Abstract: A vibration ring includes a vibration module and a latex ring. The vibration module is provided with at least a battery, a circuit board and a vibration motor that are connected electrically in a spherical shell, along with a switch that is exposed out of the shell. The latex ring includes an annular wearing part that is processed with latex, and a spherical vibration part that encloses the shell of the vibration module. The spherical vibration part and the enclosed vibration module act onto a female's clitoris without pressing on other parts of the body, so as to increase the comfortableness in wearing the vibration ring and form a better exciting effect in vibration.

Abstract: The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the silica nanomembranes can be used for solid phase extraction of nucleic acids. The inventive silica nanomembranes are suitable for nucleic acid purification and isolation and demonstrated better performance than commercial particles in terms of DNA recovery yield and integrity. In addition, the silica nanomembranes have extremely high nucleic acid capacity due to its significantly enlarged specific surface area of silica. Methods of use and devices comprising the silica nanomembranes are also provided.

Abstract: Disclosed is an low carbon steel alloy composition, including 98.5 to 99.7 parts by weight of Fe, 0.1 to 0.3 parts by weight of C, 0.1 to 0.6 parts by weight of Si, and 0.15-0.45 parts by weight of Cr. The low carbon steel alloy composition can be sprayed by gas to form powders, which are sintered by laser additive manufacturing to form a sintered object.

Abstract: A method of bonding substrates includes steps as follows. Providing a curved glass substrate and a flexible light-transmissive film; moving a roller to press the flexible light-transmissive film onto the curved glass substrate so that the flexible light-transmissive film matches a curvature of the curved glass substrate to gradually fit and bond onto the curved glass substrate; sensing the attaching level of at least one local area of the flexible light-transmissive film bonded on the curved glass substrate; and adjusting a press force exerted by the roller to the local area of the flexible light-transmissive film according to the attaching level during the flexible light-transmissive film is bonded onto the curved glass substrate.

Abstract: A method for inhibiting mammalian TOR in a cell, comprising: providing a compound of formula (1): and incubating the cell with the compound. Also provided is a method for extending life span of a subject, comprising: providing the compound; and administering the compound to the subject. Yet also provided is a method for treating a mammalian TOR activation-caused disease in a subject, comprising: providing the compound; and administering the compound to the subject.

Abstract: A quantitative dispensing device includes amounting seat, an elastic cap, a dispensing element, a regulating member, a rotatable seat and a press button that has a positioning unit. The regulating member includes a regulating unit that has a stepped-shaped top surface having a plurality of contacting surface portions. The press button is movable between a raised position, where the positioning unit is spaced apart from a selected one of the contacting surface portions, and a pressed position, where the positioning unit abuts against the selected one of the contacting surface portions and the press button is pressed downwardly against the elastic cap.

Abstract: The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the silica nanomembranes can be used for solid phase extraction of nucleic acids. The inventive silica nanomembranes are suitable for nucleic acid purification and isolation and demonstrated better performance than commercial particles in terms of DNA recovery yield and integrity. In addition, the silica nanomembranes have extremely high nucleic acid capacity due to its significantly enlarged specific surface area of silica. Methods of use and devices comprising the silica nanomembranes are also provided.

Abstract: A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.

Abstract: A method for inhibiting mammalian TOR in a cell, comprising: providing a compound of formula (1): and incubating the cell with the compound. Also provided is a method for extending life span of a subject, comprising: providing the compound; and administering the compound to the subject. Yet also provided is a method for treating a mammalian TOR activation-caused disease in a subject, comprising: providing the compound; and administering the compound to the subject.

Abstract: A method of bonding substrates includes steps as follows. Providing a curved glass substrate and a flexible light-transmissive film; moving a roller to press the flexible light-transmissive film onto the curved glass substrate so that the flexible light-transmissive film matches a curvature of the curved glass substrate to gradually fit and bond onto the curved glass substrate; sensing the attaching level of at least one local area of the flexible light-transmissive film bonded on the curved glass substrate; and adjusting a press force exerted by the roller to the local area of the flexible light-transmissive film according to the attaching level during the flexible light-transmissive film is bonded onto the curved glass substrate.

