Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Abstract: A ball bat includes outer shell segments longitudinally spaced apart from each other to form a gap between them. A joint connects the segments. A first outer shell segment may include a barrel portion of the ball bat and at least part of a tapered portion of the ball bat. A second outer shell segment may include at least part of the tapered portion. The joint may include a tubular element having a first portion positioned within the first outer shell segment and at least partially overlapping an interior surface of the first outer shell segment, and a second portion positioned within the second outer shell segment and at least partially overlapping an interior surface of the second outer shell segment. The tubular element may include an elastomeric material. In some embodiments, the joint may be formed by an elastomeric material connecting the outer shell segments in the gap.

Abstract: A method of making a ball bat may include forming a bat frame with a handle and an inner barrel structure, providing spacer elements extending radially outwardly from the inner barrel structure, and forming a barrel shell having a main barrel and a tapered section. An inner diameter in the tapered section may be equal to an outer diameter of a first one of the spacer elements. The method may include mechanically locking the barrel shell to the bat frame by passing the handle through the barrel shell and moving the barrel shell toward the inner barrel structure until the barrel shell contacts the first one of the spacer elements. A gap is maintained between an outer diameter of the inner barrel structure and the barrel shell. The barrel shell may deflect during a hit to create a trampoline effect, while the inner barrel structure limits the deflection.

Abstract: An end-cap assembly for a ball bat or other sporting-good implement includes one or more removable weights, so that the weight of the end cap—and of the ball bat—may be adjusted. The one or more weights may reside in a receiving space or recess in an end-cap cup of the end-cap assembly. A fastener removably attaches the one or more weights to the end-cap cup. In some embodiments, the fastener may include threads that engage threads in a bore in the end-cap cup.

Abstract: A ball bat may include a barrel wall formed at least in part by a plurality of concentric first composite laminate layers and a plurality of second composite laminate layers oriented transverse to the first composite laminate layers. In some embodiments, a ball bat may include composite material with a plurality of fibers oriented along a direction transverse to the longitudinal axis of the bat.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Abstract: An end-cap assembly for a ball bat or other sporting-good implement includes one or more removable weights, so that the weight of the end cap—and of the ball bat—may be adjusted. The one or more weights may reside in a receiving space or recess in an end-cap cup of the end-cap assembly. A fastener removably attaches the one or more weights to the end-cap cup. In some embodiments, the fastener may include threads that engage threads in a bore in the end-cap cup.

Abstract: A ball bat includes outer shell segments longitudinally spaced apart from each other to form a gap between them. A joint connects the segments. A first outer shell segment may include a barrel portion of the ball bat and at least part of a tapered portion of the ball bat. A second outer shell segment may include at least part of the tapered portion. The joint may include a tubular element having a first portion positioned within the first outer shell segment and at least partially overlapping an interior surface of the first outer shell segment, and a second portion positioned within the second outer shell segment and at least partially overlapping an interior surface of the second outer shell segment. The tubular element may include an elastomeric material. In some embodiments, the joint may be formed by an elastomeric material connecting the outer shell segments in the gap.

Abstract: A ball bat includes a first bat portion (such as a barrel portion) and a second bat portion (such as a handle). The portions may be spaced apart along the bat's longitudinal axis. A joint connects the first and second bat portions. The joint may be positioned at or near, or centered about, a location of maximum vibration, such as an antinode of the bat. The joint may include a filler material (such as an elastomeric material) at least partially surrounding a rod element. The filler material and the rod element may span a gap between the first and second bat portions. The filler material and the rod element may extend into the first bat portion or the second bat portion. A cover material may be positioned around the filler material. The joint may form a structural link between the bat portions and it may be configured to absorb vibration.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating MAGL-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, Alzheimer's disease, a metabolic disorder, stroke, or cancer.

Abstract: A ball bat includes a first bat portion (such as a barrel portion) and a second bat portion (such as a handle). The portions may be spaced apart along the bat's longitudinal axis. A joint connects the first and second bat portions. The joint may be positioned at or near, or centered about, a location of maximum vibration, such as an antinode of the bat. The joint may include a filler material (such as an elastomeric material) at least partially surrounding a rod element. The filler material and the rod element may span a gap between the first and second bat portions. The filler material and the rod element may extend into the first bat portion or the second bat portion. A cover material may be positioned around the filler material. The joint may form a structural link between the bat portions and it may be configured to absorb vibration.

