Abstract: A head-mounted display (HMD) system includes a lens element supported by a support structure. The lens element includes a waveguide that includes an incoupler, an outcoupler, and an exit pupil expander. The incoupler is disposed within a first area of the waveguide. The outcoupler is disposed within a second area of the waveguide. The exit pupil expander is disposed within a third area of the waveguide. An anti-reflection coating is formed via fabrication used to form the incoupler, the outcoupler, and the exit pupil expander. The anti-reflection coating is disposed within a fourth area of the waveguide different than the first, second, and third areas of the waveguide.

Abstract: A method includes receiving data associated with a sleep session of a user. The method also includes determining that the user is experiencing or has experienced an event based at least in part on the data. The method also includes causing pressurized air to be directed from a respiratory device to a multi-compartment bladder in response to determining that the user is experiencing or has experienced the event to aid in modifying a position of a head of the user.

Abstract: A system and method for provisionally authenticating a host moving from a source port of a switch device to a destination port of the switch device is disclosed. The host is initially authenticated at the source port and blocked from forwarding network traffic at the destination port. During a provisional authentication session, an authentication agent executing on the switch intercepts one or more authentication packets sourced by the host and headed for the destination port of the switch device and redirects the authentication packets to an authentication server for validating the host at the destination port of the switch device. The switch device removes the block at the destination port in response to receiving an acknowledgment of successful authentication at the destination port from the authentication server.

Abstract: The disclosure herein describes use of an air corridor model to enable aerial vehicles to travel an air corridor while maintaining safe separation distance from other vehicles. A trained air corridor model associated with an air corridor is received by an aerial vehicle, wherein the trained air corridor model is configured to maintain safe separation distance between vehicles in the air corridor. The current position of the aerial vehicle in the air corridor is identified and positions of other agents in the air corridor are received. A next position of the aerial vehicle is determined based on the trained air corridor model, the current position, and the agent positions. The aerial vehicle is controlled to travel from the current position to the determined next position, whereby the aerial vehicle and other agents are enabled to efficiently use the airspace of the air corridor while maintaining safe distances between each other.

Abstract: There is provided an optical element including a light guide, an incoupler, and a beam splitter disposed in an optical path of a display beam between the incoupler and a light engine to generate the display beam. The display beam may comprise first and second beams. The beam splitter may split the display beam to form a first offspring beam including the first beam and a first portion of the second beam, and to form a second offspring beam including a second portion of the second beam. The first and second offspring beams may be incident upon the incoupler at first and second incidence positions respectively. The first incidence position may be different than the second incidence position. The incoupler may direct at least a portion of each of the first and second offspring beams into the light guide to form incoupled first and second offspring beams respectively.

Abstract: The present disclosure relates to antimicrobial compositions, particularly to antibiotic compositions; to methods for identification of antimicrobial compositions involving in silico prediction of antimicrobial activity; and to use of antimicrobial compositions and methods.

Abstract: A head-mounted display (HMD) system includes a micro-display configured to project light beams, each of light beams encompassing a range of wavelengths different from each of the other light beams, and a waveguide having multiple incouplers configured to receive and direct light into the waveguide. Each of the incouplers is a diffraction grating with a fill factor different from each of the other incouplers. In some embodiments, each of the incouplers has a different period value from each of the other incouplers and the period value of each of the incouplers is based on the range of wavelengths of light each of the incouplers is configured to receive.

Abstract: Display systems, such as near eye display systems or wearable heads up displays, may include a laser projection system having an optical engine and an optical scanner. Light output by the optical engine may be directed into the optical scanner as two angularly separated laser light beams. The angularly separated laser light beams may overlap at an entrance pupil plane along a first dimension at a first scan mirror of the optical scanner, or at a location between the first scan mirror and an optical relay of the optical scanner. The angularly separated laser light beams may overlap at an exit pupil plane along the first dimension at a second scan mirror of the optical scanner or at an incoupler of the laser projection system.

Abstract: A networkable device is coupled to a wireless IP gateway or paired to a personal area network (PAN) via the use of a sonic tone, which may be a human audible tone, which encodes a symbol sequence representing a binary message useful for implementing connection to a wireless IP gateway or pairing with a PAN. In one embodiment the sonic tone conveys a media access controller (MAC) address, to facilitate connection and/or pairing. Alternatively, or in addition, the sonic tone may encode a Service Set Identifier (SSID) and password for connection to a wireless network (Wi-Fi), or a BLUETOOTH (IEEE 802.15.1) identifier and/or PIN for connection to a BLUETOOTH (IEEE 802.15.1) PAN. In particular implementation of this embodiment the tone is produced by the IP gateway and used to initiate Wi-Fi connection, and/or the tone is produced by the master device of a PAN to initiate BLUETOOTH (IEEE 802.15.1) connection.

Abstract: Display systems, such as near eye display systems or wearable heads up displays, may include a laser projection system having an optical engine and an optical scanner. Light output by the optical engine may be directed into the optical scanner as two angularly separated laser light beams. The angularly separated laser light beams may overlap at an entrance pupil plane along a first dimension at a first scan mirror of the optical scanner, or at a location between the first scan mirror and an optical relay of the optical scanner. The angularly separated laser light beams may overlap at an exit pupil plane along the first dimension at a second scan mirror of the optical scanner or at an incoupler of the laser projection system.

