Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

Abstract: A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.

Abstract: The invention relates to hulls for planing or semi-planing water craft. The hull (4) has an abruptly down-swept trailing edge portion (18) which, in the preferred embodiment, is in the form of a flap extending across the full width of the transom of the hull and which projects beyond the level of an upswept portion of the underside (14) of the hull by only a small fraction of the length (L) of the hull. According to another aspect of the invention, a hull (4) having a lightly cambered nose portion (5, 10, 12) is also described and claimed. The claimed hulls offer higher lift coefficients and lift/drag ratios than conventional planing hulls, and can operate at zero angle of attack at design speed.

Abstract: The solid component comprises a finely divided component, preferably a sensitiser, and a specific polymeric component, whereby the solid component has a tressed Heubach Index of less than 1000. The solid component is preferably present in the detergent composition, preferably in a granular composition, a tablet or bar.

Abstract: A wireless communication device coupled to a wave antenna that provides greater increased durability and impedance matching. The wave antenna is a conductor that is bent in alternating sections to form peaks and valleys. The wireless communication device is coupled to the wave antenna to provide wireless communication with other communication devices, such as an interrogation reader. The wireless communication device and wave antenna may be placed on objects, goods, or other articles of manufacture that are subject to forces such that the wave antenna may be stretched or compressed during the manufacture and/or use of such object, good or article of manufacture. The wave antenna, because of its bent structure, is capable of stretching and compressing more easily than other structures, reducing the wireless communication device's susceptibility to damage or breaks that might render the wireless communication device coupled to the wave antenna unable to properly communicate information wirelessly.

Abstract: A pedicle attachment assembly includes a pedicle attachment device having a head. A polyaxial housing has a through bore comprising a base portion and two posts upstanding from the base portion, the posts defining therebetween a slot for receiving a rod. A saddle-shaped element is disposable in the slot and has a part cylindrical recess in an upper surface for engagement in use with the rod. The saddle-shaped element has a convex lower portion for engagement in a complimentary concave recess in an upper surface of the head of the attachment device. The lower surface of the head of the attachment device and the lower end of the through bore in the housing have complementary part spherical surfaces for engagement with one another. A cap assembly is provided for clamping the rod in the housing.

Abstract: A condenser assembly for a vehicle air conditioning system. The condenser assembly includes a core comprised of a plurality of parallel tubes between which are located a plurality of fins. A pair of headers are located on opposite ends and in fluid communication with the tubes of the core. The headers are constructed such that their primary components exhibit constant cross sectional profiles along their lengths. This enables the volumetrics of the condenser assembly to be altered with a minimal amount of tooling change over being required.

Abstract: There is described a device for indicating whether a conductive element has an electrical resistance equal to or less than a predetermined value or whether the conductive element is reliably connected to earth reference potential by a resistance equal to or less than a predetermined value. The device commonly takes the form of a grounding clamp (1) for connecting said device to the conductive element, the clamp (1) conveniently taking the form of a pair of spring loaded jaws (2, 3).

Abstract: There is disclosed lighting apparatus suitable for being positioned adjacent to an area or an object for indicating the location or orientation of the area or object. The apparatus is provided with a set of light emitters for emitting light and which are positioned side by side relative to one another. The light emitters are staggered for emitting the light outwardly from the apparatus at an increasing angle along the set relative to a plane of reference. In a particularly preferred embodiment, the light emitters are light emitting, diodes. The apparatus finds particular application as an airstrip light for indicating the position and orientation of the airstrip to approaching aircraft. Signalling apparatus for being positioned adjacent to an area for indicating the position of the area and which are provided with infrared emitting diodes for emitting an infrared signal are also described.

Abstract: A wireless communication device coupled to a wave antenna that provides greater increased durability and impedance matching. The wave antenna is a conductor that is bent in alternating sections to form peaks and valleys. The wireless communication device is coupled to the wave antenna to provide wireless communication with other communication devices, such as an interrogation reader. The wireless communication device and wave antenna may be placed on objects, goods, or other articles of manufacture that are subject to forces such that the wave antenna may be stretched or compressed during the manufacture and/or use of such object, good or article of manufacture. The wave antenna, because of its bent structure, is capable of stretching and compressing more easily than other structures, reducing the wireless communication device's susceptibility to damage or breaks that might render the wireless communication device coupled to the wave antenna unable to properly communicate information wirelessly.

Abstract: 1,2,4-triazolo[4,3-b]pyridazine derivatives, possessing a fluoro-substituted phenyl ring at the 3-position and a heteroaryl-alkoxy moiety at the 6-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, are useful in the treatment of anxiety and convulsions.

Abstract: A wireless communication device coupled to a wave antenna that provides greater increased durability and impedance matching. The wave antenna is a conductor that is curved in alternating sections. The wireless communication device is coupled to the wave antenna to provide wireless communication. The wireless communication device and wave antenna may be placed on objects, goods, or other articles of manufacture that are subject to forces such that the wave antenna may be stretched or compressed during the manufacture and/or use of such object, good or article of manufacture. The wave antenna, because of its curved structure, is capable of stretching and compressing more easily than other structures, reducing the wireless communication device's susceptibility to damage or breakage that might render the wireless communication device coupled to the wave antenna unable to properly communicate information wirelessly.

Abstract: A wireless communication device coupled to a wave antenna that provides greater increased durability and impedance matching. The wave antenna is a conductor that is bent in alternating sections to form peaks and valleys. The wireless communication device is coupled to the wave antenna to provide wireless communication with other communication devices, such as an interrogation reader. The wireless communication device and wave antenna may be placed on objects, goods, or other articles of manufacture that are subject to forces such that the wave antenna may be stretched or compressed during the manufacture and/or use of such object, good or article of manufacture. The wave antenna, because of its bent structure, is capable of stretching and compressing more easily than other structures, reducing the wireless communication device's susceptibility to damage or breaks that might render the wireless communication device coupled to the wave antenna unable to properly communicate information wirelessly.

Abstract: A class of substituted or 6,7-ring fused 1,2,3-triazolo[4,5-b]pyridine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

Abstract: Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

Abstract: A class of substituted and/or ring-fused pyrazolo[3,4-b]pyridine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent on the pyrazole nitrogen atom adjacent the pyridine nucleus, and an optionally substituted cycloalkyl-alkoxy, aryl-alkoxy or heteroaryl-alkoxy substituent on the carbon atom adjacent the pyridine ring nitrogen atom, are selective ligands for GABAA receptors, in particular having high affinity for the &bgr;2 and/or &bgr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse neurological disorders, including anxiety and convulsions.

Abstract: A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-&agr;]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or ◯subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

Abstract: The heat treatment of an age-hardenable aluminium alloy, having alloying elements in solid solution includes the stages of holding the alloy for a relatively short time at an elevated temperature TA appropriate for ageing the alloy; cooling the alloy from the temperature TA at a sufficiently rapid rate and to a lower temperature so that primary precipitation of solute elements is substantially arrested; holding the alloy at a temperature TB for a time sufficient to achieve a suitable level of secondary nucleation or continuing precipitation of solute elements; and heating the alloy to a temperature which is at, sufficiently close to, or higher than temperature TA and holding for a further sufficient period of time at temperature TC for achieving substantially maximum strength.