Abstract: A method of making a ball bat may include forming a bat frame with a handle and an inner barrel structure, providing spacer elements extending radially outwardly from the inner barrel structure, and forming a barrel shell having a main barrel and a tapered section. An inner diameter in the tapered section may be equal to an outer diameter of a first one of the spacer elements. The method may include mechanically locking the barrel shell to the bat frame by passing the handle through the barrel shell and moving the barrel shell toward the inner barrel structure until the barrel shell contacts the first one of the spacer elements. A gap is maintained between an outer diameter of the inner barrel structure and the barrel shell. The barrel shell may deflect during a hit to create a trampoline effect, while the inner barrel structure limits the deflection.

Abstract: The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R9, X, m and n are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating kappa opioid (?-opioid) associated disorders including, e.g., a neurological disorder, or psychiatric disorder such as a neurocognitive disorder, substance abuse disorder, depressive disorder, anxiety disorder, trauma and stressor related disorder and feeding and eating disorder.

Abstract: A ball bat includes a first bat portion (such as a barrel portion) and a second bat portion (such as a handle). The portions may be spaced apart along the bat's longitudinal axis. A joint connects the first and second bat portions. The joint may be positioned at or near, or centered about, a location of maximum vibration, such as an antinode of the bat. The joint may include a filler material (such as an elastomeric material) at least partially surrounding a rod element. The filler material and the rod element may span a gap between the first and second bat portions. The filler material and the rod element may extend into the first bat portion or the second bat portion. A cover material may be positioned around the filler material. The joint may form a structural link between the bat portions and it may be configured to absorb vibration.

Abstract: A method of making a ball bat may include forming a bat frame with a handle and an inner barrel structure, providing spacer elements extending radially outwardly from the inner barrel structure, and forming a barrel shell having a main barrel and a tapered section. An inner diameter in the tapered section may be equal to an outer diameter of a first one of the spacer elements. The method may include mechanically locking the barrel shell to the bat frame by passing the handle through the barrel shell and moving the barrel shell toward the inner barrel structure until the barrel shell contacts the first one of the spacer elements. A gap is maintained between an outer diameter of the inner barrel structure and the barrel shell. The barrel shell may deflect during a hit to create a trampoline effect, while the inner barrel structure limits the deflection.

Abstract: A barrel of a ball bat may include a composite laminate with a plurality of composite plies. One or more translaminar elements may pass through the composite plies and around a circumference of the barrel to reduce relative movement between the plies. The translaminar elements may include a first line of stitching, which may include aramid fiber. In some embodiments, the first line of stitching forms two or more coils around the barrel. Lines of stitching may be positioned on opposing sides of a center of percussion of the ball bat. In some embodiments, the translaminar elements may include a line of staples distributed around the circumference of the barrel. A method of making a ball bat may include arranging plies of composite material to form a cylinder, passing a first translaminar element through the plies, and curing the assembly of plies to form a barrel of the ball bat.

Abstract: A ball bat includes a barrel wall with a composite laminate structure that includes an outwardly facing skin, an inwardly facing skin, a stack of composite laminate plies positioned between the outwardly facing skin and the inwardly facing skin, and a discontinuity in the stack forming a gap along a longitudinal axis of the bat. A rigid or semi-rigid appliance may be positioned in the gap. The appliance may be a ring element, which may have a cross-section that traverses the composite laminate plies in the stack in a direction that is perpendicular or oblique to the longitudinal axis of the bat. The cross-section of the ring element may be triangular. A second ring element may be positioned in the barrel wall. The second ring element may be connected to the other ring element with an adhesive bond or a connecting element.

Abstract: Representative embodiments of the present technology may include a ball bat with a handle, a barrel attached to or continuous with the handle along a longitudinal axis of the bat, and a reduced-durability region positioned in the barrel. The reduced-durability region may include two adjacent stacks of composite laminate plies, wherein the stacks are spaced apart from each other along the longitudinal axis to form a first gap therebetween. A separation ply may be positioned in the first gap between the stacks. The separation ply may include a non-woven mat material. At least one cap ply element may be positioned around an end of one of the stacks. In some embodiments, an axis of the first gap is oriented at an oblique angle relative to the longitudinal axis of the bat.

Abstract: A sleeve or grip for use on a ball bat or other sporting-good implement includes a low-friction inner surface and a longitudinal slit that facilitates its positioning on, and removal from, a handle of the implement. The grip is rotatable about the handle so that a user's hand may move into an optimal position during a swing. The grip may be readily removable from the implement so that, after a swing, it stays with the user, as opposed to remaining on the implement.

Abstract: A sporting-good implement, such as a ball bat or a lacrosse stick, includes a first handle section rotatably connected to a second handle section. The second handle section may be attached to or integral with a tapered region or barrel region of a ball bat, or with a shaft section or head of a lacrosse stick, or with another sporting-good feature. This rotatable engagement allows the relative position of the user's hands to change during the course of a swing, shot, or pass, ideally placing the user's hands in a position to generate improved power or control.