Abstract: A system includes one or more sensors one or more sensors configured to generate data associated with a sleep session of a user. The system also includes a multi-compartment bladder configured to be positioned adjacent to a user during the sleep session. The system also includes a memory storing machine-readable instructions. The system also includes a control system including one or more processors configured to execute the machine-readable instructions to determine, based at least in part on the generated data associated with the sleep session, that the user is experiencing or has experienced an event and responsive to determining that the user is experiencing or has experienced the event, cause the multi-compartment bladder to be modified to aid in causing the user to move.

Abstract: Systems and methods of separating the input light path from the output light path of a scanning mirror in a laser projector system while keeping the overall footprint of the laser projector system to a minimum. The system includes a scanning mirror, an optical engine, and an input/output (1/0) separator disposed between the optical engine and the scanning mirror to direct light from the optical engine towards the scanning mirror along an input path and to direct light reflected from the scanning mirror along an output path. The I/O separator, disposed to intersect both the input and output paths, can be implemented as a prism or a combination of a polarizing beam splitter and a quarter wave plate.

Abstract: A laser projection system utilizes a waveguide having a narrow incoupler for double-bounce mitigation and form factor reduction. An optical scanner includes an optical relay positioned in between two scan mirrors. The first scan mirror scans laser light into the optical relay in a first dimension, and the optical relay and converges the scanned laser light towards a second scan mirror. The second scan mirror scans laser light along a second dimension substantially perpendicular to a path over which the laser light is scanned across the second scan mirror, and the convergence introduced by the optical relay causes the laser light to be scanned as a line or arc path of an exit pupil plane that is coincident with the incoupler. The optical relay may include one or more lenses or may be a monolithic molded structure, which may be an Offner-style relay or a molded reflective relay.

Abstract: Systems, devices, and assemblies for implementing multi-focal lens portions in wearable heads-up displays are described. Multi-focal lens portions may include at least two regions having different optical power, and at least one transition region between regions having different optical power. If display light is directed through a transition region, aberrations or distortion may be visible in the display presented to the user. The present systems, devices, and assemblies address this issue through shaping, positioning, and orienting of regions of a multi-focal lens portion, through positioning, orientation, and aiming of display optics, and/or through arrangements of lens assemblies which prevent display light from travelling through a multi-focal lens portion.

Abstract: In a reclosable folding box (41, 42, 43) having a safety and tamper-evident closure (84), the side wall surfaces (2 to 6, 64, 65) of which are formed by a one-piece blank (1, 1a, 1b) and glued together in such a way that the folding box (41, 42, 43) cannot be opened without destroying a glued joint and/or at least one disconnectable tear line area (16, 17, 16a, 16b, 17a, 17b), a solution for a reclosable medical packaging having a safety and tamper-evident closure is to be created, which provides an improved graspability and visual recognizability of a pull tab forming at least the substantial part of the safety and tamper-evident closure.

Abstract: An optical element for implementation in a heads-up display or other near-eye display system includes a lightguide and an incoupler optically coupled to the lightguide. The incoupler receives a display beam incident upon the lightguide at a first incidence position. The incoupler directs a first portion of the display beam into the lightguide to form an incoupled beam and causes a second portion to remain non-incoupled relative to the lightguide to form a non-incoupled beam. The optical element further includes a reflector to receive the non-incoupled beam and to reflect the non-incoupled beam towards the incoupler to form a reflected beam incident upon the incoupler at a second incidence position. The incoupler direct a corresponding portion of the reflected beam into the lightguide to form a further incoupled beam.

Abstract: Methods and systems are for identifying the cell type of an unknown microorganism. The device includes: an apparatus for culturing unknown organism(s), a diagnostic data acquisition tool and a computer program. The method includes: incubation of the sample with a growth medium (with or without toxins), and an analysis of the metabolites detected in the sample. The computer system compares the results collected from the device to reference metabolite profiles.

Abstract: The present invention relates to dosing regimen of avelumab for the treatment of cancer. In particular, the invention relates to improved dosing regimen of avelumab for the treatment of cancer.

Abstract: The present disclosure provides compositions and methods capable of potentiating the effects of antibiotics against bacterial infections that either have developed, or that possess the potential to develop, antibiotic tolerance. Methods of sensitizing antibiotic tolerant bacteria to antibiotics, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at antibiotic tolerant bacteria are also provided.

Abstract: A head-mounted display system includes a head-mounted display unit and a positioning and stabilising structure structured and arranged to hold the head-mounted display unit in an operational position over a user's face in use. The positioning and stabilising structure includes a rear support structure adapted to contact posterior regions of a user's head and a forehead support connector, which includes a forehead support strap, which extends generally along and in the direction of the sagittal plane and connects the rear support structure to a superior edge region of the head-mounted display unit. The forehead support connector further includes a forehead support rigidiser that provides rigidification to a portion of the forehead support connector.