Abstract: Provided are novel tetrahydropyridine derivatives bearing substituents. These compounds can be used for alleviating the symptoms of CNS disorders.

Abstract: The invention provides methods of monitoring the production of a target polypeptide by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken from multiple cell culture batches or of samples taken at different times from a given batch. The invention additionally provides methods for monitoring the purification of a target polypeptide from a mixture by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken at various times during a purification process. In addition, the invention relates to methods of identifying conditions that can be used in increasing the scale of a given purification process.

Abstract: The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry.

Abstract: Disclosed are 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles. Also disclosed are methods for making 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles, including those having the formulae. The methods include contacting a 4-substituted-6,7-dihydro indole, benzofuran, benzothiophene, benzimidazole, benzoxazole, or benzothiazole compound or a 7-substituted-4,5-dihydro indole, benzofuran, benzothiophene, benzimidazole, benzoxazole, or benzothiazole compound with a vinyldiazo compound in the presence of a dirhodium catalyst.

Abstract: Two aluminium alloy work-pieces are welded together. Firstly, a portion (2) of each work-piece (1) is prepared, the preparation including the performance of a surface treatment, such as friction stir welding, that results in a region (A) extending from the exterior surface into the work-piece having a grain structure that is finer than the grain structure of the work-piece outside (region C) that region. Then the work-pieces are welded together by means of a fusion welding process, such as electron beam welding, that joins the respective prepared portions (2) of the two work-pieces (1). The preparation of the work-pieces is so performed that said region (A) extends into the work-piece to a depth that exceeds the depth of material (region D) that is caused to melt during the fusion welding process.

Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. In addition, the invention provides appropriate treatment interventions and methods for measuring response to treatment. Certain biomarkers of the invention may also be suitable for employment as radio-labeled ligands in non-invasive imaging techniques such as Positron Emission Tomography (PET).

Abstract: A toothbrush comprises a handle and a head for improved cleaning to the interdental regions of the teeth, the head comprising a linear arrangement of bristles transverse to the general longitudinal axis of the brush and extending along a length equal to or greater than a third of the width of the toothbrush head at the location of the arrangement, characterised in that a portion of the bristles at either end of the arrangement are angled away from the vertical such that the arrangement presents a fan-shaped transverse brushing array.

Abstract: Compounds having the formula are disclosed. M1 and M2 are the same or different and are transition metal atoms or ions; Z2 and Z3, independently, are the atoms necessary to complete a 3-12 membered heterocyclic ring; Z1 is an alkylene or arylene group; Q1 and Q2 are the same or different and are electron withdrawing groups; L1 and L3, taken together, represent —O—CR13—O—; L2 and L4, taken together, represent —O—CR14—O—; and R13 and R14 are the same or different and are selected from the group consisting of alkyl groups and aryl groups or R13 and R14 represent alkylene or arylene groups that are directly or indirectly bonded to one another. Methods for making such compounds are also disclosed, as are intermediates which can be used in their preparation. Also disclosed are methods for carrying out C—H insertion reactions using bis-transition metal catalysts, such as the above compounds. Procedures for preparing d-threo methylphenidate, tolterodine, CDP-840, nominfensine, and sertraline, are described.

Abstract: A toothbrush comprising a resilient element, said resilient element comprising an elastomer into which is incorporated an abrasive, characterized in that the abrasive is perlite.

Abstract: A method is provided for individualizing an electric toothbrush as well as a cover for a handle of a motorized toothbrush wherein the cover is firmly and removeably attacheable to the handle, characterized in that the toothbrush can be used with the cover in place.

Abstract: Toothbrush comprising a handle and a bristle-bearing head attached thereto, said head comprising a bristle-bearing face and an opposite face, said opposite face comprising an array of resilient wall-like massaging flaps.

Abstract: A cover for a handle of a motorised toothbrush wherein the cover is firmly and removeably attachable to the handle, characterised in that the toothbrush can be used with the cover in place

Abstract: A toothbrush comprising a resilient element, said resilient element comprising an elastomer into which is incorporated an abrasive, characterized in that the abrasive is perlite.

Abstract: Electric toothbrush comprising a housed motor, which motor drives a brushing head about an oscillation axis, said head comprising bristles arranged in bristle tufts, said toothbrush comprising a longitudinal axis, said brush head comprising a transverse axis perpendicular to said longitudinal axis and passing through said longitudinal axis at said oscillation axis, characterised in that at least 50% of the bristle tufts within 45° either side of the transverse axis of the brush head when in a rest position have an average length of from 106 to 140% that of the average length of the other bristle tufts on the brush head located outside this area. The invention also provides a replaceable head therefor.

Abstract: A toothbrush comprises a handle and a head for improved cleaning to the interdental regions of the teeth, said head comprising a linear arrangement of bristles transverse to the general longitudinal axis of the brush and extending along a length equal to or greater than a third of the width of the toothbrush head at the location of the arrangement, characterised in that a portion of the bristles at either end of the arrangement are angled away from the vertical such that the arrangement presents a fan-shaped transverse brushing array.

Abstract: The invention provides methods of monitoring the production of a target polypeptide by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken from multiple cell culture batches or of samples taken at different times from a given batch. The invention additionally provides methods for monitoring the purification of a target polypeptide from a mixture by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken at various times during a purification process. In addition, the invention relates to methods of identifying conditions that can be used in increasing the scale of a given purification process.

Abstract: Pharmaceutical compositions comprising an inhibitor of ras farnesylation of formula (I) wherein, R1 is for example H and further values as defined in the specification; R2 is for example H and further values as defined in the specification; R3 is for example H or a substituent having values as defined in the specification; p is 0-3 in which R3 values can be the same or different; L is a linking moiety for example —CO—NH2— and further values as defined in the specification; A is selected from phenyl; naphthyl; a 5-10 membered monocyclic or bicyclic heteroaryl ring containing up to 5 heteroatoms where the heteroatoms are independently selected from O, N and S; or a —S—S-dimer thereof when R2=H; or an enantiomer, diastereoisomer, pharmaceutically acceptable salt, prodrug or solvate thereof together with a pharmaceutically acceptable diluent or carrier. A particular use is cancer therapy.

Abstract: Toothbrush comprising a head and a handle, the head comprising massaging wings extending from a bristle-bearing face said massaging wings flanking a central bristle area and angled outwardly from said area, wherein the bristles are arranged in bristle tufts and of the bristle tufts which are adjacent a wing, at least a portion are angled towards said wing.

Abstract: An electric toothbrush comprising a handle and an oscillating brush head which oscillates about an oscillating axis, said head comprising a rubbery cleaning element, in wherein the rubbery cleaning element is in the form of a radially-extending resilient wall.

Abstract: A cover for a handle of a motorized toothbrush wherein the cover is firmly and removeably attachable to the handle, characterized in that the toothbrush can be used with the cover in place