperature of 600° C.

Abstract: A wellbore is plugged using a bismuth alloy. The wellbore is arranged so that a liquid bismuth alloy sets with an excess pressure of the plug relative to the borehole fluid pressure along a desired seal height distance.

Abstract: A wellbore is plugged using a bismuth alloy. In one embodiment, the bismuth alloy comprises an alloy of bismuth and tin. In another embodiment, the bismuth alloy comprises an alloy of bismuth and silver. The wellbore can be arranged so that a liquid bismuth alloy sets with an excess pressure of the plug relative to the borehole fluid pressure along a desired seal height distance. Other aspects are described and claimed.

Abstract: A wellbore is plugged using a bismuth alloy. The wellbore is arranged so that a liquid bismuth alloy sets with an excess pressure of the plug relative to the borehole fluid pressure along a desired seal height distance.

Abstract: The present disclosure relates to the technical field of energy storage devices, and particularly, to a battery module. The battery module includes a lower case, a plurality of battery cells sequentially stacked and received in the lower case, and a heat conducting plate. The lower case is connected to the heat conducting plate through an engaging assembly. In the battery module according to the present disclosure, the heat conducting plate and the lower case are connected through the engaging assembly, without performing a welding process required in the related art, thereby avoiding failures of other components caused by metal spattering.

Abstract: A single-cell screening device, a screening assembly, a screening method, and use thereof. The single-cell screening device includes a body, a plurality of spray holes, heating portions, and a flow channel. The spray holes are located in the body, the heating portions are located in the spray holes and used for heating a liquid entering the spray holes to generate bubbles so as to spray out cells. The flow channel is located in the body and extends to the spray holes according to a preset path, so as to deliver a cell suspension into the spray holes. The single-cell screening device of the present disclosure has a simple design and is easy to fabricate. Cell printing (spraying) using the screening assembly of the present disclosure has a much higher cell printing speed than conventional methods, allowing for a rapid cell sorting process.

Abstract: The present invention discloses an antibody specifically binding to a human endothelin receptor and uses thereof, where the antibody can inhibit the functions of the human endothelin receptor. The present invention includes the preparation, cloning, expression, and characterization of the antibody. The present invention can be used to effectively treat pulmonary arterial hypertension, a disease associated with pulmonary arterial hypertension, and a reproductive organ cancer in a human.

Abstract: A humanized CD 19 antibody, and a chimeric antigen receptor thereof, an immune cell thereof and the use thereof are provided. The humanized CD19 antibody is based on a FMC63 chimeric antibody, which is subjected to humanization modification. A CAR-T and a dual CAR-T cell constructed based on the humanized antibody and the related use thereof are also provided. Compared with a CAR-T cell constructed by using FMC63, the CAR-T cell constructed based on the humanized antibody has higher killing effect and tumor removal ability.