Patents by Inventor Ian Hardcastle
Ian Hardcastle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11733169Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.Type: GrantFiled: December 14, 2020Date of Patent: August 22, 2023Assignee: ALVERIX, INC.Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
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Publication number: 20210096082Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.Type: ApplicationFiled: December 14, 2020Publication date: April 1, 2021Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
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Patent number: 10866193Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.Type: GrantFiled: April 16, 2018Date of Patent: December 15, 2020Assignee: ALVERIX, INC.Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
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Patent number: 10344017Abstract: The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the prophylaxis or treatment of a disease state or condition mediated by ERK5, in particular cancers.Type: GrantFiled: September 18, 2015Date of Patent: July 9, 2019Inventors: Tristan Reuillon, Duncan Miller, Stephanie Myers, Lauren Molyneux, Celine Cano, Ian Hardcastle, Roger Griffin, Laurent Rigoreau, Bernard Golding, Martin Noble
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Publication number: 20180231470Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.Type: ApplicationFiled: April 16, 2018Publication date: August 16, 2018Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
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Publication number: 20180170911Abstract: The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the prophylaxis or treatment of a disease state or condition mediated by ERK5, in particular cancers.Type: ApplicationFiled: September 18, 2015Publication date: June 21, 2018Applicant: CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Tristan REUILLON, Duncan MILLER, Stephanie MYERS, Lauren MOLYNEUX, Celine CANO, Ian HARDCASTLE, Roger GRIFFIN, Laurent RIGOREAU, Bernard GOLDING, Martin NOBLE
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Patent number: 9945789Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.Type: GrantFiled: January 16, 2007Date of Patent: April 17, 2018Assignee: Alverix, Inc.Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
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Patent number: 9857520Abstract: A lighting assembly includes a light guide having opposed major surfaces between which light propagates by total internal reflection and a light input edge. The light assembly also includes a light engine. The light engine has a heat conductive armature having a receptacle for a portion of the light guide that includes the light input edge and a light source retained by and thermally coupled to the armature. The armature functions as a heat sink for dissipating heat generated by the light source. The light guide is mechanically retained in the receptacle, and the light guide and the armature cooperate to align the light input edge with the light source for inputting light from the light source into the light guide through the light input edge.Type: GrantFiled: September 29, 2014Date of Patent: January 2, 2018Assignee: Rambus Delaware LLCInventors: Jeffery R Parker, Timothy A McCollum, Martin E Ligas, Joseph Crookston, Fumitomo Hide, Alexey Titov, Ian Hardcastle
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Patent number: 9778410Abstract: A lighting assembly includes a light guide to propagate light by total internal reflection and having a light output region on a major surface thereof. The lighting assembly also includes an optical adjuster having a major surface juxtaposed with and conforming to the light guide's major surface. The optical adjuster has a first region and a second region, the first region having a light modifying characteristic. The optical adjuster and light output region are variably positionable relative to one another to selectively apportion light emitted from the light output region between the first region and the second region. In this way, light apportioned to the first region is modified by the light modifying characteristic so that light output from the lighting assembly is modified based on relative positioning of the optical adjuster and the light guide.Type: GrantFiled: March 15, 2012Date of Patent: October 3, 2017Assignee: Rambus Delaware LLCInventors: Jeffrey R. Parker, Timothy A. McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
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Patent number: 9707641Abstract: Optical elements with small increments in average density are formed in a substrate by laser micromachining using a variable aperture and a pattern mask set of pattern masks each having of shape-defining elements whose density differs among the pattern masks in first density increments. A laser light beam passes through a combined mask formed by the variable aperture and one pattern mask selected from the pattern mask set. The variable aperture controls beam size and the pattern mask spatially modulates its intensity. A focusing element focuses light from the combined mask on a small averaging region of the substrate. Different combinations of the size of the aperture mask and the selected pattern mask are used in combination at respective averaging regions of the substrate. The resulting average densities of the optical elements vary among the averaging regions in increments that are small compared to the first density increments.Type: GrantFiled: September 14, 2012Date of Patent: July 18, 2017Assignee: Rambus Delaware LLCInventors: Timothy A McCollum, Fumitomo Hide, Ian Hardcastle
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Patent number: 9513428Abstract: A lighting assembly includes a light engine and a light guide. The light engine edge lights the light guide and includes a control assembly that controls light output according to one or more parameters to produce light output from the lighting assembly with a desired characteristic. Lighting assemblies are combined to form a modular lighting assembly.Type: GrantFiled: July 22, 2015Date of Patent: December 6, 2016Assignee: Rambus Delaware LLCInventors: Jeffery R Parker, Timothy A McCollum, Matthew R Wancata, Fumitomo Hide, Alexey Titov, Ian Hardcastle
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Patent number: 9477029Abstract: A lighting assembly includes a light guide having opposed major surfaces between which light propagates by total internal reflection, a light input edge, and two light output regions of different optical characteristics and at least one of which is associated with a corresponding one of the major surfaces. The lighting assembly also includes a light source located adjacent the light input edge. The light source and the light guide variably positionable relative to one another to vary a location on the light input edge at which the light is input to the light guide such that the light is emitted from the light guide selectively apportioned between the light output regions so that a characteristic of the light output from the lighting assembly is modified based on the optical characteristics associated with the light output regions and the relative positioning of the light source and the light guide.Type: GrantFiled: September 15, 2014Date of Patent: October 25, 2016Assignee: Rambus Delaware LLCInventors: Jeffery R Parker, Timothy A McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
