Abstract: A gaming machine includes at least one sound-generating display device. The sound-generating display device is configured to not only display information such as game information, but to generate sound. In one embodiment one or more transducers are mounted to a back or rear portion of a video display and cause one or more portions of the video display, such as a front panel thereof, to move, thus generating sound. The one or more transducers are controlled to generate sound, including to generate sound which has sound which is perceived to emanate from particular areas of the video display.

Abstract: Disclosed herein are novel formulations containing relacorilant ((R)-(1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone) that are suitable for administration, including oral administration, to patients suffering from disorders amenable to treatment by glucocorticoid receptor modulators (GRMs). Single unit dosage forms comprise softgel capsules containing these formulations. Such softgel capsules may contain, e.g., relacorilant formulations containing 25 milligrams (mg), 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg, or other amounts of relacorilant. These novel formulations and single unit dosage forms may be used to treat diseases and disorders including Cushing's syndrome, Cushing's Disease, and other disorders.

Abstract: A hinge has a door interface comprising a serrated surface and an oversized hole, a bolt at least partially extending into the oversized hole, and a washer disposed on the bolt and captured between the door interface and a head of the bolt, the washer comprising a serrated surface facing toward the serrated surface of the door interface. The oversized hole has a diameter selected to allow significant radial movement of the bolt within the oversized hole.

Abstract: Described herein is a beverage system that is configured to produce beverages having different characteristics, such as different levels of carbonation including producing substantially non-carbonated beverages and carbonated beverages with a single machine. The beverage system includes a beverage appliance and a beverage container. The beverage container includes a beverage material, which can include a flavoring ingredient for a target beverage. The beverage appliance is used to access the beverage material from the beverage container and produce the target beverage. The beverage appliance and beverage container are adaptable to produce the target beverage having any of a range of carbonation levels or other characteristics.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)—N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Abstract: A computer system receives a request to instantiate a virtual machine (VM) in a first target cloud and a second target cloud. The target clouds operate with different configuration parameters. The system modifies a generic VM disk image that is not formatted for the first or second target cloud to create a cloud-formatted VM disk image for the first target cloud and a cloud-formatted VM disk image for the second target cloud. The first target cloud cloud-formatted VM disk image is based on the first target cloud configuration parameters, and the second target cloud cloud-formatted VM disk image is based on the second target cloud configuration parameters. The system instantiates a VM in the first target cloud using the first target cloud cloud-formatted VM disk image and a VM in the second target cloud using the second target cloud cloud-formatted VM disk image.

Abstract: A beverage pod for a beverage machine is provided. The beverage pod can include a container having an internal space and a container flange defining an opening to the internal space, a plug sealing the opening of the container, and a cap secured to the container flange. A beverage medium can be located within the internal space of the container. The cap can be operable to selectively engage a portion of the plug to release the beverage medium through the plug and the cap.

Abstract: A gaming machine includes at least one sound-generating display device. The sound-generating display device is configured to not only display information such as game information, but to generate sound. In one embodiment one or more transducers are mounted to a back or rear portion of a video display and cause one or more portions of the video display, such as a front panel thereof, to move, thus generating sound. The one or more transducers are controlled to generate sound, including to generate sound which has sound which is perceived to emanate from particular areas of the video display.

Abstract: An automatic vertical farming system may include a frame defining at least one growth area and configured to support a plurality of vertical plant growth structures within the at least one growth area. The system may include at least one light, at least one liquid conduit, and at least one gas conduit. The system may include at least one robot disposed on a top side of the frame and movably supported by the frame. The at least one robot may include at least one tool configured to manipulate the plurality of vertical plant growth structures. The system may include a control system including at least one processor configured to automatically control illumination by the at least one light, liquid flow through the at least one liquid conduit, gas flow through the at least one gas conduit, and operation of the at least one robot.

Abstract: A coating of an Al—Zn—Si—Mg alloy on a steel strip that is applied by a hot dip process and is subsequently heat treated to improve the ductility of the coating.

Abstract: Systems, methods and containers for forming a beverage. A beverage container includes an enclosure arranged with a movable element that is movable to pierce a membrane and permit beverage material in the container to exit. The movable element can also be moveable to permit pressurized gas entry into the container and through the membrane. Gas can be introduced into the container to force beverage material to exit the container. A gas inlet port can be provided with the enclosure and arranged to mate with a gas source of a beverage machine.

Abstract: A valve assembly for inflatable bodies such as a recreational toy, is located in a recessed cup that is flush with the surface of the inflatable body. The cup has a central boss that has both an internal and external thread. The valve assembly is secured to the boss with the internal threads and a cap is secured to the boss with the external threads. The valve assembly provides for inflation using an air hose or a manual inflation device. The valve assembly is removable from the cup to facilitate deflation of the body after use. The cap provides sealing between the cup and valve member to inhibit loss of air.

Abstract: A server computer system determines that configuring a first virtual machine in a cloud depends on a configuration result of configuring a second virtual machine. The server computer system configures the second virtual machine in the cloud and configures the first virtual machine in the cloud using the configuration result of the second virtual machine.

Abstract: Applicant provides formulations and pharmaceutical compositions containing glucocorticoid receptor modulators (GRMs) and suitable for treating diseases including Cushing's syndrome, prostate cancer, breast cancer, and other cancers, liver diseases, depression, dementia, stress disorders, and substance abuse disorders. The GRM may be a non-steroidal GRM, and may be an octahydro azadecalin GRM. In particular, the GRM may be CORT125281, which is: ((4aR,8aS)-1-(4-fluorophenyl)-6-((2-methyl-2H-1,2,3-triazol-4-yl)sulfonyl)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone. Methods of treating diseases including Cushing's syndrome, liver diseases, cancers, and psychiatric disorders by administration of a GRM in such pharmaceutical compositions are also provided.

Abstract: In one aspect the invention provides an electromechanical device having a conductive component which is stretchable and having a conductive lead to connect the component to an electrical circuit. The conductive lead may be arranged as threaded through the component at multiple locations on the component layer to integrate the lead with the component. Aspects provide a laminated capacitor formed of elastic material with first and second elastic electrode layers. The conductive lead may comprises an inner conductor and an outer conductor arranged to cover the inner conductor. A length of exposed inner conductor is arranged threaded through the first component and an exposed length the outer conductor is arranged threaded through the second conductive component.

Abstract: A hinge has a door interface comprising a serrated surface and an oversized hole, a bolt at least partially extending into the oversized hole, and a washer disposed on the bolt and captured between the door interface and a head of the bolt, the washer comprising a serrated surface facing toward the serrated surface of the door interface. The oversized hole has a diameter selected to allow significant radial movement of the bolt within the oversized hole.

Abstract: Systems, methods and containers for forming a beverage. A container includes a closure arranged with a movable element that is movable to pierce a membrane and permit beverage material in the container to exit. The movable element can include a piercing element that pierces the membrane. Gas can be introduced into the container to force beverage material to exit the container. A gas inlet port can be provided with the closure and arranged to mate with a gas source of a beverage machine.