Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: A spool winding assembly for winding a composite strip onto a spool having a hub is disclosed. The strip includes an elongate plastic strip having a flat base portion and a plurality of laterally spaced apart lengthwise extending rib portions upstanding from the base portion; and a plurality of elongate reinforcing members extending lengthwise within respective rib portions, the rib portions and the reinforcing members forming composite ribs. The assembly includes: a main frame, a spool holder for rotatably supporting the spool relative to the main frame, a spool drive unit for driving the spool with respect to the main frame, a carriage mounted for lateral movement with respect to the spool, a bender mounted to the carriage for receiving the strip as it is fed towards the hub of the spool and for deforming the strip to give it a curved base portion, and a bender drive unit operably connected to the bender for driving the strip through the bender.

Abstract: The invention relates to methods for producing endothelial cells, pericytes and/or muscle cells (in particular smooth muscle cells), cell preparations and pharmaceutical compositions comprising the cells or preparations, and the use of the cells, preparations and compositions in research or commercial applications. In aspects, the invention provides a method of treating a patient with a condition involving endothelial cells, endothelial precursor cells, pericytes and/or muscle cells, such as a peripheral vascular disease, comprising administering to the patient endothelial precursor cells, endothelial cells, pericytes and/or muscle cells obtained from multipotent CD45+HLA-ABC+Lin? cells.

Abstract: A user interface and associated computer readable medium for a user interface within a media management application. In one aspect, the user interface comprises a plurality of panes displaying a list of one or more media file sources, a list of user selectable media file identifiers, selected information associated with the listed media file identifiers, instructional information as to how a user can cause one of the panes to display selected information associated with the listed media file identifiers and a media player control interface. In one aspect, the user interface comprises panes displaying an instant messaging platform as a media file source and a list of indicia representing messaging users that a user communicates with. In another aspect, selecting the indicia representing a messaging user can cause a pane to display information associated with media files found in a media library of the selected messaging user.

Abstract: A method, system, and media management application for providing a user access to a media file from multiple locations on a network. In one aspect, a user communicates a desire to access a media file at a future time and is able to access the bookmarked media file from various locations on a network at any future time. In one aspect, the media file is available from multiple locations on the network and in different media formats.

Abstract: A media management system for managing a user's media files and information related to such media files and a method of the same. In one aspect, the system and method are operable on a user's computing device. In one aspect, the system comprises a storage management component, a server communication component, a media player component, an instant messaging component, and a media engine component. In one aspect, the method allows a user to browse and/or exchange media files with other users via a network using an instant messaging component.

Abstract: The invention relates to cellular compositions comprising hematopoietic cells with the potential or increased potential to form non-hematopoietic cells; methods for producing such cellular compositions; methods for differentiation of cells of cellular compositions of the invention into cells that exhibit morphological, physiological, functional, and/or immunological features of non-hematopoietic cells; and uses of the cellular compositions. The invention also relates to a method for the expansion of hematopoietic stem and progenitor cells.

Abstract: A method and a computer readable medium for searching for media items from a network of users using a media management application and an instant messenger platform and a system for handling searches such searches. In one aspect, the method comprises receiving from a user having a group of messenger friends, a search request for a media item, identifying other users of the instant messaging service to form a list of candidate users, searching media items associated with each candidate user to develop a search result that fulfills the search request, and returning to the searching user the search result comprising information identifying which candidate user is associated with a media item source that can act as a source of a media item identified in the search result.

Abstract: The invention relates to the dispensing of wipes (10), in which the wipe dispenser applies information to the wipe at the time of dispensing. The information can also be stored, so as to allow wipes to be controlled. When a wipe is disposed of, the information can be read from it, and by comparing this with the stored information it is possible to ascertain if any dispensed wipes have not yet been disposed of. If the information identifies the time of dispensation (14a, 14b), the operator (12) and/or the number or length of wipes dispersed (16), then the location of missing wipes is facilitated.