Abstract: A quantitative dispensing device includes amounting seat, an elastic cap, a dispensing element, a regulating member, a rotatable seat and a press button that has a positioning unit. The regulating member includes a regulating unit that has a stepped-shaped top surface having a plurality of contacting surface portions. The press button is movable between a raised position, where the positioning unit is spaced apart from a selected one of the contacting surface portions, and a pressed position, where the positioning unit abuts against the selected one of the contacting surface portions and the press button is pressed downwardly against the elastic cap.

Abstract: The present invention provides a PCR-free, multiplexed ligation assay for miRNA expression analysis that produces highly quantitative, 10-100 plex miRNA profiling in a single reaction. The inventive methods use a 2-step ligation assay to generate an array of miRNA specific ligation products that can be decoded and quantified by a size discrimination method such as gel electrophoresis or single molecule separation. One embodiment is a low-cost assay that can be performed using standard tools available in nearly all molecular biology laboratories. This assay requires nothing more than a gel apparatus and reader for detection. Other embodiments include use of magnetic beads and other size exclusion apparatus which give increasingly higher sensitivity, lower sample consumption, and reduced processing steps.

Abstract: The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the silica nanomembranes can be used for solid phase extraction of nucleic acids. The inventive silica nanomembranes are suitable for nucleic acid purification and isolation and demonstrated better performance than commercial particles in terms of DNA recovery yield and integrity. In addition, the silica nanomembranes have extremely high nucleic acid capacity due to its significantly enlarged specific surface area of silica. Methods of use and devices comprising the silica nanomembranes are also provided.

Abstract: A JBOD subsystem for providing storage to a host entity. The JBOD subsystem contains at least one external JBOD emulation controller coupled to the host entity for emulating IO operations in response to the IO requests and a set of at least one physical storage device coupled to the JBOD emulation controller for providing storage to the host entity through the JBOD emulation controller. The JBOD emulation controller defines at least one logical media unit (LMU) consisting of sections of the set of physical storage device (PSD) and communicates with the PSD through a point-to-point serial-signal interconnect. As an example, the point-to-point serial-signal interconnect can be a Serial ATA IO device interconnect.

Abstract: A vibration ring includes a vibration module and a latex ring. The vibration module is provided with at least a battery, a circuit board and a vibration motor that are connected electrically in a spherical shell, along with a switch that is exposed out of the shell. The latex ring includes an annular wearing part that is processed with latex, and a spherical vibration part that encloses the shell of the vibration module. The spherical vibration part and the enclosed vibration module act onto a female's clitoris without pressing on other parts of the body, so as to increase the comfortableness in wearing the vibration ring and form a better exciting effect in vibration.

Abstract: The present invention is directed to a microfluidic system comprising a microfluidic chip and a method of performing a chemical assay wherein a sample is processed into multiple daughter droplets and said daughter droplets are incubated with varying reagents. The properties of these droplets can be detected to provide assay data.

Abstract: Provided is a sample processing cartridge. The sample processing cartridge can include a housing and a channel disposed in the housing. The housing can include a sample inlet for receiving at least one biological sample. The channel can in fluidic communication with the sample inlet and can be defined by an upper surface and a lower surface. The upper surface can include a hydrophilic portion and a hydrophobic portion. The lower surface can include a hydrophilic portion and a hydrophobic portion. The hydrophilic and hydrophobic portions of the upper and lower surfaces of the channel can be configured to isolate at least one aqueous reagent.

Abstract: A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.

Abstract: A dropper assembly includes a dropper mechanism that includes a locking connector, an adjusting cap, and a press button. The locking connector has at least one dosage guide unit with a plurality of dosage guide grooves having different depths. The press button has at least one alignment rib portion insertable into one of the dosage guide grooves. The press button is driven by the adjusting cap to rotate between a locked position, where the alignment rib portion abuts against a top end of the locking connector and is thereby limited from being pressed downward, and a pressable position, where the alignment rib portion is aligned with one of the dosage guide grooves to enable pressing movement of the press button.

Abstract: Techniques are disclosed for virtualizing internet protocol (IP) addresses in terminal server sessions. Techniques include receiving requests for a virtual IP address from a client component, determining whether the requestor can use the virtual IP address, and either returning a requested virtual IP address or returning an indication that the requestor cannot use a virtual IP address. Methods for determining whether a virtual IP address can be used and methods for choosing a virtual IP address are disclosed.