Patents by Inventor Ian Hardcastle

Ian Hardcastle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10344017
    Abstract: The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the prophylaxis or treatment of a disease state or condition mediated by ERK5, in particular cancers.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: July 9, 2019
    Inventors: Tristan Reuillon, Duncan Miller, Stephanie Myers, Lauren Molyneux, Celine Cano, Ian Hardcastle, Roger Griffin, Laurent Rigoreau, Bernard Golding, Martin Noble
  • Publication number: 20180231470
    Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
  • Publication number: 20180170911
    Abstract: The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the prophylaxis or treatment of a disease state or condition mediated by ERK5, in particular cancers.
    Type: Application
    Filed: September 18, 2015
    Publication date: June 21, 2018
    Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Tristan REUILLON, Duncan MILLER, Stephanie MYERS, Lauren MOLYNEUX, Celine CANO, Ian HARDCASTLE, Roger GRIFFIN, Laurent RIGOREAU, Bernard GOLDING, Martin NOBLE
  • Patent number: 9945789
    Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: April 17, 2018
    Assignee: Alverix, Inc.
    Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
  • Patent number: 9857520
    Abstract: A lighting assembly includes a light guide having opposed major surfaces between which light propagates by total internal reflection and a light input edge. The light assembly also includes a light engine. The light engine has a heat conductive armature having a receptacle for a portion of the light guide that includes the light input edge and a light source retained by and thermally coupled to the armature. The armature functions as a heat sink for dissipating heat generated by the light source. The light guide is mechanically retained in the receptacle, and the light guide and the armature cooperate to align the light input edge with the light source for inputting light from the light source into the light guide through the light input edge.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: January 2, 2018
    Assignee: Rambus Delaware LLC
    Inventors: Jeffery R Parker, Timothy A McCollum, Martin E Ligas, Joseph Crookston, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Patent number: 9778410
    Abstract: A lighting assembly includes a light guide to propagate light by total internal reflection and having a light output region on a major surface thereof. The lighting assembly also includes an optical adjuster having a major surface juxtaposed with and conforming to the light guide's major surface. The optical adjuster has a first region and a second region, the first region having a light modifying characteristic. The optical adjuster and light output region are variably positionable relative to one another to selectively apportion light emitted from the light output region between the first region and the second region. In this way, light apportioned to the first region is modified by the light modifying characteristic so that light output from the lighting assembly is modified based on relative positioning of the optical adjuster and the light guide.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: October 3, 2017
    Assignee: Rambus Delaware LLC
    Inventors: Jeffrey R. Parker, Timothy A. McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Patent number: 9707641
    Abstract: Optical elements with small increments in average density are formed in a substrate by laser micromachining using a variable aperture and a pattern mask set of pattern masks each having of shape-defining elements whose density differs among the pattern masks in first density increments. A laser light beam passes through a combined mask formed by the variable aperture and one pattern mask selected from the pattern mask set. The variable aperture controls beam size and the pattern mask spatially modulates its intensity. A focusing element focuses light from the combined mask on a small averaging region of the substrate. Different combinations of the size of the aperture mask and the selected pattern mask are used in combination at respective averaging regions of the substrate. The resulting average densities of the optical elements vary among the averaging regions in increments that are small compared to the first density increments.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 18, 2017
    Assignee: Rambus Delaware LLC
    Inventors: Timothy A McCollum, Fumitomo Hide, Ian Hardcastle
  • Patent number: 9513428
    Abstract: A lighting assembly includes a light engine and a light guide. The light engine edge lights the light guide and includes a control assembly that controls light output according to one or more parameters to produce light output from the lighting assembly with a desired characteristic. Lighting assemblies are combined to form a modular lighting assembly.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: December 6, 2016
    Assignee: Rambus Delaware LLC
