Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: This disclosure relates to compounds that are cystic fibrosis transmembrane conductance regulator (CFTR) modulators and pharmaceutical compositions containing the same. In certain embodiments, this disclosure relates to methods of managing a CFTR related disease or condition or respiratory distress comprising administering an effective amount of a CFTR modulator disclosed herein to a subject in need thereof.

Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: Formula I for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1 and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: The present invention relates to a method of diagnosis or prognosis of a non-healing or chronic wound comprising the step of determining the ratio of carnitine to ceramide and/or ceramide derivative in a sample, or the level of at least one metabolite in a sample.

Abstract: This disclosure relates to chimeric compounds and methods for managing neurological conditions. In certain embodiments, the compound comprises a chemical structure of a monoamine reuptake inhibitor conjugated to a chemical structure of a histone deacetylase inhibitor. In certain embodiments, this disclosure relates to methods of treating or preventing a neurological disorder, mental disorder or depression comprising administering an effective amount of a compound disclosed herein to a subject in need thereof.

Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: Formula I for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1 and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: A switching circuit, electrical energy converter, power management unit and energy harvesting system are described. Such apparatus is applicable to energy harvesting applications which involve a variety of transducers, either singly or simultaneously. The transducers may, for example, be photovoltaic, thermoelectric, piezoelectric, or electrodynamic. The described converters operate to convert impedances, voltages and currents. They incorporate inductive energy transfer elements, which are magnetically coupled. Different combinations of these energy transfer elements are used to obtain different conversion ratios, which can be referred to as “gears”. On the input side, having multiple gears enables easier and better matching to a wider variety of energy transducers. On the output side, it enables easier and better accommodation of a wider spread of energy storage voltages and of a wider variety of loads.

Abstract: Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.

Abstract: An aircraft wing assembly including: a wing having a wing box structure with an upper wing cover and a lower wing cover, and a wing tip device attached to the outboard end of the wing, the wing tip device including an upper cover and a lower cover, wherein a gap between opposing edges of the wing tip device lower cover and the lower wing cover is at least 5 mm, a seal assembly aerodynamically seals the gap, wherein the seal assembly includes a bridging component on an interior side of the gap, and a seal which fills the gap and is supported by the bridging component.

Abstract: A method of controlling a supply of a fuel to a combustor of a gas turbine having a compressor upstream of the combustor is provided. The method includes: supplying the fuel to the combustor; obtaining a property value of at least one physical property (PT8, PT7, Tinlet, THBOV) of air used for burning the fuel in the combustor; estimating a heat input (HIengmodel) of the fuel supplied to the combustor based on the property value; measuring a Caloric Value (LCVmea) of the fuel upstream of the combustor; adjusting the estimated heat input (HIengmodel) based on the measured Caloric Value (LCVmea); and controlling a fuel valve regulating the supply of the fuel to the combustor based on the adjusted estimated heat input (HIexpected) and a demanded heat input (FFDEM).

Abstract: A switching circuit, electrical energy converter, power management unit and energy harvesting system are described. Such apparatus is applicable to energy harvesting applications which involve a variety of transducers, either singly or simultaneously. The transducers may, for example, be photovoltaic, thermoelectric, piezoelectric, or electrodynamic. The described converters operate to convert impedances, voltages and currents. They incorporate inductive energy transfer elements, which are magnetically coupled. Different combinations of these energy transfer elements are used to obtain different conversion ratios, which can be referred to as “gears”. On the input side, having multiple gears enables easier and better matching to a wider variety of energy transducers. On the output side, it enables easier and better accommodation of a wider spread of energy storage voltages and of a wider variety of loads.

Abstract: A gas turbine fuel supply method and arrangement is provided. The method of controlling a supply of a fuel to a combustor of a gas turbine having a compressor upstream of the combustor, the method including: supplying the fuel to the combustor; obtaining an inlet air pressure (PT7) at a compressor inlet; obtaining an inlet air temperature (Tinlet) at the compressor inlet; obtaining an outlet air pressure (PT8) at a compressor outlet; estimating a heat input (HIengmodel, HIexpected) of the fuel supplied to the combustor based on the inlet air pressure (PT7), the inlet air temperature (Tinlet) and the outlet air pressure (PT8); comparing the estimated heat input (HIengmodel, HIexpected) with a demanded heat input (FFDEM) to derive an error signal; and controlling a fuel valve regulating the supply of the fuel to the combustor based on the error signal.

Abstract: Methods to obtain expression systems and proteins in a high-throughput protocol by utilizing mixtures of cells cultured from those transformed with a desired nucleotide sequence permit rapid production of protein for use in arrays to assess activity. In one embodiment, the proteins (or peptides) in the array are assessed for their immunological activity with regard to an infectious agent.

Abstract: Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.

Abstract: An aircraft wing assembly including: a wing having a wing box structure with an upper wing cover and a lower wing cover, and a wing tip device attached to the outboard end of the wing, the wing tip device including an upper cover and a lower cover, wherein a gap between opposing edges of the wing tip device lower cover and the lower wing cover is at least 5 mm, a seal assembly aerodynamically seals the gap, wherein the seal assembly includes a bridging component on an interior side of the gap, and a seal which fills the gap and is supported by the bridging component.

Abstract: An aircraft wing assembly including: a wing having a wing box structure with an upper wing cover and a lower wing cover, and a wing tip device attached to the outboard end of the wing, the wing tip device including an upper cover and a lower cover, wherein a gap between opposing edges of the wing tip device lower cover and the lower wing cover is at least 5 mm, a seal assembly aerodynamically seals the gap, wherein the seal assembly includes a bridging component on an interior side of the gap, and a seal which fills the gap and is supported by the bridging component.

Abstract: Contemplated compositions, devices, and methods are drawn to various antigens from Herpes Simplex Virus type 1 (HSV-1) and Herpes Simplex Virus type 2 (HSV-2) and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.

Abstract: Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.

Abstract: A gas turbine fuel supply method and arrangement is provided. The method of controlling a supply of a fuel to a combustor of a gas turbine having a compressor upstream of the combustor, the method including: supplying the fuel to the combustor; obtaining an inlet air pressure (PT7) at a compressor inlet; obtaining an inlet air temperature (Tinlet) at the compressor inlet; obtaining an outlet air pressure (PT8) at a compressor outlet; estimating a heat input (HIengmodel, HIexpected) of the fuel supplied to the combustor based on the inlet air pressure (PT7), the inlet air temperature (Tinlet) and the outlet air pressure (PT8); comparing the estimated heat input (HIengmodel, HIexpected) with a demanded heat input (FFDEM) to derive an error signal; and controlling a fuel valve regulating the supply of the fuel to the combustor based on the error signal.