Abstract: The present invention relates to a compound of the Formula: or a pharmaceutically acceptable salt thereof. The compound of the present invention inhibits Pol?. This novel therapeutic compound is therefore useful for the treatment and/or prevention of diseases and conditions in which Pol? activity is implicated, such as, for example but not limited to, the treatment and/or prevention of cancer. The present invention also relates to pharmaceutical compositions comprising the novel therapeutic compound defined herein, to processes for synthesising the compound and to their use for the treatment of diseases and/or conditions in which Pol? activity is implicated.

Abstract: The present invention relates to a compound of the Formula: or a pharmaceutically acceptable salt thereof. The compound of the present invention inhibits Pol?. This novel therapeutic compound is therefore useful for the treatment and/or prevention of diseases and conditions in which Pol? activity is implicated, such as, for example but not limited to, the treatment and/or prevention of cancer. The present invention also relates to pharmaceutical compositions comprising the novel therapeutic compound defined herein, to processes for synthesising the compound and to their use for the treatment of diseases and/or conditions in which Pol? activity is implicated.

Abstract: A head-mounted display system (100) includes a lens element (110) supported by a support structure (102). The lens element (110) includes a waveguide (212) to couple light from an image source. The waveguide (212) includes a waveguide surface (207) and a grating (250). The grating (250) is disposed onto the waveguide surface (207) and includes rows of three-dimensional, 3D, primitive structures (435), with a height of the 3D primitive structures being smaller than a wavelength of visible incident light at a surface of the sub-wavelength grating.

Abstract: A laser projection system utilizes a waveguide having a narrow incoupler for double-bounce mitigation and form factor reduction. An optical scanner includes an optical relay positioned in between two scan mirrors. The first scan mirror scans laser light into the optical relay in a first dimension, and the optical relay and converges the scanned laser light towards a second scan mirror. The second scan mirror scans laser light along a second dimension substantially perpendicular to a path over which the laser light is scanned across the second scan mirror, and the convergence introduced by the optical relay causes the laser light to be scanned as a line or arc path of an exit pupil plane that is coincident with the incoupler. The optical relay may include one or more lenses or may be a monolithic molded structure, which may be an Offner-style relay or a molded reflective relay.

Abstract: Various embodiments disclosed relate to a method of preparing aryl fluorinated ether compounds. The method involves contacting an aryl halide with a fluorinated alcohol in the presence of a photocatalyst, a base, and irradiation with electromagnetic radiation comprising a wavelength between about 200 nm and about 800 nm. The present invention also provides a method of late-stage photochemical modification of a biologically active compound, such as drugs or agrochemicals. Fluorinated derivatives of griseofulvin, clofibrate, and 2,4-D methyl ester are described herein.

Abstract: A system and method to collect collecting data for customizing a facial interfacing structure for a head-mounted display interface for virtual reality or augmented reality systems. Facial image data is correlated to a user such as by scanning the face of the user. Facial feature data related to the facial interfacing structure is determined from the facial image data. Dimensions of the facial interfacing structure are determined from the facial feature data. A design of a customized facial interfacing structure including the determined dimensions is stored to produce the customized facial interfacing structure.

Abstract: A head-mounted display system includes a positioning and stabilising structure structured and arranged to hold a display unit in an operational position over a user's face in use and an interfacing structure for the display unit constructed and arranged to be in opposing relation with the user's face. The interfacing structure comprises a substantially continuous face engaging surface adapted to contact the user's face around a periphery of the user's eyes. The interfacing structure comprises silicone. The interfacing structure is configured and arranged such that force applied to the user's face is distributed around the periphery thereof. The interfacing structure comprises a first compliance at a first region and a second compliance at a second region, wherein the first region and the second region are configured around the periphery of the interfacing structure to allow selective distribution of the force onto the user's face.

Abstract: A lanyard to hold a controller for a headset is provided. The lanyard includes a strap anchored on a top portion of a lid for a battery case of the controller, and a clip anchored to an opening pin in a bottom portion of the lid for the battery case of the controller. The strap includes a stretchable fabric and multiple sticky pads on an outer face that adhere to the stretchable fabric when the strap is looped around the clip. A headset using a controller that includes a lanyard as above, and the controller, are also provided.

Abstract: The disclosure herein describes use of an air corridor model to enable aerial vehicles to travel an air corridor while maintaining safe separation distance from other vehicles. A trained air corridor model associated with an air corridor is received by an aerial vehicle, wherein the trained air corridor model is configured to maintain safe separation distance between vehicles in the air corridor. The current position of the aerial vehicle in the air corridor is identified and positions of other agents in the air corridor are received. A next position of the aerial vehicle is determined based on the trained air corridor model, the current position, and the agent positions. The aerial vehicle is controlled to travel from the current position to the determined next position, whereby the aerial vehicle and other agents are enabled to efficiently use the airspace of the air corridor while maintaining safe distances between each other.