    Inventors: Jeffery R Parker, Timothy A McCollum, Matthew R Wancata, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Patent number: 9477029
    Abstract: A lighting assembly includes a light guide having opposed major surfaces between which light propagates by total internal reflection, a light input edge, and two light output regions of different optical characteristics and at least one of which is associated with a corresponding one of the major surfaces. The lighting assembly also includes a light source located adjacent the light input edge. The light source and the light guide variably positionable relative to one another to vary a location on the light input edge at which the light is input to the light guide such that the light is emitted from the light guide selectively apportioned between the light output regions so that a characteristic of the light output from the lighting assembly is modified based on the optical characteristics associated with the light output regions and the relative positioning of the light source and the light guide.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: October 25, 2016
    Assignee: Rambus Delaware LLC
    Inventors: Jeffery R Parker, Timothy A McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Patent number: 9310545
    Abstract: A lighting assembly includes a light guide and light source. The light guide includes light input regions, at least one of the light input regions associated with an optical modifying characteristic, and the light guide is configured to propagate light by total internal reflection. The light source is located adjacent the light input regions. The light source and light input regions are variably positionable relative to one another to vary a location at which light is incident on the light input regions such that light emitted from the light source is selectively apportioned between the light input regions. A characteristic of the light output from the lighting assembly is modified based on the optical modifying characteristic of the at least one of the light input regions and the relative positioning of the light source and the light input regions.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: April 12, 2016
    Assignee: Rambus Delaware LLC
    Inventors: Jeffery R. Parker, Timothy A. McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Publication number: 20160018588
    Abstract: A lighting assembly includes a light engine and a light guide. The light engine edge lights the light guide and includes a control assembly that controls light output according to one or more parameters to produce light output from the lighting assembly with a desired characteristic. Lighting assemblies are combined to form a modular lighting assembly.
    Type: Application
    Filed: July 22, 2015
    Publication date: January 21, 2016
    Inventors: Jeffery R. Parker, Timothy A. McCollum, Matthew R. Wancata, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Publication number: 20150268407
    Abstract: A lighting assembly includes a light guide having a first major surface, a second major surface opposite the first major surface, a light input edge, and an end edge distal the light input edge. Light input to the light guide through the light input edge propagates by total internal reflection toward the end edge. The lighting assembly further includes light extracting elements at at least one of the major surfaces of the light guide, the light extracting elements configured to extract light through the first major surface in a direction away from the light input edge and away from the first major surface, and a banding reduction element at the end edge configured to redirect light incident thereon in a direction away from the light input edge.
    Type: Application
    Filed: March 31, 2015
    Publication date: September 24, 2015
    Inventors: Timothy A. McCollum, Jeffery R. Parker, Fumitomo Hide, Alexey Titov, Ian Hardcastle, Robert M. Ezell
  • Patent number: 9116274
    Abstract: A lighting assembly includes a light engine and a light guide. The light engine edge lights the light guide and includes a control assembly that controls light output according to one or more parameters to produce light output from the lighting assembly with a desired characteristic. Lighting assemblies are combined to form a modular lighting assembly.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: August 25, 2015
    Assignee: Rambus Delaware LLC
    Inventors: Jeffrey R Parker, Timothy A McCollum, Matthew R Wancata, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Publication number: 20150131310
    Abstract: A lighting assembly includes an edge-lit light guide and a light redirecting member. Light extracting elements at the light guide extract light from the light guide as intermediate light. Light redirecting elements at the light redirecting film are configured to redirect the intermediate light received from the light guide to illuminate a target surface in accordance with a defined illumination profile.
