Abstract: A ball bat includes a barrel in which one or more stiffening elements or damping elements, or both, are located. The stiffening or damping elements may be positioned at a variety of locations, and may have a variety of configurations, for selectively reducing the barrel's performance without appreciably increasing the bat's moment of inertia.

Abstract: The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R9, X, m and n are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating kappa opioid (?-opioid) associated disorders including, e.g., a neurological disorder, or psychiatric disorder such as a neurocognitive disorder, substance abuse disorder, depressive disorder, anxiety disorder, trauma and stressor related disorder and feeding and eating disorder.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Abstract: A ball bat includes a barrel in which one or more stiffening elements are located. The stiffening element may be positioned at a variety of locations, and may have a variety of configurations, for selectively limiting the barrel's performance without appreciably increasing the bat's moment of inertia. In one configuration, the stiffening element includes two radially outer flanges, a radially inner flange, and two web members connecting the outer flanges to the inner flange. The radially outer surfaces of the radially outer flanges contact, and may be affixed to, the inner surface of the barrel wall.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: A sporting-good implement, such as a ball bat or a lacrosse stick, includes a first handle section rotatably connected to a second handle section. The second handle section may be attached to or integral with a tapered region or barrel region of a ball bat, or with a shaft section or head of a lacrosse stick, or with another sporting-good feature. This rotatable engagement allows the relative position of the user's hands to change during the course of a swing, shot, or pass, ideally placing the user's hands in a position to generate improved power or control.

Abstract: An end-cap assembly for a ball bat or other sporting-good implement includes one or more removable weights, so that the weight of the end cap—and of the ball bat—may be adjusted. The one or more weights may reside in a receiving space or recess in an end-cap cup of the end-cap assembly. A fastener removably attaches the one or more weights to the end-cap cup. In some embodiments, the fastener may include threads that engage threads in a bore in the end-cap cup.

Abstract: The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof, having the structure: or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer or diastereomer thereof, as set forth in the Description. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Abstract: A sporting-good implement, such as a ball bat or a lacrosse stick, includes a first handle section rotatably connected to a second handle section. The second handle section may be attached to or integral with a tapered region or barrel region of a ball bat, or with a shaft section or head of a lacrosse stick, or with another sporting-good feature. This rotatable engagement allows the relative position of the user's hands to change during the course of a swing, shot, or pass, ideally placing the user's hands in a position to generate improved power or control.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Abstract: A ball bat includes a barrel section welded, adhered, or mechanically affixed to a handle section at a joint positioned in a taper region of the bat. The joint may alternatively be positioned in other regions, such as in the barrel region or the handle region. The barrel section may include a different metal alloy than the handle section. For example, the barrel section may include 6061 aluminum alloy and the handle section may include 7050 aluminum alloy. In some embodiments, the welded joint may be formed from a spin-welding process. The bat provides a strong handle in combination with a barrel that meets BBCOR or other performance requirements.

Abstract: A sleeve or grip for use on a ball bat or other sporting-good implement includes a low-friction inner surface and a longitudinal slit that facilitates its positioning on, and removal from, a handle of the implement. The grip is rotatable about the handle so that a user's hand may move into an optimal position during a swing. The grip may be readily removable from the implement so that, after a swing, it stays with the user, as opposed to remaining on the implement.

Abstract: A ball bat includes a barrel in which one or more stiffening elements are located. The stiffening element may be positioned at a variety of locations, and may have a variety of configurations, for selectively limiting the barrel's performance without appreciably increasing the bat's moment of inertia. In one configuration, the stiffening element includes two radially outer flanges, a radially inner flange, and two web members connecting the outer flanges to the inner flange. The radially outer surfaces of the radially outer flanges contact, and may be affixed to, the inner surface of the barrel wall.

Abstract: A sleeve or grip for use on a ball bat or other sporting-good implement includes a low-friction inner surface and a longitudinal slit that facilitates its positioning on, and removal from, a handle of the implement. The grip is rotatable about the handle so that a user's hand may move into an optimal position during a swing. The grip may be readily removable from the implement so that, after a swing, it stays with the user, as opposed to remaining on the implement.

Abstract: A ball bat includes a barrel having one or more slats. The slats may be separated from one another by one or more apertures, cuts, or gaps. The slats may be oriented substantially parallel, substantially transverse, or substantially diagonal to a longitudinal axis of the barrel. The slatted arrangement enhances the BBCOR of the barrel. An external damping sleeve or an internal reinforcing core may be included in the barrel to limit the barrel's BBCOR to meet given regulatory standards.

Abstract: A ball bat includes a barrel in which one or more stiffening elements are located. The stiffening element may be positioned at a variety of locations, and may have a variety of configurations, for selectively limiting the barrel's performance without appreciably increasing the bat's moment of inertia. In one configuration, the stiffening element includes two radially outer flanges, a radially inner flange, and two web members connecting the outer flanges to the inner flange. The radially outer surfaces of the radially outer flanges contact, and may be affixed to, the inner surface of the barrel wall.

Abstract: A sporting-good implement, such as a ball bat or a lacrosse stick, includes a first handle section rotatably connected to a second handle section. The second handle section may be attached to or integral with a tapered region or barrel region of a ball bat, or with a shaft section or head of a lacrosse stick, or with another sporting-good feature. This rotatable engagement allows the relative position of the user's hands to change during the course of a swing, shot, or pass, ideally placing the user's hands in a position to generate improved power or control.

Abstract: A sleeve or grip for use on a ball bat or other sporting-good implement includes a low-friction inner surface and a longitudinal slit that facilitates its positioning on, and removal from, a handle of the implement. The grip is rotatable about the handle so that a user's hand may move into an optimal position during a swing. The grip may be readily removable from the implement so that, after a swing, it stays with the user, as opposed to remaining on the implement.

Abstract: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.