Abstract: A method of controlling a supply of a fuel to a combustor of a gas turbine having a compressor upstream of the combustor is provided. The method includes: supplying the fuel to the combustor; obtaining a property value of at least one physical property (PTB, PT7, Tinlet, THBOV) of air used for burning the fuel in the combustor; estimating a heat input (HIengmodel) of the fuel supplied to the combustor based on the property value; measuring a Caloric Value (LCVmea) of the fuel upstream of the combustor; adjusting the estimated heat input (HIengmodel) based on the measured Caloric Value (LCVmea); and controlling a fuel valve regulating the supply of the fuel to the combustor based on the adjusted estimated heat input (HIexpected) and a demanded heat input (FFDEM).

Abstract: The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, including benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.

Abstract: The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, including benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.

Abstract: Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.

Abstract: Contemplated compositions, devices, and methods are drawn to various antigens from Herpes Simplex Virus type 1 (HSV-1) and Herpes Simplex Virus type 2 (HSV-2) and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.

Abstract: An aircraft wing assembly comprising a wing (2) having a wing box structure including an upper wing cover (7) and a lower wing cover (8), and a wing tip device (1) attached to the outboard end of the wing, the wing tip device including an upper cover (9) and a lower cover (10), wherein a gap (g) between opposing edges of the wing tip device lower cover (10) and the lower wing cover (8) is at least 5 mm, and further comprising a seal assembly (20) for aerodynamically sealing the gap (g), wherein the seal assembly (20) includes a bridging component (21) on an interior side of the gap (g), and a seal (22) which fills the gap (g) and is supported by the bridging component (21). Also, an aircraft having the wing assembly, and a method of attaching a wing tip device (1) to the outboard end of a wing (2).

Abstract: Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen T. gondii and their use in various diagnostic tests, vaccines, and therapeutic agents. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.

Abstract: A method of starting a gas turbine engine by use of a start sequence is provided. Turbine speed and fuel delivery are coordinated so as to provide a fuel/air mixture at an ignition device allowing a successful ignition. If a successful ignition has not occurred by end of the start sequence the gas turbine engine is purged and the start sequence is repeated after the purging of the gas turbine engine.

Abstract: A valve assembly is provided for a gas turbine engine with at least two drain valves connected to the gas turbine engine to drain oil and moisture from the engine, an actuator for opening and closing the at least two drain valves, a solenoid valve connected to the actuator and to a regulated air supply for driving the actuator and a safety valve connected to an exhaust of the solenoid valve and to a compressor air supply, the compressor air supply driving the safety valve to prevent the actuator from being vented during engine operation. A method of securely operating a plurality of drain valves is also provided.

Abstract: The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, including benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.

Abstract: A method of starting a gas turbine engine by use of a start sequence is provided. Turbine speed and fuel delivery are coordinated so as to provide a fuel/air mixture at an ignition device allowing a successful ignition. If a successful ignition has not occurred by end of the start sequence the gas turbine engine is purged and the start sequence is repeated after the purging of the gas turbine engine.

Abstract: Two aluminium alloy work-pieces are welded together. Firstly, a portion (2) of each work-piece (1) is prepared, the preparation including the performance of a surface treatment, such as friction stir welding, that results in a region (A) extending from the exterior surface into the work-piece having a grain structure that is finer than the grain structure of the work-piece outside (region C) that region. Then the work-pieces are welded together by means of a fusion welding process, such as electron beam welding, that joins the respective prepared portions (2) of the two work-pieces (1). The preparation of the work-pieces is so performed that said region (A) extends into the work-piece to a depth that exceeds the depth of material (region D) that is caused to melt during the fusion welding process.

Abstract: Toothbrush having a head, a neck and a handle, the toothbrush comprising a plastic body and a metal skeleton, the plastic body being moulded around the metal skeleton, the metal skeleton extending from the handle through the neck and into the head of the toothbrush.

Abstract: Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.

Abstract: Methods to obtain expression systems and proteins in a high-throughput protocol by utilizing mixtures of cells cultured from those transformed with a desired nucleotide sequence permit rapid production of protein for use in arrays to assess activity. In one embodiment, the proteins (or peptides) in the array are assessed for their immunological activity with regard to an infectious agent.

Abstract: The invention relates to, among other things, methods of protecting against poxvirus infection or pathogenesis and including pox viruses such as small pox (variola major and variola minor), cowpox, monkey pox vaccinia virus, and Molluscum Contagiosum using compositions such as human, humanized and chimeric antibodies that specifically bind to H3L protein.

Abstract: Disclosed are methods for alleviating symptoms of neuropsychiatric disorders using tetrahydropyridine derivatives bearing aromatic substituents. The method comprises administering to an individual a tetrahydropyridine derivative bearing aromatic substituents in an amount effective to alleviate symptoms of the neuropsychiatric disorder.

Abstract: Disclosed are aromatic cyclopropane compounds with CNS activity. These compounds can be used for alleviating symptoms of CNS disorders.

Abstract: Disclosed are tropane-based prodrug compounds bearing fatty ester and aromatic substituents. The compounds can be used for alleviating symptoms of CNS disorders.

Abstract: Disclosed are novel homotropane compounds with CNS activity. These compounds can be used for alleviating symptoms of CNS disorders.