    Type: Application
    Filed: November 10, 2014
    Publication date: May 14, 2015
    Inventors: Timothy A. McCollum, Robert M. Ezell, Jeffery R. Parker, Kurt R. Starkey, Ian Hardcastle, Fumitomo Hide
  • Patent number: 8998478
    Abstract: A lighting assembly includes a light guide having a first major surface, a second major surface opposite the first major surface, a light input edge, and an end edge distal the light input edge. Light input to the light guide through the light input edge propagates by total internal reflection toward the end edge. The lighting assembly further includes light extracting elements at least one of the major surfaces of the light guide, the light extracting elements configured to extract light through the first major surface in a direction away from the light input edge and away from the first major surface, and a banding reduction element at the end edge configured to redirect light incident thereon in a direction away from the light input edge.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: April 7, 2015
    Assignee: Rambus Delaware LLC
    Inventors: Timothy A. McCollum, Jeffery R. Parker, Fumitomo Hide, Alexey Titov, Ian Hardcastle, Robert M. Ezell
  • Patent number: 8998452
    Abstract: A light bulb includes a base, light guide, and light source. The base is configured to mechanically mount the light bulb and receive electrical power. The light guide includes light input regions, at least one of the light input regions associated with an optical modifying characteristic, the light guide configured to propagate light by total internal reflection. The light source is located adjacent the light input regions. The light source and light input regions are variably positionable relative to one another to vary location at which light is incident on the light input regions such that light emitted from the light source is selectively apportioned between the light input regions. A characteristic of the light output from the light bulb is modified based on the optical modifying characteristic of the at least one of the light input regions and the relative positioning of the light source and light input regions.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: April 7, 2015
    Assignee: Rambus Delaware LLC
    Inventors: Jeffery R. Parker, Timothy A. McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Publication number: 20150092439
    Abstract: A lighting assembly includes a light guide having opposed major surfaces between which light propagates by total internal reflection, a light input edge, and two light output regions of different optical characteristics and at least one of which is associated with a corresponding one of the major surfaces. The lighting assembly also includes a light source located adjacent the light input edge. The light source and the light guide variably positionable relative to one another to vary a location on the light input edge at which the light is input to the light guide such that the light is emitted from the light guide selectively apportioned between the light output regions so that a characteristic of the light output from the lighting assembly is modified based on the optical characteristics associated with the light output regions and the relative positioning of the light source and the light guide.
    Type: Application
    Filed: September 15, 2014
    Publication date: April 2, 2015
    Inventors: Jeffery R. Parker, Timothy A. McCollum, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Publication number: 20150016143
    Abstract: A lighting assembly includes a light guide having opposed major surfaces between which light propagates by total internal reflection and a light input edge. The light assembly also includes a light engine. The light engine has a heat conductive armature having a receptacle for a portion of the light guide that includes the light input edge and a light source retained by and thermally coupled to the armature. The armature functions as a heat sink for dissipating heat generated by the light source. The light guide is mechanically retained in the receptacle, and the light guide and the armature cooperate to align the light input edge with the light source for inputting light from the light source into the light guide through the light input edge.
    Type: Application
    Filed: September 29, 2014
    Publication date: January 15, 2015
    Inventors: Jeffery R Parker, Timothy A McCollum, Martin E Ligas, Joseph Crookston, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Publication number: 20140369073
    Abstract: A lighting assembly includes a light engine and a light guide. The light engine edge lights the light guide and includes a control assembly that controls light output according to one or more parameters to produce light output from the lighting assembly with a desired characteristic. Lighting assemblies are combined to form a modular lighting assembly.
    Type: Application
    Filed: July 8, 2014
    Publication date: December 18, 2014
    Inventors: Jeffery R. Parker, Timothy A. McCollum, Matthew R. Wancata, Fumitomo Hide, Alexey Titov, Ian Hardcastle
  • Patent number: 8899813
    Abstract: A lighting assembly includes an edge-lit light guide and a light redirecting member. Light extracting elements at the light guide extract light from the light guide as intermediate light. Light redirecting elements at the light redirecting film are configured to redirect the intermediate light received from the light guide to illuminate a target surface in accordance with a defined illumination profile.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: December 2, 2014
    Assignee: Rambus Delaware LLC
    Inventors: Timothy A. McCollum, Robert M. Ezell, Jeffery R. Parker, Kurt R. Starkey, Ian Hardcastle, Fumitomo Hide