Abstract: The invention relates to cellular compositions comprising hematopoietic cells with the potential or increased potential to form non-hematopoietic cells; methods for producing such cellular compositions; methods for differentiation of cells of cellular compositions of the invention into cells that exhibit morphological, physiological, functional, and/or immunological features of non-hematopoietic cells; and uses of the cellular compositions. The invention also relates to a method for the expansion of hematopoietic stem and progenitor cells.

Abstract: This invention relates to compounds of formula (I)

Abstract: This invention relates to compounds of formula (I)

Abstract: This invention relates to compounds of formula (I).

Abstract: Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substituted by CN), or Het; R3 represents OH, CN, Het, —R4—C1-6alkyl, or CONR5R6; R4 represents —CO2—, or —O—; R5 and R6 independently represent H, C1-6alkyl (optionally substituted by OR7) or C3-8cycloalkyl; R7 represents H or C1-6alkyl; Het represents a five or six membered aromatic heterocyclic group containing (i) from one to four nitrogen heteroatom(s) or (ii) one or two nitrogen heteroatom(s) and one oxygen or one sulphur heteroatom or (iii) one or two oxygen or sulphur heteroatom(s), said heterocyclic group being optionally substituted by one or more groups selected from CN and C1-6alkyl; R8 represents C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; and R9 and R10 independently represent H, C1-6alkyl, C1-6alkyloxy, CN, CF3 or halo; may be useful for treati

Abstract: Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6-alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substituted by CN), or Het; R3 represents OH, CN, Het, —R4—C1-6alkyl, or CONR5R6; R4 represents —CO2—, or —O—; R5 and R6 independently represent H, C1-6alkyl (optionally substituted by OR7) or C3-8cycloalkyl; R7 represents H or C1-6alkyl; Het represents a five or six membered aromatic heterocyclic group containing (i) from one to four nitrogen heteroatom(s) or (ii) one or two nitrogen heteroatom(s) and one oxygen or one sulphur heteroatom or (iii)one or two oxygen or sulphur heteroatom(s), said heterocyclic group being optionally substituted by one or more groups selected from CN and C1-6alkyl; R8 represents C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R9 and R10 independently represent H, C1-6alkyl, C1-6alkyloxy, CN, CF3 or halo; may be useful for treating e

Abstract: An apparatus and method for lining an underground conduit is disclosed. The apparatus 10 comprises: an annular frame 40 having a crown portion 42 and a base portion 49; a strip guide disposed around and supported by the annular frame 40, the guide arranged to guide a strip 12 around a helical path; a pair of strip pinch rollers mounted to the frame 40 at a position circumferentially about halfway between the crown portion 42 and the base portion 49; a drive assembly mounted to the frame for driving the strip 12 downwards into the helical path in a winding direction so as to present an incoming first edge to an adjacent second edge of a wound convolution of the strip; a liquid remover mounted to the frame, the liquid remover arranged to prevent liquid that has adhered to and ascended with the second edge from descending down towards the incoming first edge; and an extruder 80 mounted to the frame 40 for extruding a molten bead of plastic onto the strip 12 at a position just before said overlap.

Abstract: This invention relates to compounds of formula (I).

Abstract: An apparatus and method for lining an underground conduit is disclosed. The apparatus 10 comprises: an annular frame 40 having a crown portion 42 and a base portion 49; a strip guide disposed around and supported by the annular frame 40, the guide arranged to guide a strip 12 around a helical path; a pair of strip pinch rollers mounted to the frame 40 at a position circumferentially about halfway between the crown portion 42 and the base portion 49; a drive assembly mounted to the frame for driving the strip 12 downwards into the helical path in a winding direction so as to present an incoming first edge to an adjacent second edge of a wound convolution of the strip; a liquid remover mounted to the frame, the liquid remover arranged to prevent liquid that has adhered to and ascended with the second edge from descending down towards the incoming first edge; and an extruder 80 mounted to the frame 40 for extruding a molten bead of plastic onto the strip 12 at a position just before said overlap.

Abstract: The present invention provides a compound of the Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of Formula (I).