Abstract: A system identifies an ordered data structure that enables a computer to follow a particular order of execution for solving blocks of equations that collectively constitute a simulation model. The system uses the ordered data structure to identify a subset of the blocks of equations that require optimizing by an optimizer program and/or a remaining set of blocks of equations which can be solved without optimization by the optimizer program. The optimizer program optimizes only the subset of the blocks of equations that require optimizing by the optimizer program, thereby reducing an amount of computer resources required for optimization, by varying any blocks of equations declared as independent variables in an iterative process until the optimizer program generates optimized values that converge on a solution. Using the optimized values, a solver program executes each calculation only once when sequentially solving the remaining set of the blocks of equations.

Abstract: A method for registering one or more Greenfield devices via a virtual Internet of Things Universal Identifier (IoT UID) is provided. The method includes identifying one or more Brownfield devices, generating device property data based at least in part on the one or more Brownfield devices, and transmitting, to an IoT device registrar server, a registration request that includes the device property data. The method further includes interpreting one or more IoT UIDs generated in response to the transmitting of the registration request.

Abstract: An apparatus for an Internet of Things device registry display includes a user input processing circuit structured to interpret one or more user input command values, an Internet of Things Universal Identification (IoT UID) identification circuit structured to determine one or more IoT UIDs, based at least in part on the one or more user input command values, a device lookup circuit structured to: generate a query that includes the one or more IoT UIDs, and retrieve device property data corresponding to the one or more IoT UIDs, a query provisioning circuit structured to transmit the query to an IoT device registrar server, a device property processing circuit structured to interpret the device property data generated by the IoT device registrar server in response to the query, and a display circuit structured to display the device property data with the corresponding one or more IoT UIDs.

Abstract: The present invention relates to an anti-transglutaminase type 2 antibody that blocks transamidase activity of the enzyme for use in the treatment of progressive chronic interstitial lung disease, such as Idiopathic pulmonary fibrosis (IPF).

Abstract: The invention relates to methods of synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.

Abstract: The invention relates to methods of synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.

Abstract: Described herein is a beverage system that is configured to produce beverages having different characteristics, such as different levels of carbonation including producing substantially non-carbonated beverages and carbonated beverages with a single machine. The beverage system includes a beverage appliance and a beverage container. The beverage container includes a beverage material, which can include a flavoring ingredient for a target beverage. The beverage appliance is used to access the beverage material from the beverage container and produce the target beverage. The beverage appliance and beverage container are adaptable to produce the target beverage having any of a range of carbonation levels or other characteristics.

Abstract: Receive a first electronics control unit (ECU) profile, the first ECU profile comprising a first set of services. Switch execution, on an ECU, by a processing device, to the first ECU profile from a second ECU profile, the second ECU profile comprising a second set of services, wherein an intersection of the first set of services and the second set of services comprises a third set of services. Start, on the ECU, a set of services included in the first ECU profile and not included in the third set of services.

Abstract: The present disclosure relates generally to methods for the preparation of Compound (I).

Abstract: Disclosed herein are novel formulations containing relacorilant ((R)-(1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone) that are suitable for administration, including oral administration, to patients suffering from disorders amenable to treatment by glucocorticoid receptor modulators (GRMs). Single unit dosage forms comprise softgel capsules containing these formulations. Such softgel capsules may contain, e.g., relacorilant formulations containing 25 milligrams (mg), 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg, or other amounts of relacorilant. These novel formulations and single unit dosage forms may be used to treat diseases and disorders including Cushing's syndrome, Cushing's Disease, and other disorders.

Abstract: At a data management service, a child template associated with a parent group of one or more cells of a first data sheet is stored. In response to detecting that a parent cell has been added to the parent group, a particular child data sheet is instantiated automatically in accordance with the template. In response to a change to a value in a first cell of the child data sheet, a corresponding value of a cell of the first data sheet is modified.

Abstract: Based on an analysis of example content items, a proposed initial version of an application to be generated on behalf of a client is determined. At least a portion of a software program implementing the application is generated, and an indication of the software program is provided to the client. Based on input received from the client, additional operations associated with the program are initiated.

Abstract: In a cartridge device for analyzing a body liquid, a first member of the cartridge has two or more wells for performing assays, and a second member of the cartridge has a compartment for holding one or more disposable pipette tips.

Abstract: Systems, methods and containers for forming a beverage. A container includes a closure arranged with a movable element that is movable to pierce a membrane and permit beverage material in the container to exit. The movable element can include a piercing element that pierces the membrane. Gas can be introduced into the container to force beverage material to exit the container. A gas inlet port can be provided with the closure and arranged to mate with a gas source of a beverage machine.

Abstract: There is disclosed a pole support for removably supporting a hollow tubular pole, wherein the pole has a latching recess provided along its length. The pole support includes a housing defining a socket that is open at its operative upper end for receiving the pole. A latch is located within the socket and is mounted on a pivot to be pivotally movable between a latched position and an unlatched position. The latch has a latching arm extending on one side of the pivot and a ballast arm extending on an opposed side of the pivot, wherein a centre-of-weight of the latch is located off-centre from the pivot in the ballast arm so that ballast arm normally biases latch under gravity into its latched position.

Abstract: Disclosed herein are novel formulations containing relacorilant ((R)-(1-(4-fluorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone) that are suitable for administration, including oral administration, to patients suffering from disorders amenable to treatment by glucocorticoid receptor modulators (GRMs). Single unit dosage forms comprise softgel capsules containing these formulations. Such softgel capsules may contain, e.g., relacorilant formulations containing 25 milligrams (mg), 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg, or other amounts of relacorilant. These novel formulations and single unit dosage forms may be used to treat diseases and disorders including Cushing's syndrome, Cushing's Disease, and other disorders.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: A multifunctional thermal exposure indicator can provide immediate reversible indications of overtemperature as well as irreversible indications of excessive thermal loading. Additionally, the multifunctional thermal exposure indicator can provide semi-reversible indications of undertemperature thermal loading, such as exposure to temperatures below the freezing point of water.

Abstract: In a cartridge device for analyzing a body liquid, a first member of the cartridge has two or more wells for performing assays, and a second member of the cartridge has a compartment for holding one or more disposable pipette tips.