Abstract: A head-mounted display system comprising a head-mounted display unit; and a positioning and stabilising structure structured and arranged to hold the head-mounted display unit in an operational position over a user's face in use, the head-mounted display unit comprising an interfacing structure constructed and arranged to be in opposing relation with the user's face, wherein the interfacing structure comprises a flexible and resilient face engaging portion, the face engaging portion having a pair of check portions configured to contact the user's checks in use, each check portion comprising at least one loop portion having an at least partially enclosed cross section; wherein the interfacing structure comprises a medial support portion medial of each check portion configured to provide support for the at least one loop portion.

Abstract: A forehead support for a head-mounted display system, the forehead support being configured to form part of a positioning and stabilising structure constructed and arranged to hold a head-mounted display unit of the head-mounted display system in an operable position on the user's head, the forehead support comprising: a forehead frame configured to be attached to a head-mounted display unit comprising a display in use; a resilient forehead pad attached to the forehead frame and being configured to engage the user's forehead in use; wherein at least a portion of the forehead frame is able to flex to conform to the shape of the user's forehead in use.

Abstract: A head-mounted display system includes a positioning and stabilising structure structured and arranged to hold a display unit in an operational position over a user's face in use and an interfacing structure for the display unit constructed and arranged to be in opposing relation with the user's face. The interfacing structure comprises a substantially continuous face engaging surface adapted to contact the user's face around a periphery of the user's eyes. The interfacing structure comprises silicone. The interfacing structure is configured and arranged such that force applied to the user's face is distributed around the periphery thereof. The interfacing structure comprises a first compliance at a first region and a second compliance at a second region, wherein the first region and the second region are configured around the periphery of the interfacing structure to allow selective distribution of the force onto the user's face.

Abstract: A lanyard to hold a controller for a headset is provided. The lanyard includes a strap anchored on a top portion of a lid for a battery case of the controller, and a clip anchored to an opening pin in a bottom portion of the lid for the battery case of the controller. The strap includes a stretchable fabric and multiple sticky pads on an outer face that adhere to the stretchable fabric when the strap is looped around the clip. A headset using a controller that includes a lanyard as above, and the controller, are also provided.

Abstract: A head-mounted display system includes a head-mounted display unit a display that, in use, is held in an operational position over a user's face. The head-mounted display system further comprises a flow generator configured to generate a flow of air, and an air guide arrangement coupled to the flow generator to enable the flow generator to direct air to, or draw air from, one or more selected areas in proximity of the head-mounted display system.

Abstract: A head-mounted display system includes a head-mounted display system, comprising a head-mounted display unit, comprising various pad options at various positions on the head including saddle shaped nose pads that deform under a reaction force applied to the apex of the nose to improve load distribution, forehead pads with an associated mounting structure and inserts that affect compliance and/or size, temporal pads configured to lie against the temporal bone which support some of the weight of the head mounted display system and, further stabilizing pads which are located on a rigid portion of the temporal arms and designed to extend along temporal regions of the users head.

Abstract: A method includes receiving data associated with a sleep session of a user. The method also includes determining that the user is experiencing or has experienced an event based at least in part on the data. The method also includes causing pressurized air to be directed from a respiratory device to a multi-compartment bladder in response to determining that the user is experiencing or has experienced the event to aid in modifying a position of a head of the user.

Abstract: Aspects of the present disclosure provide techniques for machine learning and rules integration. Embodiments include receiving input values corresponding to a subset of a set of input variables associated with an automated determination. Embodiments include generating a directed acyclic graph (DAG) representing a set of constraints corresponding to the set of input variables. The set of constraints relate to one or more machine learning models and one or more rules. Embodiments include receiving one or more outputs from the one or more machine learning models based on one or more of the input values. Embodiments include determining outcomes for the one or more rules based on at least one of the input values. Embodiments include populating the DAG based on the input values, the one or more outputs, and the outcomes. Embodiments include making the automated determination based on logic represented by the DAG.

Abstract: A head-mounted display system includes a head-mounted display unit and a positioning and stabilising structure structured and arranged to hold the head-mounted display unit in an operational position over a user's face in use. The positioning and stabilising structure includes a rear support structure adapted to contact posterior regions of a user's head and a forehead support connector, which includes a forehead support strap, which extends generally along and in the direction of the sagittal plane and connects the rear support structure to a superior edge region of the head-mounted display unit. The forehead support connector further includes a forehead support rigidiser that provides rigidification to a portion of the forehead support connector.

Abstract: A system and method for provisionally authenticating a host moving from a source port of a switch device to a destination port of the switch device is disclosed. The host is initially authenticated at the source port and blocked from forwarding network traffic at the destination port. During a provisional authentication session, an authentication agent executing on the switch intercepts one or more authentication packets sourced by the host and headed for the destination port of the switch device and redirects the authentication packets to an authentication server for validating the host at the destination port of the switch device. The switch device removes the block at the destination port in response to receiving an acknowledgment of successful authentication at the destination port from the authentication server.

Abstract: The disclosure provides antibody constructs that can reversibly bind to biological or chemical target analytes. Upon target analyte binding, the antibody construct can change its conformational state to produce a detectable readout. An antibody construct can be a single-antibody construct or a dual-antibody construct.