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Patent number: 9310545Abstract: A lighting assembly includes a light guide and light source. The light guide includes light input regions, at least one of the light input regions associated with an optical modifying characteristic, and the light guide is configured to propagate light by total internal reflection. The light source is located adjacent the light input regions. The light source and light input regions are variably positionable relative to one another to vary a location at which light is incident on the light input regions such that light emitted from the light source is selectively apportioned between the light input regions. A characteristic of the light output from the lighting assembly is modified based on the optical modifying characteristic of the at least one of the light input regions and the relative positioning of the light source and the light input regions.Type: GrantFiled: March 15, 2012Date of Patent: April 12, 2016Assignee: Rambus Delaware LLCInventors: Jeffery R. Parker, Timothy A. McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
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Publication number: 20160018588Abstract: A lighting assembly includes a light engine and a light guide. The light engine edge lights the light guide and includes a control assembly that controls light output according to one or more parameters to produce light output from the lighting assembly with a desired characteristic. Lighting assemblies are combined to form a modular lighting assembly.Type: ApplicationFiled: July 22, 2015Publication date: January 21, 2016Inventors: Jeffery R. Parker, Timothy A. McCollum, Matthew R. Wancata, Fumitomo Hide, Alexey Titov, Ian Hardcastle
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Publication number: 20150268407Abstract: A lighting assembly includes a light guide having a first major surface, a second major surface opposite the first major surface, a light input edge, and an end edge distal the light input edge. Light input to the light guide through the light input edge propagates by total internal reflection toward the end edge. The lighting assembly further includes light extracting elements at at least one of the major surfaces of the light guide, the light extracting elements configured to extract light through the first major surface in a direction away from the light input edge and away from the first major surface, and a banding reduction element at the end edge configured to redirect light incident thereon in a direction away from the light input edge.Type: ApplicationFiled: March 31, 2015Publication date: September 24, 2015Inventors: Timothy A. McCollum, Jeffery R. Parker, Fumitomo Hide, Alexey Titov, Ian Hardcastle, Robert M. Ezell
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Patent number: 9116274Abstract: A lighting assembly includes a light engine and a light guide. The light engine edge lights the light guide and includes a control assembly that controls light output according to one or more parameters to produce light output from the lighting assembly with a desired characteristic. Lighting assemblies are combined to form a modular lighting assembly.Type: GrantFiled: July 8, 2014Date of Patent: August 25, 2015Assignee: Rambus Delaware LLCInventors: Jeffrey R Parker, Timothy A McCollum, Matthew R Wancata, Fumitomo Hide, Alexey Titov, Ian Hardcastle
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Publication number: 20150131310Abstract: A lighting assembly includes an edge-lit light guide and a light redirecting member. Light extracting elements at the light guide extract light from the light guide as intermediate light. Light redirecting elements at the light redirecting film are configured to redirect the intermediate light received from the light guide to illuminate a target surface in accordance with a defined illumination profile.Type: ApplicationFiled: November 10, 2014Publication date: May 14, 2015Inventors: Timothy A. McCollum, Robert M. Ezell, Jeffery R. Parker, Kurt R. Starkey, Ian Hardcastle, Fumitomo Hide
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Patent number: 8998478Abstract: A lighting assembly includes a light guide having a first major surface, a second major surface opposite the first major surface, a light input edge, and an end edge distal the light input edge. Light input to the light guide through the light input edge propagates by total internal reflection toward the end edge. The lighting assembly further includes light extracting elements at least one of the major surfaces of the light guide, the light extracting elements configured to extract light through the first major surface in a direction away from the light input edge and away from the first major surface, and a banding reduction element at the end edge configured to redirect light incident thereon in a direction away from the light input edge.Type: GrantFiled: April 17, 2012Date of Patent: April 7, 2015Assignee: Rambus Delaware LLCInventors: Timothy A. McCollum, Jeffery R. Parker, Fumitomo Hide, Alexey Titov, Ian Hardcastle, Robert M. Ezell
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Patent number: 8998452Abstract: A light bulb includes a base, light guide, and light source. The base is configured to mechanically mount the light bulb and receive electrical power. The light guide includes light input regions, at least one of the light input regions associated with an optical modifying characteristic, the light guide configured to propagate light by total internal reflection. The light source is located adjacent the light input regions. The light source and light input regions are variably positionable relative to one another to vary location at which light is incident on the light input regions such that light emitted from the light source is selectively apportioned between the light input regions. A characteristic of the light output from the light bulb is modified based on the optical modifying characteristic of the at least one of the light input regions and the relative positioning of the light source and light input regions.Type: GrantFiled: March 15, 2012Date of Patent: April 7, 2015Assignee: Rambus Delaware LLCInventors: Jeffery R. Parker, Timothy A. McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
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Publication number: 20150092439Abstract: A lighting assembly includes a light guide having opposed major surfaces between which light propagates by total internal reflection, a light input edge, and two light output regions of different optical characteristics and at least one of which is associated with a corresponding one of the major surfaces. The lighting assembly also includes a light source located adjacent the light input edge. The light source and the light guide variably positionable relative to one another to vary a location on the light input edge at which the light is input to the light guide such that the light is emitted from the light guide selectively apportioned between the light output regions so that a characteristic of the light output from the lighting assembly is modified based on the optical characteristics associated with the light output regions and the relative positioning of the light source and the light guide.Type: ApplicationFiled: September 15, 2014Publication date: April 2, 2015Inventors: Jeffery R. Parker, Timothy A. McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle